3,223 research outputs found
Experimental Studies on the Professional Allergic Skin Reactions induced by POCI(3) Part 3. Studies on the Sensitization of Animals with POCI(3)
No full textThe author studied the sensitization of animals with POCI(3). Namely guinea pigs and rabbits percutaneously sensitized to POCI3 showed the allergic skin reaction by reinjecting POCI(3). And the results were as follows. 1) When POCI3 was injected into the skin of normal guinea pigs, the direct skin reaction was kept positive up to 1/500 of POCI(3) in 0.1cc olive oil, after 24 hours. 2) When POCI3 was injected into the skin of normal rabbits, the direct skin reaction was kept positive up to 1/1, 000 of POCI(3) in 0.2cc olive oil, after 24hours. 3) When 1/5, 0001/10, 000 of POCI(3) in 0.1cc olive oil was reinjected into the skin of intracutaneously sensitized guinea pigs, it showed the allergic skin reaction. 4) When 1/5, 0001/10, 000 of POCI(3) in 0.2cc olive oil was reinjected into the skin of rabbits actively sensitized by skin inunction, it showed the allergic skin reaction. 5) When the same quantity of POCI(3) was injected into the skin of normal animals and sensitized animals the skin reaction of sensitized animals was far more strong than that of normal animals. 6) From the above results it became clear that POCI(3) was a substance possible to sensitize animals
Synthesis of esters derived from 2,3,4-tri-O-benzyl-alpha-D-methylglucoside
No full textThe synthesis of a set of esters obtained from the D-glucose derivative by reaction with several carboxylic acids: benzoic, phenylacetic, acetylsalicylic, 2-(3-bromopropoxy)benzoic acid and 4-(toluene-4-
sulfonylamino)benzoic acid.FCT (Fundação para a Ciência e Tecnologia) and FEDER for financial support. The Bruker Avance
III 400 spectrometer is part of the National NMR network and was purchased under the framework of the National Programme for Scientific Reequipment,
contract REDE/1517/RMN/2005, with funds from POCI 2010 (FEDER) and (FCT). We are also grateful for research grant VZ MSMT-
0021627501, Czech Republic
Analisis Persepsi Dan Kepuasan Konsumen Terhadap Kualitas Produk Teh Poci
No full textBerkembangnya inovasi yang dilakukan para pesaing, membuat Teh cap Poci berusaha semaksimal mungkin agar dapat bertahan di pasar. Hal ini tidak lepas dari positioning produk tersebut pada konsumen melalui variasi rasa yang ditawarkan. Jika kepuasan konsumen telah dicapai, maka kecenderungan konsumen untuk melakukan pembelian ulang pun semakin besar dan hal ini akan berpengaruh pada kuantitas penjualan. Tujuan penelitian ini adalah untuk menganalisis persepsi konsumen terhadap produk teh Poci dan menganalisis tingkat kepuasan konsumen terhadap teh Poci. Sehingga dari dua hal tersebut, permasalahan yang ada dapat terselesaikan dan diharapkan mampu meningkatkan keuntungan perusahaan. Penelitian ini menggunakan data primer dan data sekunder. Penentuan lokasi dilakukan secara purposive. Penentuan sample menggunakan accidental sampling yang merupakan teknik pengambilan sampel secara non-probability. Jumlah sampel yang diambil adalah 70 responden dengan menggunakan pendekatan Malhorta. Metode analisis yang digunakan adalah analisis deskriptif, analisis persepsi, Importance-Peformance Analysis (IPA), dan Customer Satisfaction Index (CSI). Hasil penelitian ini menunjukkan persepsi konsumen sudah baik disemua atribut kecuali pada atribut gaya hidup (K2). Hasil analisis kesenjangan antara kinerja produk dan harapan terdapat kesenjangan sebesar -0,92 yang artinya secara keseluruhan, kinerja produk teh Cap Poci hampir memenuhi harapan konsumen. Tingkat kesesuaian menunjukkan rata-rata sebesar 78,33 yang nilai tersebut termasuk dalam kategori baik. Skala kualitas produk yang dibagi menjadi kuadaran dalam diagram kartesius, menunjukkan perusahaan harus memperhatikan atribut pada kuadaran A yaitu atribut brand image (K1) dan kandungan bahan perasa berbahaya (C2). Sedangkan pada kuadran B atribut rasa (K5), harga (H1), kepraktisan (H2), kesegaran (H3), dan kandungan bahan pengawet (C1) kinerjanya dianggap sudah memuaskan. Untuk kuadran C, meski dianggap tidak penting oleh responden namun kinerjanya perlu diperhatikan adalah atribut gaya hidup (K2), manfaat (K3), varian rasa (F1), daya simpan (T1) dan warna kemasan (D2). Dan untuk kuadran D meski responden menilai kurang penting namun kinerja atribut aroma (K4) sangat memuaskan. Berdasarkan hasil yang didapat dari perhitungan metode CSI, didapat nilai sebesar 0,82 atau bisa dibaca 82%. Hasil tersebut mengartikan bahwa produk Teh Poci masuk dalam kriteria sangat puas. Secara keseluruhan, konsumen puas terhadap kinerja atribut-atribut kualitas produk Teh Poci. Hingga saat ini produk Teh Poci yang dijual di daerah penelitian telah berhasil memuaskan konsumennya sebesar 82%
POCI CSV dataset of all the citation data
No full textThis dataset contains all the citation data (in CSV format) included in POCI, released on 27 December 2022. In particular, each line of the CSV file defines a citation, and includes the following information:
[field "oci"] the Open Citation Identifier (OCI) for the citation;
[field "citing"] the PMID of the citing entity;
[field "cited"] the PMID of the cited entity;
[field "creation"] the creation date of the citation (i.e. the publication date of the citing entity);
[field "timespan"] the time span of the citation (i.e. the interval between the publication date of the cited entity and the publication date of the citing entity);
[field "journal_sc"] it records whether the citation is a journal self-citations (i.e. the citing and the cited entities are published in the same journal);
[field "author_sc"] it records whether the citation is an author self-citation (i.e. the citing and the cited entities have at least one author in common).
