1,571 research outputs found
Trial of Captain Porteous,
No full text"The plot of Sir Walter Scott's 'Heart of Midlothian' turns upon the incidents of the Porteous riot."--Dict. nat. biog.Trial in 1736, in the High court of justiciary, for "murdering, slaughtering, maiming, and wounding divers of His Majestys̕ subjects." cf. p. 150.Bibliography: p. 352-366.Mode of access: Internet
Norman Porteous as I Remember Him
No full textThis paper describes the period (1960-67) the author spent working with Norman Porteous in the department of Old Testament at New College, Edinburgh. He describes this as a time when Porteous was at the peak of his reputation as the foremost scholar of Old Testament Theology in Great Britain. However, the magnum opus that he might have been expected to produce at this point never appeared, in particular because the publication of von Rad’s Old Testament Theology made him realise that, with an already crowded schedule, he would not be able to devote sufficient time to be able to engage properly with such a major departure from the established ways of working in biblical theology. The paper does however give us insights into Porteous’ thinking on the subject around this time, based on a report of his Stone Lectures and from one-to-one interaction with the author
Supporting offenders who are also victims [Blog post]
No full textIn, May 2015, the London Mayoral Office for Policing and Crime published research undertaken at Middlesex University into the development of support services for young people who have offended but have themselves been a victim of crime, abuse and violence. One of the authors of the report, Associate Professor in Criminology at Middlesex University Dr David Porteous, considers the issues raised by the study
A review of flow-induced noise from finite wall-mounted cylinders
No full textAbstract not availableRic Porteous, Danielle J. Moreau, Con J. Doola
Identification of polymorphic and off-target probe binding sites on the Illumina Infinium MethylationEPIC BeadChip
No full textGenome-wide analysis of DNA methylation has now become a relatively inexpensive technique thanks to array-based methylation profiling technologies. The recently developed Illumina Infinium MethylationEPIC BeadChip interrogates methylation at over 850,000 sites across the human genome, covering 99% of RefSeq genes. This array supersedes the widely used Infinium HumanMethylation450 BeadChip, which has permitted insights into the relationship between DNA methylation and a wide range of conditions and traits. Previous research has identified issues with certain probes on both the HumanMethylation450 BeadChip and its predecessor, the Infinium HumanMethylation27 BeadChip, which were predicted to affect array performance. These issues concerned probe-binding specificity and the presence of polymorphisms at target sites. Using in silico methods, we have identified probes on the Infinium MethylationEPIC BeadChip that are predicted to (i) measure methylation at polymorphic sites and (ii) hybridise to multiple genomic regions. We intend these resources to be used for quality control procedures when analysing data derived from this platform
Modulation of NMDA receptor surface expression by DISC1 and its pathway partners
No full textDisrupted in Schizophrenia 1 (DISC1) is a well supported risk factor for
schizophrenia, bipolar disorder and major recurrent depression. DISC1 is a
multifunctional multicompartmentalised scaffold protein with essential roles in
neuronal proliferation, differentiation, migration and integration. DISC1 also
modulates pathways of vital importance for neuronal signalling and plasticity. One of
the major hypotheses for the cause of psychiatric illness is N-methyl-D-aspartate
(NMDA) receptor hypofunction. It was observed that NMDA receptor antagonists
can induce symptoms of schizophrenia in unaffected individuals, and exacerbate
symptoms in patients with schizophrenia. Recent work in our laboratory showed that
DISC1 complexes with NMDA receptors within the cell body and at synapse of
neurons. Here I studied whether DISC1, or DISC1 missense variants, affect the
trafficking of NMDA receptors. This was done by quantifying surface NMDA
receptor expression in the presence of DISC1 or variant DISC1. I found that one
common variant, 607F, causes a significant reduction in surface expressed NMDA
receptors. I went on to show that DISC1 reduces the number of internalised receptors
associating with early RAB5-containing endosomes. This indicates that DISC1 may
be involved in the trafficking and recycling of NMDA receptors, a process that may
be affected by the missense DISC1 variant 607F. Further to this I studied the effects
on NMDA receptor trafficking of DISC1 pathway partners Nuclear Distribution
Element 1 (NDE1) and Trafficking-protein kinesin binding 1 (TRAK1), both
regulators of neuronal intracellular trafficking. Phosphorylation of NDE1 at T131 has
been shown to be modulated by DISC1. Using phospho-mimic and phospho-dead
NDE1 expression constructs I observed a significant reduction in the surface-expressed
NMDA receptors in cells expressing the phospho-mimic form of NDE1.
