1,720,962 research outputs found
Silver Sulfadoxinate: Synthesis, Structural And Spectroscopic Characterizations, And Preliminary Antibacterial Assays In Vitro
No full textThe sulfa drug sulfadoxine (SFX) reacted with Ag+ ions in aqueous solution, affording a new silver(I) complex (AgSFX), which was fully characterized by chemical, spectroscopic and structural methods. Elemental, ESI-TOF mass spectrometric and thermal analyses of AgSFX suggested a [Ag(C12H13N4O2S)] empirical formula. Infrared spectroscopic measurements indicated ligand coordination to Ag(I) through the nitrogen atoms of the (deprotonated) sulfonamide group and by the pyrimidine ring, as well as through oxygen atom(s) of the sulfonamide group. These hypotheses were corroborated by 13C and 15N SS-NMR spectroscopy and by an unconventional structural characterization based on X-ray powder diffraction data. The latter showed that AgSFX crystallizes as centrosymmetric dimers with a strong Ag⋯Ag interaction of 2.7435(6) Å, induced by the presence of exo-bidentate N,N′ bridging ligands and the formation of an eight-membered ring of [AgNCN]2 sequence, nearly planar. Participation of oxygen atoms of the sulfonamide residues generates in the crystal a 1D coordination polymer, likely responsible for its very limited solubility in all common solvents. Besides the analytical, spectroscopic and structural description, the antibacterial properties of AgSFX were assayed using disc diffusion methods against Escherichia coli and Pseudomonas aeruginosa (Gram-negative), and Staphylococcus aureus (Gram-positive) bacterial strains. The AgSFX complex showed to be active against Gram-positive and Gram-negative bacterial strains, being comparable to the activities of silver sulfadiazine.1082180187Kean, W.F., Hart, L., Buchanan, W.W., (1997) Br. J. Rheumato., 36, pp. 560-572Atiyeh, B.S., Costagliola, M., Hayek, S.N., Dibo, S.A., (2007) Burns, 33, pp. 139-148Klasen, H.J., (2000) Burns, 26, pp. 117-130Klasen, H.J., (2000) Burns, 26, pp. 131-138Fox, C.L.J., (1983) Surg. Gynecol. Obstet., 157, pp. 82-88Fox, C.L., Modak, S.M., (1974) Antimicrob. Ag. Chemother., 5, pp. 582-588Cavicchioli, M., Massabni, A.C., Heinrich, T.A., Costa-Neto, C.M., Abrão, E.P., Fonseca, B.A.L., Castellano, E.E., Leite, C.Q.F., (2010) J. Inorg. Biochem., 104, pp. 533-540Lalueza, P., Monzón, M., Arruebo, M., Santamaría, J., (2011) Mater. Res. Bull., 46, pp. 2070-2076Clement, J.L., Jarrett, P.S., (1994) Metal Based Drugs, 1, pp. 467-482Silver, S., (2003) FEMS Microbiol. Rev., 27, pp. 341-353Wright, J.B., Lam, K., Burrell, R.E., (1998) Am. J. Infect. Control, 26, pp. 572-577Abbehausen, C., Heinrich, T.A., Abrão, E.P., Costa-Neto, C.M., Lustri, W.R., Formiga, A.L.B., Corbi, P.P., (2011) Polyhedron, 30, pp. 579-583De Paiva, R.E.F., Abbehausen, C., Gomes, A.F., Gozzo, F.C., Lustri, W.R., Formiga, A.L.B., Corbi, P.P., (2012) Polyhedron, 36, pp. 112-119Liu, W., Bensdorf, K., Hagenbach, A., Abram, U., Niu, B., Mariappan, A., Gust, R., (2011) Eur. J. Med. Chem., 46, pp. 5927-5934Mack, D.G., McLeod, R., (1984) Antimicrob. 