1,433 research outputs found
2000 Commencement Address: G. Timothy Johnson, M.D.
No full textTimothy Johnson, M.D., medical editor for ABC News will deliver the principal address and receive an honorary degree at the 154th commencement exercises at the College of the Holy Cross on Friday, May 26, beginning at 10:30 a.m. at Fitton Field.
Johnson, one of the nation’s leading medical communicators of health care information, has provided commentary on medical problems and answers for viewers since 1975. In addition to commentary on Good Morning America, Johnson provides on-air analysis of medical news for World News Tonight, Nightline and 20/20. He consults with ABC News regardingcoverage of medical news. He is also medical editor for WCVB-TV, Channel 5 in Boston.
Johnson holds joint positions in medicine at Harvard University and Massachusetts General Hospital in Boston. He is the founding editor of the Harvard Medical School Health Letter and co-editor of the Harvard Medical School Health Letter Book. He is also coeditor of the book, “Your Good Health,” published by Harvard Press, as well as co-author with former US Surgeon General Dr. C. Everett Koop of the book, “Let’s Talk,” published by Zondervan in 1992.
He originally intended to join the ministry and graduated from the North Park Seminary in 1963. Two years later he decided to enter medicine. Johnson, who is a Phi Beta Kappa graduate of Augustana College, graduated summa cum laude from Albany Medical College and holds a master’s degree in public health from Harvard University. Johnson served as an assisting minister at the Community Covenant Church in West Peabody, Mass.https://crossworks.holycross.edu/commence_address/1012/thumbnail.jp
MARQUIS: A multiplex method for absolute quantification of peptides and posttranslational modifications
No full textAbsolute quantification of protein expression and posttranslational modifications by mass spectrometry has been challenging due to a variety of factors, including the potentially large dynamic range of phosphorylation response. To address these issues, we have developed MARQUIS—Multiplex Absolute Regressed Quantification with Internal Standards—a novel mass spectrometry-based approach using a combination of isobaric tags and heavy-labelled standard peptides, to construct internal standard curves for peptides derived from key nodes in signal transduction networks. We applied MARQUIS to quantify phosphorylation dynamics within the EGFR network at multiple time points following stimulation with several ligands, enabling a quantitative comparison of EGFR phosphorylation sites and demonstrating that receptor phosphorylation is qualitatively similar but quantitatively distinct for each EGFR ligand tested. MARQUIS was also applied to quantify the effect of EGFR kinase inhibition on glioblastoma patient-derived xenografts. MARQUIS is a versatile method, broadly applicable and extendable to multiple mass spectrometric platforms.United States-Israel Binational Science FoundationNational Institutes of Health (U.S.) (Grant U54 CA112967)National Institutes of Health (U.S.) (Grant R01 CA118705)National Institutes of Health (U.S.) (Grant R01 CA096504)Mayo Brain Tumor SPORE CA10896
Evaluating Research Impact through Open Access to Scholarly Communication
No full textScientific research is a competitive business – in order to secure funding, promotion and tenure researchers must demonstrate their work has impact in their field. To maximise impact researchers undertake high priority research, aim to get results first, and publish in the highest impact journals. The Internet now presents a new opportunity to the scholarly author seeking higher impact: s/he can now make their work instantly accessible on the Web through author self-archiving. This growing body of open access literature (coupled with new publishing models that make journals available for-free to the reader) maximises research impact by maximising the number of people who can read it, and making it available sooner. Open access also provides a new opportunity for bibliometric research. This thesis describes the relatively recent phenomenon of open access to research literature, tools that were built to collect and analyse that literature, and the results of analyses of the effect of open access and its effect on author behaviour. It shows that articles self-archived by authors receive between 50-250% more citations, that rapid pre-printing on the Web has dramatically reduced the peak citation rate from over a year to virtually instant and how citation-impact – now widely used for evaluation – can be expanded to include a new web metric of download impact
Book Review: Sun Tzu in Space: What International Relations, History, and Science Fiction Teach Us About Our Future
No full textAuthor: Gregory D. Miller
Reviewed by: Lieutenant Colonel Timothy S. Martin, director, Defense Strategy Course, US Army War College, and Captain Stephanie St. Louis, strategic planner, Office of the Chief of Army Reserve, Fort Belvoir
Sun Tzu in Space combines an examination of history and science fiction to assess what humanity’s future in space could look like through an international relations lens. The reviewer sees it as “a pulse check on the potential for violent future conflicts” and recommends it for policymakers and science fiction enthusiasts alike.
