17,526 research outputs found
Metagit GitHub Repository
No full textMetagit-py and metagit-mac are prototype tools to demonstrate the Metagit model, discussed in the following publication: Scott, Mark, Steven J. Johnston, and Simon J. Cox (2016). "Metagit: Decentralised Metadata Management With Git". In: Information Systems. DOI: 10.1016/j.is.2016.09.002.
This dataset contains clones of the GitHub repositories metagit-py (https://github.com/mscottuk/metagit-py) and metagit-mac (https://github.com/mscottuk/metagit-mac) as they were on 14/09/2016 to support the above publication.</span
Charlie May Simon materials
No full textThis collection contains materials relating to Arkansas author Charlie May Simon
Jerome R. Cox, Jr. Oral History
Get PDFJerome R. Cox, Jr. was interviewed by Simon Igielnik on June 7, 2006 for approximately 2 hours and 47 minutes.https://digitalcommons.wustl.edu/oralhistories/1086/thumbnail.jp
Interview with David Cox
No full textInterview with David Cox, conducted on 30 October 2012 by Simon David, a student at Duke University. This work was done for an undergraduate course taught by Robert Cook-Deegan, "A Social and Political History of Genomics.
Selective COX-2 inhibitors and risk of myocardial infarction
Get PDFSelective inhibitors of cyclooxygenase- 2 ( COX- 2, ` coxibs') are highly effective anti-inflammatory and analgesic drugs that exert their action by preventing the formation of prostanoids. Recently some coxibs, which were designed to exploit the advantageous effects of non- steroidal anti-inflammatory drugs while evading their side effects, have been reported to increase the risk of myocardial infarction and atherothrombotic events. This has led to the withdrawal of rofecoxib from global markets, and warnings have been issued by drug authorities about similar events during the use of celecoxib or valdecoxib/ parecoxib, bringing about questions of an inherent atherothrombotic risk of all coxibs and consequences that should be drawn by health care professionals. These questions need to be addressed in light of the known effects of selective inhibition of COX- 2 on the cardiovascular system. Although COX- 2, in contrast to the cyclooxygenase-1 ( COX- 1) isoform, is regarded as an inducible enzyme that only has a role in pathophysiological processes like pain and inflammation, experimental and clinical studies have shown that COX- 2 is constitutively expressed in tissues like the kidney or vascular endothelium, where it executes important physiological functions. COX- 2- dependent formation of prostanoids not only results in the mediation of pain or inflammatory signals but also in the maintenance of vascular integrity. Especially prostacyclin ( PGI(2)), which exerts vasodilatory and antiplatelet properties, is formed to a significant extent by COX- 2, and its levels are reduced to less than half of normal when COX- 2 is inhibited. This review outlines the rationale for the development of selective COX- 2 inhibitors and the pathophysiological consequences of selective inhibition of COX- 2 with special regard to vasoactive prostaglandins. It describes coxibs that are currently available, evaluates the current knowledge on the risk of atherothrombotic events associated with their intake and critically discusses the consequences that should be drawn from these insights. Copyright (C) 2005 S. Karger AG, Basel
The Raspberry Pi: A technology disrupter, and the enabler of dreams
No full textThe Raspberry Pi Foundation aims to promote the teaching of Computer Science and is inspired by devices such as the ZX81 and Spectrum [1], the first home computers from the 1980s, and government backed in-school devices such as the BBC Acorn [2].[...
Development and applications of high performance computing
No full textIn this thesis we demonstrate the application of high performance computing techniques to three scientific problems. The first uses the Maximum Entropy method to determine structure in players' choices of numbers in the UK National Lottery. The resulting equations are solved using an efficient parallel algorithm. We find that players preferentially pick numbers in the centre of the ticket. The second is a model for cooperation in groups, in which the parameter space of the model is explored using task farming. We demonstrate, using a simple model, that it is possible to sustain cooperation in large groups when there is repeated interaction, recognition of the identity of individual participants, and memory of the outcomes of previous encounters. In larger groups, players with longer memories are favoured, supporting the conjecture that the selection pressures leading to large primate groups resulted in an increased neocortex size. Thirdly we have constructed a theoretical model for the electro-optic properties of polymer dispersed liquid crystal systems and provided a full numerical solution for the governing equations. This yields a detailed description of the optical response of the system to an applied field.</p
Simon Nyakot
Get PDFabstract: Simon Nyakot left his village when he was six years old.
“Lost Boys Found” is an ongoing, interdisciplinary project that is collecting, recording and archiving the oral histories of the Lost Boys/Girls of Sudan. The collection is a work-in-progress, seeking to record the oral history of as many Lost Boys/Girls as are willing, and will be used in a future book.Age: 27Region: LakeThis picture and bio was donated to the Lost Boys Found project from The Arizona Lost Boys Cente
Combining physical simulations and chargeable web service applications in engineering workflows
No full textWe demonstrate with a case study extending previous work how to integrate and consume a distributed framework for chargeable Web services providing a specialist software package for engineering applications and show with an example how this service can be integrated into scientific research problems in science and engineering. We discuss the complexity of the problem and list some of the issues encountered
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