1,721,699 research outputs found
Investigating Consumption Values and Purchase Intentions in Metaverse Shopping: A Pilot Study
No full textConsumers are increasingly using the metaverse to enjoy memorable shopping experiences. However, to date, research has yet to focus on the predictors of consumer behaviour in these digital environments. To address this gap, we empirically validate the metaverse-specific consumption values theorized by Venturini and Columbano (2023) to predict the antecedents of the purchase intention in these virtual platforms. An online experiment was conducted with 187 respondents from MTurk and analyzed using a linear regression model. Utilitarianism, social identity, and pro-enviromental engagement were found to significantly influence purchase intention. These findings have important implications for both theory and practice
Investigating Consumption Values and Purchase Intentions in Metaverse Shopping: A Pilot Study.
No full textConsumers are increasingly using the metaverse to enjoy memorable shopping experiences. However, to date, research has yet to focus on the predictors of consumer behaviour in these digital environments. To address this gap, we empirically validate the metaverse-specific consumption values theorized by Venturini and Columbano (2023) to predict the antecedents of the purchase intention in these virtual platforms. An online experiment was conducted with 187 respondents from Amazon mTurk and analyzed using a linear regression model. Utilitarianism, social identity, and pro-enviromental engagement were found to significantly influence purchase intention. These findings have important implications for both theory and practice
Columbano, 1857-1929
Get PDFRecursos Educativos - HumanidadesA vida e obra do pintor Columbano Bordalo Pinheiro através da exposição "Columbano Bordalo Pinheiro (1900-1929) ", que esteve patente no Museu do Chiado-Museu Nacional de Arte Contemporânea, em Lisboa.
Participação de Maria de Aires Silveira, comissária da exposição "Columbano”, de Carlos Reis, Reitor da Universidade Aberta e de Alexandra Gago da Câmara, docente da Universidade Aberta.N/
Raul Brandão and Columbano Bordalo Pinheiro, between literature and painting
No full textIn the late 18th century, Portugal experienced the friendly relationship between two artists who were outstanding in Literature and Painting. Raul Brandão and Columbano Bordalo Pinheiro portrayed each other in their works over the course of that relationship, which lasted approximately thirty years. In recent decades, researchers of Brandão and Columbano's works have observed the incursion of traces of Columbano Bordalo's pictorial art into the territory of the Foz do Douro writer. Based on letters and documents dating from 1895, this article seeks to present the inter-artistic dialogue existing in the literary work História dum Palhaço and in the painting Retrato de Raul Brandão.
Keywords: Raul Brandão; Columbano Bordalo Pinheiro; Interart Studies
Translated with www.DeepL.com/Translator (free version)No período finissecular do oitocentos, Portugal conheceu a relação de amizade entre dois artistas que destacavam-se na Literatura e na Pintura. Raul Brandão e Columbano Bordalo Pinheiro retrataram-se reciprocamente nas suas obras ao longo dessa convivência que perdurou aproximadamente trinta anos. Nas últimas décadas, pesquisadores das obras brandonianas e columbanas observaram a incursão de traços da arte pictórica de Columbano Bordalo no território do escritor da Foz do Douro. Com base em cartas e documentos datados desde 1895, este artigo busca apresentar o diálogo interartístico existente na obra literária História dum Palhaço e no quadro Retrato de Raul Brandão.
Palavras-chave: Raul Brandão; Columbano Bordalo Pinheiro; Estudos Interarte
Gadd 45beta is induced through a CAR-dependent, TNF-independent pathway in murine liver hyperplasia
No full textHepatology. 2005 Nov;42(5):1118-26.
Gadd45beta is induced through a CAR-dependent, TNF-independent pathway in murine liver hyperplasia.
Columbano A, Ledda-Columbano GM, Pibiri M, Cossu C, Menegazzi M, Moore DD, Huang W, Tian J, Locker J.
