1,721,422 research outputs found
Dédéyan (Charles). Madame de Lafayette
No full textCollin R. Dédéyan (Charles). Madame de Lafayette. In: Revue belge de philologie et d'histoire, tome 36, fasc. 1, 1958. Antiquité — Oudheid. pp. 174-176
Dédéyan (Charles). Madame de Lafayette
No full textCollin R. Dédéyan (Charles). Madame de Lafayette. In: Revue belge de philologie et d'histoire, tome 36, fasc. 1, 1958. Antiquité — Oudheid. pp. 174-176
Fromilhague (René). La Vie de Malherbe. Apprentissages et Luttes, {1555-1610)
No full textCollin R. Fromilhague (René). La Vie de Malherbe. Apprentissages et Luttes, {1555-1610). In: Revue belge de philologie et d'histoire, tome 33, fasc. 4, 1955. pp. 936-938
Fromilhague (René). La Vie de Malherbe. Apprentissages et Luttes, {1555-1610)
No full textCollin R. Fromilhague (René). La Vie de Malherbe. Apprentissages et Luttes, {1555-1610). In: Revue belge de philologie et d'histoire, tome 33, fasc. 4, 1955. pp. 936-938
A rapid dual staining procedure for the quantitative discrimination of prion amyloid from tissues reveals how interactions between amyloid and lipids in tissue homogenates may hinder the detection of prions
No full textTransmissible spongiform encephalopathies (TSEs) are fatal neurodegenerative diseases with no cure to this day, and are often associated with the accumulation of amyloid plaques in the brain and other tissues in affected individuals. The emergence of new variant Creutzfeldt-Jakob disease, an acquired TSE with a relatively long asymptomatic incubation period and unknown prevalence or incidence, which could potentially be iatrogenically transmitted, has prompted the need for sensitive and rapid methods of detection of the pathology indicator, the protease-resistant prion protein (PrP(Sc)), in tissues and on surgical instruments. To discriminate between common tissue proteins and amyloid-rich aggregates such as those formed by abnormal prion, we developed a quantitative thioflavin T/SYPRO Ruby dual staining procedure, used in combination with episcopic differential interference contrast/epifluorescence (EDIC/EF) microscopy for rapid scanning of samples. The detection limit of this direct observation technique applied to brain homogenates was greatly enhanced by the addition of Tween 20, as demonstrated in double-blind studies using various proportions of ME7-infected brain mixed with normal brain homogenate. The characteristic thioflavin T signal correlated with the relative amount of prion amyloid and proved at least 2-log more sensitive than the classic Western blot using the same prepared samples. This new sensitive microscopy procedure, which can be easily applied in instrument decontamination surveys, is likely to be more sensitive that Western blot in practice since it does not rely on the elution of resilient PrP(Sc) bound to the instrument surfaces. Our study also demonstrates how interactions between prion and lipid-rich tissue homogenates may reduce the sensitivity of such detection assays
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Metal-promoted C1 polymerizations
No full textC1 polymerizations provide a means to grow polymer chains one carbon atom at a time. Such methodology enables the synthesis of persubstituted polymers that are challenging to prepare using conventional C2 polymerizations, which typically utilize alkene-based monomers and thus grow polymer chains two carbons at a time. Persubstituted polymers feature higher densities of pendant functional groups and, as such, offer the potential to exhibit enhanced physical and/or chemical properties over their monosubstituted C2 polymer analogues. This review summarizes the various metals that have been used to promote Cl polymerizations in a catalytic or stoichiometric manner. Discussions are stratified according to the monomers used, which are formally carbenes or carbynes and typically employed as their respective ylides, isocyanides, diazo compounds, or geminal di- or trihalides. Emphasis is placed on the scope of the polymerization chemistry, underlying mechanisms, and outstanding opportunities in the field. (C) 2018 Elsevier B.V. All rights reserve
MHC class I receptors on natural killer cells: on with the old and in with the new
No full textThe functions of natural killer (NK) cells are controlled by an abundance of activating and inhibitory receptors. Many of these interact with MHC class I molecules. The MHC system also interacts with cytotoxic T-lymphocytes and has been shown to comprise a rapidly evolving family of molecules. This challenges the functional relationship of NK cell receptors with their ligands. Although individual receptors have become subject to species-specific expansions over evolutionary time, the main themes of the NK cell interaction with MHC class I have been preserved. This review details the interaction of NK cell receptors with MHC class I and discusses their unexpectedly rapid evolution
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
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