64 research outputs found
Rheological properties of pestil enriched wheat, potato and corn flour using simplex lattice mixture design
No full textIn this study, pestil was made using various concentrations of wheat, corn, and potato flours and the ideal flour combination amounts were determined using the simplex lattice mixture design technique. The apparent viscosity, G' (elastic modulus), G'' (viscous modulus), and tan δ (G''/G') analyses were determined. In all samples, it is seen that viscosity reduces while shear rate increases. This type of behaviour is pseudoplastic behaviour. While the highest apparent viscosity was observed in the 13th sample (12 g/100 g potato flour), the lowest was seen in the 11th sample (12 g/100 g wheat flour). In all samples, the elastic modulus (G') was higher than the viscous modulus (G''). The ANOVA table shows that linear data have a significant (p<0.05) effect on apparent viscosity, G', G'', and tan δ values. In general, formulations using potato flour show higher apparent viscosity values. Also, it is observed that the tan δ, G', G'' and apparent viscosity values increase with the addition of potato flour. © 2024 by the author(s)
Implantable, 3D-Printed Alginate Scaffolds with Bismuth Sulfide Nanoparticles for the Treatment of Local Breast Cancer via Enhanced Radiotherapy
No full textSurgical removal of tumor tissue remains the primary clinical approach for addressing breast cancer; however, complete tumor excision is challenging, and the remaining tumor cells can lead to tumor recurrence and metastasis over time, which substantially deteriorates the life quality of the patients. With the aim to improve local cancer radiotherapy, this work reports the fabrication of alginate (Alg) scaffolds containing bovine serum albumin (BSA)-coated bismuth sulfide (Bi2S3@BSA) nanoradiosensitizers using three-dimensional (3D) printing. Under single-dose X-ray irradiation in vitro, Alg-Bi2S3@BSA scaffolds significantly increase the formation of reactive oxygen species, enhance the inhibition of breast cancer cells, and suppress their colony formation capacity. In addition, scaffolds implanted under tumor tissue in murine model show high therapeutic efficacy by reducing the tumor volume growth rate under single-dose X-ray irradiation, while histological observation of main organs reveals no cytotoxicity or side effects. 3D-printed Alg-Bi2S3@BSA scaffolds produced with biocompatible and biodegradable materials may potentially lower the recurrence and metastasis rates in breast cancer patients by inhibiting residual tumor cells following postsurgery as well as exhibit anticancer properties in other solid tumors
The preliminary ethnobotanical survey of medicinal plants in Develi (Kayseri/Turkey)
No full textBackground and Aims: In Turkey, there is a growing interest in ethnobotany due to the wealth of biological and cultural diversity. The main purpose of this study is to record and highlight the medicinal plants used therapeutically in the Develi district
Implantable, 3D-Printed Alginate Scaffolds with Bismuth Sulfide Nanoparticles for the Treatment of Local Breast Cancer via Enhanced Radiotherapy
No full textSurgical removal
of tumor tissue remains the primary clinical approach
for addressing breast cancer; however, complete tumor excision is
challenging, and the remaining tumor cells can lead to tumor recurrence
and metastasis over time, which substantially deteriorates the life
quality of the patients. With the aim to improve local cancer radiotherapy,
this work reports the fabrication of alginate (Alg) scaffolds containing
bovine serum albumin (BSA)-coated bismuth sulfide (Bi2S3@BSA) nanoradiosensitizers using three-dimensional (3D) printing.
