132,060 research outputs found
Farmacoutilizzazione e farmacovigilanza nell'anziano : analisi delle segnalazioni spontanee di sospette reazioni avverse in italia nel 2007
No full textL'influenza e l'incertezza: Un binomio inscindibile nella storia e nella letteratura del "nemico invisibile" : riflessioni clinico-storiche per il prossimo autunno
No full textInvecchiamento e consumo di farmaci : uno studio campionario
No full textOfficial statistics of the SSN (Italian National health service) do not provide information about how many drugs are used by whom and for what diseases. The study carried out by Saniteia on a large Health District (ASL) in Lombardy can supply exhaustive responses to these questions and allow to build-up scenarios for the next future. In this ASL elderly patients, representing 16% of the population, attract 47% of pharmaceutical expenditure. An elderly person costs, for drugs, four times more than an adult. In general, those buying drugs are chronic ill patients (16% of population and 64% of expenditure), whose demand is inelastic to co-payments, while most of the population uses drugs occasionally (less than 100 euros per year) and has a demand elastic to charges. The ageing of the population, associated with many other factors affecting drug spending, could increase the SSN pharmaceutical expenditure - by 2010 - from a minimum of 9%, due to demographic changes only, to a maximum of 124%, including rises in consumption and average prices, similar to those occurred in the last five years
Effect of diastereoisomeric epoxyrotenones on hepatic epoxide hydrase activity
No full textThe effect on epoxide hydrase activity of the two diastereomeric (6′R) and (6′S)-6′,7′-epoxyrotenones formed during the oxidative metabolism of rotenone on the isopropenyl side chain is reported. The activity of microsomal epoxide hydrase was determined using styrene oxide as substrate. The results indicate that the two diastereomeric 6′,7′-epoxyrotenones are good substrates for epoxide hydrase and are noncompetitive inhibitors for the hydration of styrene oxide. The more polar of the two isomers is more active as inhibitor of this enzyme
“That’s Deep!”: The Role of Being Moved and Feelings of Profundity in the Appreciation of Serious Narratives
No full textThis registry contains the materials and data corresponding to: Cova, F., Deonna, J., & Sander, D. (2018). “That’s deep!”: The role of being moved and feelings of profundity in the appreciation of serious narratives. In D. R. Wehrs & T. Blake (Eds.), The Palgrave handbook of affect studies and textual criticism (pp. 347–369). Cham, Switzerland: Palgrave Macmillan
Power GaN FET boards thermal and electromagnetic optimization by FE modeling
No full textThis work deals with optimization of boards with commercial discrete power GaN FETs in applications where natural air convection is a strict constraint. In these cases, both thermal and electromagnetic behaviours are critical reliability issues for the board design, and they are modeled by Finite Element (FE) analysis, starting from literature description of the device structure, and measurements on a simple test circuit. For improved accuracy and more realistic modeling, verification and validation simulation steps are introduced, in order to evaluate the relevant error parameters for different FEM solutions. The results obtained demonstrate a good fitting with experimental and make it possible to improve board thermal characteristic. The electromagnetic simulations allow the evaluation, and possibly the reduction, of parasitic inductances for different layouts. Then, the proposed approach enables thermal and electromagnetic optimization of the layout design by simple FEM simulations, without any preliminary prototype, with time and cost saving
Epoxide metabolites of opiates and their interaction with the hepatic microsomal epoxide hydrolase
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