306 research outputs found
Letter from Carl Hayden to Joseph J. Cotter
No full textLetter from Carl Hayden to Joseph J. Cotter regarding suggestions on the proposed national park bill
Letter from Joseph J. Cotter to Carl Hayden
No full textLetter from Joseph J. Cotter to Carl Hayden regarding the use of water power and summer homes in the proposed park boundaries
Letter from Joseph J. Cotter, U.S. National Park Service, to Representative Hayden
No full textLetter from Joseph J. Cotter to Carl Hayden detailing the approximate amount of patented land within the proposed borders of the national park. Thomas J. Croaff is mentioned in his belief that he owns half the land in the proposed area; however, Joseph J. Cotter disputes this claim. Ralph Cameron's mining interests in the park are also mentioned. Circa 1917
Energy conserving upwinded compatible finite element schemes for the rotating shallow water equations
No full textWe present an energy conserving space discretisation of the rotating shallow water equations using compatible finite elements. It is based on an energy and enstrophy conserving Hamiltonian formulation as described in McRae and Cotter (2014), and extends it to include upwinding in the velocity and depth advection to increase stability. Upwinding for velocity in an energy conserving context was introduced for the incompressible Euler equations in Natale and Cotter (2017), while upwinding in the depth field in a Hamiltonian finite element context is newly described here. The energy conserving property is validated by coupling the spatial discretisation to an energy conserving time discretisation. Further, the discretisation is demonstrated to lead to an improved field development with respect to stability when upwinding in the depth field is included.18 pages, 8 figures, first version: all comments welcom
The ‘recovered space’ advection scheme for lowest-order compatible finite element methods
No full textThis is the author accepted manuscript. The final version is available from the publisher via the DOI in this record.We present a new compatible finite element advection scheme for the compressible Euler equations. Unlike the discretisations described in Cotter and Kuzmin (2016) and Shipton et al. (2018), the discretisation uses the lowest-order family of compatible finite element spaces, but still retains second-order numerical accuracy. This scheme obtains this second-order accuracy by first ‘recovering’ the function in higher-order spaces, before using the discontinuous Galerkin advection schemes of Cotter and Kuzmin (2016). As well as describing the scheme, we also present its stability properties and a strategy for ensuring boundedness. We then demonstrate its properties through some numerical tests, before presenting its use within a model solving the compressible Euler equations.Engineering and Physical Science Research Council (EPSRC
Bcr-Abl upregulates cytosolic p21WAF-1/CIP-1by a phosphoinositide-3-kinase (PI3K)-independent pathway
No full textChronic myeloid leukaemia invariably progresses from a drug-sensitive to a drug-resistant, aggressive acute leukaemia. The mechanisms responsible for this are unknown, although loss of p53 has been reported in approximately 25% of cases. Elevated expression of Bcr-Abl is also associated with disease progression. We have shown that cells expressing high levels of Bcr-Abl also express elevated levels of p53 and the cell cycle inhibitor, p21WAF-1. Despite this, cells continue to cycle and are drug resistant. As p21WAF-1 inhibitory activity is associated with nuclear localization, we investigated its localization in Bcr-Abl-expressing cells, and found that it is predominantly cytoplasmic. We have also shown that it associates physically with the serine/threonine kinase AKT, but this association and the cytosolic location of p21WAF-1 are phosphinositide-3-kinase (PI3K) independent. Cytosolic p21WAF-1 has been reported to have a prosurvival role in other transformed cells. In Bcr-Abl-expressing cells, p21WAF-1 rapidly diminishes as the cells are sensitized to apoptosis, using the inhibitor STI571. It is possible therefore that p21WAF-1 could also have a positive, prosurvival role in these cells. This study suggests that, by retaining p21WAF-1 in a cytosolic location, Bcr-Abl can evade the cell cycle arrest normally induced by nuclear p21WAF-1 and therefore also enable the cells to negate an important feature of a tumour suppressor response.LR: 20061115; PUBM: Print; JID: 0372544; 0 (Biological Markers); 0 (CDKN1A protein, human); 0 (Cyclin-Dependent Kinase Inhibitor p21); 0 (Cyclins); 0 (Fusion Proteins, bcr-abl); 0 (Proto-Oncogene Proteins); 0 (Pyrimidines); 0 (ST 1571); 136601-57-5 (Cyclin D1); EC 2.7.1.137 (1-Phosphatidylinositol 3-Kinase); EC 2.7.1.37 (AKT1 protein, human); EC 2.7.1.37 (Protein-Serine-Threonine Kinases); EC 2.7.1.37 (Proto-Oncogene Proteins c-akt); ppublishSource type: Electronic(1
