12 research outputs found
Increased urine semaphorin-3A is associated with renal damage in hypertensive patients with chronic kidney disease: a nested case-control study
No full textLeft ventricular dilatation and subclinical renal damage in primary hypertension
No full textObjective: A new classification of left ventricular geometry based on left ventricular dilatation and concentricity has recently been developed. This classification identifies subgroups differing with regard to systemic haemodynamics, left ventricular function and cardiovascular prognosis. We investigated the relationship between the new classification of left ventricular geometry and subclinical renal damage, namely urine albumin excretion and early intrarenal vascular changes in primary hypertensive patients. Methods: A total of 449 untreated hypertensive patients were studied. Four different patterns of left ventricular hypertrophy (eccentric nondilated, eccentric dilated, concentric nondilated and concentric dilated hypertrophy) were identified by echocardiography. Albuminuria was measured as the albumin-to-creatinine ratio. Early intrarenal vascular changes, expressed as the renal volume to resistive index ratio, were evaluated by ultrasound and Doppler scan. Results: Patients with concentric dilated left ventricular hypertrophy had higher albumin excretion rates (P = 0.0258) and prevalence of microalbuminuria (P < 0.0001) and lower renal volume to resistive index ratio than patients with concentric nondilated hypertrophy (P = 0.0093). Patients with eccentric dilated hypertrophy showed a higher prevalence of microalbuminuria than patients with eccentric nondilated hypertrophy (P < 0.0001). Moreover, patients with chamber dilatation showed a higher prevalence of microalbuminuria (P = 0.0002) and lower renal volume to resistive index ratio (P = 0.0107) than patients without chamber dilatation. After adjusting for potentially confounding variables, left ventricular chamber dilatation was an independent predictor of subclinical renal damage. Conclusion: Left ventricular dilatation is associated with subclinical renal damage in hypertension. These findings extend previous reports and provide a pathophysiological rationale for the observed unfavourable prognosis in patients with left ventricular dilatation
URAT 1 INHIBITION PROTECTS HUMANS PROXIMAL TUBULE CELLS FROM APOPTOTIC DAMAGE INDUCED BY URIC ACID
No full textIndivision. Droit de demander le partage
No full textInternational audience(Cons. const. décis. 99-419 DC du 9 nov. 1999 - loi relative au pacte civil de solidarité - JO 16 nov. 1999, p. 16962 ; D. 2000.Somm.424, obs. S. Garneri ; Petites affiches, 1er déc. 1999.6, chron. J.-E. Schoettl ; Dr. fam. Le pacs, hors série, déc. 1999.46, chron. G. Drago ; JCP 2000.I.210, chron. N. Molfessis ; RD publ. 2000.203 et s., chron. Ph. Blachèr et J.-B. Seube
Serum uric acid and its relationship with metabolic syndrome and cardiovascular risk profile in patients with hypertension: Insights from the I-DEMAND study
No full textBACKGROUND AND AIMS:
The independent role of serum uric acid (SUA) as a marker of cardio-renal risk is debated. The aim of this study was to assess the relationship between SUA, metabolic syndrome (MS), and other cardiovascular (CV) risk factors in an Italian population of hypertensive patients with a high prevalence of diabetes.
METHODS AND RESULTS:
A total of 2429 patients (mean age 62 ± 11 years) among those enrolled in the I-DEMAND study were stratified on the basis of SUA gender specific quartiles. MS was defined according to the NCEP-ATP III criteria, chronic kidney disease (CKD) as an estimated GFR (CKD-Epi) <60 ml/min/1.73 m(2) or as the presence of microalbuminuria (albumin-to-creatinine ratio ≥2.5 mg/mmol in men and ≥3.5 mg/mmol in women). The prevalence of MS, CKD, and positive history for CV events was 72%, 43%, and 20%, respectively. SUA levels correlated with the presence of MS, its components, signs of renal damage and worse CV risk profile. Multivariate logistic regression analysis revealed that SUA was associated with a positive history of CV events and high Framingham risk score even after adjusting for MS and its components (OR 1.10, 95% CI 1.03-1.18; P = 0.0060; OR 1.28, 95% CI 1.15-1.42; P < 0.0001). These associations were stronger in patients without diabetes and with normal renal function.
