2,601 research outputs found
Idiopathic epilepsy in dogs: owners’ perspectives on management with phenobarbitone and/or potassium bromide.
No full textFischl et al MOLECULAR-CELL-D-16-01934
No full textFigures 1-6, Supplementary data and graphical abstract for MOLECULAR-CELL-D-16-0193
James Mellor: English Convert and Handcart Pioneer - A Biography
No full textFor many years the descendants of John and James Mellor -- a large family who have made contributions to the cultural and educational activities of their various communities -- have been desirous of preserving for their posterity, and others, a record of the Mellors. Several years ago Amy Mellor Howe initiated the project by compiling and editing the first Mellor History. The foreword in her book wherein she ...hoped that the information and data herein contained may form the nucleus for further research... served as the incentive to continue the project.
It is planned to incorporate the following biography into one of the section of the book The Mellors Through the Years which this author has consented to compile and edit for the family. In this biography will be presented the highlights in the life of James Mellor: his youth and early married life in England, his sharing in the experiences of the ill-fated handcart pioneers, and his coping with the problems involved in subduing a primitive frontier in settling the Mormon community of Fayette, Sanpete County, Utah.
This study has been based on excerpts from James Mellor\u27s own diary and on the diaries of other members of his family; on old letters, documents, and other unpublished information; on newspaper clippings; on personal interviews, letters which the author has received, and available community, church, and government records. It is hoped that this evaluation will result in an objective biography of James Mellor that is as accurate as available information permits. Some previously published historical information has been inter-woven with the original diary of James Mellor in order to enhance both the interest and the authenticity of this document.
Grateful appreciation is hereby acknowledged for invaluable assistance rendered by Roy Delbert Mellor, president of the Mellor family organization; his wife, Vivian Margaret Anderson Mellor; and to Martha Wintach Bartholomew, Fayette historian, in the compilation of extensive information and illustrations used in writing this thesis. Likewise, the author wishes to express appreciation to numerous other writers whose statements have been cited in this work, and to Ronald B. Jensen, business instructor at Manti high School, for assisting with the enormous task of typing this information. The author also desires to express sincere thanks to Professor J. Lynn Mortensen, members of her graduate committee at Utah State University, for their invaluable suggestions and professional guidance given in the preparation of this thesis
The beneficial health effects of green tea amino acid l-theanine in animal models: Promises and prospects for human trials
No full textl-Theanine (l-THE) is a nonproteinogenic amino acid derived from green tea (Camellia sinensis), which exhibits strong antioxidant-like properties and contributes to the favourable umami taste sensation. Several studies have reported that the consumption of this amino acid has many therapeutic effects, including improvements in brain and gastrointestinal function, cancer drug therapeutic efficacies, antihypertensive effects, and improved immune function. Considering the recent Western commercialisation and popularity of green tea consumption as a nootropic agent in humans, the aims of this review were to consolidate the existing knowledge from ex vivo and in vitro animal models and attempt to highlight the applicability of l-THE towards the human clinical trials. Considering the anti-inflammatory and antioxidants effects of l-THE presented in the current review, further research must translate the existing knowledge gained from animal and cell models to exploring the potential metabolic health benefits and moderating effects on the pathogenesis of conditions such as obesity, arthritis, depression, and type 2 diabetes in human trials. This will bridge the gap in literature and provide more insights into the mechanisms driving pathologies characterised by the inflammatory response and oxidative stress
A stochastic space-time rainfall forecasting system for real time flow forecasting II: Application of SHETRAN and ARNO rainfall runoff models to the Brue catchment: Application of SHETRAN and ARNO rainfall runoff models to the Brue catchment
No full textKey issues involved in converting MTB ensemble forecasts of rainfall into ensemble forecasts of runoff are addressed. The physically-based distributed modelling system, SHETRAN, is parameterised for the Brue catchment, and used to assess the impact of averaging spatially variable MTB rainfall inputs on the accuracy of simulated runoff response. Averaging is found to have little impact for wet antecedent conditions and to lead to some underestimation of peak discharge under dry catchment conditions. The simpler ARNO modelling system is also parameterised for the Brue and SHETRAN and ARNO calibration and validation results are found to be similar. Ensemble forecasts of runoff generated using both SHETRAN and the simpler ARNO modelling system are compared. The ensemble is more spread out with the SHETRAN model, and a likely explanation is that the ARNO model introduces too much smoothing. Nevertheless, the forecasting performance of the simpler model could be adequate for flood warning purposes.</p