A structure-preserving approximation of the discrete split rotating shallow water equations
No full textWe introduce an efficient split finite element (FE) discretization of a y-independent (slice) model of the rotating shallow water equations. The study of this slice model provides insight towards developing schemes for the full 2D case. Using the split Hamiltonian FE framework (Bauer, Behrens and Cotter, 2019), we result in structure-preserving discretizations that are split into topological prognostic and metric-dependent closure equations. This splitting also accounts for the schemes' properties: the Poisson bracket is responsible for conserving energy (Hamiltonian) as well as mass, potential vorticity and enstrophy (Casimirs), independently from the realizations of the metric closure equations. The latter, in turn, determine accuracy, stability, convergence and discrete dispersion properties. We exploit this splitting to introduce structure-preserving approximations of the mass matrices in the metric equations avoiding to solve linear systems. We obtain a fully structure-preserving scheme with increased efficiency by a factor of two
Energy-enstrophy conserving compatible finite element schemes for the rotating shallow water equations with slip boundary conditions
No full textWe describe an energy-enstrophy conserving discretisation for the rotating
shallow water equations with slip boundary conditions. This relaxes the
assumption of boundary-free domains (periodic solutions or the surface of a
sphere, for example) in the energy-enstrophy conserving formulation of McRae
and Cotter (2014). This discretisation requires extra prognostic vorticity
variables on the boundary in addition to the prognostic velocity and layer
depth variables. The energy-enstrophy conservation properties hold for any
appropriate set of compatible finite element spaces defined on arbitrary meshes
with arbitrary boundaries. We demonstrate the conservation properties of the
scheme with numerical solutions on a rotating hemisphere
Scale-selective dissipation in energy-conserving finite element schemes for two-dimensional turbulence
No full textWe analyze the multiscale properties of energy-conserving upwind-stabilized finite-element discretizations of the two-dimensional incompressible Euler equations. We focus our attention on two particular methods: the Lie derivative discretization introduced by Natale and Cotter and the Streamline Upwind/Petrov–Galerkin (SUPG) discretization of the vorticity advection equation. Such discretizations provide control on enstrophy by modelling different types of scale interactions. We quantify the performance of the schemes in reproducing the non-local energy backscatter that characterizes two-dimensional turbulent flows
Poetry reading and discussion: translating a moving target: poetry of a new Romania
No full textThis is the archive of a poetry reading and discussion given by Liliana Ursu, internationally acclaimed Romanian poet, prose writer, and translator. Ursu's first book in English, The Sky Behind the Forest (Bloodaxe Books, 1997), translated by Ursu, Adam J. Sorkin, and Tess Gallagher, became a British Poetry Book Society Recommended Translation and was shortlisted for Oxford's Weidenfeld Prize. Sean Cotter has translated several books of Romanian poetry, including Goldsmith Market (Zephyr Press, 2004) and the forthcoming Lightwall (Zephyr Press, 2009). Moderator: Askold Melnyczuk, founder and former editor of AGNI, professor at UMass Boston and in Bennington’s MFA program, and author of the new Europe-trotting, gripping, noirish family mystery The House of Widows. Watch video on BUniverse at http://www.bu.edu/buniverse/view/?v=Kyino84.Center for International Relations (Boston University); AGNI (literary journal); American Literary Translators Association (ALTA); Zephyr Press; European Commission Delegation (Washington, DC
- …
