1,721,157 research outputs found
Hybrid Power-Energy Electrodes
Full text linkL'abstract è presente nell'allegato / the abstract is in the attachmen
WIPO (World Intellectual Property Organization) Method and system for facilitating the determination of the end-point in plasma etching process
No full textReplication Data for: "Blood Revenge in Civil War: Proof of Concept"
No full textThese files contain the data and supportive sources needed to replicate the tables and figures included in the article "Blood Revenge in Civil War: Proof of Concept.
A new splicing site mutation of the ABCB4 gene in intrahepatic cholestasis of pregnancy with raised serum gamma-GT
No full textBackground: Intrahepatic cholestasis of pregnancy is a liver disorder a with multifactorial etiology characterized
by maternal pruritus, abnormal liver function tests and increased fetal risk. The main biochemical
finding is the increase in total serum bile acid concentrations. In a subgroup ofwomen, the serum gammaglutamyl
transpeptidase level is also increased. There is evidence that dysfunction of the ABCB4 gene
might play a role in intrahepatic cholestasis of pregnancy development.
Aim: To investigate the role of the ABCB4 gene in Italian women with intrahepatic cholestasis of pregnancy
and raised gamma-glutamyl transpeptidase by, analyzing the complete coding sequence andmRNA
splicing products.
Methods: Among 299 women with intrahepatic cholestasis of pregnancy, 10 showing raised gammaglutamyl
transpeptidase were enrolled in this study. DNA and RNA were extracted from peripheral blood
mononuclear cells using standard procedures. The 27 coding exons and the promoter region were amplified
by polymerase chain reaction and analyzed by sequencing. Reverse transcript-polymerase chain
reaction analysis of ABCB4 mRNA and cDNA analysis was also performed.
Results: A novel splicing mutation that causes a truncated protein of 249 amino acid was identified in
a woman who had the highest serum levels of gamma-glutamyl transpeptidase, alkaline phosphatase,
bile acids, and the highest pruritus score. We identified also one already described p.R590Q mutation
in a woman who had significantly higher serum levels of alkaline phosphatase, aspartate, and alanine
aminotransferase.
Conclusions: Our study demonstrates that splicing mutations in the ABCB4 gene can cause ICP in women
with high gamma-glutamyl transpeptidase and thus a complete analysis of coding sequence and cDNA
products is required.
© 2009 Editric
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Recent origin and spread of a common Welsh MAPT splice mutation causing frontotemporal lobar degeneration.
No full textIVS10+16C>T is the most prevalent mutation in
the microtubule-associated protein tau gene (MAPT) causing
frontotemporal lobar degeneration (FTLD) in populations
of British descent. A highly conserved 17q21
haplotype was identified in IVS10+16C>T chromosomes
from North Wales, Greater Manchester and the London
areas of the UK, Australia, and the USA, suggesting the
occurrence of a common founder effect. To test this
hypothesis, the age of the mutation was estimated by
parametric and Bayesian analysis of linkage disequilibrium's
decay over generations, and the results were
compared with historical and geographical data on FTLD
families. The inferred age (23 generations; 95% confidence
interval, 9 74 generations) dates the most recent common
ancestor of IVS10+16C>T chromosomes before Welsh
people started emigrating to the USA and Australia, where
they introduced the mutation. The identification of a cohort
of FTLD families with a homogeneous genetic background
within and around the MAPT locus will further the
investigation of the different clinical and pathological
presentations of patients with identical MAPT mutations
Dispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
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