NDE1 may therefore be involved in the trafficking of NMDA receptors, and this role
may be modulated by phosphorylation of NDE1. Finally, TRAK1 was shown to
associate robustly with the GluN2B subunit, and to decrease the surface expression
of NMDA receptors, most likely by sequestering them. The TRAK1-induced
GluN2B sequestration may be an artefact, but the association of the trafficking
molecule TRAK1 with this subunit may point towards a role in NMDA receptor
trafficking. These proteins have been shown to associate with each other and may
form a complex in order to traffic NMDA receptors. Disruption of this complex by
defective DISC1 expression may affect NMDA receptor trafficking. In the brain this
could conceivably contribute to NMDA receptor hypofunction and the development
of psychiatric illness
Flow-induced noise of a wall-mounted finite airfoil at low-to-moderate Reynolds number
No full textAbstract not availableDanielle J.Moreau, Zebb Prime, Ric Porteous, Con J. Doolan, Vincent Valea
Is bipolar disease more common in highly intelligent people?
No full textAnecdotal and biographical reports have long suggested that bipolar disorder is more common in people with exceptional cognitive or creative ability. Epidemiological evidence for such a link is sparse. We investigated the relationship between intelligence and subsequent risk of hospitalisation for bipolar disorder in a prospective cohort study of 1?049?607 Swedish men. Intelligence was measured on conscription for military service at a mean age of 18.3 years and data on psychiatric hospital admissions over a mean follow-up period of 22.6 years was obtained from national records. Risk of hospitalisation with any form of bipolar disorder fell in a stepwise manner as intelligence increased (P for linear trend <0.0001). However, when we restricted analyses to men with no psychiatric comorbidity, there was a ‘reversed-J’ shaped association: men with the lowest intelligence had the greatest risk of being admitted with pure bipolar disorder, but risk was also elevated among men with the highest intelligence (P for quadratic trend=0.03), primarily in those with the highest verbal (P for quadratic trend=0.009) or technical ability (P for quadratic trend <0.0001). At least in men, high intelligence may indeed be a risk factor for bipolar disorder, but only in the minority of cases who have the disorder in a pure form with no psychiatric comorbidit
Directivity pattern of flow-induced noise from a wall-mounted, finite length circular cylinder
No full textSound emanating from a wall-mounted, finite length cylinder immersed in cross flow presents a significant engineering problem and is relevant to a range of applications including aircraft landing gear and automobile appendages. However, despite its frequent occurrence in industry, there exists little experimental data on the noise created by such objects. To characterise this type of flow-induced noise source, acoustic directivity measurements have been taken in an anechoic wind tunnel at the University of Adelaide for wall-mounted cylinders of circular cross section. The aspect ratio (the cylinder length to diameter ratio, L/D) and orientation of the cylinders were varied to determine the influence of these parameters on noise directivity. Furthermore, the results were compared with the radiation pattern of the two dimensional case as well as with a dipole source (of equivalent power) at the assumed origin. The experimental data give further insight into the characteristics of the sound generated from wall-mounted, finite length cylinders in cross flow.Ric Porteous, Con Doolan, Danielle Morea
The trial of Capt. John Porteous, [electronic resource] : before the High Criminal Court, or Lords of Justiciary, in Scotland.
No full textWith a final advertisement leaf.The ornaments are those used by Henry Woodfall.Price from imprint: price Sixpence.Electronic reproduction.English Short Title Catalog,Reproduction of original from British Library
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