Cell membrane permeabilisation by alkylpyridinium sponge toxin preparations and their utilisation as noveltransfection reagents
No full textFc-gamma receptor polymorphisms, cetuximab therapy, and survival in the NCIC CTG CO.17 trial of colorectal cancer
No full textAbstract not availableGeoffrey Liu, Dongsheng Tu, Marcia Lewis, Dangxiao Cheng, Leslie A. Sullivan, Zhuo Chen, Eric Morgen, John Simes, Timothy J. Price, Niall C. Tebbutt, Jeremy D. Shapiro, G. Mark Jeffery, J. Daniel Mellor, Thomas Mikeska, Shakeel Virk, Lois E. Shepherd, Derek J. Jonker, Christopher J. O'Callaghan, John R. Zalcberg, Christos S. Karapetis, and Alexander Dobrovi
Risk attitudes and Medicare Part D enrollment decisions
No full textThe new Medicare Part D program provides prescription drug coverage for older Americans through highly subsidized and tightly regulated plans offered by private insurance firms. For most eligible individuals without coverage from other sources, obtaining Part D coverage would be rational, but it requires active enrollment and plan choice decisions. We investigate if non-enrollment in Medicare Part D can partly be explained by risk aversion. Data are taken from a national online survey conducted just after the introduction Part D. The survey included a context-free and a context-related hypothetical lottery to measure an individual’s attitude towards risk. Respondents who are risk tolerant according to these measures were significantly less likely to enroll in Part D. We also illustrate that hypothetical choice questions designed to elicit risk attitudes are subject to reference-point effects. Even minor differences in the priming of respondents can result in potentially misleading conclusions about the role of risk aversion in the insurance decisions
The effect of shot peening on notched low cycle fatigue
No full textThe improvement in low cycle fatigue life created by shot peening ferritic heat resistant steel was investigated in components of varying geometries based on those found in conventional power station steam turbine blades. It was found that the shape of the component did not affect the efficacy of the shot peening process, which was found to be beneficial even under the high stress amplitude three point bend loads applied. Furthermore, by varying the shot peening process parameters and considering fatigue life it has been shown that the three surface effects of shot peening; roughening, strain hardening and the generation of a compressive residual stress field must be included in remnant life models as physically separate entities. The compressive residual stress field during plane bending low cycle fatigue has been experimentally determined using X-ray diffraction at varying life fractions and found to be retained in a direction parallel to that of loading and to only relax to 80% of its original magnitude in a direction orthogonal to loading. This result, which contributes to the retention of fatigue life improvement in low cycle fatigue conditions, has been discussed in light of the specific stress distribution applied to the components. The ultimate aim of the research is to apply these results in a life assessment methodology which can be used to justify a reduction in the length of scheduled plant overhauls. This will result in significant cost savings for the generating utility
Modulation of nicotinic acetylcholine and N-methyl-D-aspartate receptors by some Hymenopteran venoms
No full textThe effect of 19 venoms from solitary wasps, solitary bees, social wasps and ants were investigated for their effects on nicotinic acetylcholine receptors (nAChR) and ionotropic glutamate receptors (IGRs) of both the N-methyl-D-aspartate (NMDAR) and non-NMDAR type. Whole-cell patch clamp of human muscle TE671 cells was used to study nAChR, and of rat cortical and cerebellar granule cells for IGRs. Solitary wasp venoms caused significant voltage-dependent antagonism of nAChR responses to 10 mu M ACh and NMDAR responses to 100 mu M NMDA (+ 10 mu m glycine) when co-applied at 1 mu g/ml with the agonists. At positive holding potentials (V(H)) potentiation of these receptors was observed with some venoms. Solitary bee venoms only affected nAChR by causing either voltage-independent antagonism or potentiation of their responses to 10 mu M ACh. Of four social wasp venoms, one acted on nAChR by potentiating responses to 10 ACh, while another generated an ACh-like response when applied alone. They had no effect on IGRs. Of the two ant venoms, one caused voltage-independent inhibition of nAChR. Neither affected IGRs. The data indicate the presence of nAChR agonists and antagonists and NMDAR antagonists in Hymenopteran venoms and warrant further investigation to separate and identify these venom components. (c) 2005 Elsevier Ltd. All rights reserved
- …
