125,594 research outputs found
Going Beyond Counting First Authors in Author Co-citation Analysis
No full textThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Dispelling the Myths Behind First-author Citation Counts
No full textWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
Estudio del funcionamiento neurocognitivo en la infección por VIH en la era de las terapias antirretrovirales combinadas
No full textLa tesis titulada "Estudio del Funcionamiento Neurocognitivo en la Infección por VIH en la Era de las Terapias Antirretrovirales Combinadas" desarrollada por el doctorando Jose Antonio Muñoz-Moreno se planteó como objetivos principales a su inicio: 1.- Centrar la problemática de la disfunción neurocognitiva dentro del marco de la investigación científica en el ámbito de la infección por VIH. 2.- Recoger datos preliminares en España sobre la frecuencia de las alteraciones neurocognitivas en la época de las terapias antirretrovirales combinadas en la infección por VIH. 3.- Identificar el perfil de afectación neurocognitiva que se produce en las personas infectadas por el VIH y determinar las áreas neuropsicológicas que están principalmente implicadas. 4.- Determinar algunos de los principales factores de riesgo para el desarrollo de la alteración neurocognitiva por VIH y evaluar su efecto en las personas infectadas. 5.- Establecer ciertas hipótesis iniciales orientadas hacia la prevención o mejora de la disfunción neurocognitiva asociada al VIH. Para lograr esos objetivos, el doctorando finalizó los trabajos previstos inicialmente y además publicó un capítulo de libro en inglés y cuatro artículos científicos, dos de ellos como trabajos originales, y los otros dos como artículos de revisión en revistas con impacto internacional. Todos estos trabajos se enmarcaron en la línea de investigación a la que pertenece la presente tesis doctoral y fueron los siguientes: 1. Muñoz-Moreno JA (2007). Neurocognitive and motor disorders in HIV infection. Assessment and interventions. In: Research focus on cognitive disorders. (Eds: Plishe VN). Hauppauge, NY: Nova Science Publishers, 133-147. 2. Muñoz-Moreno JA, Fumaz CR, Ferrer MJ, Prats A, Negredo E, Garolera M, Pérez-Álvarez N, Moltó J, Gómez G, Clotet B. Nadir CD4 cell count predicts neurocognitive impairment in HIV-infected patients. AIDS Res Hum Retroviruses 2008 Oct; 24(10): 1301-1307. 3. Muñoz-Moreno JA, Blanch Andreu J. Trastornos neurocognitivos en la infección por el virus de inmunodeficiencia humana. Med Clin 2009 May 30; 132(20):787-791. 4. Muñoz-Moreno JA, Fumaz CR, Ferrer MJ, González-García M, Moltó J, Negredo E, Clotet B. Neuropsychiatric symptoms associated with efavirenz: prevalence, correlates, and management. A neurobehavioral review. AIDS Rev 2009 Apr-Jun; 11(2):103-9. 5. Muñoz-Moreno JA, Fumaz CR, Prats A, Ferrer MJ, Negredo E, Pérez-Álvarez N, Moltó J, Gómez G, Garolera M, Clotet B. Interruptions of antiretroviral therapy in HIV infection: are they detrimental to neurocognitive functioning? J Neurovirol 2010 Jun; 16(3):208-18.The thesis entitled "Study of Neurocognitive Functioning in HIV Infection in the Era of Combination Antiretroviral Therapy" and developed by the pre-doctoral student Jose Antonio Muñoz-Moreno established as main initial objectives: 1.- To address the concern of neurocognitive dysfunction in the setting of the research in HIV infection. 2.- To obtain preliminary data in Spain about the frequency of neurocognitive impairment in the era of combination antiretroviral therapy. 3.- To know the neurocognitive profile existing in people with HIV and to determine the neuropsychological areas most commonly involved. 4.- To identify some of the most relevant risk factors for the development of HIV-associated neurocognitive impairment and to assess its impact on the infected people. 5.- To establish preliminary hypothesis focused on the prevention and improvement of the neurocognitive dysfunction in HIV infection. To reach those objectives the student finished the expected initial works and, in addition, he published a book chapter in English and four scientific reports, two out of them as original articles, and the two other as review articles in scientific journals with international impact factor. The setting in which those works were published was the same line of research of this thesis and, concretely, they were the following: 1. Muñoz-Moreno JA (2007). Neurocognitive and motor disorders in HIV infection. Assessment and interventions. In: Research focus on cognitive disorders. (Eds: Plishe VN). Hauppauge, NY: Nova Science Publishers, 133-147. 2. Muñoz-Moreno JA, Fumaz CR, Ferrer MJ, Prats A, Negredo E, Garolera M, Pérez-Álvarez N, Moltó J, Gómez G, Clotet B. Nadir CD4 cell count predicts neurocognitive impairment in HIV-infected patients. AIDS Res Hum Retroviruses 2008 Oct; 24(10): 1301-1307. 3. Muñoz-Moreno JA, Blanch Andreu J. Trastornos neurocognitivos en la infección por el virus de inmunodeficiencia humana. Med Clin 2009 May 30; 132(20):787-791. 4. Muñoz-Moreno JA, Fumaz CR, Ferrer MJ, González-García M, Moltó J, Negredo E, Clotet B. Neuropsychiatric symptoms associated with efavirenz: prevalence, correlates, and management. A neurobehavioral review. AIDS Rev 2009 Apr-Jun; 11(2):103-9. 5. Muñoz-Moreno JA, Fumaz CR, Prats A, Ferrer MJ, Negredo E, Pérez-Álvarez N, Moltó J, Gómez G, Garolera M, Clotet B. Interruptions of antiretroviral therapy in HIV infection: are they detrimental to neurocognitive functioning? J Neurovirol 2010 Jun; 16(3):208-18
