102 research outputs found

    Genetic polymorphisms of the SHBG gene can be the effect on SHBG and HDL-cholesterol levels in Coronary Heart Disease: a case-control study

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    Akadam Teker, Aysegul Basak/0000-0003-3618-0560WOS: 000478684300060PubMed: 31111369Sex hormone binding globulin (SHBG) level is positively associated with the high-density lipoprotein cholesterol (HDL-C) levels. The aim of this study was to investigate the effects of the SHBG gene variations (D356N, rs1799941, and P156L) on SHBG and HDL-C levels and Coronary Heart Disease (CHD) risk. The SHBG D356N (rs6259,G>A), P156L (rs6258,C>T), and rs1799941(G>A) polymorphisms were determined in 131 male CHD patients and 55 male controls by PCR-RFLP and real-time PCR techniques. SHGB levels were measured by Electro-chemiluminescence immunoassay (ECLIA). In the patients who had SHBG levels lower than threshold 35nmol/l value, the risk of being HDL-C levels lower than threshold 0.90mmol/l value was observed statistically significant (p=0.017; OR 2.522, 95% CI 1.170-5.438). The rs1799941 GG was associated with increased CHD risk when compared with the A allele carriers (GA+AA) (p=0.019, OR 2.222, 95% CI 1.130-4.371). In addition, the rs1799941 GG genotype and D356NN allele were associated with lower SHBG in the CHD group (p<0.01). The logistic regression analysis also revealed the rs1799941 GG genotype was significantly associated with low SHBG in CHD patients. It was observed that Haplotype-1(rs1799941 G allele-P156L P allele-D356N D allele) was associated with increased CHD risk, while Haplotype-2 (rs1799941 rare A allele-P156L C allele- D356N G allele) was correlated with the decreased CHD risk (p=0.0167). Our findings suggest that there is a positive correlation between SHBG and HDL-C levels in CHD patients, and this association might be affected by SHBG gene variations.Research Fund of Istanbul UniversityIstanbul University [12104]The present work was supported by the Research Fund of Istanbul University. Project No. 12104. The authors would like to thank Professor Oguz Ozturk and Associate Professor Ozlem Kucukhuseyin for their statistical contribution and valuable comments and suggestions, which were helpful in improving the paper

    Ergonomics risk analysis in automobile cable manufacturing

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    Bu çalışma, 04-05, Haziran 2015 tarihlerinde İstanbul[Türkiye]’de düzenlenen Global Business Research Congress (GBRC) Kongresi‘nde bildiri olarak sunulmuştur.Musculoskeletal diseases are one of the most important issues among occupationFal health illnesses because the workforce, not only developing but also developed countries are affected and burdens social security systems with high financial costs, further decreases qualified emloyees. This study analysis the musculoskeletal diseases in a cable manufacturing facility and provides new applications to eliminate physical risk factos. Based on video records, Quick Exposure Check (QEC) are made for ergonomic risk analysis and required arrangements are suggested for the related departments. Then, results are assesed in terms of efficiency. Finally, it was seen that ergonomics analysis have decreased musculoskeletal disease risks

    Ergonomic analysis of working postures that cause strain on workers that work in hand placement business of transporting containers

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    Bu çalışma, 04-05, Hazziran 2015 tarihlerinde Istanbul[Türkiye]’de düzenlenen Global Business Research Congress (GBRC) Kongresi‘nde bildiri olarak sunulmuştur.Due to increased competition in the globalized world, technological innovations and higher production rates have become very important for businesses. Despite advances and innovations in technology, the employees who work in countries which have developed industry resulting musculoskeletal disorders causes serious economic losses, it has been shown to affect the entire community rather than individuals in it. Reducing the fatigue and stress consists physical overloading on human provides significant contributions on productivity and labor costs. To be understanding of this situation emerges the i mportance of working stance. Today has started to benefit from t he ergonomic analysis for the elimination of all actions and activities that do not contribute to production. Poor posture is observed during the some works such as hand placement business of transporting containers. For study of analysis, these works are selected and the methods of REBA and BAUA are benefited to investigate the posture of employees during work. BAUA analysis method cares about all body posture, carried load and time of carrying but REBA analysis method considers also the score of stance of upper limb. In this study, REBA and BAUA ergonomic analysis methods are evaluated by comparing to learn what the results are in a predetermined proces

