385 research outputs found
Supplemental_Material - Analysis of Surface Levels of IL-1 Receptors and Macrophage Scavenger Receptor I in Peripheral Immune Cells of Patients With Alzheimer Disease
No full textSupplemental_Material for Analysis of Surface Levels of IL-1 Receptors and Macrophage Scavenger Receptor I in Peripheral Immune Cells of Patients With Alzheimer Disease by Philipp Spitzer, Johannes Weinbeer, Martin Herrmann, Timo Jan Oberstein, Mateja Condic, Piotr Lewczuk, Johannes Kornhuber and Juan Manuel Maler in Journal of Geriatric Psychiatry and Neurology</p
Work on the role of Adder in the play "Striborov's Forest"
No full textŠuma Striborova je diplomska predstava četvero studenata: Laure Kolesarić, Luke Selmana, Matka Trnačića i Mateje Tustanovski pod mentorstvom Maje Lučić, izv. prof. dr. art., i sumentorstvom umjetničkog suradnika Gorana Guksića. Mateja Tustanovski ovim radom dramaturški analizira komad, obrazlaže i argumentira izbor tehnike te opisuje svoj proces rada na ulozi Guje kao i cjelokupnoj predstavi. Na kraju autorica donosi zaključak o stečenom iskustvu tijekom procesa.„Stribor's forrest“ is a graduation thesis of four students, including Laura Kolesarić, Luka Selman, Matko Trnačić and Mateja Tustanovski, under the mentorship of izv. prof. ArtD. Maja 24 Lučić and co-mentorship of ass. Goran Guksić umj. sur. With this thesis, Mateja Tustanovski explains and argues the choice of technique, dramaturgically analyzes the play, and describes her process of the work on the role and the play. At the end, the author draws the conclusion about the experience gained in the process
Work on the role of Adder in the play "Striborov's Forest"
No full textŠuma Striborova je diplomska predstava četvero studenata: Laure Kolesarić, Luke Selmana, Matka Trnačića i Mateje Tustanovski pod mentorstvom Maje Lučić, izv. prof. dr. art., i sumentorstvom umjetničkog suradnika Gorana Guksića. Mateja Tustanovski ovim radom dramaturški analizira komad, obrazlaže i argumentira izbor tehnike te opisuje svoj proces rada na ulozi Guje kao i cjelokupnoj predstavi. Na kraju autorica donosi zaključak o stečenom iskustvu tijekom procesa.„Stribor's forrest“ is a graduation thesis of four students, including Laura Kolesarić, Luka Selman, Matko Trnačić and Mateja Tustanovski, under the mentorship of izv. prof. ArtD. Maja 24 Lučić and co-mentorship of ass. Goran Guksić umj. sur. With this thesis, Mateja Tustanovski explains and argues the choice of technique, dramaturgically analyzes the play, and describes her process of the work on the role and the play. At the end, the author draws the conclusion about the experience gained in the process
Carniolan and Styrian identity in Posavje
No full textV magistrskem delu se avtorica ukvarja z raziskovanjem lokalnega pojava v Posavju, natančneje z aktualizacijo uporabe deželne identitete. V teoretičnem delu je pozornost sprva namenjena osnovnim pojmom, ki so povezani s tematiko. V nadaljevanju sta izpostavljeni dve zgodovinski dejstvi za lažje razumevanje raziskovalnega vprašanja, in sicer do kdaj so upravno obstajale dežele in kakšno je stanje na področju regionalizacije po osamosvojitvi Slovenije. Nato se je avtorica osredotočila na različne (neupravne) regionalizacije, znotraj katerih je umestila tudi raziskovalni prostor – Posavje. V okviru teorije je govora prav tako še o meji ter identiteti. Na koncu teoretičnega dela se je avtorica osredotočila konkretno še na deželno identiteto v Posavju. Medtem ko glavni del magistrskega dela predstavlja analiza aktualizacije uporabe deželne identitete v Posavju. V analizi se je avtorica osredotočila na identificiranje ljudi z deželno identiteto nasplohkdo in kakšna je oseba z deželno identiteto oz. kaj je zanjo značilnokakšni so razlogi za uporabo deželne identitete pri ljudehkako se deželna identiteta uporablja in da se uporablja predvsem na način šaljenjakakšna čustva se pojavijo pri uporabi deželne identitetekje se pojavi deželna identiteta v družabnem življenju in kaj je lahko v pomoč pri izražanju deželne identitete. V magistrskem delu se je za posebno pomembno pokazala ena ugotovitev, za katero avtorica lahko reče, da je kar glavna ugotovitev raziskovanja, in sicer da je za uporabo deželne identitete značilno šaljenje oz. da se uporablja na šaljiv način. Drugače pa je avtorica z analiziranim gradivom in smernimi vprašalnicami pokazala oz. dokazala, da se v Posavju aktualizira uporaba deželne identitete.In the master\u27s thesis