SourceDepartment of Toxicology, Oncology and Molecular Pathology Unit, University of Cagliari, Italy. [email protected]
Abstract
We previously observed that Gadd45/MyD118, a member of the Gadd45 family of inducible factors, showed the strongest immediate-early induction common to two distinctive proliferation responses of the liver: (1) regeneration induced by surgical partial hepatectomy and (2) hyperplasia induced by the primary mitogen TCPOBOP, a ligand of the constitutive androstane receptor (CAR). Gadd45 is known to be stimulated by nuclear factor (NF) B, which is activated by tumor necrosis factor alpha (TNF) in the early response to partial hepatectomy. We therefore investigated whether TNF and NFB also stimulated Gadd45 as part of the response to CAR ligands, or whether activation occurred by an alternative pathway. TCPOBOP effects were characterized in three mouse genotypes: wild-type, TNFR1-/-, and TNFR1-/-TNFR2-/-. The results showed that TCPOBOP did not activate NFB in any of the mice, but a strong induction of Gadd45 messenger RNA was observed in all three genotypes, where TCPOBOP also induced CyP2b10, a classical target gene of activated CAR, and cyclin D1, a proliferation linked gene. Thus, the absence of TNFR signaling and induction of NFB did not impair CAR-mediated gene induction. Moreover, hepatocyte proliferation was strongly induced, and at significantly higher levels than wild type, in both TNFR1-/- and TNFR1-/-TNFR2-/- mice. Further studies evaluated TCPOBOP-induced gene expression in CAR-/- mice, by microarray expression profiling and Northern blot. The induced changes in gene expression, including the stimulation of Gadd45, were almost completely abolished--hence all were mediated via CAR activation. In conclusion, in the liver, Gadd45 can be induced by a distinctive pathway that requires CAR and is independent of TNF-NFB. The greater induction of proliferation in TNFR-null mice suggests negative cross-talk between the CAR and TNF-NFB controls that regulate proliferation
Are credit rating agencies users of government accounting information? Evidence from the sovereign rating process
No full textThis article examines whether credit rating agencies (CRAs) qualify as users of sovereign government accounting information. The analysis of two rating methodologies and 18 interviews with rating analysts reveal that sovereign ratings are generated using data drawn primarily from government finance statistics, rather than government financial reports. The reason is that only the former produce information that, while far from comprehensive, is comparable across sovereigns; a quality that government financial reports presently lack. Accordingly, CRAs are not users of sovereign government accounting information
Measuring fiscal guidance transparency
Get PDFThe public disclosure of medium-term fiscal plans – “fiscal guidance” – represents an increasingly important, yet understudied element of fiscal transparency frameworks. This article introduces a dataset that contains a large set of forecasts on fiscal and economic items issued by all European Union governments over the period 2001-2018. These forecasts are used to build an index of fiscal guidance transparency and to explore its main characteristics and correlates. The analysis reveals that governments are more transparent in their guidance on fiscal flows and macroeconomic aggregates than on liabilities, assets, and exogenous assumptions. In addition, transparency declines in the forecast horizon and in the strength of the governing coalition. Collectively, the results suggest that fiscal guidance transparency may be a sensitive area of policymaking that deserves scholarly attention. Possible uses of the measure of fiscal guidance transparency in research are discussed
COLUMBANO BORDALO PINHEIRO
No full textA pintura de Columbano nunca me atraiu particularmente. Aliás, só recentemente aprendi a olhar a pintura naturalista da segunda metade do século XIX. O meu coração está com o expressionismo e as correntes subsequentes até 1970, sem esquecer o prévio cubismo e os trabalhos de Amadeo Souza-Cardoso. A minha alegria está quando visito a exposição permanente do Museu do Chiado (pintura do século XX) ou as três últimas salas de pintura do Museu Soares dos Reis (Porto) (igualmente pintura do século ..
