2,879 research outputs found
Architectural illustrations... 1899
No full textArchitectural illustrations / A.W. Leh. [s.l.] : The author, 1899. 1 leaf, 23 plates ; 21 x 29 cm
Festuca ovina L., s.l. en Festuca rubra L., s.l. in Nederland
No full textThe author gives a survey of the taxa belonging to Festuca ovina L., s.l. and F. rubra L., s.l. as they occur in the Netherlands. Four species are distinguished, viz. F. ovina L., F. trachyphylla (Hack.) Kraj., F. heterophylla Lamk., and F. rubra L. F. ovina L. is represented by 3 subspecies, subsp. tenuifolia (Sibth.) Čelak., subsp. ovina, and subsp. cinerea (Vill.) Duyfjes, nov. comb.; F. rubra L. can be subdivided into 2 subspecies, subsp. rubra and subsp. juncifolia (St. Am.) R. Lit.
Of these taxa F. heterophylla is most probably introduced with grass-seeds; the others are native
Emerging paradigms in anti-infective drug design.
No full textThe need for new drugs to treat microbial infections is pressing. The great progress made in the middle part of the twentieth Century was followed by a period of relative inactivity as the medical needs relating to infectious disease in the wealthier nations receded. Growing realisation that anti-infectives are needed in many parts of the world, to treat neglected diseases as well as to combat the burgeoning risk of resistance to existing drugs, has galvanised a new wave of research into anti-microbial drugs. The transfer of knowledge from the Pharmaceutical industry relating to the importance of understanding how to target drugs successfully within the body, and improved understanding of how pathogens interact with their hosts, is driving a series of new paradigms in anti-infective drug design. Here we provide an overview of those processes as an introduction to a series of articles from experts in this area that emerged from a meeting entitled "Emerging Paradigms in Anti-Infective Drug Design" held in London on the 17th and 18th September 2012. The symposium was organised jointly by British Society for Parasitology (BSP) and the Biological & Medicinal Chemistry sector of the Royal Society of Chemistry (RSC) and held at the London School of Hygiene & Tropical Medicine. The symposium set out to cover all aspects of the identification of new therapeutic modalities for the treatment of neglected and tropical diseases. We aimed to bring together leading scientists from all the disciplines working in this field and cover the pharmacology, medicinal chemistry and drug delivery of potential new medicines. Sessions were held on: "Target diseases and targets for drugs", "Target based medicinal chemistry", "Bioavailability and chemistry", "Targeting intracellular microbes", "Alternative approaches and models", and "New anti-infectives - how do we get there?" This symposium was organised by Simon Croft (LSHTM) and Mike Barrett (University of Glasgow) for the BSP, and David Alker (David Alker Associates) and Andrew Stachulski (University of Liverpool) for the Biological & Medicinal Chemistry sector of the RSC
Genetics of virulence and intraspecific interactions in Heterobasidion annosum s.l.
No full textThe present thesis summarizes and concludes the work of four separate studies on Heterobasidion annosum (Fr.) Bref. s.l.. The basic aim of these studies was to provide a tool for investigation and cloning of genetic regions in H. annosum s.l. and apply this tool to different regions of interest. The progeny isolates of a cross between North American intersterility groups S and P were used in an inoculation experiment on two-week-old Pinus sylvestris and demonstrated the nuclear contribution to be important for virulence. From the same population, a genetic linkage map was constructed based on 358 AFLP markers, consisting of 19 larger and 20 smaller linkage groups (LG). Based on further virulence tests on both one-year-old Pinus sylvestris and two-year-old Picea abies, several regions controlling virulence were identified and mapped to these LG. In particular, LG 15 was of interest, containing QTLs for pathogenicity to both pine and spruce. The tests also indicated that hybridization negatively affects virulence. An investigation of somatic incompatibility was conducted, using two heterokaryotic populations made from the progeny, backcrossed with a parental strain or crossed with an unrelated strain. The number of incompatibility loci was estimated to four and it was shown that the allelic differences alone are not enough to determine the degree of the incompatibility reaction. Furthermore, several strong QTLs for different intraspecific interactions that may be important to the incompatibility phenomenon were located. Future work includes map based cloning and investigation of the QTLs identified in this thesis; a task that will benefit substantially from the upcoming sequencing of the H. annosum s.l. genome
Kinetoplastida: new therapeutic strategies.