This version of the dataset contains:
717,654,703 citations;
26,024,862 bibliographic resources.
The size of the zipped archive is 9.6 GB, while the size of the unzipped CSV file is 50 GB. Additional information about POCI at official webpage.</p
POCI N-Triples dataset of all the citation data
No full textThis dataset contains all the citation data (in N-Triples format) included in POCI, released on 27 December 2022. In particular, any citation in the dataset, defined as an individual of the class cito:Citation, includes the following information:
[citation IRI] the Open Citation Identifier (OCI) for the citation, defined in the final part of the URL identifying the citation (https://w3id.org/oc/index/coci/ci/[OCI]);
[property "cito:hasCitingEntity"] the citing entity identified by its PMID URL (https://pubmed.ncbi.nlm.nih.gov/[PMID]);
[property "cito:hasCitedEntity"] the cited entity identified by its PMID URL (https://pubmed.ncbi.nlm.nih.gov/[PMID]);
[property "cito:hasCitationCreationDate"] the creation date of the citation (i.e. the publication date of the citing entity);
[property "cito:hasCitationTimeSpan"] the time span of the citation (i.e. the interval between the publication date of the cited entity and the publication date of the citing entity);
[type "cito:JournalSelfCitation"] it records whether the citation is a journal self-citations (i.e. the citing and the cited entities are published in the same journal);
[type "cito:AuthorSelfCitation"] it records whether the citation is an author self-citation (i.e. the citing and the cited entities have at least one author in common).
This version of the dataset contains:
717,654,703 citations;
26,024,862 bibliographic resources.
The size of the zipped archive is 25 GB, while the size of the unzipped N-Triples file is 610 GB.
Additional information about POCI can be retrieved in the official webpage.</p
The use of a geographic information system to increase outdoor tourism
No full textThis project is being carried out within the scope of the TURNOUT
Project Development of Outdoor Tourism of Northern Portugal, POCI-01-0145-ERDF032289, financed by the European Investment Fund Regional Development (FEDER)
through the Operational Program of Competitiveness and Innovation (POCI) and the
Foundation for Science and Technology, I.P. (OE). UNIAG, R&D unit funded by the
FCT – Portuguese Foundation for the Development of Science and Technology, Ministry of Science, Technology and Higher Education; "Project Code Reference:
UIDB/04752/2020".info:eu-repo/semantics/publishedVersio
Recommended from our members
Genes driving potato tuber initiation and growth : identification based on transcriptional changes using the POCI array
No full textThe increasing amount of available expressed gene
sequence data makes whole-transcriptome analysis of certain
crop species possible. Potato currently has the second largest number of publicly available expressed sequence tag (EST) sequences among the Solanaceae. Most of these ESTs, plus other proprietary sequences, were combined and used togenerate a unigene assembly. The set of 246,182 sequences
produced 46,345 unigenes, which were used to design a 44K
60-mer oligo array (Potato Oligo Chip Initiative: POCI). In
this study, we attempt to identify genes controlling and driving the process of tuber initiation and growth by implementing large-scale transcriptional changes using the newly developed POCI array. Major gene expression profiles could be identified exhibiting differential expression at key developmental stages. These profiles were associated with functional roles in cell division and growth. A subset of genes involved in the regulation of the cell cycle, based on their Gene Ontology classification, exhibit a clear transient upregulation at tuber onset indicating increased cell division during these stages. The POCI array allows the study of potato gene expression on a much broader level than previously possible and will greatly enhance analysis of transcriptional control mechanisms in a wide range of potato research areas. POCI sequence and annotation data are publicly available through the POCI database (http://pgrc.ipk-gatersleben.de/poci)
Bioinformatic approaches for the genetic and phenotypic characterization of a Saccharomyces cerevisiae wine yeast collection
No full textThe objective of the present study was to compare genetic and phenotypic variation of 103 Saccharomyces cerevisiae strains isolated from winemaking environments. We used bioinformatics approaches to identify genetically similary strains with specific phenotypes and to estimate a strain's biotechnological potential. 
