196,145 research outputs found
CogniScan : Présentation d’un Inventaire de plaintes cognitives
No full textÀ partir de 55 ans, la moitié de la population rapporte des plaintes cognitives[1]. Les plaintes cognitives subjectives (PCS) se définissent par une perception de déclin cognitif par rapport à un fonctionnement antérieur, malgré des performances normales lors de tests standardisés[2]. Leur présence semble augmenter le risque de développer un trouble neurocognitif mineur[3], rendant crucial leur identification rapide. Toutefois, les outils disponibles en français pour investiguer les PCS sont peu développés ou axés sur une seule sphère cognitive, souvent mnésique, alors que les PCS peuvent toucher toutes les fonctions cognitives. Dès lors, nous avons créé un outil permettant de sonder plus largement ces plaintes, le CogniScan. Il se compose de 40 items couvrant cinq fonctions cognitives : mémoire, attention, fonctions exécutives, langage et orientation. Deux versions ont été constituées pour confronter la plainte rapportée par une personne (auto-évaluation) à la perception d’un membre de son entourage (hétéro-évaluation). La complétion en échelle de type Likert à cinq niveaux (de « beaucoup plus difficile » à « beaucoup plus facile ») permet de statuer sur la perception d’un changement dans le fonctionnement cognitif par rapport aux cinq dernières années. Sa passation rapide permet d’obtenir un score par domaine cognitif ainsi qu’un score global. La validité de contenu a été évaluée auprès de 10 neuropsychologues. Pour la validité de surface, 7 néophytes ont jugé de la clarté et de la compréhension des items. Les résultats préliminaires auprès de 26 personnes (19 femmes, 7 hommes, 62.2 ans +/- 6.9 ans) montrent un score moyen de 6.65/80 (σ = 13.56) au score global du CogniScan et de 2.23 (σ = 3.36) au sous-domaine mémoire, 1.23 (σ = 4.51) pour les fonctions exécutives, 2.65 (σ = 3.62) pour l’attention, 0.42 (σ = 2.5) pour le langage et enfin, 0.12 (σ = 1.28) pour l’orientation. Ces résultats préliminaires, à considérer avec précaution, semblent indiquer que les plaintes attentionnelles et mnésiques sont les plus fréquentes, quel que soit l’âge. Cet outil innovant fera l’objet d’une normalisation à large échelle pour pouvoir le mettre à disposition du terrain. Sa rapidité d’administration en fait un outil pratique pour les cliniciens. Références :
[1] Haute Autorité de Santé. (2014). Réponse à la saisine du 30 octobre 2014 en application de l’article L.161-39 du code de la sécurité sociale : Identification des troubles mnésiques et stratégie d’intervention chez les séniors de 70 ans et plus [Argumentaire]. https://www.has-sante.fr/upload/docs/application/pdf/2015- 02/argumentaires_art_53_troublesmnesiquesdusujetage_vf_2015-02-16_15-31-37_875.pd
[2] Jessen, F., Amariglio, R. E., Van Boxtel, M., Breteler, M., Ceccaldi, M., Chételat, G., Dubois, B., Dufouil, C., Ellis, K. A., Van Der Flier, W. M., Glodzik, L., Van Harten, A. C., De Leon, M. J., McHugh, P., Mielke, M. M., Molinuevo, J. L., Mosconi, L., Osorio, R. S., Perrotin, A., … Subjective Cognitive Decline Initiative (SCD I) Working Group. (2014). A conceptual framework for research on subjective cognitive decline in preclinical Alzheimer’s disease. Alzheimer’s & Dementia, 10(6), 844 852. https://doi.org/10.1016/j.jalz.2014.01.001
[3] Liew, T. M. (2020). Trajectories of subjective cognitive decline, and the risk of mild cognitive impairment and dementia. Alzheimer’s Research & Therapy, 12(1), 1-12. https://doi.org/10.1186/s13195-020-00699-
Dr. Duane M. Jackson, Morehouse College, July 2011
No full textThis video is a conversation with Dr. Duane M. Jackson. Dr. Jackson talks about his paper, "Recall and the Serial Position Effect: The Role of Primacy and Recency on Accounting Students' Performance." Jackie Daniel, AUC Woodruff Library, is the interviewer
"Reflections on the subject of Emigration from Europe with a view to Settlement in the United States" By M. Carey.
No full text"Reflections on the subject of Emigration from Europe with a view to Settlement in the United States: containing bried sketches of the moral and political character of those states.
By M. Carey, member of the American philosophical, and of the American Antiquarian Society, and author of The Olive Branch, Cindiciae Hibernicae, essays on banking, on political economy, and on internal improvement.