No full textNew formulations and therapeutic switching of the established drugs, amphotericin B and paromomycin, together with the discovery of miltefosine, have significantly improved the opportunities for treatment of visceral leishmaniasis (VL) chemotherapy. However, for human African trypanosomiasis (HAT), Chagas disease and cutaneous leishmaniases there has been limited progress. For HAT, a novel diamidine, parfuramidine, is in phase III clinical trial for early-stage disease, but for the treatment of late-stage disease there are no new drugs and combinations of eflornithine with melarsoprol or nifurtimox have been the focus of clinical studies. For Chagas disease, different classes of compounds that have validated biochemical targets, sterol biosynthesis methylases and cysteine proteases, are in various stages of development. The genome sequences that are now available for the pathogens that cause the leishmaniases and trypanosomiases, and new methods for rapid validation of targets, are part of the solution to discover new drugs. The integration of medicinal chemistry, pharmacokinetics, project planning and interaction with the pharma/biotech sector are essential if progress is to be made. Although there are financial constraints, the appearance of new funding sources and not-for-profit product development partnerships offers hope for drug development
Análise de perfil do público feminino do campus Araranguá com relação ao jogos digitais e de tabuleiro
No full textApesar dos jogos digitais estarem cada vez mais presentes na cultura brasileira, alguns estereótipos de que o perfil destes jogadores seja formado por um público predominantemente masculino e jovem continua sendo difundido. No entanto, algumas pesquisas têm mostrado que dependendo do estilo de jogo as mulheres já são maioria e o público não se concentra mais apenas na faixa etária de jovens, ou seja, o público jovem de décadas passadas continua jogando. Algumas pesquisas científicas têm atuado no sentido de apresentar o papel das mulheres na indústria de jogos, o sexismo dos personagens e a inclusão das mulheres no mundo da tecnologia. Buscando mais informações para ações que minimizem o efeito dos estereótipos,foi realizada uma pesquisa quantitativa com base em uma análise do perfil das mulheres com relação aos jogos digitais e de tabuleiro na UFSC de Araranguá. Para esta tarefa foi disponibilizado um questionário online, onde acadêmicas e docentes da UFSC/Campus Araranguá puderam responder questões referentes às mulheres e os jogos. Como resultado dessa pesquisa, observou-se que a maioria das mulheres gosta de jogos e cerca de dois terços (2/3) respondeu que joga algum tipo de jogo durante a semana, principalmente pelo smartphone, notebook e videogame (console). Essas mulheres independentes da área profissional gostam de tecnologia, bem como de jogar, mas não tem o hábito de comprar jogos. Os jogos preferidos são do tipo raciocínio, corrida, tabuleiro e simulação e isto se confirma na afirmação de o joystick não é necessário para os jogos que elas gostam.The use of Computer games in Brazil is growing more than ever, it's a culture that engages more and more userseveryday and it's believed that the stereotype of the players is of the male gender and of young age. However, new surveys show that this stereotype depends on the type of game because they can interest different groups of people, such as women and older adults, meaning that people who used to play games when they were younger keep playing them when they become an adult. Scientific research has helped to make the female role in the gaming industry more known in respect of gender awareness and inclusion of women in technology. This document is part of an academic research made to find more information about those facts and how to help with gender awareness and minimise the effects of stereotyping in games. A quantitative survey was also conducted to analyse the female role in digital games and board games at the Araranguá Campus of Federal University of Santa Catarina (UFSC). This survey was conducted online, where female lecturers and students from the Araranguá Campus of UFSC answered questions about women playing games. With the results of this research, it's possible to say that most of the women answered the survey like playing games and two thirds of them like playing some kind of game during the week using smartphones, laptops or consoles. The researched women are mostly independent professionals, who like technology in general, as well as playing games, but they have a preference for free games rather than buying them, and also prefer puzzles, running games, board games and simulations, also that games that need joysticks are not really their favourites
When is a query a question? Reconstructing wh-requests from ad hoc-queries
No full textContains fulltext :
83649.pdf (Author’s version preprint ) (Open Access)SIGIR 2010, 19 juli 201
Treatment of localised cutaneous Leishmania tropica infection in Aleppo, Syria and drug sensitivity of clinical isolates
No full textAnthroponotic cutaneous leishmaniasis caused by Leishmania tropica has been
endemic in Aleppo, Syria for centuries. The first modem description of the disease
was also done in Aleppo. A surveillance system is in place, and the numbers of
annual recorded cases have been rising from a few hundred to thousands in the
late 1980s, to more than 5,000 in most years from 1990, and to more than 10,000
since 2003.
