1,436 research outputs found
The press reception of Austrian works of Vergangenheitsbewältigung
No full textThis thesis explores the relationship between literature and historical memory in Austria through five case studies of literary press reception, examining the validity of common conceptions of Austrian Vergangenheitsbewättigung. The introduction provides an overview and explanation of the historico-political context of the thesis, considering cultural narratives on Vergangenheitsbewaltigung, the position of the Austrian press and its relationship with contemporary, socially critical literature. Chapters One and Two compare 'the press reception of Hans Lebert'ร Die Wolfshaut and Gerhard Fritsch's Fasching to the widely held view of a failed Vergangenheitsbewältigung in 1960ร Austria. Chapter Three considers the reception of Elfriede Jelinek's Die Ausgesperrten in the context of the Sozialpartnerschaft and the politics of memory associated with this period of forced political harmony. Chapter Four deals with the most extreme case, Thomas Bemhard's Heldenplatz, questioning the common assumption that the late 1980s marked a turning point in Austria's troubled relationship with its past. This is developed in Chapter Five, which examines the reception of Robert Schindel’s Gebürtig and considers the extent to which Austrian Vergangenheitsbewältigung can be viewed as a completed process. In the Conclusion the findings of the previous five chapters are brought together and compared with the grand cultural narrative on Austrian historical memory in a consideration of the validity of a linear conceptualisation of Vergangenheitsbewältigung
A nutraceutical approach (Armolipid Plus) to reduce total and LDL cholesterol in individuals with mild to moderate dyslipidemia: Review of the clinical evidence
No full textCompelling evidence supports the effectiveness of the reduction of total and LDL cholesterol (TC and LDL-C) in primarily preventing cardiovascular events, within the framework of life-long prevention programs mainly consisting in lifestyle changes. Pharmacological treatment should be introduced when lifestyle changes, including use of nutraceuticals, have failed. ESC/EAS guidelines list a number of nutraceutical compounds and functional foods which have been individually studied in randomized, controlled clinical trials (RCTs). To date only a proprietary formulation of three naturally occurring substances with putative complementary lipid-lowering properties − red yeast rice, policosanol and berberine – combined with folic acid, astaxanthin, and coenzyme Q10 (Armolipid Plus®) has been extensively investigated in several RCTs, 7 of which were placebo-controlled, 2 were ezetimibe comparators and 4 were “real life” studies comparing diet and Armolipid Plus to diet alone. The trials included mostly patients with mild to moderate dyslipidemia, treated for 6–48 weeks. The trials also included special populations and patients in whom statins were contraindicated or who could not tolerate them. Armolipid Plus has proved to be able to achieve significant reductions in TC (11–21%) and in LDL-C (15–31%) levels, which is equivalent to expectations from low dose statins. In patients intolerant to statins, who do not achieve their therapeutic target with ezetimibe, Armolipid Plus can achieve a further 10% improvement in TC and LDL-C. The safety and tolerability of Armolipid Plus were excellent, thought likely due to the intentional combination of low doses of its active ingredients: low enough not to be associated with untoward effects, but high enough to exert therapeutic effects in combination with other complementary substances. Consequently, in the event of intolerance to statins, Armolipid Plus offers an effective alternative, which is devoid of the safety risks associated with synthetic pharmacological therapy. In conclusion Armolipid Plus, in addition to dietary measures, could be a rational choice for individuals with mild to moderate hyperlipidemia and for all dyslipidemic patients in whom statins are not indicated or who cannot tolerate them
Management of dyslipidaemia in patients with comorbidities-facing the challenge
No full textThis review aims to examine the evidence on the benefits and risks of lipid-lowering drugs in patients with liver disease. Elevated liver enzyme levels often lead to cautious discontinuation of these drugs, potentially withholding from patients their benefit in reducing cardiovascular disease morbidity and mortality. Using a literature search of PubMed, we examine the efficacy and safety profiles of various lipid-lowering agents, including statins, ezetimibe, bempedoic acid, PCSK9 inhibitors, fibrates, and icosapent ethyl, focusing particularly on their potential side effects related to liver health. A major challenge in the assessment of drug-induced hepatotoxicity is the fact that it relies heavily on case reports rather than real-world evidence. There is currently a lack of robust evidence on lipid-lowering therapy in people with pre-existing liver disease. Nevertheless, we have attempted to summarize the available data for all the drugs mentioned in order to provide guidance for the treatment of patients with liver dysfunction. This review highlights the need for further research to optimize treatment strategies for patients with coexisting liver and cardiovascular disease
