171,151 research outputs found
Head and neck neoplasms treated with conformal and Intensity-Modulated Radiotherapy in the Instituto Nacional de Cancerologia
No full textObjetivo: Describir las características sociodemográficas, clínicas, complicaciones, supervivencia global y libre de enfermedad y adherencia al tratamiento en pacientes con cáncer escamocelular de cabeza y cuello, tratados con radioterapia externa técnica conformacional (3DCRT) o radioterapia de intensidad modulada (IMRT) en el Instituto Nacional de Cancerología, entre el periodo de enero 1 del 2005 y diciembre 31 del 2012.
Métodos: Estudio de series de casos en pacientes con cancer de cabeza y cuello tratados con radioterapia externa tecnica 3D-CRT y de intensidad modulada (IMRT), se emplearon medidas de tendencia central y dispersión para las variables numéricas y frecuencias simples y porcentajes para las variables categóricas. Para el análisis de supervivencia se empleó el método de Kaplan-Meier en la descripción de la supervivencia y el modelo de regresión de Cox para el análisis multivariable
Resultados: Se incluyeron 49 pacientes con cáncer de cabeza y cuello que fueron atendidos entre enero de 2005 y diciembre 2012, y que fueron tratados con radioterapia con técnica conformacional (3DCRT) o radioterapia de intensidad modulada (IMRT), se observó adherencia en 85% de los pacientes, principalmente en aquellos tratados con IMRT (64,3 %) en comparación con los pacientes que recibieron terapia conformacional (37,7 %). Solo fueron analizados 32 pacientes (65,3 %) para la supervivencia libre de recaída, debido a que los 17 pacientes restantes no tenía información registrada en las historias clínicas. No fue posible calcular la mediana de supervivencia, la tasa de recaída fue de 4,6 por cada 1000/año (IC=95% 1,9 a 11,1).
Conclusiones: El seguimiento fue corto y limita la posibilidad de realizar comparaciones con series internacionales, las variables asociadas a peligro de muerte concuerdan con las reportadas en la literatura internacional, la única variable que presenta asociación estadística con la supervivencia es el estadio clínico global y en cuanto a la toxicidad se evidencia una tendencia a mayor toxicidad con tecnica 3D-CRT por lo que se recomienda tratar a los pacientes con tecnica IMRT para disminuir la toxicidad del tratamiento.Objective: To describe the sociodemographic and clinical characteristics, complications, and overall disease-free survival and adherence to treatment in patients with squamous cell cancer of the head and neck treated with conformal external radiotherapy technique (3DCRT) or intensity modulated radiotherapy (IMRT) in the National Cancer Institute, between the period of January 1, 2005 and December 31, 2012.
Methods: case series study in patients with cancer of head and neck treated with external radiotherapy technique 3D-CRT and intensity modulated (IMRT), measures of central tendency and dispersion for simple numeric variables and frequencies and percentages were used for categorical variables. For the analysis of survival the Kaplan-Meier in the description of survival and Cox regression model for multivariate analysis was used
Results: 49 patients with head and neck were treated between January 2005 and December 2012 cancer were included, and were treated with radiotherapy with conformal technique (3DCRT) or intensity modulated radiation therapy (IMRT), adhesion was observed in 85% patients, mainly in those treated with IMRT (64.3%) compared to patients receiving therapy conformational (37.7%). Only 32 patients were analyzed (65.3%) for relapse-free survival, because the remaining 17 patients had no information recorded in medical records. It was not possible to calculate the median survival, relapse rate was 4.6 per 1,000 / year (95% CI = 1.9 to 11.1).
Conclusions: The follow-up was short and limited the possibility of making comparisons with international series, the variables associated with risk of death match those reported in international literature, the only variable that presented statistical association with survival is the global clinical stage and for toxicity is a tendency to increased toxicity with 3D-CRT technique so it is recommended to treat patients with IMRT technique to reduce treatment toxicity.Ningun
29th Division in the Cotes de Meuse, October 1918.