Under single-dose X-ray irradiation in vitro, Alg-Bi2S3@BSA scaffolds significantly increase the formation of reactive
oxygen species, enhance the inhibition of breast cancer cells, and
suppress their colony formation capacity. In addition, scaffolds implanted
under tumor tissue in murine model show high therapeutic efficacy
by reducing the tumor volume growth rate under single-dose X-ray irradiation,
while histological observation of main organs reveals no cytotoxicity
or side effects. 3D-printed Alg-Bi2S3@BSA scaffolds
produced with biocompatible and biodegradable materials may potentially
lower the recurrence and metastasis rates in breast cancer patients
by inhibiting residual tumor cells following postsurgery as well as
exhibit anticancer properties in other solid tumors
Implantable, 3D-Printed Alginate Scaffolds with Bismuth Sulfide Nanoparticles for the Treatment of Local Breast Cancer via Enhanced Radiotherapy
No full textSurgical removal
of tumor tissue remains the primary clinical approach
for addressing breast cancer; however, complete tumor excision is
challenging, and the remaining tumor cells can lead to tumor recurrence
and metastasis over time, which substantially deteriorates the life
quality of the patients. With the aim to improve local cancer radiotherapy,
this work reports the fabrication of alginate (Alg) scaffolds containing
bovine serum albumin (BSA)-coated bismuth sulfide (Bi2S3@BSA) nanoradiosensitizers using three-dimensional (3D) printing.
Under single-dose X-ray irradiation in vitro, Alg-Bi2S3@BSA scaffolds significantly increase the formation of reactive
oxygen species, enhance the inhibition of breast cancer cells, and
suppress their colony formation capacity. In addition, scaffolds implanted
under tumor tissue in murine model show high therapeutic efficacy
by reducing the tumor volume growth rate under single-dose X-ray irradiation,
while histological observation of main organs reveals no cytotoxicity
or side effects. 3D-printed Alg-Bi2S3@BSA scaffolds
produced with biocompatible and biodegradable materials may potentially
lower the recurrence and metastasis rates in breast cancer patients
by inhibiting residual tumor cells following postsurgery as well as
exhibit anticancer properties in other solid tumors
Performance analysis of pretrained convolutional neural network models for ophthalmological disease classification
No full textABSTRACT Purpose: This study aimed to evaluate the classification performance of pretrained convolutional neural network models or architectures using fundus image dataset containing eight disease labels. Methods: A publicly available ocular disease intelligent recognition database has been used for the diagnosis of eight diseases. This ocular disease intelligent recognition database has a total of 10,000 fundus images from both eyes of 5,000 patients for the following eight diseases: healthy, diabetic retinopathy, glaucoma, cataract, age-related macular degeneration, hypertension, myopia, and others. Ocular disease classification performances were investigated by constructing three pretrained convolutional neural network architectures including VGG16, Inceptionv3, and ResNet50 models with adaptive moment optimizer. These models were implemented in Google Colab, which made the task straight-forward without spending hours installing the environment and supporting libraries. To evaluate the effectiveness of the models, the dataset was divided into 70%, 10%, and 20% for training, validation, and testing, respectively. For each classification, the training images were augmented to 10,000 fundus images. Results: ResNet50 achieved an accuracy of 97.1%; sensitivity, 78.5%; specificity, 98.5%; and precision, 79.7%, and had the best area under the curve and final score to classify cataract (area under the curve = 0.964, final score = 0.903). By contrast, VGG16 achieved an accuracy of 96.2%; sensitivity, 56.9%; specificity, 99.2%; precision, 84.1%; area under the curve, 0.949; and final score, 0.857. Conclusions: These results demonstrate the ability of the pretrained convolutional neural network architectures to identify ophthalmological diseases from fundus images. ResNet50 can be a good architecture to solve problems in disease detection and classification of glaucoma, cataract, hypertension, and myopia; Inceptionv3 for age-related macular degeneration, and other disease; and VGG16 for normal and diabetic retinopathy.</div