    The evelotion of lifting and moving with vacuming systems effects on public health

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    Bu çalışma, 04-05, Haziran 2015 tarihlerinde İstanbul[Türkiye]’de düzenlenen Global Business Research Congress (GBRC) Kongresi‘nde bildiri olarak sunulmuştur.Workers are applying momentum and power which different duration and time in their working area. There are differences between workers, cause ofsex, a ge, health s tatus, e xperience, disabling. Also s ettling of w orks effects the l imits of p ower a nd m omentum w hich applied. There are a lot of different accounting method which obtained reserch and experience to determine power and momentum applied by workers. In this study it was analaysed weight on workers who works in lift and movement job with vacuming systems. Rubber goods between 9 and 25 kg weight were moved from container to conveyor in this study. 150 pcs rubber good which is different weight and size has moved every day by a worker who employed on this job. Analaysis by REBA method and ergonomic risk evalaution has done depend on Assessment Methods of Occupational Safety and Occupational Medicine Institutions of Germany. By the studies has contributed to reducing the disease ofmusculoskeletal system in the health management

    Comparing the Effectiveness of SPSS and EduG using Different Designs for Generalizability Theory

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    Generalizability theory (G theory) provides a broad conceptual framework for social sciences such as psychology and education, and a comprehensive construct for numerous measurement events by using analysis of variance, a strong statistical method. G theory, as an extension of both classical test theory and analysis of variance, is a model which can deal with multiple sources of error. In conducting the analysis of the G theory, there are several software programs that can be used such as GENOVA, SPSS, SAS, EduG, and G-String. In this study, the general perspectives of G theory are first explained broadly. Then, the SPSS and EduG software programs are used to conduct generalizability analyses on the data obtained from the answers of 30 students (p) to nine open-ended questions (i) as rated by three raters (r). There are three different designs in the study. Two of them are random effects designs, pxixr and pxi:r, and the last one is pxixr design using a fixed rater. According to the findings from the study, SPSS and EduG give the same results for variance component estimates as well as for G (Generalizability) and D (Decision) studies of all designs, as expected. Besides comparing the program outputs, their weaknesses and strengths were also discussed regarding different designs and data sets in this study

    Open heart surgery in a patient with liver transplantation: A case report

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    Karaciğer nakli olan hasta sayısı arttıkça, geç dönemde gelişen kalp ve diğer sistem patolojileri Damar Cerrahisi Kliniği, Florya, İstanbul, nedeniyle cerrahi uygulamaları da sıklaşmıştır. Karaciğer nakli olan hastalarda koroner arter hastalığının görülme oranı artmaktadır. Karaciğer transplantı hastaları, asemptomatik olsa bile, koroner arter hastalığı için yüksek risk alt grubudur. Karaciğer transplantı gerçekleştirilen bir Turkey. hastada koroner arter hastalığı gelişmesi, kötü bir prognostik faktördür; Bu nedenle, risk altındaki kişilerin belirlenmesi klinik önceliğe sahip olmalıdır. Bu çalışmamızda, on iki yıl önce karaciğer nakli uygulanan 68 yaşındaki bir erkek hastaya iskemik kalp hastalığı tanısı ile kardiopulmoner Çıkar Çatışması: Yazarlar çıkar çatışması.As the number of patients with liver transplantation increased, surgical applications were also frequent due to late-onset heart and other systemic pathologies. The incidence of coronary artery disease is increasing in patients with liver transplantation. Liver transplanted patients are a high risk subgroup for coronary artery disease, even if they are asymptomatic. Coronary artery disease is a predictor of poor outcomes in patients with liver transplantation; therefore, identiŞcation of those Sorumlu yazar / Corresponding author patients at risk for coronary artery disease should be a key clinical priority. In this study, it was Melike Elif Teker aimed to present coronary artery bypass grafting surgery in a 68-year-old male patient with previous ve Damar Cerrahisi Hastanesi, Eski Londra Asfaltı liver transplantation 12 years ago. Coronary artery bypass grafting operation was performed using left internal mammarian artery and autogenous vein graft for three vessels. There was no complication in the pre- and post-operative periods. Coronary artery bypass grafting operation can be performed safely for patients with previous liver transplantaion in experienced centers

