1,354,162 research outputs found
Patolologia neoplastica e libertà di cura: aspetti medico legali della prescrizione off label in oncologia
No full textRIASSUNTO
Gli Autori, dopo aver preso in rassegna le varie forme attraverso le quali può articolarsi la prescrizione off label e dopo aver esaminato l’iter autorizzativo che precede l’immissione in commercio di un farmaco, analizzano l’epidemiologia del fenomeno, con particolare riguardo all’ambito dell’Oncologia, e le ragioni che in ambito clinico possono portare alla prescrizione di un farmaco al di fuoi delle indicazioni per le quali vi è stata l’autorizzazione da parte delle Autorità Regolatorie. Vengono quindi presi in considerazione gli aspetti medico legali dell’utilizzo secondo modalità off label di un farmaco, in particolare per ciò che concerne la libertà di cura del medico e i relativi profili di responsabilità professionale, alla luce del quadro normativo italiano e delle indicazioni giurisprudenziali in materia
Going Beyond Counting First Authors in Author Co-citation Analysis
No full textThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
The treatment of non-small cell lung carcinoma with vinorelbine in monotherapy [TRATTAMENTO DEL CARCINOMA POLMONARE NON A PICCOLE CELLULE CON VINORELBINA IN MONOCHEMIOTERAPIA]
No full textIfosfamide in the elderly: clinical considerations for a better drug management
No full textThe therapeutic strategy used for elderly affected by malignant neoplasms should take into account the common variables present in oncological patients, and the specific alteration of the elderly metabolism and their possible morbidity. Ifosfamide is an active drug for various tumors with elevated incidence in the elderly. We analyze the principle criteria in the selection of these patients and the alterations of metabolism which correlates to aging with their consequences on the pharmacokinetics of ifosfamide. Finally, we propose clinical guidelines to optimize the use of ifosfamide in elderly patients affected by malignant tumors
Variations on the Author
No full text“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
No full textWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Corrigendum to “Italian consensus conference on management of uterine sarcomas on behalf of S.I.G.O. (Societa' italiana di Ginecologia E Ostetricia)” [Eur J Canc. vol. 139 November (2020) Pages 149–168] (European Journal of Cancer (2020) 139 (149–168), (S0959804920304676), (10.1016/j.ejca.2020.08.016))
No full textThe authors would like to apologise for any inconvenience caused. The authors regret that the Author affiliation details in the published article are incomplete. The affiliation details for Author Vittorio Quagliuolo should appear as Chirurgia Sarcomi, Melanomi, tumori rari, Humanitas Research and Clinical Hospital IRCCS. The full Author list and affiliation details are given here. Gabriella Ferrandina a,b, Cynthia Aristei c, Pietro Raimondo Biondetti d, Ferdinando Carlo Maria Cananzi e, Paolo Casali f,g, Francesca Ciccarone a, Nicoletta Colombo h, Alessandro Comandone i,j, Renzo Corvo' k,l, Pierandrea De Iaco m, Angelo Paolo Dei Tos n,o, Vittorio Donato p, Marco Fiore q, Franchi r, Angiolo Gadducci s, Alessandro Gronchi t, Stefano Guerriero u, Amato Infantev, Franco Odicino w, Tommaso Pirronti v,x, Vittorio Quagliuolo y, Roberta Sanfilippo z, Antonia Carla Testa a,b, Gian Franco Zannoni aa,ab, Giovanni Scambia a,b, Domenica Lorussoa,b a Fondazione Policlinico Universitario A. Gemelli IRCCS, Gynecologic Oncology Unit, Roma, Italy b Universita' Cattolica Del Sacro Cuore, Roma, Italy c Radiation Oncology Section, Perugia General Hospital, Perugia, Italy d Department of Radiology, Ca' Granda IRCSS Maggiore Policlinico Hospital Foundation Trust, Milan, Italy e Surgical Oncology Unit - Humanitas Clinical and Research Center, Rozzano, Italy f Department of Cancer Medicine, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy g Department of Oncology and Hemato-Oncology, University of Milan, Milan, Italy h Gynecologic Cancer Program, University of Milan-Bicocca and European Institute of Oncology, IRCCS, Milan, Italy i Division of Medical Oncology, Humanitas Gradenigo Hospital, Turin, Italy j ASL Città di Torino, Turin, Italy k Radiation Oncology Department, IRCCS Ospedale Policlinico San Martino, Genoa, Italy l Health Science Department (DISSAL), University of Genoa, Genoa, Italy m Unit of Oncologic Gynecology, Department of Obstetrics and Gynecology, University of Bologna, Hospital of Bologna Sant'Orsola-Malpighi Polyclinic, Bologna, Italy n Department of Pathology, Treviso General Hospital Treviso, Padova, Italy o University of Padua, Padova, Italy p Radiation Oncology Division, Oncology and Specialty Medicine Department, San Camillo-Forlanini Hospital, Roma, Italy q Department of Surgery, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy r Department of Obstetrics and Gynecology, AOUI Verona, University of Verona, Verona, Italy s Department of Clinical and Experimental Medicine, Division of Gynecology and Obstetrics, University of Pisa, Pisa, Italy t Chair Sarcoma Service, Department of Surgery, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy u Department of Obstetrics and Gynecology, University of Cagliari, Policlinico Universitario Duilio Casula, Monserrato, Cagliari, Italy v UOC COVID-2, Department of Bioimaging and Radiological Sciences, Fondazione Policlinico Universitario A. Gemelli, IRCCS, Italy w Division of Obstetrics and Gynecology, ASST Spedali Civili di Brescia, Università degli Studi di Brescia, Italy x Catholic University of Sacred Hearth, Department of Radiology, Rome, Italy y Chirurgia Sarcomi, Melanomi, tumori rari, Humanitas Research and Clinical Hospital IRCCS z Medical Oncology Department, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy aa Fondazione Policlinico Universitario A. Gemelli IRCCS, Department of Woman, Child and Public Health Sciences, Gynecopathology and Breast Pathology Unit, Rome, Italy ab Pathological Anatomy Institute, Catholic University of Sacred Hearth, Rome, Italy The authors would like to apologise for any inconvenience caused
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