1,721,422 research outputs found
Intervista a Craig Thomas (How I Met Your Mother, American Dad)
No full textIntervista a Craig Thomas, co-creatore di How I Met Your Mother, sulle tecniche di scrittura seriale e sulle specificità della situation comedy per un network generalista
State of Utah v. Robert Craig Thomas : Reply Brief
Full text linkConsolidated appeals from (i) conviction for possession of a controlled substance in violation of Utah Code Ann. 58-37-8(2)(a)(i)(Supp. 2005), a third degree felony, and attempted forgery in violation of Utah Code Ann. 76-4-101 (Supp. 2005) and 76-6-506.1 (2003), a class A misdemeanor, and theft by deception in violation of Utah Code Ann. 76-6-502 (2003), a third degree felony, in teh Third Judicial District Court, Salt Lake County, Utah, the Honorable Leslie A. Lewis, presiding. Robert Craig Thomas, the Defendant.Ap
Computational modelling of cyclic peptides incorporating reverse turn peptidomimetics
No full textAs part of an effort to develop a model system for peptide recognition by proteins, two monoclonal antibodies (DB19/1 and DB19/25) were raised which recognised the pentapeptide Ac.PYPYDV which had been observed to adopt a type II turn in aqueous solution. As beta turns are commonly found in biologically active peptides and have been postulated to be the recognition element of several linear peptides, there has been considerable interest in the development of peptidomimetic analogues which stabilise beta turn conformation. Although such peptide analogues may exhibit increased potency and selectivity in their biological properties, any failure of the analogue to bind to its receptor may be due to the inability of the binding site to accommodate chemical modification of the peptide ligand rather than the analogue mimicking an inactive conformation.Our strategy in the elucidation of the bound conformation of Ac.YPYDV was to form a cyclic peptide incorporating the YPYD epitope. In this case, the cyclisation of the YPYD sequence to a rigid template was proposed. The chimeric analogue so formed would limit the conformation of the attached loop by fixing the geometry of the ends of the YPYD loop. It was noted that the use of a beta turn mimetic as the template group should induce a complementary beta turn across the tetrapeptide sequence. In contrast to traditional structure-function studies employing conformationally well-defined amino acid analogues such an "external" restraint would not affect the chemical structure of the peptide.In this case molecular modelling techniques were employed in the prediction of conformation as a preliminary study prior to any synthesis of chimeric mimetics. We therefore undertook an investigation of the conformation of the unconstrained peptides by the molecular modelling of the peptides using a Monte Carlo (MC) conformational search procedure. In order to effectively model this system a working understanding of the factors underlying adoption of secondary structure in solution as related to the sequence of peptide was required. Consequently, a limited nuclear magnetic resonance (NMR) analysis of the conformation of peptides related to the pentapeptide Ac.YPYDV was carried out. The computational results were then evaluated and interpreted on the basis of experimental NMR measurements.</p
How Should Religious Fraud and Religious Undue Influence be Regulated by English Courts?
Full text linkHow should the law regulate religious influence motivating gifts? Should criminal fraud laws
apply to religious representations? When do religious officials take advantage of adherents in
making a financial gain? These are challenging questions that this thesis sets out to assess. The
focus is upon the regulation of religious fraud and religious undue influence in English law.
Commentators on religious fraud have left significant questions unanswered concerning how
such conduct can be regulated by s2 of the Fraud Act 2006, fraud by false representation. One
of the objectives of this thesis is to justify why it is possible to litigate religious representations
alleged to be false, even if juries are prohibited from testing the falsity of religious beliefs by
the jurisprudence on Article 9 of the European Convention of Human Rights.
The second objective of this thesis is to illustrate the problems with how courts determine when
religious influence, an inevitable part of any religious experience, becomes undue in equitable
settings. Fundamental differences exist between religious and nonreligious contexts that are
not explicitly recognised by courts in finding that religious defendants have taken advantage
of an adherent’s trust in presumed cases of undue influence.
Based on this analysis, the thesis engages with a third objective and develops a rationale
explaining when defendants should be convicted for religious fraud under s2 FA06 and found
liable for religious undue influence in presumed undue influence cases. Normative discussions
on autonomy and exploitation are examined. This thesis provides reasons why courts should
take account of the features of religious relationships and religious motivations for gifts in
cases. The rationale reduces the concern identified that decisions in both areas of law are
unprincipled and give rise to religious bias. In turn, the thesis describes how religious influence
should be regulated by English courts in a way that ensures more consistent regulation of gifts
motivated by religious faith across the two different areas of law
State of Utah v. Robert Craig Thomas : Brief of Appellant
Full text linkConsolidated appeals from the following two judgments of conviction: (1) possession of a controlled substance, a third degree felony, in violation of Utah Code Annotated section 58-37-8(2)(a)(i) (Supp. 2004) and attempted forgery, a class A misdemeanor, in violation of Utah Code Annotated sections 76-4-101 (Supp. 2004) and 76-6-501 (2003); and, (2) attempted unlawful use of a financial transaction card, a class A misdemeanor in violation of Utah Code Annotated sections 76-4-101 (Supp. 2004) and 76-6-506.1 (2003) and theft by deception, a third degree felony, in violation of Utah Code Annotated sections 76-6-502 (2003), in the Third Judicial District Court, in and for Salt Lake County, State of Utah, the Honorable Leslie A. Lewis, presiding. Appellant Robert Craig Thomas remains incarcerated pending the outcome of this appeal
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
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