1,720,981 research outputs found
Oxidative stress in evolution of adenomiosis
Full text linkUniversitatea de Stat de Medicină şi Farmacie „Nicolae Testemiţanu”, Chişinău, Republica MoldovaIntroducere. Răspândirea adenomiozei este rezultatul proceselor distructive în membrana miocitelor, în țesutul conjunctiv în zona de joncțiune endomiometrul, cauzat de acțiunea radicalilor liberi și activarea proceselor de peroxidare a lipidelor. Scopul lucrării. Estimarea gradului stresului oxidativ la pacientele cu adenomioză și determinarea dinamicei indicelui de protecție antioxidantă AAO/DAM în urma diferitelor metode de tratament. Material și metode. Au fost investigați 130 de paciente cu adenomioză în diferite stadia, cărora li s-au administrat diferite metode de tratament. Gradul de stres oxidativ a fost estimat prin determinarea produsului final de peroxidare lipidica (POL) (dialdehida malonica (DAM)), a activității antioxidante serice (AAO) și a enzimelor: superoxid dismutaza (SOD), catalaza și glutation peroxidaza (GP), și calculat indicele de protecție antioxidantă AAO/DAM. Rezultate. Dinamica DAM este corelată cu severitatea bolii, constatată valorile maximale în stadiul 4 al maladiei, ce depășește de două ori (p<0,01) normativul fiziologic din RM (4,56±0,09 nmol/l). Pe de altă parte, indicele de activitate antioxidantă marchează o tendință de scădere pe măsură progresiei adenomiozei, fiind în stadiul 4 doar de 54,83±0,80% față de normativul 74,28±0,48% (p<0,01%). Histerectomia - o metodă radicală de tratament utilizată stadiul 4 a adenomiozei, modifică indicele AAO/DAM, dar rămâne de 2 ori sub norma. Concluzii. Indicele de protecție antioxidantă AAO/DAM, care a fost calculat în această lucrare, poate servi drept criteriu preclinic suplimentar pentru a obiectiva severitatea adenomiozei, a prezice evoluția bolii, eficacitatea tratamentului și riscul de progresie a procesului patologic sau malignizare.Background. The spread of adenomyosis is the result of destructive processes in the myocyte membrane, in the connective tissue in the endo-myometrium junction area, caused by the action of free radicals and the activation of lipid peroxidation processes. Objective of the study. Estimation of the oxidative stress degree in patients with adenomyosis and to determine the oxidant/antioxidant potential of different treatment methods. Material and methods. There was investigated 130 patients with adenomyosis in different stages of the disease, which were administered different methods of treatment. The oxidative stress degree was estimated by determining lipid peroxidation (POL) final product (malonic dialdehyde (DAM)), the serum antioxidant activity (AAO) and the enzymes: superoxide dismutase (SOD), catalase, and glutathione peroxidase (GP), and then calculated the antioxidant activity index AAO/DAM. Results. DAM dynamics is correlated with severity of the disease, and in 4th stage it exceeds almost twice (p<0.01) the physiological normative in Republic of Moldova (4.56±0.09 nmol/l). The antioxidant activity index is suppressed as the disease progresses, in the 4th stage reaching 54, 83±0, 80% comparing with the tolerable normative 74,28±0,48% (p<0,01). Hysterectomy - a radical method of treatment in 4th stage of adenomiosis, changes the AAO/DAM index, but in the same time it remains 2 times below the tolerable normative. Conclusions. The antioxidant protection index AAO/DAM, which has been calculated in this work, can serve as a supplementary preclinical criterion to objectivize the adenomyosis severity, to predict the disease evolution, treatment efficacy and the risk of progression of the pathologic process or malignization
Oxidative stress in evolution of endometriosis
Full text link1st Obstetrics and Gynecology department, State University of Medicine and Pharmacy,
Republic of Moldova, Al VI-lea Congres Național de Obstetrică și Ginecologie cu participare internațională, 13-15 septembrie 2018, Chișinău, Republica MoldovaSpreading of endometriosis is succeeded by the destructive processes in the myocytes membrane, in the myometrium connective tissue, and also by the activation of lipid peroxidation processes.