'Shadowy Copies'? Film Adaptations of the Second Austrian Republic
No full textFor many years adaptation has been passed between literature and film studies, frequently dismissed as ‘shadowy copies’ and parasitic reproductions, the unwanted bastard child of the disciplines searching in vain for an academic home. Despite the emergence of insightful new scholarship into the development of Austrian film in the twentieth century, the role of the adaptation genre within Austria’s film industry and literary landscape remains an academic blind spot. This study aims to address this gap in critical knowledge, reviewing the potential function of filmic adaptations within the field of Austrian studies. Through five case studies of canonical works of post-war Austrian literature, this thesis sets out to establish adaptation both as a critical tool through which to approach literature and as an object of academic interest in its own right. Drawing on psychoanalytic theory and its application in film studies, these studies compare and contrast the position occupied by the film’s implied spectator with the relationship of the implied reader to the literary text. Rereading the novels retrospectively in light of their adaptations, this approach has the ability to ‘light up dark corners’ of the novels, illuminating those aspects hitherto left in the shadows by literary criticism. It will be argued that adaptation is uniquely positioned to hold up a mirror to literary texts, reflecting their concerns not through the filters of established grand narratives and generic taxonomies but through their creative, cinematic reworking of the novels. In challenging those assumptions that have become commonplace within Austrian literary history, this study calls for a more nuanced approach to literature of the Second Republic and proposes adaptation as the means by which this may be achieved
Abstract P3-15-01: The effect of participation in RCT on outcomes in patients with early breast cancer compared to the general breast cancer population
No full textAbstract
Background: Breast cancer trial enrollment, while slightly higher than some other histologies, still remains low, at less than 4%. Research suggests lack of clinical trial participation is due to poor patient and clinician commitment and interest. Increasing incentive for trial participation may enhance engagement of patients and healthcare providers leading to increased patient enrollment. One incentive would be to understand benefits of trial participation with regards to better survival and outcomes. The purpose of this study is to determine differences in survival, overall and breast cancer specific, and surgical management, for women who participate in early breast cancer randomized clinical trials (RCT) compared to the general breast cancer population who received similar standard therapy outside of a RCT.
Methods: Patients included in this retrospective analysis were from one of three (3) international, randomize, adjuvant breast cancer trials (RCT-participants) and women with breast cancer from the general U.S. population, from Surveillance Epidemiology and End Results Program (SEER-13), the controls. Women diagnosed between 1997-2004 with invasive breast cancer, tumor (T) size 1-3, lymph node (LN) positive (LN1/2), hormone receptor positive or negative, HER2 positive or negative, treated with surgery, adjuvant radiation, and chemotherapy were included in the analysis. In this study, propensity score analysis (PSA) was done to provide weight to each data point for each variable in order to more closely represent similar populations. PSA, considered superior to a standard Cox multivariate analysis as it attempts to reduce the bias due to confounding or correlated predictive variables. Subsequently, the propensity score was applied to a Cox proportional hazards model to determine hazard ratios (HR), with a Wald 95% confidence interval (CI), of trial participation on survival. Similarly, PSA was done for surgical outcomes. A multivariate logistic regression was performed to calculate the odds ratios, with a Wald 95% CI, to determine if RCT participation compared to the SEER-13 control had an impact on surgical outcomes, mastectomy versus breast conserving surgery (BCS).