Sugammadex-Induced Hypersensitivity Reaction in a Pediatric Patient
No full textWe report a case of a 3-year-old boy who administered sugammadex and developed an allergic reaction several minutes after the administration. He developed an increase in airway pressures and a decrease in peripheral oxygen saturation; auscultation revealed widespread wheezing in the lungs. He was successfully treated with immediate administration of methylprednisolone, pheniramine, and theophylline. We assumed an allergic reaction to sugammadex based on the clinical condition of the patient
Monuments et inscriptions de la ville de Buṣrā aux époques umayyade et salǧūqide
No full textPostgraduate thesis by Solange Ory, original copy annotated by the author, taken from her archive held at the Media Library of the Mediterranean House of Social Sciences and Humanities (Maison méditerranéenne des sciences humaines et sociales - Mmsh).Excerpt from the foreword: "The classification of the Max van Berchen archives in Geneva, intended to serve as a basis for the continued compilation of the Corpus of Arabic Epigraphy, is the origin of this work. Our goal at the time was solely to study the inscriptions with a view to compiling the Corpus of Busra. Our harvest was abundant and the results of this initial investigation quadrupled the number of inscriptions. [...]This new direction – the archaeological study of Islamic monuments – added to what was originally intended to be only the Corpus of Arabic Inscriptions of Busra, led us to consider writing this work in two volumes. Indeed, we do not currently have the necessary documentation to study the citadel and the various buildings attached to it, the plans of which were drawn up during the excavation of the theatre.To ensure unity and balance in each of the two volumes, we have divided the study of the monuments and inscriptions of Busra into two parts:- monuments and inscriptions from the Umayyad and Seljuk periods.- monuments and inscriptions from the Ayyubid and Mamluk periods.In the first part, we also dealt with the epitaphs in the cemeteries, grouped in part around the monuments from the periods studied, the study of which constitutes a whole.In the second volume, we will add to the Ayyubid and Mamluk monuments the inscriptions scattered throughout various modern buildings in the city – a dispersion due to the reuse of the materials on which the inscriptions were engraved – which are currently preserved in the Lapidary Museum of the Citadel."Thèse de Troisième Cycle de Solange Ory, exemplaire original annoté par l'auteure, tiré de son fonds d'archives conservé à la Médiathèque de la Maison méditerranéenne des sciences humaines et sociales.Extrait de l'avant propos : "Le classement des archives Max van Berchen à Genève, destiné à servir de base à la poursuite de la rédaction des Corpus d’Épigraphie arabe, est à l'origine de cet ouvrage. Notre but visait alors uniquement l'étude des inscriptions en vue de la rédaction du Corpus de Busra. Notre moisson fut abondante et les résultats de cette première enquête quadruplèrent le nombre d'inscriptions. [...]Cette orientation nouvelle - étude archéologique des monuments islamiques - ajoutée à ce qui, primitivement, ne devait être que le Çorpus des Inscriptions arabes de Busra, nous amena à envisager la rédaction de cet ouvrage en deux volumes. En effet, nous ne disposons pas actuellement de la documentation nécessaire à l'étude de la citadelle et des diverses constructions qui y étaient annexées et dont les plans ont été relevés lors du déblaiement du théâtre.Pour assurer unité et équilibre à chacun des deux volumes, nous avons divisé l'étude des monuments et inscriptions de Busra en deux parties :- les monuments et inscriptions des périodes umayyade et salguqide.- les monuments et inscriptions des périodes ayyubide et mameluke.Dans la première partie, nous avons également traité des épitaphes des cimetières groupés en partie, autour des monuments des périodes étudiées et dont l'étude constitue un tout.Dans le second volume, nous ajouterons aux monuments ayyübides et mameluks les inscriptions dispersées dans différentes constructions modernes de la ville - dispersion due au remploi des matériaux sur lesquels elles étaient gravées les inscriptions déplacées qui sont actuellement conservées au Musée lapidaire de la citadelle.