the author deals with the research of a local phenomenon in Posavje, the so-called modernisation of state identity use. The theoretical part deals with basic terms connected with the main topic. In the following chapters stress two historical facts to understand the research question easier – how long state administration has been present and what is the situation in the field of regionalisation after Slovenian\u27s independence. Furthermore, the author focuses on different (non-administrative) regionalisations within which the research area of Posavje is placed. The theory explains also border and identity. The theoretical part ends with focus on state identity in Posavje. The main part of the thesis, on the other hand, presents the analysis of state identity use modernisation in Posavje. The author deals with identification of people with state identity in general, who is or what characteristics such a person has, what is typical of this person, what are the reasons to use state identity among people, how state identity is used and when teasing is used, what emotions are present in state identity use, where state identity is used in social life and what kind of help is used when expressing state identity. The master\u27s thesis has pointed out one vital finding which is treated by the author as the most important research finding – teasing or joking is used when state identity takes place. The author has concluded that state identity use is modernized in Posavje which has been supported by material analyzed and guided questions
Žurnalistika – rizikinga profesija? Politikos įtaka saugiam žurnalistų įdarbinimui Lenkijoje 2015–2023 metais
No full textRaising questions about how risky it was (and still is) to practice journalism in Poland, author Magdalena Mateja examines cases from 2015 to 2023, when the Polish government not only regulated the public broadcaster TVP, but also interfered in the management of national commercial television and radio stations. During this period, journalists who did not please the authorities were fired from various media outlets. Among other things, the author concludes that in 2023, after the change of government, the situation of journalists did not improve either in the public broadcaster or in the media market as a whole.Keldama klausimus apie tai, kaip Lenkijoje buvo (ir tebėra) rizikinga imtis žurnalisto profesijos, norėčiau pradėti nuo sąvokos „įdarbinimo saugumas“ paaiškinimo, kuri patenka į socialinių mokslų sritį, tačiau veikiau siejama su darbo teise, higienos ir saugos vadyba, nei su socialinės komunikacijos ir medijų mokslų sričiai priklausančiu tyrimu. Šią sąvoką pritaikiau siekdama nagrinėti politiką kaip veiksnį, lemiantį žurnalistų, profesionalų, kurių veiklos sritys ir pareigos apibrėžiamos 1984 m. Lenkijos spaudos įstatymu, saugumo jausmą
Comparison of mechanisms involved in impaired vascular reactivity between high sucrose and high fat diets in rats
No full textAbstract Background To determine the effects of high sucrose diets on vascular reactivity. We hypothesized that similar to high fat diets (HFD), HSD feeding would lead to increased adiposity resulting in inflammation and oxidative stress-mediated impairment of vasodilation. Methods Male Sprague-Dawley rats were fed control chow (Chow), HSD or HFD diets for 6 weeks. The role of inflammation and oxidative stress on impaired vasodilation were assessed in isolated mesenteric arterioles. Results HSD and HFD induced increased adiposity, oxidative stress and inflammation. HFD rats developed fasting hyperglycemia. Both HSD and HFD rats developed impaired glucose tolerance and hyperleptinemia. Nitric oxide (NO)-mediated vasodilation was significantly attenuated in both HSD and HFD rats but was normalized by treatment with antioxidants or anti-inflammatory drugs. Endothelial NO synthase (eNOS) protein expression was not affected by diet. Sensitivity to NO was reduced since NOS inhibition attenuated vasodilation in Chow rats but did not further impair vasodilation in HSD or HFD rats. Likewise, responsiveness to a NO donor was attenuated in both experimental groups. Conclusions Oxidative stress diminishes vasodilatory responsiveness in HSD and HFD rats through ROS-mediated scavenging of NO and decreased smooth muscle sensitivity to NO. Inflammation also plays a significant role in the impaired vasodilation.</p
AUTHOR IMPACT BEAMPLOTS: PROFILY NAMIESTO METRÍK - NÁSTROJ NA SPRAVODLIVEJŠIE HODNOTENIE VEDY?