Objectives: the purpose of this work was to estimate the oxidative stress degree in patients with adenomyosis and to determine the oxidant/antioxidant potential of different treatment methods.
Materials and methods: There were investigated 130 patients with adenomyosis in different stages of the disease, which were administered different methods of treatment. The oxidative stress degree was estimated by determining lipid peroxidation (POL) final product (malonic dialdehyde (DAM)), the serum antioxidant activity (AAO) and the
enzymes: superoxide dismutase (SOD), catalase, and glutathione peroxidase (GP), and then calculated the antioxidant activity index AAO/DAM.
Results: DAM dynamics are correlated with the severity of the disease, and in the 4th stage, it exceeds almost twice (p<0, 01) the physiological normative in the Republic of Moldova (4, 56±0, 09 nmol/l). The antioxidant activity index marks a similar tendency and this activity is suppressed as the disease progresses, in the 4th stage reaching 54, 83±0, 80% compared with the tolerable normative 74,28±0,48% (p<0,01).
Conclusions: The antioxidant protection index AAO/DAM, which has been calculated in this work, can serve as a supplementary preclinical criterion to objectivize the adenomyosis severity, to predict the disease evolution and treatment efficacy. Hysterectomy - a radical method of treatment, changes the AAO/DAM index, but at the same time, it remains 2 times below the tolerable normative, persisting the risk of progression of the pathologic process, of spreading or malignization
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Deep endometriosis – diagnosis and impact on quality of life
Full text linkIntroduction. Deep infiltrating endometriosis (DIE) is considered the most painful form of endometriosis, responsible for
reducing the women’s quality of life (QoL). Its management presents difficulties in medicine. The #Enzian classification
reflects locations of DIE and simplifies its medical management. International guidelines recommend studies of QoL in
women with endometriosis.
Objective. To investigate the symptoms of DIE and determine its impact on QoL to optimize its diagnostics.
Materials and methods. A cohort study was conducted over 2 years at the Gheorghe Paladi Municipal Clinical Hospital, including 190 patients with endometriosis, who were divided into groups: main group - 85 patients with DIE, control group
- 105 other endometriosis forms. To objectify the pain, Visual Analog Scale and Biberoglu and Behrman (B&B) were used.
Endometriosis was staged with the #Enzian classification. For the analysis of QoL, three standardized questionnaires were
used. Data were recorded in Excel and statistically calculated with the SPSS program.
Results. Pelvic pain syndrome according to the Visual Analog Scale and B&B scales in the main group was 3 times more
pronounced than in the control group (p < 0.01). Lesions of DIE according to the #Enzian statistically correlated with
chronic pelvic pain, dysmenorrhea, dyspareunia, dysuria, dyschezia >7 points (VAS), catamenial rectal tenesmus, defecation disorders, menometrorrhagia, hematuria, bladder tenesmus, hydronephrosis with ureteral stenting during pregnancy,
catamenial cough and hemoptysis, chest pain and spontaneous pneumothorax, hemorrhagic scar, hiccups, and the frenicus
symptom (p < 0.05). According to the questionnaires of QoL, DIE significantly influences life determinants by 44.27%,
compared to the control group at 3.64% (p < 0.01), allowing realization of life determinants in a maximum of 58.54% vs.
the control group’s 92.18% (p < 0.01). Additionally, psychological well-being in patients with DIE is lower than that in the
control group (44.29% vs. 81.38%, p < 0.01).