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Unserer Zeit, 20, pp. 178-180Cuin, A., Massabni, A.C., Leite, C.Q.F., Sato, D.N., Neves, A., Szpoganicz, B., Silva, M.S., Bortoluzzi, A.J., (2007) J. Inorg. Biochem., 101, pp. 291-296Shefter, E., Chmielewicz, Z.F., Blount, J.F., Brennan, T.F., Sackman, B.F., Sackman, P., (1972) J. Pharm. Sci., 61, pp. 872-877Baeziger, N.C., Struss, A.W., (1976) Inorg. Chem., 15, pp. 1807-1809Kolodziejski, W., Klinowski, J., (2002) Chem. Rev., 102, pp. 613-628Nakamoto, K., (1997) Infrared and Raman Spectra of Inorganic and Coordination Compounds, Part B, , 5th ed. John Wiley & Sons New York p. 102Altoparlak, U., Erol, S., Akcay, M.N., Celebi, F., Kadanali, A., (2004) Burns, 30, pp. 660-664Carvalho, M.A., De Paiva, R.E.F., Bergamini, F.R.G., Gomes, A.F., Gozzo, F.C., Lustri, W.R., Formiga, A.L.B., Corbi, P.P., (2013) J. Mol. Struct., 1031, pp. 125-131Costa, G.S.M., Corbi, P.P., Abbehausen, C., Formiga, A.L.B., Lustri, W.R., Cuin, A., (2012) Polyhedron, 34, pp. 210-21
A New Platinum Complex With Tryptophan: Synthesis, Structural Characterization, Dft Studies And Biological Assays In Vitro Over Human Tumorigenic Cells
No full textA new platinum(II) complex with the amino acid L-tryptophan (trp), named Pt-trp, was synthesized and characterized. Elemental, thermogravimetric and ESI-QTOF mass spectrometric analyses led to the composition [Pt(C 11H11N2O2)2] ×6H2O. Infrared spectroscopic data indicate the coordination of trp to Pt(II) through the oxygen of the carboxylate group and also through the nitrogen atom of the amino group. The 13C CP/MAS NMR spectroscopic data confirm coordination through the oxygen atom of the carboxylate group, while the 15N CP/MAS NMR data confirm coordination of the nitrogen of the NH2 group to the metal. Density functional theory (DFT) studies were applied to evaluate the cis and trans coordination modes of trp to platinum(II). The trans isomer was shown to be energetically more stable than the cis one. The Pt-trp complex was evaluated as a cytotoxic agent against SK-Mel 103 (human melanoma) and Panc-1 (human pancreatic carcinoma) cell lines. The complex was shown to be cytotoxic over the considered cells. © 2013 Elsevier B.V. All rights reserved.122209215Barefoot, R.R., (2001) J. Chromatogr. B, 751, pp. 205-211Lebwohl, D., Canetta, R., (1998) Eur. J. Cancer, 34, pp. 1522-1534Rafique, S., Idrees, M., Nasim, A., Akbar, H., Athar, A., (2010) Biotechnol. Mol. Biol. Rev., 5, pp. 38-45Kelland, L., (2007) Nat. Rev. Cancer, 7, pp. 573-584Ivanov, A.I., Christodoulou, J., Parkinson, J.A., Barnham, K.J., Tucker, A., Woodrow, J., Sadler, P.J., (1998) J. Biol. Chem., 273, pp. 14721-14730Khalailar, I., Allardyce, C.S., Verna, C.S., Dyson, P.J., (2005) ChemBioChem, 6, pp. 1788-1795Cutillas, N., Yellol, G.S., Haro, C., Vicente, C., Rodriguez, V., Ruiz, J., (2013) Coord. Chem. Rev., 257, pp. 2784-2797Chiririwa, H., Moss, J.R., Hendricks, D., Smith, G.S., Meijboom, R., (2013) Polyhedron, 49, pp. 29-35Castello, W.S., Spera M B, M., Gomes, A.F., Gozzo, F.C., Lustri, W.R., Formiga, A.L.B., Corbi, P.P., (2011) J. Coord. Chem., 64, pp. 272-280Spera, M.B.M., Quintão, F.A., Ferraresi, D.K.D., Lustri, W.R., Magalhães, A., Formiga, A.L.B., Corbi, P.P., (2011) Spectrochim. Acta A, 78, pp. 313-318Corbi, P.P., Massabni, A.C., Moreira, A.G., Medrano, F.J., Jasiulionis, M.G., Costa-Neto, C.M., (2005) Can. J. Chem.-Revue Canadienne de Chimie, 83, pp. 104-109Corbi, P.P., Massabni, A.C., (2006) Spectrochim. Acta A, 64, pp. 418-419Cavicchioli, M., Massabni, A.C., Heinrich, T.A., Costa-Neto, C.M., Abrão, E.P., Fonseca, B.A.L., Castellano, E.E., Leite, C.Q.F., (2010) J. Inorg. Biochem., 104, pp. 533-540Dunbar, R.C., Steill, J.D., Polfer, N.C., Oomens, J., (2008) J. Phys. Chem. A, 112, pp. 10823-10830Wagner, C.C., Baran, E.J., (2004) Acta Farm. Bonaerense, 23, pp. 339-342Kazachenko, A.S., Legler, A.V., Peryanova, O.V., Vstavskaya, Y.A., (2000) Pharm. Chem. J., 34, pp. 