No full textThis study discusses the 29th Division encounter with gas warfare in the Cotes de Meuse and covers types of gases, artillery operations and analyzes the actual attack
Evaluation of the stability of human erythropoietin in samples for radioimmunoassay
No full textRadioimmunoassays for erythropoietin are limited so far to a few specialized laboratories and this requires transport and storage of samples. We therefore tested the stability of immunoreactive erythropoietin in serum and plasma samples obtained from a uremic and a nonuremic anemic patient. No significant change in the concentration of immunoreactive erythropoietin was found in either serum or plasma samples for up to 14 days of storage. This type of stability was observed no matter whether the samples were stored at room temperature, 4 degrees C, or -20 degrees C. There was no difference between the estimates of erythropoietin in serum and heparinized plasma. Validity of the radioimmunoassay used in this study was demonstrated by parallelism of dilution curves of test specimens and the 2nd International Reference Preparation for erythropoietin and by a close correlation between the immunoreactivity and the bioactivity of the hormone, as assessed in the same samples by the exhypoxic polycythemic mouse bioassay. In conclusion the data obtained clearly indicate that the necessity of storage and transport of clinical samples does not limit the practicability of the radioimmunoassay for erythropoietin
Going Beyond Counting First Authors in Author Co-citation Analysis
Get PDFThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
A New Error Estimation of Even Order Newton-Cotes Formula
No full text牛顿-柯特斯(Newton-Cotes)求积公式在数值积分方面具有广泛的应用性.在插值型求积公式的基础上,利用泰勒展式对偶数阶Newton-Cotes公式的截断误差进行改进,获得不带积分项的一种新误差估计式.同时也得到相应的复化求积公式的误差估计.Newton-Cotes formulas have a wide range of applications in numerical integration. In this paper, error estimation of even order Newton-Cotes formula is improved by using Taylor expansion, and the new error estimation formula without integration is given. Meanwhile, the error estimation of complex N-C formula is also obtained.广西高等教育教改工程项目(2016JGB187)； 广西民族大学研究生创新项目(gxun-chxzs2018035
Deux " pêches au large " des cotes bretonnes de l'Atlantique, langouste et thon
No full textRobert-Muller C. Deux " pêches au large " des cotes bretonnes de l'Atlantique, langouste et thon. In: L'information géographique, volume 4, n°1, 1939. pp. 1-4
Mitomycin C in highly myopic eyes - Author reply
No full textOphthalmology. 2005 Feb;112(2):208-18; discussion 219.
Mitomycin C modulation of corneal wound healing after photorefractive keratectomy in highly myopic eyes.
Gambato C, Ghirlando A, Moretto E, Busato F, Midena E.
SourceRefractive Surgery Service and Antimetabolite Therapy Research Unit, Department of Ophthalmology, University of Padova, Padova, Italy.
Abstract
PURPOSE: To evaluate the role of topical mitomycin C in corneal wound healing (CWH) after photorefractive keratectomy (PRK) in highly myopic eyes.
DESIGN: Prospective, double-masked, randomized clinical trial.
PARTICIPANTS: Seventy-two eyes of 36 patients affected by high (>7 diopters) myopia.
METHODS: In each patient, one eye was randomly assigned to PRK with intraoperative topical 0.02% mitomycin C application, and the fellow eye was treated with a placebo. Postoperatively, mitomycin C-treated eyes received artificial tears (3 times daily, tapered in 3 months), whereas the fellow eye was treated with fluorometholone sodium 2% and artificial tears (3 times daily, tapered in 3 months).
MAIN OUTCOME MEASURES: Uncorrected visual acuity (UCVA) and best-corrected visual acuity (BCVA), contrast sensitivity, manifest refraction, and biomicroscopy. Contrast sensitivity was determined using the Pelli-Robson chart. Corneal confocal microscopy documented CWH.
RESULTS: Mean follow-up was 18 months (range, 12-36). No side effects or toxic effects were documented. At 12-month follow-up examination, UCVAs (logarithm of the minimum angle of resolution) were 0.4+/-0.48 and 0.5+/-0.53 (P = .03) in mitomycin C-treated eyes and corticosteroid-treated eyes, respectively. At 1 year, corneal haze developed in 20% of corticosteroid-treated eyes, versus 0% of mitomycin C-treated eyes. At 12, 24, and 36 months, corneal confocal microscopy showed activated keratocytes and extracellular matrix significantly more evident in untreated eyes (Ps = 0.004, 0.024, and 0.046, respectively).
CONCLUSION: Topical intraoperative application of 0.02% mitomycin C can reduce haze formation in highly myopic eyes undergoing PRK.
Comment in
Ophthalmology. 2006 Feb;113(2):357; author reply 357-8
Cleaner design and production of lightweight aggregates (LWAs) to use in agronomic application
Get PDFThis research focused on the obtainment of sustainable lightweight aggregates (LWAs) for agronomic application. The cleaner production is based on saving matter through the valorization of waste available in industry as a substitute of clays into the formulation of the lightweight aggregates (LWAs). Three different types of clays (white, black, and red) and alternative raw materials were blended. Cattle bone flour ash (CBA) and a fertilizer glass (FG) were used to introduce K and P into the mixture in amounts suitable for fertilizer application, and a sewage sludge from a brewery wastewater treatment plant was used as pore forming agent. For the production of the LWAs, we mixed different percentage of waste in two different clay mixtures, which were thermally treated at 1000 °C for 1 h. Technological parameters such as loose bulk and oven dry density, total porosity, water absorption capacity, pH, and electrical conductivity were determined to evaluate the potential use of LWAs as a growing media. Moreover, scanning electron microscopy (SEM) and mercury intrusion porosimetry (MIP) techniques were used, and leaching tests were performed to complete the samples’ characterization. The results indicated the potential for manufacturing highquality LWAs for the agronomic field by using energy-saving and matter-processing involving low temperatures with respect to the conventional process
Dispelling the Myths Behind First-author Citation Counts
Get PDFWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
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