Monuments et inscriptions de la ville de Buṣrā aux époques umayyade et salǧūqide
No full textPostgraduate thesis by Solange Ory, original copy annotated by the author, taken from her archive held at the Media Library of the Mediterranean House of Social Sciences and Humanities (Maison méditerranéenne des sciences humaines et sociales - Mmsh).Excerpt from the foreword: "The classification of the Max van Berchen archives in Geneva, intended to serve as a basis for the continued compilation of the Corpus of Arabic Epigraphy, is the origin of this work. Our goal at the time was solely to study the inscriptions with a view to compiling the Corpus of Busra. Our harvest was abundant and the results of this initial investigation quadrupled the number of inscriptions. [...]This new direction – the archaeological study of Islamic monuments – added to what was originally intended to be only the Corpus of Arabic Inscriptions of Busra, led us to consider writing this work in two volumes. Indeed, we do not currently have the necessary documentation to study the citadel and the various buildings attached to it, the plans of which were drawn up during the excavation of the theatre.To ensure unity and balance in each of the two volumes, we have divided the study of the monuments and inscriptions of Busra into two parts:- monuments and inscriptions from the Umayyad and Seljuk periods.- monuments and inscriptions from the Ayyubid and Mamluk periods.In the first part, we also dealt with the epitaphs in the cemeteries, grouped in part around the monuments from the periods studied, the study of which constitutes a whole.In the second volume, we will add to the Ayyubid and Mamluk monuments the inscriptions scattered throughout various modern buildings in the city – a dispersion due to the reuse of the materials on which the inscriptions were engraved – which are currently preserved in the Lapidary Museum of the Citadel."Thèse de Troisième Cycle de Solange Ory, exemplaire original annoté par l'auteure, tiré de son fonds d'archives conservé à la Médiathèque de la Maison méditerranéenne des sciences humaines et sociales.Extrait de l'avant propos : "Le classement des archives Max van Berchen à Genève, destiné à servir de base à la poursuite de la rédaction des Corpus d’Épigraphie arabe, est à l'origine de cet ouvrage. Notre but visait alors uniquement l'étude des inscriptions en vue de la rédaction du Corpus de Busra. Notre moisson fut abondante et les résultats de cette première enquête quadruplèrent le nombre d'inscriptions. [...]Cette orientation nouvelle - étude archéologique des monuments islamiques - ajoutée à ce qui, primitivement, ne devait être que le Çorpus des Inscriptions arabes de Busra, nous amena à envisager la rédaction de cet ouvrage en deux volumes. En effet, nous ne disposons pas actuellement de la documentation nécessaire à l'étude de la citadelle et des diverses constructions qui y étaient annexées et dont les plans ont été relevés lors du déblaiement du théâtre.Pour assurer unité et équilibre à chacun des deux volumes, nous avons divisé l'étude des monuments et inscriptions de Busra en deux parties :- les monuments et inscriptions des périodes umayyade et salguqide.- les monuments et inscriptions des périodes ayyubide et mameluke.Dans la première partie, nous avons également traité des épitaphes des cimetières groupés en partie, autour des monuments des périodes étudiées et dont l'étude constitue un tout.Dans le second volume, nous ajouterons aux monuments ayyübides et mameluks les inscriptions dispersées dans différentes constructions modernes de la ville - dispersion due au remploi des matériaux sur lesquels elles étaient gravées les inscriptions déplacées qui sont actuellement conservées au Musée lapidaire de la citadelle.
Pairwise Multiple Comparison Adjustment Procedure for Survival Functions with Right-Censored Data
No full textThe aim of this study is to propose a new pairwise multiple comparison adjustment procedure based on Genz’s numerical computation of probabilities from a multivariate normal distribution. This method is applied to the results of two-sample log-rank and weighted log-rank statistics where the survival data contained right-censored observations. We conducted Monte Carlo simulation studies not only to evaluate the familywise error rate and power of the proposed procedure but also to compare the procedure with conventional methods. The proposed method is also applied to the data set consisting of 815 patients on a liver transplant waiting list from 1990 to 1999. It was found that the proposed method can control the type I error rate, and it yielded similar power as Tukey’s and high power with respect to the other adjustment procedures. In addition to having a straightforward formula, it is easy to implement.</jats:p
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