257-258Carvalho, M.A., Souza, B.C., Paiva, R.E.F., Bergamini, F.R.G., Gomes, A.F., Gozzo, F.C., Lustri, W.R., Corbi, P.P., (2012) J. Coord. Chem., 65, pp. 1700-1711Carvalho, M.A., De Paiva, R.E.F., Bergamini, F.R.G., Gomes, A.F., Gozzo, F.C., Lustri, W.R., Formiga, A.L.B., Corbi, P.P., (2013) J. Mol. Struct., 1031, pp. 125-131Schmidt, M.W., Baldridge, K.K., Boatz, J.A., Elbert, S.T., Gordon, M.S., Jensen, J.H., Matsunaga, S.K.N., Montgomery, Jr.J.A., (1993) J. Comput. Chem., 14, pp. 1347-1363Hay, P.J., Wadt, W.R., (1985) J. Chem. Phys., 82, pp. 299-310Ditchfie, R., Hehre, W.J., Pople, J.A., (1971) J. Chem. Phys., 54, pp. 724-728Hehre, W.J., Ditchfie, R., Pople, J.A., (1972) J. Chem. Phys., 56, pp. 2257-2261Francl, M.M., Pietro, W.J., Hehre, W.J., Binkley, J.S., Gordon, M.S., Defrees, D.J., Pople, J.A., (1982) J. Chem. Phys., 77, pp. 3654-3665Harihara, P.C., Pople, J.A., (1973) Theor. Chim. Acta, 28, pp. 213-222Becke, A.D., (1993) J. Chem. Phys., 98, pp. 5648-5652Lee, C.T., Yang, W.T., Parr, R.G., (1988) Phys. Rev. B, 37, pp. 785-789Miertus, S., Scrocco, E., Tomasi, J., (1981) Chem. Phys., 55, pp. 117-129Bonacin, J.A., Formiga, A.L.B., Melo, V.H.S., Toma, H.E., (2007) Vib. Spectrosc., 44, pp. 133-141Scott, A.P., Radom, L., (1996) J. Phys. Chem., 100, pp. 16502-16513Mosmann, T., (1983) J. Immunol. Methods, 65, pp. 55-63(1994) Powder Diffraction Database - CD ROM, , File 46-1043 (JCPDS-ICDD)Hu, J., Fu, R., Ye, C., (1992) Chem. Phys. Lett., 195, pp. 159-162Çakir, S., Biçer, E., (2010) J. Chil. Chem. Soc., 55, pp. 236-239Gao, H., (2011) Spectrochim. Acta A, 79, pp. 687-69
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Chemical, Spectroscopic Characterization And Antibacterial Activities In Vitro Of A Novel Gold(i)-ibuprofen Complex
No full textA novel gold(I) complex with ibuprofen was synthesized and characterized by chemical and spectroscopic measurements. Elemental analysis led to the composition AuC14H18O2N. Infrared, 1H and 13C NMR data suggest coordination of the ligand to Au(I) through the oxygen atom of the carboxylic group in a monodentate form. An antibiotic sensitive profile indicated antibacterial activity in vitro of the complex against Gram-negative (E. coli and P. aeruginosa) and Gram-positive (S. aureus) microorganisms. © 2010 Elsevier B.V. All rights reserved.145738740Sadler, P.J., Sue, R.E., The chemistry of gold drugs (1994) Met.-Based Drugs, 1, pp. 107-144Fricker, S.P., Metal based drugs: From serendipity to design (2007) Dalton Transactions, (43), pp. 4903-4917. , DOI 10.1039/b705551jYoun, H.S., Lee, J.Y., Saitoh, S.I., Miyake, K., Hwang, D.H., Auranofin, as an anti-rheumatic gold compound, suppresses LPS-induced homodimerization of TLR4 (2006) Biochemical and Biophysical Research Communications, 350 (4), pp. 866-871. , DOI 10.1016/j.bbrc.2006.09.097, PII S0006291X06021462Fox, C.L., Modak, S.M., Mechanism of silver sulfadiazine action on burn wound infections (1974) Antimicrob. Agents Chemother., 5, pp. 582-588Elsome, A.M., Hamilton-Miller, J.M.T., Brumfitt, W., Noble, W.C., Antimicrobial activities in vitro and in vivo of transition element complexes containing gold(I) and osmium(VI) (1996) Journal of Antimicrobial Chemotherapy, 37 (5), pp. 911-918. , DOI 10.1093/jac/37.5.911Corbi, P.P., Quintão, F.A., Ferraresi, D.K.D., Lustri, W.R., Amaral, A.C., Massabni, A.C., Chemical, spectroscopic characterization, and in vitro antibacterial studies of a new gold(I) complex with N-acetyl-L-cysteine (2010) J. Coord. Chem., 63, pp. 1390-1397Abbehausen, C., Heinrich, T.A., Abrão, E.P., Costa-Neto, C.M., Lustri, W.R., Formiga, A.L.B., Corbi, P.P., Chemical, spectroscopic