©2025 Timothy G. Martin and Stephanie St. Louishttps://press.armywarcollege.edu/parameters_bookshelf/1108/thumbnail.jp
Analysis of watersheds and river systems: short course
No full textShort course: Analysis of Watersheds and River Systems, Session I and II, held on May 28-June 1, 1979 and June 4-June 8, 1979 at Colorado State University, Fort Collins, Colorado.Speakers: Dr. E. V. Richardson, Dr. David Duttweiller, Mr. Lee Mulkey, Dr. Stanley A. Schumm, Dr. Daryl B. Simons, Dr. Ross Carder.Includes bibliographical references.This short course is designed for individuals dealing with the analysis of watersheds and rivers. Practical applications concerning physical processes will be emphasized.Chapter 1. General introduction / Daryl B. Simons and Ruh-Ming Li -- Chapter 2. Introduction to watershed and river analysis / Daryl B. Simons and Ruh-Ming Li -- Chapter 3. Physical processes governing response of watersheds and rivers / Daryl B. Simons, Timothy J. Ward and Ruh-Ming Li -- Chapter 4. Sediment transport / H. W. Shen -- Chapter 5. Alluvial bed roughness / H. W. Shen -- Chapter 6. Overview of flood routing methods / Ruh-Ming Li and V. Miguel Ponce -- Chapter 7. Water routing and yield from watersheds, Part I and II / Ruh-Ming Li, Daryl B. Simons, and Kenneth G. Eggert -- Chapter 8. Water routing in rivers / Yung-Hai Chen -- Chapter 9. Stage discharge relations / Robert K. Simons, Ruh-Ming Li, and Daryl B. Simons -- Chapter 10. Watershed sediment yield / Ruh-Ming Li, Daryl B. Simons, and Timothy J. Ward -- Chapter 11. Unsteady sediment routing models in rivers / Yung-Hai Chen and Daryl B. Simons -- Chapter 12. Known discharge sediment routing / Glenn O. Brown and Ruh-Ming Li -- Chapter 13. Landslide potential delineation / Timothy J. Ward, Ruh-Ming Li, and Daryl B. Simons -- Chapter 14. Application of Kalman filtering in watershed and river analysis / Nguyen Duong -- Chapter 15. Handheld calculator programs for analysis / Kenneth G. Eggert, Ruh-Ming Li, and Daryl B. Simons -- Chapter 16. Overview of case studies and data management / Daryl B. Simons, Ruh-Ming Li, and Nguyen Duong -- Chapter 17. Canal and channel design and river response analysis / Daryl B. Simons, Ruh-Ming Li, and Yung-Hai Chen -- Chapter 18. Degradation and aggradation analysis / Ruh-Ming Li and Daryl B. Simons -- Chapter 19. Watershed best management analysis / Ruh-Ming Li, Timothy J. Ward, and Daryl B. Simons -- Chapter 20. Large river basin analysis: Yazoo River Sedimentation Study / Daryl B. Simons and Ruh-Ming Li
Computer aided manual validation of mass spectrometry-based proteomic data
No full textAdvances in mass spectrometry-based proteomic technologies have increased the speed of analysis and the depth provided by a single analysis. Computational tools to evaluate the accuracy of peptide identifications from these high-throughput analyses have not kept pace with technological advances; currently the most common quality evaluation methods are based on statistical analysis of the likelihood of false positive identifications in large-scale data sets. While helpful, these calculations do not consider the accuracy of each identification, thus creating a precarious situation for biologists relying on the data to inform experimental design. Manual validation is the gold standard approach to confirm accuracy of database identifications, but is extremely time-intensive. To palliate the increasing time required to manually validate large proteomic datasets, we provide computer aided manual validation software (CAMV) to expedite the process. Relevant spectra are collected, catalogued, and pre-labeled, allowing users to efficiently judge the quality of each identification and summarize applicable quantitative information. CAMV significantly reduces the burden associated with manual validation and will hopefully encourage broader adoption of manual validation in mass spectrometry-based proteomics.National Institutes of Health (U.S.) (Grant R24DK090963)National Institutes of Health (U.S.) (Grant U54CA112967)National Cancer Institute (U.S.). Integrative Cancer Biology Program (Fellowship)Charles S. Krakauer FellowshipHugh Hampton Young Fellowshi
Increasing Distributed Generation Penetration using Soft Normally-Open Points