A S. cerevisiae collection, comprising 440 strains that were obtained from winemaking environments in Portugal has been constituted during the last years. All strains were genetically characterized by a set of eleven highly polymorphic microsatellites and showed unique allelic combinations. Using neural networks, a subset of 103 genetically most diverse strains was chosen for phenotypic analysis, that included growth in synthetic must media at various temperatures, utilization of carbon sources (glucose, ribose, arabinose, xylose, saccharose, galactose, rafinose, maltose, glycerol, potassium acetate and pyruvic acid), growth in ethanol containing media, evaluation of osmotic and oxidative stress resistance, H2S production and utilization of different nitrogen sources. Using supervised data mining approaches we have found that genotype represented with presence/absence of eleven microsatellites relates well with geographical location (performance evaluation using leave-out-out technique resulted in high performance scores; e.g., area under ROC curve was above 0.8 for a number of standard machine learning approaches tested). To find relations between phenotypes and genotypes, we used a two-step approach which first hierarchically clusters the strains according to their phenotype, and then tests if the resulting sub-clusters are identifiable using strain’s genetic data. Several groups of strains with similar phenotype profiles and common features in genotype were identified this way, and they are subject to further investigations. 

Financially supported by the programs POCI 2010 (FEDER/FCT, POCTI/AGR/56102/2004) and AGRO (ENOSAFE, Nº 762).

Functional Genetic Variants in ATG10 Are Associated with Acute Myeloid Leukemia
No full textThis research was funded by FEDER and Foundation for Science and Technology (FCT),
grant number POCI-01-0145-FEDER-028159 and POCI-01-0145-FEDER-030782); by Fondo de Investigaciones
Sanitarias (Madrid, Spain), grant number ISCIII-FEDER PI20/01845, ISCIII-FEDER
PI12/02688, and ISCIII-FEDER PI17/02276. B.S.M. was funded by FCT, grant number DL 57/2016.
A.C.A. was funded by FCT, grant number POCI-01-0145-FEDER-028159. C.C. was funded by FCT,
grant number CEECIND/04058/2018. A.C. was funded by FCT, grant number CEECIND/03628/2017.The data presented in this study are available on request from the
corresponding author. The data are not publicly available due to ethical reasons.Simple Summary
Acute myeloid leukemia (AML) is a hematological neoplasm with a very poor survival rate. To date, diagnostic tools to monitor individuals at higher risk of developing AML are scarce. Single nucleotide polymorphisms (SNPs) have emerged as good candidates for disease prevention. AML is characterized by altered autophagy, a vital mechanism to remove and recycle unnecessary or dysfunctional cellular components. ATG10 is one of the autophagy core genes involved in the autophagosome formation. We hypothesize that SNPs located in regulatory regions of the ATG10 gene could predispose individuals to AML development. We therefore genotyped three SNPs within the ATG10 locus. We identified the ATG10(rs3734114) as a potential risk factor for developing AML, whereas the ATG10(rs1864182) was associated with decreased risk. These findings highlight ATG10 as a key regulator of susceptibility to AML. Furthermore, we believe that ATG10 SNPs could be exploited in the clinical setting as an AML prevention strategy.
Acute myeloid leukemia (AML) is the most common acute leukemia, characterized by a heterogeneous genetic landscape contributing, among others, to the occurrence of metabolic reprogramming. Autophagy, a key player on metabolism, plays an essential role in AML. Here, we examined the association of three potentially functional genetic polymorphisms in the ATG10 gene, central for the autophagosome formation. We screened a multicenter cohort involving 309 AML patients and 356 healthy subjects for three ATG10 SNPs: rs1864182T>G, rs1864183C>T and rs3734114T>C. The functional consequences of the ATG10 SNPs in its canonical function were investigated in vitro using peripheral blood mononuclear cells from a cohort of 46 healthy individuals. Logistic regression analysis adjusted for age and gender revealed that patients carrying the ATG10(rs1864182G) allele showed a significantly decreased risk of developing AML (OR [odds ratio] = 0.58, p = 0.001), whereas patients carrying the homozygous ATG10(rs3734114C) allele had a significantly increased risk of developing AML (OR = 2.70, p = 0.004). Functional analysis showed that individuals carrying the ATG10(rs1864182G) allele had decreased autophagy when compared to homozygous major allele carriers. Our results uncover the potential of screening for ATG10 genetic variants in AML prevention strategies, in particular for subjects carrying other AML risk factors such as elderly individuals with clonal hematopoiesis of indeterminate potential.European CommissionPortuguese Foundation for Science and Technology
European Commission
POCI-01-0145-FEDER-028159
POCI-01-0145-FEDER-030782Instituto de Salud Carlos III
ISCIII-FEDER PI20/01845
ISCIII-FEDER PI12/02688
ISCIII-FEDER PI17/02276Portuguese Foundation for Science and Technology
European Commission
POCI-01-0145-FEDER-028159
DL 57/2016
CEECIND/04058/2018
CEECIND/03628/201
Fluorescence studies of new potential antitumoral indole derivatives in lipid membranes
No full textThis work was funded by FCT and FEDER through CFUM and CQ-UM, project POCI/QUI/59407/2004 and post-Doc grant (SFRH/BPD/24548/2005) of A.S.
- …