    FEMALE GENDER AND ENTREPRENEURSHIP

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    Global Business Research Congress (GBRC) -- MAY 26-27, 2016 -- Istanbul, TURKEYThe increasing number of women entrepreneurs is an important indicator of development socially. This study will examine the effects of having a female gender to the entrepreneurship. The databases in the social sciences and health sciences scanned, the results of research has compiled. Women live some problems because of being a woman in the entrepreneurial process. Some problems such as role conflict, insecurity, sexual expectations, experiences failure, the lack of information society that values and pressure on women, expectations of failure, difficulty in finding partners, housework and child care, blocking competitors, legal and bureaucratic obstacles, the difficulty of finding capital, prevent the entry of women into working life. Contributing to the economy in order to improve both social and economic development of our country to increase the number of women entrepreneurs, to that provided at the obstacles they face because they are women, and women are required to eliminate the difficulties

    THE IMPORTANCE OF PERSONALITY STRUCTURE WITHIN AN ORGANIZATION

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    Global Business Research Congress (GBRC) -- MAY 26-27, 2016 -- Istanbul, TURKEYPurpose: In this article, it is aimed to debate the importance of personality structure within organization and to evaluate its results. Method: For this article, in international and national databases were reviewed. Findings: The harmony between the work to be done and the individual's personality is an important subject which needs a focus in terms of people and organizations. In the situation of unability to select appropriate individual to the work, the additional costs stem from the re-recruitment process, the time spent for adjustment process of new employee and the negative results of occupational-work accidents cause extra costs for organization. Furthermore there are different personality types. A type personalities are aggressive, impatient and business-oriented even B type personalities are experiences less conflict with other individuals and time and also they are more stable. Discussion: It is supported with scientific researches that there is a significant relationship between personality characteristics of employees and organizational variables such as job satisfaction, leadership, conflict management styles. Result: In order to create a positive atmosphere within the organization to employees, the regular training programs such as communication, dealing with stress, self-knowledge, and personality features are very important for the welfare of the organization

    Airport Slot Coordination System: an Implementation At Ataturk Airport

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    Global Business Research Congress (GBRC) -- MAY 26-27, 2016 -- Istanbul, TURKEYWOS: 000460870800011To realize the airline service process, an airline has to have numbers of services in different level such as ground handling, passenger/cargo terminal service, airport navigation service, customs service, security service etc. Because of the concept of the service, producing and consuming take place at the same time. Therefore, airport capacity should be planned, monitored and managed in advance by assigning time, park position and boarding/unloading process. Airport capacity is detected with the assessment of construction of facilities and other factors affecting the capacity. This acquired capacity is allocated to the demanders according to specific conditions and privileges. In the first stage of this paper, the theoretical research of airport slot coordination system has been examined. In the second part, with the data acquired by study in practice airport coordination, slot, slot types, slot allocation and slot allocation types has been stated with tables. In the final part of the study, the categorization of slot allocation has been discussed and evaluated by employees working at both airport and airline business by means of semi-structured interview. With analyzing the obtained results, the slot coordination system used in Ataturk Airport has been identified and on the purpose of improvement of system some recommendations have been made
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