CELL-DEATH - CURRENT DIFFICULTIES IN DISCRIMINATING APOPTOSIS FROM NECROSIS IN THE CONTEXT OF PATHOLOGICAL PROCESSES IN-VIVO
No full textThe term apoptosis was proposed to define a type of cell death morphologically, biochemically, and molecularly distinct from necrosis, which plays a fundamental regulatory function in the control of the overall size of cell populations, being complementary but opposite to cell proliferation [Kerr et al. (1972): Br J Cancer 26:239-257]. This view has led to the appreciation that apoptosis is an integral part of normal biological processes and may impact on disease states. Introduction of the concept of apoptosis has raised great interest and many studies have been aimed to the identification of genes responsible for the induction of cell death. Indeed, over the past few years, many genes whose expression is associated with cell death have been described, and the molecular mechanisms underlying cell death have been, in some circumstances, clearly established. However, it is now evident that extension of the conclusions achieved by studies performed with highly selected in vitro systems (simple systems), to in vivo conditions (complex systems), has generated a certain degree of confusion. Th is is in part due to the indiscriminate use of the term apoptosis and to the uncertainty whether apoptosis is always different from necrosis, and, if this is the case, to the lack of well established criteria to discriminate the two processes; in addition, it still remains to be established whether both types of cell death, although different, could be induced simultaneously by the same agent, depending on the cell type and the experimental condition used. The distinction between apoptosis and necrosis, is not simply a problem of terminology; ii necrosis and apoptosis are different from a mechanistic point of view, and if necrosis is merely the passive result of cellular injury (still to be shown), it becomes critical to discriminate between the two processes, in order to understand how to modulate apoptosis in view of its potential therapeutic use. This review will summarize existing informations and discuss some of the conflicting issues related to cell death in the liver. (C) 1995 Wiley-Liss, Inc
Profili ragionieristici della contabilità nazionale
No full textIl presente lavoro esamina la contabilità nazionale in una prospettiva ragionieristica, indagando la logica, il metodo e il sistema dei conti nazionali in vigore nell’Unione Europea: il Sistema europeo dei conti - SEC 2010. Lo studio è motivato dall’evidente processo di ‘contaminazione’ macroeconomica dei sistemi contabili pubblici, a seguito del quale alcuni saldi di contabilità nazionale hanno assunto, in Italia, rilievo costituzionale – su tutti, il ‘saldo del conto economico consolidato delle amministrazioni pubbliche’. Allo scopo di consentire agli studiosi di ragioneria pubblica di contribuire con pienezza di strumenti ai processi evolutivi della contabilità delle amministrazioni pubbliche, il lavoro decostruisce questi saldi alla luce dei loro elementi costituenti, svelando così la dimensione ragionieristica della contabilità nazionale. In particolare, l’analisi rivela che la contabilità nazionale adotta il metodo partiduplistico in forma propria, rilevando sia l’aspetto economico sia l’aspetto finanziario dei fatti di gestione. L’analisi rivela, inoltre, che il principio di competenza economica adottato nella contabilità nazionale è basato su una logica di anticipazione dei ricavi, il che comporta una valutazione degli elementi del patrimonio generalmente basata sul prezzo di mercato e sul costo netto di sostituzione. Infine, l’analisi riconosce nel patrimonio netto e nelle sue variazioni l’oggetto principale delle rilevazioni, e illustra le diverse configurazioni di reddito rinvenibili nella contabilità nazionale a seconda di quali flussi sono ritenuti di competenza di un determinato esercizio. Con particolare riferimento alle amministrazioni pubbliche, l’analisi dimostra che il principio di competenza economica non è generalmente applicato alla rilevazione delle operazioni economiche tipiche delle amministrazioni pubbliche, la quale segue una logica essenzialmente finanziaria. Pertanto, l’adozione della contabilità economico-patrimoniale nelle amministrazioni pubbliche non può essere motivata dalla volontà di facilitare l’inserimento dei bilanci delle amministrazioni stesse nei conti nazionali, se non per quanto riguarda la rilevazione e la valutazione degli elementi che compongono il patrimonio pubblico.This work examines national accounts from an accounting perspective, inquiring into the logic, the method and the objective of the system of national accounts currently adopted in the European Union: the European System of Accounts – ESA 2010. The study is motivated by the evident process of macroeconomic ‘contamination’ of public sector accounting systems, following which some accounting balances typical of national accounts have gained constitutional relevance in Italy – above all, the ‘net lending/net borrowing of the general government sector’. In order to allow public sector accounting researchers to fully contribute to the evolution of governmental accounting systems, this study deconstructs these balances into their constituent elements, thus unveiling the accounting dimension of national accounts. Specifically, the analysis reveals that national accounting adopts double-entry bookkeeping in proper form, as it records both the economic and the financial aspect of transactions. Also, the analysis reveals that the accrual principle adopted in the national accounts is based upon the anticipation of revenues, which implies a valuation of balance sheet elements at either market prices or net replacement values. Finally, the analysis shows that the objective of national accounts is to evaluate net wealth and its variations, and it elucidates the various configurations of income that emerge in the national accounts, depending on which flows are judged to accrue to a period. Focussing on public administrations, the analysis shows that the accrual principle is not generally applied to the recording of the typical government operations, which follows a financial logic. Therefore, adopting accrual accounting in public administrations cannot be motivated with the willingness to ease the compilation of national accounts, save for what concerns the recording and the valuation of the elements of government wealth
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