No full textProblematika hodnotenia vedy a hľadanie optimálnych nástrojov rezonujú vo vedeckom a akademickom prostredí už niekoľko desaťročí. Na posudzovanie kvality vedeckých výstupov, kvalifikačný rast i na financovanie vedy sa využívajú scientometrické údaje o publikáciách a citáciách, ktoré do veľkej miery redukujú prácu vedcov na jednočíselné hodnotenie výkonu. Pokračujúca závislosť od zjednodušujúcich metrík založených najmä na kvantite, navyše často nesprávne používaných alebo interpretovaných, vyvoláva čoraz viac kritiky zo strany vedcov i vedeckých inštitúcií. Platforma Web of Science ponúka nástroj, ktorý môže významne pomôcť silnejúcim snahám o zodpovedné hodnotenie vedy
Methods for simulation of dark matter dynamics in cosmology
No full textWhile dark matter accounts for approximately 85% of the matter content of the observable
universe, its fundamental nature is one of the most important mysteries of modern physics. Many
different theories of dark matter have been proposed. We are studying ultra-light dark matter, a
scenario in which the dark matter particle is far lighter than any particle currently known to have a
non-zero mass. The behaviour of ultra-light dark matter is governed by the “Schroedinger-Poisson
equations”. We will introduce PyUltraLight, the code we have developed at the University of
Auckland to solve this system of coupled partial differential equations. PyUltraLight is written in
Python and can run inside a Jupyter notebook; it is currently the only freely shared, open-source
Schroedinger-Poisson solver available to astrophysicists. We are now using PyUltraLight to study
galaxy formation and galaxy-galaxy interactions in a universe with ultra-light dark matter.
One of the main challenges we are now facing is the need to simultaneously simulate large
physical volumes while resolving dynamics on small scales, e.g. in the central regions of the
galaxies or the detailed dynamics of galactic mergers. Increasing spatial resolution across the
whole simulation is computationally expensive and we are developing a simulation tool that uses
adaptive mesh refinement (AMR), a standard technique used to tackle problems where a significant
proportion of the simulation volume is empty. AMR codes allow the resolution to be increased only
in the locations of greatest interest, on the basis of specified refinement criteria. We will describe
the numerical methods we are now developing to simulate dark matter dynamics and discuss some
recent results and future research directions. ABOUT THE AUTHOR(S) Emily Kendall is a PhD student under Richard Easther at the University of Auckland. Mateja
Gosenca is a Postdoctoral researcher in the cosmology group at the University of Auckland. Both
are working on the theory and computational modelling of ultra-light dark matter.</div
Cyclooxygenase-2, P53 and Glucose Transporter-1 as Predictors of Malignancy in the Development of Gallbladder Carcinomas
No full textGallbladder carcinoma is the fifth most common malignancy of the gastrointestinal tract. The absolute characteristics of the disease are the high mortality rate due to the late discovery of a tumor and the low therapeutic possibilities except by surgical intervention. In oncology we can predict the outcome of the disease with a combination of classical standard clinico/pathological parameters (stage of the tumors, differentiation) and the intrinsic genetic and biochemical properties of the tumor. Such intrinzic properties of the tumors that are connected with the outcome of the disease are the denominators (markers). The author searched extensively for the expression and influence of 3 markers included in chronic inflammation and early carcinogenesis, cell cycle regulation and tissue hypoxia: cyclooxygenase-2 (COX-2), p53 gene and glucose transporter-1 protein (GLUT-1). The author discusses their possible role in the development as well as fighting this disease, if specific medications targeting them were availabl
About life at the Novi Klošter mansion after the Second World War through various sources
No full textMagistrska naloga je nadaljevanje diplomske naloge, v kateri je avtorica raziskovala življenje na dvorcu Novi Klošter po drugi svetovni vojni skozi ustna pričevanja in spomine ljudi. Spomine in ustna pričevanja iz diplomske naloge avtorica ovrednoti skozi pričevanja, ki jih ponujajo drugi viri (pisni, arhivski, fotografije). Avtorica ugotavlja, kakšna podoba o življenju na dvorcu Novi Klošter po drugi svetovni vojni se je zarisovala skozi ustne vire v diplomski nalogi oziroma skozi kombinacijo ustnih in pisnih (arhivskih) virov v magistrski nalogi, kakšna je (ne)skladnost med ustnimi in pisnimi viri ter kakšna je raba in izpovednost različnih virov. Avtorica primerja različne vire in razmišlja o razmerju med etnološkim oziroma kulturnoantropološkim in historičnim raziskovanjem.The master\u27s thesis is a continuation of the diploma thesis, in which the author researched life at the Novi Klošter mansion after the Second World War through oral testimonies and memories of people. Memoirs and oral testimonies from the diploma thesis are evaluated by the author through testimonies offered by other sources (written, archival, photographs). The author finds out what image of life at the Novi Klošter mansion after the Second World War was drawn through oral sources in the diploma thesis or through a combination of oral and written (archival) sources in the master\u27s thesis, what is the (in) consistency between oral and written sources and what is the use and confession of different sources. The author compares different sources and considers the relationship between ethnological or cultural anthropological and historical research
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