Results: The total sample size was 9255 patients, 1795 RCT-participants and 7460 SEER-13 controls. After controlling for all other significant predictors of survival, RCT participation significantly reduced risk of breast cancer related death at 5-years by more than 25% and 18% at 10 years [HR: 0.75 (95% CI: 0.64-0.87); p=0.00020; and HR: 0.83 (95% CI: 0.74-0.93); p=0.00165, respectively]. Additionally, we demonstrated a significant reduction in risk of all-cause mortality for RCT-participants, at both 5-years and 10-years [HR: 0.83 (95% CI: 0.72--0.95); p=0.009; and HR: 0.79 (95% CI: 0.71-0.87); p<0.00001, respectively]. Additionally, RCT-participants were significantly less likely to undergo invasive surgical management (mastectomy) compared to SEER-13 controls [OR: 0.78 (95% CI: 0.66-0.92;) p=0.03].
Conclusion: RCT-participants have a reduced risk of death at 5 years and 10 years compared to the general breast cancer population. Additionally, RCT-participants are less likely to undergo mastectomy than the SEER-13 controls.
Citation Format: Brennan MB, Wiley D, Wang D, Wang X, Fasching P. The effect of participation in RCT on outcomes in patients with early breast cancer compared to the general breast cancer population [abstract]. In: Proceedings of the 2017 San Antonio Breast Cancer Symposium; 2017 Dec 5-9; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2018;78(4 Suppl):Abstract nr P3-15-01.</jats:p
Maszkos alakoskodások - térképeken : a néprajzi kartográfia alkalmazása népszokások szinkronikus elemzésében
No full textParallel zu den Arbeiten am „Ungarischen Ethnographischen Atlas" wurde in den 60er und 70er Jahren des 20. Jahrhunderts der erste regionale ethnographische Atlas Ungarns, der „Ethnographische Atlas des Komitates Szolnok" (ung. Szolnok Megye Néprajzi Atlasza; ung Abkürzung: SZMNA) fertiggestellt. Erschienen ist aber bisher nur der erste Band, in dem die materielle Kultur bearbeitet, kommentiert und kartographiert wurde. Im vorliegenden Aufsatz werden aus dem im Manuskript seit 1976/77 fertig vorliegenden zweiten Band die Bearbeitung und die kartographische Darstellung der Maskentypen (Fragenkreis Nr. 97) veröffentlicht. Fragebogen 97: Maskentypen I. Die Fragen richten sich auf Maskentypen, die mit Festen im Jahreskreis (Fasching), wichtigen Ereignissen des menschlichcn Zusammenlebens (Hochzeit) und mit bestimmten gemeinschaftlichen Arbeiten (Schlachtfest. Weinlese) verbunden sind. II. 1. Gelegenheiten, bei denen Masken getragen wurden 2.a. Bezeichnung des Maskenumzuges bei Schlachtfesten 2.b. Maskentypen bei Schlachtfesten 2 c. Die Teilnehmer des Maskenumzuges bei Schlachtfesten nach Altersgruppen (Erwachsene, Jugendliche) 2.d. Besuchsziele der Maskenumzüge (Bekannte, Verwandte, Fremte) 2.e. Feste Texte 2. f. Der Ablauf des Maskenzuges 2.g. Gabensammlung 3.a. Bezeichnung und Bekleidung der Teilnehmer der Maskenumzüge bei Hochzeiten 3.b. Zeitpunkt der Maskenumzüge bei Hochzeiten 3.c. Die Teilnehmer der Maskenumzüge bei Hochzeiten 4.a. Ort der Maskenumzüge im Fasching (Festlichkeiten, Spinnstube, Strassenumzug) 4.b. Maskenkostüme im Fasching 4.c. Bezeichnung der verkleideten Personen 5.a. Die Verbreitung der Winzerfeste 5.b. Bezeichnung der Personen in Kostüm und Maske beim Winzerfest 6. Tiermasken III. Unter diesem Punkt werden - entsprechend der obigen Einteilung - die kartographisch nicht erfassbaren Angaben aufgeführt
Inklusion, Bildung und Übergang
No full texthttp://www.pedocs.de/frontdoor.php?source_opus=14816&la=d
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