To which are now added the English editor's comments on the subject; together with Important Advice to Emigrants, and Cautions Against Impositions Practiced in the Outports
Dispelling the Myths Behind First-author Citation Counts
No full textWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
Dr. Glendon Swarthout
No full textHosted by Roger M. Busfield, MSU Assistant Professor of Speech and Theater, Meet the Author is designed to introduce a general audience to a contemporary author and their work through in-depth interviews. This episode features a conversation between Dr. Glendon Swarthout, prolific author and English professor at MSU, and assistant professors Sam S. Baskett and Theodore B. Strandness
Simulation of thermal plant optimization and hydraulic aspects of thermal distribution loops for large campuses
No full textFollowing an introduction, the author describes Texas A&M University and its utilities system. After that, the author presents how to construct simulation models for chilled water and heating hot water distribution systems. The simulation model was used in a $2.3 million Ross Street chilled water pipe replacement project at Texas A&M University. A second project conducted at the University of Texas at San Antonio was used as an example to demonstrate how to identify and design an optimal distribution system by using a simulation model. The author found that the minor losses of these closed loop thermal distribution systems are significantly higher than potable water distribution systems. In the second part of the report, the author presents the latest development of software called the Plant Optimization Program, which can simulate cogeneration plant operation, estimate its operation cost and provide optimized operation suggestions. The author also developed detailed simulation models for a gas turbine and heat recovery steam generator and identified significant potential savings. Finally, the author also used a steam turbine as an example to present a multi-regression method on constructing simulation models by using basic statistics and optimization algorithms. This report presents a survey of the author??s working experience at the Energy Systems Laboratory (ESL) at Texas A&M University during the period of January 2002 through March 2004. The purpose of the above work was to allow the author to become familiar with the practice of engineering. The result is that the author knows how to complete a project from start to finish and understands how both technical and nontechnical aspects of a project need to be considered in order to ensure a quality deliverable and bring a project to successful completion. This report concludes that the objectives of the internship were successfully accomplished and that the requirements for the degree of Degree of Engineering have been satisfied
Characterization of KIR + NK cell subsets with a monoclonal antibody selectively recognizing KIR2DL1 and blocking the specific interaction with HLA-C
No full textThe phenotypic identification of different NK cell subsets allows more in-depth characterization of KIR repertoire and function, which are of potential interest in KIR and disease association studies. KIR genes are highly polymorphic, but a great homology exists among the various sequences and few monoclonal antibodies (mAbs) specifically recognize a single KIR. This is the case of HP-DM1 which was demonstrated by analysis of cell transfectants and epitope mapping to be exclusively KIR2DL1-specific, covering all allotypes identified to date, except for KIR2DL1*022 and *020, and also to react with KIR2DS1*013. Here, we compared in immunofluorescence analyses the staining of HP-DM1 with other available mAbs to precisely identify KIR2DL1+ NK cells in potential donors for αβT/B-depleted haplo-HSCT, with known KIR genotype. HP-DM1 mAb was used in combination with EB6 or 11PB6 (anti-KIR2DL1/S1 and anti-KIR2DL3*005), 143211 (anti-KIR2DL1/S5), and HP-MA4 (anti-KIR2DL1/S1/S3/S5) mAbs, allowing the accurate identification of different KIR+ NK cell subsets. These phenotypic evaluations appeared useful to dissect the expression pattern of various KIR2D in NK cells from KIR2DL3*005+ individuals, particularly if KIR2DS1 is present. HP-DM1 mAb remarkably refined NK cell phenotyping of donors carrying KIR2DS5, either in the centromeric or telomeric region. Functional assays with KIR2DL1+ /S1+ /S5+ NK cells confirmed that only HP-DM1 exclusively reacts with KIR2DL1. Finally, we demonstrated that HP-DM1 mAb blocked KIR2DL1 recognition of C2+ HLA-C. Altogether, the data support that HP-DM1 is a unique reagent valuable for characterizing KIR+ NK cell subsets.This work was supported by a network grant of the European Commission (H2020-MSCA-ITN-765104-MATURE-NK) to Miguel Lopez-Botet and Daniela Pende; Natalia Colomar-Carando and Anna Rea are fellows in the project. This work was also supported by Italian Ministry of Health (Ricerca Corrente G. Gaslini, Ricerca Corrente and 5xmille-2016 Ospedale Policlinico San Martino), Fondazione AIRC 5 per mille 2018 id 21147 to Franco Locatelli and Lorenzo Moretta
Evaluación tecno-económica y ambiental de un sistema de desalinización autónomo alimentado con fuentes de energía renovables híbridas y diseño de una planta de ósmosis inversa con una capacidad de 2.000 m³/día
No full text[ES] La escasez de agua dulce es uno de los problemas más importantes a los que se enfrenta el mundo en la actualidad. El rápido crecimiento de la demanda de energía y agua está teniendo un fuerte impacto en el cambio climático y, por tanto, en el agotamiento de las reservas de agua dulce. La desalinización del agua de mar es una solución viable para producir agua dulce, especialmente en las zonas costeras. Sin embargo, su sostenibilidad se ve limitada por el elevado consumo energético de las tecnologías actuales. Las energías renovables son una solución atractiva para alimentar las plantas desalinizadoras y reducir los costes y las emisiones de carbono. El objetivo de este trabajo es diseñar una planta desalinizadora de agua de mar por ósmosis inversa con una capacidad de 2.000 m³/día y luego un sistema híbrido de energía renovable para satisfacer la demanda de carga eléctrica de la planta desalinizadora autónoma que estará en la isla de El Hierro, España.