CONCLUSIONS:
Mild hyperuricemia is a strong, independent marker of MS and high cardio-renal risk profile in hypertensive patients under specialist care. Intervention trials are needed to investigate whether the reduction of SUA levels favorably impacts outcome in patients at high CV risk
Two new species of Neoentobdella (Monogenea: Capsalidae: Entobdellinae) from the skin of Australian stingrays (Dasyatidae)
No full textTwo new species of entobdelline (capsalid) monogeneans are described from the skin of Australian dasyatid stingrays, namely Neoentobdella cribbi sp. n., a small parasite from the estuarine stingray, Dasyatis fluviorum Ogilby (Elasmobranchii: Dasyatidae) and Neoentobdella baggioi sp. n., a relatively large parasite from the porcupine ray, Urogymnus asperrimus (Bloch et Schneider) (Elasmobranchii: Dasyatidae). A striking feature of both of these new parasite species is a pad, possibly located within the genital atrium, armed with rows of closely spaced, rod-shaped microsclerites. Both species also possess a muscular papilla in the genital tract and a club-shaped structure near the common genital opening on the left lateral margin of the body. In N. cribbi, the latter feature is large and located anterior to the genital pad and in N. baggioi, it is small and located in a more posterior position. Similar embellishments in the genital area occur in N. natans Kearn et Whittington, 2005 and in N. parvitesticulata Kearn et Whittington, 2005, while other species (e.g. N. garneri Whittington et Kearn, 2009 and N. taiwanensis Whittington et Kearn, 2009) lack these features and differ also in functional aspects of the male copulatory apparatus and the haptor. Separate generic status for these two groupings is indicated, but must await a comparative and comprehensive review of all Neoentobdella spp.Ian D. Whittington and Graham C. Kearnhttp://www.paru.cas.cz/folia/detail.php?id=2113
Two new species of entobdelline skin parasites (Monogenea, Capsalidae) from the blotched fantail ray, Taeniura meyeni, in the Pacific Ocean, with comments on spermatophores and the male copulatory apparatus
No full textWe made a comparative anatomical study of entobdelline monogenean skin parasites from the blotched fantail ray, Taeniura meyeni (= T. melanospila) from public aquaria and fish-holding facilities distributed widely across the western Pacific Ocean. These facilities were located in Australia (Mooloolaba, southern Queensland; Cairns, northern Queensland), Taiwan and Japan. The capture localities of the aquarium fishes are unknown to us, with the exception of the individual fish from northern Queensland which came from Sudbury Reef, a local inshore reef. Entobdellines from southern Queensland differed morphologically from those from northern Queensland and Taiwan and the 2 new monogenean species are described and named Neoentobdella garneri sp. nov. and N. taiwanensis sp. nov., respectively. We determined that an entobdelline collected by Dyer and co-workers from a ray identified as T. melanospila (= T. meyeni) from an aquarium in Okinawa, Japan and identified by them as Entobdella squamula (Heath, 1902) Johnston, 1929 was misidentified and is tentatively assigned to N. taiwanensis sp. nov. The male copulatory organ of each new species resembles a penis, but evidence that these organs are eversible like a cirrus is presented. Caution is advised in deciding whether the male copulatory organs of capsalids may function as a penis or as a cirrus and we suggest that possession of a penis versus a cirrus may not necessarily indicate wide evolutionary divergence. In N. garneri, spermatophores consist of a sausage-shaped capsule and a long hollow stalk. A spermatophore received from a donor is anchored in the vagina by means of the stalk, with the capsule protruding outside the body
Modelo multicritério de apoio à identificação e seleção de municípios visando projetos de modernização tributária
