1,720,981 research outputs found
INFLUENCE OF ANTISECRETORY DRUGS IN THE CLINICAL EVOLUTION OF ACUTE POSTOPERATIVE PANCREATITIS
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Going Beyond Counting First Authors in Author Co-citation Analysis
Get PDFThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Get PDF“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Get PDFWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Get PDFWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
koamabayili/VECTRON-author-checklist: VECTRON author checklist
No full textWe have done our best to complete the author checklist relating to the use of animals in the hut study. Note that the objective for the hut study was to evaluate the IRS treatment applications for residual efficacy against Anopheles mosquitoes, including the local An. coluzzii mosquito population. Cows were only used to attract mosquitoes into the huts and no tests were carried out directly on the cows. The author checklist is intended for use with studies where experiments are carried out on animals, which is why we have had such difficulty in completing this for the hut study, as many of the questions do not relate to how the cows were used
Treatment in breast cancer using the CRISPR/Cas9 system
Get PDFBackground. Breast cancer is the leading cause of death in the oncological population of female
gender and the second most prevalent cause of overall death in the United States of America and the
third most prevalent cancer death in Europe. There is a trend for breast cancer in caucasian, hispanic
and asian women. Numerous methods of treatment are accepted – chemotherapy, molecular targeted
therapy, radiotherapy, immunotherapy, phototherapy and surgical interventions (lumpectomy,
mastectomy). The genome editing methods – clustered regularly interspaced short palindromic repeats
(CRISPR) technology is developed based on the protection systems found in bacteria, the one which
is useful in treating cancer is the Cas9 protein thus defining the CRISPR-Cas9 system. It’s main
components are crRNA and tancrRNA (sgRNA) with the Cas protein.
Material and methods. We used the PubMed database in order the collect the information. After
introducting the key-words „CRISPR-Cas9” and „breast cancer” we revealed up to 571 sources. We
have reviewed the first 100 sources and have studied 18 of them. One source was added non-
sistematically. Overall we have reviewed 19 sources.
Results. The CRISPR-Cas9 system can be delivered to the target cells via protein, lipid, polymer and
inorganic based nanocarriers. Other method of delivery is via the lentiviral/adenoviral vectors. The
most efficient ones are the gold nanocarriers (inorganic). The genome editing technology is based on
plasmid systems that act via interference and activation thus making them useful for identifying
biomarkers and in the diagnosis of breast cancer.The main genes that are targeted by the CRISPR-Cas9
system in breast cancer are BRCA1, BRCA2, MYC, CDK9, UBR5, ZNF319 kinome (HER2, PI3KCA
and FGFR), CXCR4+CXCR7 (CXCL) and other tumour supressor genes (p53, PTEN, RB1 and NF1).
The genes involved in metabolic pathways are upregulated in a secondary manner because of
alterations in canceromatous states. Carcinogenesis, metastasis and resistance to drugs and
radiotherapy is reduced after using this treatment method.
Conclusions. CRISPR-Cas9 system is efficient in breast cancer treatment and diagnosis. It has
perspectives in order to be used as an adjuvant method in this condition without regard to it’s high
costs
Author-wise bibliometric analysis based on entropy.
No full textAuthor-wise bibliometric analysis based on entropy.</p
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