De este modo, se trata de encontrar el dimensionamiento óptimo a través de una evaluación tecno-económica y ambiental de diferentes configuraciones de energía híbrida fuera de la red mediante el software HOMER Pro¿. Se propusieron dos escenarios sin red (con y sin generador diésel) con diferentes configuraciones de sistemas energéticos y se compararon entre sí. En ambos escenarios, los sistemas de energía son una combinación de una fotovoltaica, una turbina eólica y baterías. Por otro lado, es necesario diseñar la planta de ósmosis inversa de agua de mar que consta del pretratamiento donde se realiza la etapa de ultrafiltración con el software WAVE¿, el proceso de ósmosis inversa y el postratamiento mediante el software IMSDesign¿. Además, gracias a la incorporación de un dispositivo de recuperación de energía, el consumo energético específico de la planta se reduce a un valor de 2,18 kWh/m³. Además, los resultados de la optimización de los sistemas híbridos de energía renovable muestran que la mejor configuración que minimiza el coste actual neto estaba formada por el generador diésel de 550 kW, el sistema fotovoltaico de 274 kW, 28 turbinas eólicas, 518 baterías de 1,02 kWh y el convertidor CC/CA de 341 kW, en función de los recursos energéticos del emplazamiento y del perfil de la demanda de electricidad. Además, se ha considerado la posibilidad de implantar un depósito de agua en sustitución de las baterías. Esto dio lugar a una reducción del 10% del CNP. Por último, todo el sistema mostró unos valores de coste de producción de agua reducidos en comparación con otras tecnologías similares.[EN] Freshwater scarcity is one of the most important problems facing the world today. The rapid growth in energy and water demand is having a strong impact on climate change and thus the depletion of freshwater reserves. Seawater desalination is a viable solution to produce fresh water, especially in coastal areas. However, its sustainability is constrained by the high energy consumption of current technologies. Renewable energy is an attractive solution to power desalination plants to reduce costs and carbon emissions. The aim of this work is to design a seawater reverse osmosis desalination plant with a capacity of 2,000 m³/day and then hybrid renewable energy system to meet the electrical load demand of the autonomous desalination plant that will be in the island El Hierro, Spain.
In this way, the procedure is to find the optimal sizing through a techno-economic and environmental assessment of different off-grid hybrid energy configurations by means of the HOMER Pro¿ software. Two off-grid scenarios (with and without diesel generator) with different energy system configurations were proposed and compared to each other. In both scenarios, the energy power systems are a combination of a photovoltaic, wind turbine, and batteries. On the other hand, it is necessary to design the seawater reverse osmosis plant which consist of the pre-treatment where the ultrafiltration stage is made with the WAVE¿ software, the reverse osmosis process and post-treatment by means of the IMSDesign¿ software. In addition, thanks to the incorporation of an energy recovery device, the specific energy consumption of the plant is reduced to a value of 2.18 kWh/m³. Besides, the optimization results of the hybrid renewable energy systems shows that the best configuration which minimizes the net present cost consisted of the 550-kW diesel generator, 274-kW photovoltaic system, 28 wind turbines, 518 batteries of 1.02 kWh, and 341-kW DC/AC converter based on the site power resources and the profile of electricity demand. Furthermore, the implementation of a water tank replacing the batteries has also been considered. This resulted in a 10% reduction of the NPC. Finally, the whole system showed reduced water production cost values compared to other similar technologies.Pilato Colomar, A. (2021). Evaluación tecno-económica y ambiental de un sistema de desalinización autónomo alimentado con fuentes de energía renovables híbridas y diseño de una planta de ósmosis inversa con una capacidad de 2.000 m³/día. Universitat Politècnica de València. https://riunet.upv.es/handle/10251/178894TFG
Laboratory bioassay of different insecticides against Ceratitis capitata (Wied.) on apples
No full textIntern experience at CH���M Hill, Inc.: an internship report
No full textIncludes author's vita"Submitted to the College of Engineering of Texas A&M University in partial
fulfillment of the requirement for the degree of Doctor of Engineering."Includes bibliographical referencesA review of the author's internship experience with CH���M HILL, Inc.
during the period September 1975 through May 1976 is presented. During this nine month
internship the author worked as an Engineer II in the Industrial Processes discipline of this
large consulting engineering firm... The author's prime responsibility was as one of three
lead design engineers on the design of a large wastewater treatment facility for a pulp mill
in Hoquiam, Washington owned by ITT Rayonier Inc. The work generally consisted of the design
of individual treatment units and associated piping and pumping. The purpose of the project
was to provide wastewater treatment capabilities that would satisfy the effluent limitations
(standards) imposed upon the mill by the State of Washington Department of Ecology and the
U.S. Environmental Protection Agency. The author's assignment also entailed necessary
interaction with the project manager and other CH���M HILL design engineers and support staff
members, the client's representatives, and representatives of two other consulting engineering
firms working on the project. Thus, the internship position at CH���M HILL provided considerable
experience coordinating the author's work with the work of other engineers, guiding the design
and administrative efforts of a support staff, and interacting regularly with the client and
other consulting firms. This broad exposure to a variety of engineering and organizational
problems provided a valuable educational experience
- …