No full textThis paper considers the effects of various voltage control solutions on facilitating an increase in allowable levels of distributed generation installation before voltage violations occur. In particular, the voltage control solution that is focused on is the implementation of `soft' normally-open points (SNOPs), a term which refers to power electronic devices installed in place of a normally-open point in a medium-voltage distribution network which allows for control of real and reactive power flows between each end point of its installation sites. While other benefits of SNOP installation are discussed, the intent of this paper is to determine whether SNOPs are a viable alternative to other voltage control strategies for this particular application. As such, the SNOPs ability to affect the voltage profile along feeders within a distribution system is focused on with other voltage control options used for comparative purposes. Results from studies on multiple network models with varying topologies are presented and a case study which considers economic benefits of increasing feasible DG penetration is also given
Lack of quantitative training among early-career ecologists: a survey of the problem and potential solutions
No full textProficiency in mathematics and statistics is essential to modern ecological science, yet few studies have assessed the level of quantitative training received by ecologists. To do so, we conducted an online survey. The 937 respondents were mostly early-career scientists who studied biology as undergraduates. We found a clear self-perceived lack of quantitative training: 75% were not satisfied with their understanding of mathematical models; 75% felt that the level of mathematics was “too low” in their ecology classes; 90% wanted more mathematics classes for ecologists; and 95% more statistics classes. Respondents thought that 30% of classes in ecology-related degrees should be focused on quantitative disciplines, which is likely higher than for most existing programs. The main suggestion to improve quantitative training was to relate theoretical and statistical modeling to applied ecological problems. Improving quantitative training will require dedicated, quantitative classes for ecology-related degrees that contain good mathematical and statistical practice
Early signaling dynamics of the epidermal growth factor receptor
No full textDespite extensive study of the EGF receptor (EGFR) signaling network, the immediate posttranslational changes that occur in response to growth factor stimulation remain poorly characterized; as a result, the biological mechanisms underlying signaling initiation remain obscured. To address this deficiency, we have used a mass spectrometry-based approach to measure system-wide phosphorylation changes throughout the network with 10-s resolution in the 80 s after stimulation in response to a range of eight growth factor concentrations. Significant changes were observed on proteins far downstream in the network as early as 10 s after stimulation, indicating a system capable of transmitting information quickly. Meanwhile, canonical members of the EGFR signaling network fall into clusters with distinct activation patterns. Src homology 2 domain containing transforming protein (Shc) and phosphoinositol 3-kinase (PI3K) phosphorylation levels increase rapidly, but equilibrate within 20 s, whereas proteins such as Grb2-associated binder-1 (Gab1) and SH2-containing tyrosine phosphatase (SHP2) show slower, sustained increases. Proximity ligation assays reveal that Shc and Gab1 phosphorylation patterns are representative of separate timescales for physical association with the receptor. Inhibition of phosphatases with vanadate reveals site-specific regulatory mechanisms and also uncovers primed activating components in the network, including Src family kinases, whose inhibition affects only a subset of proteins within the network. The results presented highlight the complexity of signaling initiation and provide a window into exploring mechanistic hypotheses about receptor tyrosine kinase (RTK) biology.National Institutes of Health (U.S.) (Grants U54CA112967, R01CA118705, and R01CA096504)National Institutes of Health (U.S.) (Biotechnology Training Grant T32GM008334
f(G,T) and its Cosmological Implications
No full textA coupled formulation of the Gauss-Bonnet invariant term G and the
energy momentum trace T term provide a modified f(G,T) gravity,
has been analyzed in this study. The functional form for the
f(G,T) gravity has been taken as f(G,T)=αT+ βGThe presentation of the authors' names and (or) special characters in the title of the pdf file of the accepted manuscript may differ slightly from what is displayed on the item page. The information in the pdf file of the accepted manuscript reflects the original submission by the author
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