169,762 research outputs found
Nuovi dati sulla frequentazione appenninica del sito di Oratino - La Rocca (CB)
No full textThe recent research at the site of Oratino- La Rocca (CB) has allowed to detect an archaeological deposit belonging to the Bronze age Apennine phase, the first period of occupation of the site. The occupation during this period was suggested by some sporadic pottery finds, but now it has been possible to identify some structures and a stratigraphic sequence. The paper presents new data on these Apennine structures and the catalogue of pottery finds related to them
Implementation and evaluation of a complex outpatient oral antimicrobial therapy program (COpAT) in Canada
No full textAbstract
Objective:
We describe the implementation, outcomes, and challenges of a complex outpatient oral antimicrobial therapy program (COpAT) in Canada to provide a framework for those interested in establishing such a program.
Setting:
Outpatient ambulatory clinic led by infectious diseases physicians, serving patients from a tertiary hospital and a small community hospital.
Design:
Retrospective observational study that evaluated the efficacy, safety, and cost savings of patients enrolled in the program from August 2023 to June 2024.
Results:
One hundred three patients were included, of which 84.4% achieved successful clinical outcomes. Mean age of the patients was 62 years and 30% had diabetes. The top three sources of infections were bone and joint, intra-abdominal, and skin-and-soft tissue. Mean duration of COpAT was 37 days. Seventy-five percent of patients required only a single agent, and amoxicillin/clavulanic acid was most commonly used. Twenty-two patients developed an adverse reaction, of which three required a change in therapy and one resolved with antibiotic dose reduction. No C. difficile infections or mortality were reported 30-days post COpAT discharge. Twelve patients were re-admitted to the hospital; 50% of the cases were unrelated to infections. Compared to outpatient intravenous therapy, the total cost savings from COpAT were estimated to be 2500 CAD per patient per year.
Conclusion:
We demonstrated favorable clinical and safety outcomes with our COpAT program and substantial cost savings using existing infrastructure. COpAT allows efficient use of healthcare resources including decongestion of hospitals
Coppa Nevigata: catalogo dei reperti
No full textSi presenta un catalogo critico e ragionato di una selezione di materiali ceramici, in bronzo ed in osso lavorato provenienti dall'insediamento fortificato dell'età del Bronzo di Coppa Nevigat
Museum experience and its impact on visitor reactions
No full textDesigning engaging visitor experiences has become a paramount concern for
museums; however, a comprehensive understanding of the impact of museum experiences
on visitors' reactions remains incomplete. Our paper aims to assist museums
in implementing more effective strategies. By examining three distinct characteristics
of museum experiences—subjectivity, multidimensionality, and co-creation—we formulate
four hypotheses to assess the influence of visitor journeys on their reactions.
We concentrate on the journey at the Capitoline Museums, employing qualitative
and quantitative methods (in-depth interviews, subjective personal introspection,
non-participant observation, and questionnaires) involving 110 participants. Our findings
indicate that (a) Visitor attitudinal and behavioral reactions exhibit consistency
for the overall experience but not when analyzed for specific areas; (b) Visitor satisfaction
is correlated with the number of companions but not with the number of visited
areas in the museum experience; (c) Visitor's apparent dominance over visitor
satisfaction is not linked to visitor satisfaction. We develop a managerial decisionmaking
framework that empowers museums to create captivating experiences for
their visitors
Going Beyond Counting First Authors in Author Co-citation Analysis
No full textThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
L’approccio metodologico dell’archeologia dei paesaggi per una revisione critica di un caso studio: le ricognizioni di G. Barker nella Valle del Biferno
No full textThe authors reassess data coming from the archaeological survey conducted by G. Barker in the Biferno Valley (Molise region) during the Seventies, trying to outline the settlement patterns of this area during the Bronze age. This paper analyse all the evidence available from Barker’s study, including sporadic finds, in order to determine not only the character of each settlement, but also the possible use of landscape and its relationship with subsistence activities, in a diachronic perspective
Mitomycin C in highly myopic eyes - Author reply
No full textOphthalmology. 2005 Feb;112(2):208-18; discussion 219.
Mitomycin C modulation of corneal wound healing after photorefractive keratectomy in highly myopic eyes.
Gambato C, Ghirlando A, Moretto E, Busato F, Midena E.
SourceRefractive Surgery Service and Antimetabolite Therapy Research Unit, Department of Ophthalmology, University of Padova, Padova, Italy.
Abstract
PURPOSE: To evaluate the role of topical mitomycin C in corneal wound healing (CWH) after photorefractive keratectomy (PRK) in highly myopic eyes.
DESIGN: Prospective, double-masked, randomized clinical trial.
PARTICIPANTS: Seventy-two eyes of 36 patients affected by high (>7 diopters) myopia.
METHODS: In each patient, one eye was randomly assigned to PRK with intraoperative topical 0.02% mitomycin C application, and the fellow eye was treated with a placebo. Postoperatively, mitomycin C-treated eyes received artificial tears (3 times daily, tapered in 3 months), whereas the fellow eye was treated with fluorometholone sodium 2% and artificial tears (3 times daily, tapered in 3 months).
MAIN OUTCOME MEASURES: Uncorrected visual acuity (UCVA) and best-corrected visual acuity (BCVA), contrast sensitivity, manifest refraction, and biomicroscopy. Contrast sensitivity was determined using the Pelli-Robson chart. Corneal confocal microscopy documented CWH.
RESULTS: Mean follow-up was 18 months (range, 12-36). No side effects or toxic effects were documented. At 12-month follow-up examination, UCVAs (logarithm of the minimum angle of resolution) were 0.4+/-0.48 and 0.5+/-0.53 (P = .03) in mitomycin C-treated eyes and corticosteroid-treated eyes, respectively. At 1 year, corneal haze developed in 20% of corticosteroid-treated eyes, versus 0% of mitomycin C-treated eyes. At 12, 24, and 36 months, corneal confocal microscopy showed activated keratocytes and extracellular matrix significantly more evident in untreated eyes (Ps = 0.004, 0.024, and 0.046, respectively).
CONCLUSION: Topical intraoperative application of 0.02% mitomycin C can reduce haze formation in highly myopic eyes undergoing PRK.
Comment in
Ophthalmology. 2006 Feb;113(2):357; author reply 357-8
Igiene ambientale; capitolo: Inquinamento degli ambienti confinati (indoor)
No full textL’obiettivo principale di questo testo è fornire, anche tramite una forma grafica snella e di facile consultazione, una solida ed aggiornata base scientifica per lo studio dell’Igiene Ambientale. Questo libro si distingue per il suo approccio chiaro e didattico, rappresentando un ottimo strumento per gli studenti universitari che desiderano una guida rigorosa ma accessibile. Negli undici capitoli in cui si articola il testo vengono
delineati: l’inquadramento generale del rapporto ambiente e salute, gli strumenti metodologici per una sua corretta interpretazione, il tema del cambiamento climatico e dei suoi effetti sull’habitat e sulla salute umana. Vengono successivamente trattati i diversi comparti ambientali (aria, acqua, suolo, alimenti) e gli effetti sanitari conseguenti al loro degrado, inclusi i riferimenti normativi più significativi e le principali modalità di prevenzione
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