A retrospective analysis of routinely collected demographic data was
performed. The clinical course was examined in a subset of patients. One hundred
and thirty-two patients were recruited for follow-up study. Parasites were isolated
from the lesions of these patients before treatment and during the course of
treatment. Eighty isolates were tested for drug sensitivity in amastigotemacrophage
system and typed to species level. Molecular fingerprinting was
applied to a subset of isolates. Interviews were held with patients or accompanying
adults about their knowledge, attitudes and practices regarding prevention,
diagnosis and treatment.
Leishmaniasis patients in Aleppo were younger than the general population
(median age 13 vs. 19 years), and females predominated among adults. Children
and males were more likely to have lesions on the face. Smear positivity decreased
with patient age (OR=O.5 in over-forties compared to under-tens). Smear positivity
peaked at two-month lesion duration (OR=2.2 compared to lesion duration of
<1 month). A significant proportion of patients, especially adults, did not complete
their treatment course.
The isolated parasites were insensitive (median ECso=229 fig Sbv Iml) to
pentavalent antimony, the drug used in Aleppo, and to paromomycin but were
sensitive to amphotericin B. No relationship was found between baseline parasite
in vitro sensitivity and treatment duration. All the typed parasites were L. tropica.
Parasite schizodemes clustered by place of isolation and by family
Life of Saint Gregory the Great Written in Four Books by John the Deacon: A Translation and Commentary of Book III
No full textThose interested in St. Gregory and his times find constant reference to the life of that pope written by John the Deacon. Because no translation of that work has hitherto appeared in English, a group of students, at the suggestion of Dr. L.V. Jacks, director of the classical department of The Creighton University, decided to undertake a translation and commentary on the Vita as their piece of research. |Since Books I and II of the Vita Sancti Gregorii Magni were already in process of translation when this work was begun, the original plan was to present a translation and commentary on Books III and IV. However, as the manuscript took shape, it ran into a forbidding length--some three hundred pages of translation alone; hence the first plan was abandoned and the scope of the work was limited to the third book alone. The text used was that of J.P. Migne, Volume LXXV of Patrologlae cursus completus Patrum Latinorum, which in the course of this study will be referred to as the Patrologia Latina. |Through the commentary the author has endeavored to supplement and clarify the text and to present various views on controversial questions. No textual, grammatical, or stylistic problems are handled, herein since these points have already been treated by competent scholars in this field. |This study has the secondary purpose of examining the historiography of John the Deacon in the Vita III. As background material a chapter containing the few known facts about this Roman deacon of the ninth century and his works has been included; also a chapter dealing with the early life and writings of St. Gregory because this material is not included in Book III.ProQuest Traditional Publishing Optio
An Estimation of the Entomological Inoculation Rate for Ifakara: A Semi-Urban Area in a Region of Intense Malaria Transmission in Tanzania.
No full textAn entomological study on vectors of malaria and their relative contribution to Plasmodium falciparum transmission in the semi-urban area of Ifakara, south-eastern Tanzania, was conducted. A total of 32 houses were randomly sampled from the area and light trap catches (LTC) performed in one room in each house every 2 weeks for 1 year. A total of 147 448 mosquitoes were caught from 789 LTC; 26 134 Anopheles gambiae s.l., 615 A. funestus, 718 other anophelines and 119 981 culicines. More than 60% of the total A. gambiae s.l. were found in five (0.6%) LTCs, with a maximum of 5889 caught in a single trap. Of 505 A. gambiae s.l. speciated by polymerase chain reaction, 91.5% were found to be A. arabiensis. Plasmodium falciparum sporozoite enzyme-linked immunosorbent assay tests were performed on 10 108 anopheles mosquitoes and 39 (0.38%) were positive. Entomological inoculation rate (EIR) estimates were generated using a standard method and an alternative method that allows the calculation of confidence intervals based on a negative binomial distribution of sporozoite positive mosquitoes. Overall EIR estimates were similar; 31 vs. 29 [95% confidence interval (CI): 19, 44] infectious bites per annum, respectively. The EIR ranged from 4 (95% CI: 1, 17) in the cool season to 108 (95% CI: 69, 170) in the wet season and from 54 (95% CI: 30, 97) in the east of the town to 15 (95% CI: 8, 30) in the town centre. These estimates show large variations over short distances in time and space. They are all markedly lower than those reported from nearby rural areas and for other parts of Tanzania
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