No full textDissertação (mestrado) - Universidade Federal de Santa Catarina, Centro-Sócio Econômico. Programa de Pós-Graduação em AdministraçãoA última década representou um marco fundamental para a modernização da gestão pública brasileira, trazendo à tona inúmeros projetos de fortalecimento e desenvolvimento dos entes federativos, especialmente o nível municipal. Este trabalho foi elaborado com o objetivo de construir um modelo multicritério que sirva de apoio à identificação e seleção de municípios catarinenses visando à elaboração de projetos de modernização tributária, utilizando a Metodologia Multicritério de Apoio à Decisão - MCDA. Trata-se de uma metodologia que permite compreender melhor o contexto decisório e que considera não somente aspectos quantitativos, mas também aspectos qualitativos, que não menos importantes que os anteriores, traduzem o ambiente nebuloso que via de regra não é internalizado na seleção de projetos. Os critérios foram adaptados à realidade de um banco de desenvolvimento, com base nas opiniões de um gerente responsável pela captação de projetos dessa natureza e que pretende utilizar indicadores econômico-financeiros, assim como indicadores sócio-demográficos em suas análises. Como contextualização desta pesquisa, é feita uma breve revisão de alguns tópicos relacionados à análise de projetos, abordagens multicritério de apoio à decisão e programas e políticas públicas voltados para a administração tributária municipal. A partir de dados de domínio público desenvolveu-se o referido modelo apresentando-se os resultados através da operacionalização de seis exemplos, que indicam o perfil de cada município revelando as potencialidades existentes, necessidades de aperfeiçoamento, riscos e méritos
Forage Kochia and Russian Wildrye Potential for Rehabilitating Gardner’s Saltbush Ecosystems Degraded by Halogeton
No full textGardner's saltbush ecosystems are increasingly being invaded by halogeton (Halogeton glomeratus [M. Bieb.] C.A. Mey.), an annual halophyte that increases soil surface salinity and reduces plant biodiversity. Thus, a study was established in the Flaming Gorge National Recreation Area within the lower Green River Basin of Wyoming to evaluate the potential for rehabilitating halogeton-dominated Gardner's saltbush ecosystems with forage kochia (Bassia prostrata [L.] A.J. Scott), Russian wildrye (Psathyrostachys juncea [Fisch.] Nevski), tall wheatgrass (Thinopyrum ponticum [Podp.] Z.-W. Liu & R.-C. Wang), Indian ricegrass (Achnatherum hymenoides [Roem. & Schult.] Barkworth), and Gardner's saltbush (Atriplex garneri [Moq.] D. Dietr.). A seeding evaluation, with and without prior disking, was conducted to determine ability of these species to establish. A transplant evaluation determined the effect of established plants on halogeton frequency at four 10-cm intervals (10-20, 20-30, 30-40, and 40-50 cm) distal from transplants. Gardner's saltbush, tall wheatgrass, and Indian ricegrass did not establish in the seeded study or persist beyond the first year in transplant study. In contrast, Russian wildrye and forage kochia established and persisted, with Russian wildrye establishment higher (P=0.05) in the disked treatment compared with no-till (4.5 and 1.7 plants m-2, respectively) and no-till favoring (P = 0.05) forage kochia establishment (2.3 and 0.8 plantsm-2, respectively). Transplants of these two species reduced halogeton frequency by 52% relative to the control. Moreover, this interference of halogeton establishment by Russian wildrye and forage kochia had extended to 50 cm distal from transplant by the second year of the study. By the third year (2014), transplant survival and halogeton frequency were highly correlated (r = -0.61, P = 0.0001), indicating the importance of plant persistence. Results indicate that Russian wildrye and forage kochia can establish and reduce halogeton frequency, thereby providing an opportunity for rehabilitation of halogeton-invaded areas. © Published by Elsevier Inc. on behalf of The Society for Range Management.The Rangeland Ecology & Management archives are made available by the Society for Range Management and the University of Arizona Libraries. Contact [email protected] for further information
Epitomē, Sev Brachylogia loimōdēs Desvmpta Ex Magno Libro Georgii Garneri, Philosophiæ & Medicinæ Doctoris, De Peste, quæ grassata est Venetijs An[n]o D[omi]ni 1576 & Bruntruti, Anno D[omi]ni 1582. Et Iisce Pericvlosis Temporibvs Diligenter Revisa Atqve multis egregijs maximeque probatis remedijs locupletata, & ad totius Reipub. Christianæ vtilitatem promulgata atq[ue] excusa
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