characterization, DFT studies and initial pharmacological assays of a silver(I) complex with N-acetyl-l-cysteine (2011) Polyhedron, 30, pp. 579-583Cavicchioli, M., Massabni, A.C., Heinrich, T.A., Costa-Neto, C.M., Abrão, E.P., Fonseca, B.A.L., Castellano, E.E., Leite, C.Q.F., Pt(II) and Ag(I) complexes with acesulfame: Crystal structure and a study of their antitumoral, antimicrobial and antiviral activities (2010) J. Inorg. Biochem., 104, pp. 533-540El-Gamel, N.E.A., The interactions of metal ions with nonsteroidal anti-inflammatory drugs (oxicams) (2009) J. Coord. Chem., 62, pp. 2239-2260Defazio, S., Cini, R., Synthesis, X-ray structural characterization and solution studies of metal complexes containing the anti-inflammatory drugs meloxicam and tenoxicam (2003) Polyhedron, 22, pp. 1355-1366Kovala-Demertzi, D., Transition metal complexes of diclofenac with potentially interesting anti-inflammatory activity (2000) Journal of Inorganic Biochemistry, 79 (1-4), pp. 153-157. , DOI 10.1016/S0162-0134(99)00175-0, PII S0162013499001750Harrak, Y., Casula, G., Basset, J., Rosell, G., Plescia, S., Raffa, D., Cusimano, M.G., Pujol, M.D., Synthesis, anti-inflammatory activity, and in vitro antitumor effect of a novel class of cyclooxygenase inhibitors: 4-(Aryloyl)phenyl methyl sulfones (2010) J. Med. Chem., 53, pp. 6560-6571Zawidlak-Wegrzynska, B., Kawalec, M., Bosek, I., Luczyk-Juzwa, M., Adamus, G., Rusin, A., Filipczak, P., Kurcok, P., Synthesis and antiproliferative properties of ibuprofeneoligo(3- hydroxybutyrate) conjugates (2010) Eur. J. Med. Chem., 45, pp. 1833-1842Nakamoto, K., (1997) Infrared and Raman Spectra of Inorganic and Coordination Compounds, Part B, , fifth ed. John Wiley & Sons New YorkBauer, A.W., Kirby, W.M., Sheris, J.C., Turck, M., Antibiotic susceptibility testing by a standardized single disk method (1966) Am. J. Clin. Pathol., 45, pp. 493-496Clinical, L., (2007) Performance Standards for Antimicrobial Susceptibility TestingSeventeenth Informational Supplement, , Wayne, PA USALemaire, S., Glupczynski, Y., Duval, V., Joris, B., Tulkens, P.M., Bambeke, F.V., Activities of ceftobiprole and other cephalosporins against extracellular and intracellular (THP-1 macrophages and keratinocytes) forms of methicillin-susceptible and methicillin-resistant Staphylococcus aureus (2009) Antimicrob. Agents Chem., 53, pp. 2289-2297Nomiya, K., Noguchi, R., Ohsawa, K., Tsuda, K., Oda, M., Synthesis, crystal structure and antimicrobial activities of two isomeric gold(I) complexes with nitrogen-containing heterocycle and triphenylphosphine ligands, [Au(L)(PPh3)] (HL = pyrazole and imidazole) (2000) J. Inorg. Biochem., 78, pp. 363-37
Dispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
koamabayili/VECTRON-author-checklist: VECTRON author checklist
No full textWe have done our best to complete the author checklist relating to the use of animals in the hut study. Note that the objective for the hut study was to evaluate the IRS treatment applications for residual efficacy against Anopheles mosquitoes, including the local An. coluzzii mosquito population. Cows were only used to attract mosquitoes into the huts and no tests were carried out directly on the cows. The author checklist is intended for use with studies where experiments are carried out on animals, which is why we have had such difficulty in completing this for the hut study, as many of the questions do not relate to how the cows were used
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