Pragmatic Case Studies as a Source of Unity in Applied Psychology
No full textTo unify or not to unify applied psychology: that is the question. In this article we review pendulum swings in the historical efforts to answer this question—from a comprehensive, positivist, “top-down,” deductive yes between the 1930s and the early 60s, to a postmodern no since then. A rationale and proposal for a limited, “bottom-up,” inductive yes in applied psychology is then presented, employing a case-based paradigm that integrates both positivist and postmodern themes and components. This paradigm is labeled “pragmatic psychology” and, its specific use of case studies, the “Pragmatic Case Study Method” (“PCS Method”). We call for the creation of peer-reviewed journal-databases of pragmatic case studies as a foundational source of unifying applied knowledge in our discipline. As one example, the potential of the PCS Method for unifying different angles of theoretical regard is illustrated in an area of applied psychology, psychotherapy, via the case of Mrs. B. The article then turns to the broader historical and epistemological arguments for the unifying nature of the PCS Method in both applied and basic psychology.Peer reviewe
The anti-HIV activity of ADS-J1 targets the HIV-1 gp120
No full textRecent data suggest that heparin sulfates may bind to a CD4 induced epitope in the HIV-1 gp120 that constitutes the coreceptor binding site. We have studied the mechanism of action of ADS-J1, a non-peptidic compound selected by docking analysis to interact with gp41 and to interfere with the formation of N-36/C-34 complexes in sandwich ELISA experiments. We show that ADS-J1 blocked the binding of wild-type HIV-1 NL4-3 strain to MT-4 cells but not virus-cell binding of a polyanion-resistant virus. However, ADS-J1 blocked the replication of polyanion-resistant, T-20- and C34-resistant HIV-1, suggesting a second mechanism of action. Development of resistance to ADS-J1 on the polyanion-resistant HIV-1 led to mutations in gp120 coreceptor binding site and not in gp41. Time of addition experiments confirmed that ADS-J1, but not polyanions such as dextran sulfate or AR177, worked at a step that mimics the activity of an HIV coreceptor antagonist but prior to gp41-dependent fusion. We conclude that ADS-J1 may bind to the HIV coreceptor binding site as its mechanism of anti-HIV activity
Dr. Edwin Wright Collection: Author Unknown
No full textNotes - The author relates several short stories about his neighbours including Alex McDonell, homesteading and life around Meanook and Athabasca (1 page
Appropriate Similarity Measures for Author Cocitation Analysis
No full textWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
High risk and probability of progression to osteoporosis at 10 years in HIV-infected individuals: the role of PIs
No full textThis is a pre-copyedited, author-produced PDF of an article accepted for publication in Journal of antimicrobial chemotherapy following peer review. The version of record Negredo, E., Langohr, K., Bonjoch, A., Perez, N., Estany, C., Puig, J., Echevarría, P., Clotet, B., Gómez Melis, G. High risk and probability of progression to osteoporosis at 10 years in HIV-infected individuals: the role of PIs. "Journal of antimicrobial chemotherapy", 1 Setembre 2018, vol. 73, núm. 9, p. 2452-2459 is available online at: https://academic.oup.com/jac/article-abstract/73/9/2452/5026321.Peer ReviewedPostprint (author's final draft
Frequent hepatitis B virus rebound among HIV-hepatitis B virus-coinfected patients following antiretroviral therapy interruption.
No full textHigh risk and probability of progression to osteoporosis at 10 years in HIV-infected individuals: the role of PIs
No full textThis is a pre-copyedited, author-produced PDF of an article accepted for publication in Journal of antimicrobial chemotherapy following peer review. The version of record Negredo, E., Langohr, K., Bonjoch, A., Perez, N., Estany, C., Puig, J., Echevarría, P., Clotet, B., Gómez Melis, G. High risk and probability of progression to osteoporosis at 10 years in HIV-infected individuals: the role of PIs. "Journal of antimicrobial chemotherapy", 1 Setembre 2018, vol. 73, núm. 9, p. 2452-2459 is available online at: https://academic.oup.com/jac/article-abstract/73/9/2452/5026321.Peer Reviewe
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