632 research outputs found
Neural Cartography: Methods for Mapping the Structure of Neural Networks
No full textThesis (Ph.D.)--University of Washington, 2025Recent advancements in volumetric electron microscopy (vEM) allow neuroscientists to map the nervous system at unprecedented scale and resolution. This offers an opportunity to unravel structural organization, cellular morphology, and connectivity, providing new insights into circuit function. This dissertation presents new tools for scalable analytical solutions and circuit analyses to extract testable biological insights from vEM wiring diagrams. In the first section, I utilize cell-body morphology and connectivity to train a hierarchical model for cell-type prediction in a cubic millimeter vEM dataset of mouse visual cortex. This method bypasses the need for complete cell reconstructions, is adaptable to multiple cell-typing schemes, and is computationally inexpensive. Further, this method produced predictions for nearly 100,000 cells with 91% accuracy compared to expert-labeled ground truth. These predictions, publicly available with a new feature set, can be used for unsupervised search of rare cell-types and demonstrated the surprising sufficiency of the somatic region for cell identification.In the second section, I reconstructed the wiring diagram of tactile sensory neurons in the fly ventral nerve cord to elucidate how spatial information is organized within somatosensory circuits, specifically regarding spatially targeted leg grooming. Using genetic labeling and vEM, I defined the foreleg somatotopic map. Downstream connectivity revealed 60 interneurons receiving substantial synaptic input exclusively from tactile neurons. These interneurons exhibit unique axonal projections, diverse dendritic morphologies, and distinct postsynaptic partners. Optogenetic experiments and kinematic analyses demonstrated that activating distinct interneurons initiates spatially guided grooming strategies consistent with our structurally derived receptive field predictions. From these results I propose a four-layer circuit where interneurons form distinct functional modules, each sampling a portion of the leg to elicit spatially targeted grooming. The third section extends this spatial mapping analysis to chemosensory information from the fly leg, using a similar approach to examine how a distinct circuit structure might also maintain spatial information for a different sensory system within the same body segment. Overall, this dissertation examines neural network maps broadly, quantifying structural variability in cell bodies and connectivity across large populations. It then zooms in on specific sensory circuits, exploring how their structural organization informs our understanding of neural computations
Forrest Spaulding, author, Library Bill of Rights, 2008
No full textBrief history of Forrest Spaulding, head of the Des Moines Public Library from 1917-195
The Life of Leaders: Learning from Those Who Have Led Before
No full textDr. Bengamin Forrest of the School of Divinity presented on the Life of Leaders at the Jerry Falwell Library\u27s Faculty Author Series on November 2, 2017
Forrest Gump in the Book and on the Screen.
No full textCílem této bakalářské práce je zjistit, jak byla kniha Forrest Gump přepracovaná do filmové podoby. Teoretická část se zabývá životem a prací autora a režiséra. Praktická část se zabývá porovnáním příběhu a hlavních postav.Katedra anglického jazyka a literaturyNeobhájenoThe aim of this bachelor thesis is to examine how the book Forrest Gump was adapted into the movie. The theoretical part deals with life and works of author and director. The practical part deals with comparison the story and main characters
Us Civil War Menurut Forrest Carter
No full textA novel may reflect the political interests and actions of the author. The author can make a story that is purposed to alter common consciousness. This article uses historicism as an interpretation theory. Historicism is used to avoid careless interpretation. With historicism, the story written in the novel is matched with historical events written in some history books. Forrest Carter writes a lot about US Civil War. He, in purpose, does not write about slavery that is commonly read as the cause of the US Civil War. He writes a lot about the murder of women and children by the northern US army soldiers in southern districts. He also writes a lot about the cooperation of his white character with a Cherokee. Above all written by Forrest Carter, the influence of his life and his political interests are seen
US CIVIL WAR MENURUT FORREST CARTER
No full textA novel may reflect the political interests and actions of the author. The author can make a story that is purposed to alter common consciousness. This article uses historicism as an interpretation theory. Historicism is used to avoid careless interpretation. With historicism, the story written in the novel is matched with historical events written in some history books. Forrest Carter writes a lot about US Civil War. He, in purpose, does not write about slavery that is commonly read as the cause of the US Civil War. He writes a lot about the murder of women and children by the northern US army soldiers in southern districts. He also writes a lot about the cooperation of his white character with a Cherokee. Above all written by Forrest Carter, the influence of his life and his political interests are seen.
Correspondence to Don Clarke From Forrest Green, May 4, 1960
No full textCorrespondence from Forrest Green, President at the Detroit Morehouse Alumni Association to Don Clarke of the Student Defense Fund at Morehouse College. The letter includes a donation to the Student Defense Fund with plans to raise and donate $1,500. Donation in support of the Appeal for Human Rights. 1 page
Academic perspectives on The Forrest review: creating parity
No full textThis compilation provides an overview of the issues and challenges identified by academics as needing to be addressed when thinking about the recommendations of the Forrest Review and the impact they could have on people\u27s lives if implemented.
Abstract
This CAEPR Topical Issue contains the collected works of academics engaged in the examination of The Forrest review: creating parity which was commissioned by the Prime Minister Tony Abbott to examine Indigenous training and employment in Australia. Each work represents the author\u27s considered specialist disciplinary perspective informed by on-the-ground experience. Consequently, this paper provides an overview of the issues and challenges identified by academics as needing to be addressed when thinking about the recommendations of the Forrest Review and the impact they could have on people\u27s lives if implemented.
Lydia: Anthem to the Unity of Women
No full textDr Kally Forrest, the author of Metal that Will not Bend – a history of the National Union of Metalworkers of South Africa(NUMSA) – is a former trade unionist and editor of the South African Labour Bulletin. Now she has written a remarkablebiography Lydia: Anthem to the Unity of Women
Self-Concept Portrayed In The Main Character Of Winston Groom’s Forrest Gump Novel: Humanistic Psychological Approach
No full textThis study entitled Self-concept Portrayed in The Main Character of Winston Groom’s Forrest Gump novel: Humanistic Psychological Approach. The aims of this study was to analyse and describe the self-concept characteristics of main character in the novel of Forrest Gump by Winston Groom as the author addressed the reasons of raising the issue of self-concept. The type of this study was literary study. The type of data to be conducted this study consisted of two data sources. The primary data was the text from Winston Groom’s Forrest Gump novel. The secondary data to be used was collected from Psychology books, E-books, articles, E-thesis and reviews from internet. The conclusion of this study: firstly, the portrayal of self-concept characteristics in Forrest Gump as the main character of the novel. Secondly, Forrest Gump as the main character overcoming his problem in life applied the self-concept. Thirdly, the reasons why Winston Groom as the author addressed the issue of self-concept in life to be applied that people to be intuitive, open to new experiences, believe in oneself choices and stay optimistic in life
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