Conclusions. High-intensity pain syndrome and extragenital symptoms correlated with compartments of #Enzian will
assist in the preoperative multidisciplinary diagnosis of DIE. The high influence on life determinants, the low realization of
life potential, and the low psychological well-being confirm the significant impact of DIE on QoL, classifying it as a disability
The impact of oligoamniosis on perinatal results
Full text linkUniversitatea de Stat de Medicină şi Farmacie „Nicolae Testemiţanu”, Chişinău, Republica MoldovaIntroducere. Oligoamnioza reprezintă o problemă actuală obstetricală , fiind o complicație cu efecte perinatale negative și un predictor al morbidității și mortalității perinatale înalte. Scopul lucrării. Estimarea impactului oligoamniozei în evoluția sarcinii, nașterii și asupra rezultatelor materno-fetale. Material și metode. Studiul a fost realizat în incinta SCM „Gheorghe Paladi”, în cadrul secțiilor Obstetricală nr 1 și nr 2, în perioada 2019–2021. Au fost analizate fișe de observație a gravidelor cu selectarea a 223 paciente, care au fost repartizate în 2 loturi. Lotul I a fost constituit din 105 paciente diagnosticate cu oligoamnioză, iar lotul II a cuprins 118 paciente cu un nivel de lichid amniotic normal. Rezultate. Studiul comparativ a evoluției sarcinii în loturile de studiu, a evaluat prezența următoarelor complicații mai frecvent în lotul cu oligoamnioză: RCIU de 11 ori (OR = 11,7913 CI = 4,42:31,49 (95%) P = 0,0001), prezentația pelvină de 3 ori (OR = 3,1935 CI = 1,1:9,29 (95%) P = 0,0330), stările hipertensive de 2 ori (OR = 2,2599 CI = 1,12:4,55 (95%) P = 0,0224). Morbiditatea materno-fetală în naștere a fost repartizată în modul următor: nașteri premature OR = 2,3182 CI = 1,17:4,58 (95%) P = 0,0156, operația cezariană OR = 2,0435 CI = 1,12:3,73 (95%) P = 0,020, suferința fetală acută OR = 2,8406 CI = 1,05:7,69 (95%) P = 0,0398, greutatea mică la naștere OR = 3,2828 CI = 1,73:6,22 (95%) P = 0,0003, scorul Apgar ≤ 6 puncte OR = 3,1935 CI = 1,1:9,29 (95%) P = 0,033. Concluzii. Oligoamnioza poate condiționa o morbiditate materno-fetală înaltă, statistic constatată, care frecvent necesită rezolvarea chirurgicală a sarcinii în condiții de urgență majoră, iar copiii necesită asistența neonatală specializată, care poate fi asigurată doar în condițiile centrelor perinatale.Background. Oligoamniosis represents an actual obstetric problem, being a complication with negative perinatal effects and a predictor of high perinatal morbidity and mortality. Objective of the study. Estimation of the impact of oligoamniosis in the course of pregnancy, birth and on maternal-fetal outcomes. Materials and Methods. The study was carried out in the Gheorghe Paladi Municipal Clinical Hospital, within the Obstetrical departments no. 1 and no. 2, in the period 2019-2021. Observation sheets of pregnant woman were analyzed with the selection of 223 patients, who were divided into 2 groups. Group I consisted of 105 patients with oligoamniosis, and group II included 118 patients with normal amniotic fluid level. Results. The comparative study of the evolution of pregnancy in the study groups, evaluated the presence of the following complications more frequently in the group with oligoamniosis: IUGR 11 times (OR = 11.7913 CI = 4.42:31.49 (95%) P = 0.0001), pelvic presentation 3 times (OR = 3.1935 CI = 1.1:9.29 (95%) P = 0.0330), hypertensive conditions 2 times (OR = 2.2599 CI = 1.12:4.55 (95%) P = 0.0224). Maternal-fetal morbidity in childbirth was distributed as follows: premature births OR = 2.3182 CI = 1.17:4.58 (95%) P = 0.0156, caesarean section OR = 2.0435 CI = 1.12:3.73 (95%) P = 0.020, acute fetal distress OR = 2.8406 CI = 1.05:7.69 (95%) P = 0.0398, low birth weight OR = 3.2828 CI = 1.73:6.22 (95%) P = 0.0003, Apgar score ≤ 6 points OR = 3.1935 CI = 1.1:9.29 (95%) P = 0.033. Conclusion. Oligoamniosis can condition a high maternal-fetal morbidity, statistically proven, and frequently requires surgical resolution of the pregnancy in conditions of major emergency. The newborns may require specialized neonatal assistance, which can be provided only in perinatal centers
Dispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
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