653 research outputs found
Illustrator's flat signature in The novels and stories of Richard Harding Davis
No full textThis edition includes the flat signature of Illustrator Charles Dana Gibson on the frontispiece in "Gallegher, and other stories"; and a second signature in "Soldiers of Fortune". This is a limited-edition, 256-copy run of "The novels and stories of Richard Harding Davis" [v. 4]. Richard Harding Davis, author, 1864-1916.--v.1. The bar sinister and other stories.--v.2. The exiles and other stories.--v.3. Gallegher and other stories.--v.4. Soldiers of fortune.--v.5. Captain Macklin: his memoirs.--v.6. Ranson's Folly.--v.7. The White mice.-- v.8. The Scarlet car.--v.9. The bar sinister.--v.10. The man who could not lose.--v.11. The red cross girl.--v.12. The lost road.
Davis, Richard Harding, 1864-1916
Interview of Verna E. Howard
No full textNoted radio evangelist, author and businessman, V. E. Howard was inducted into the Harding College Oral History library on August 14, 1970
Quality of life and wellbeing among HIV outpatients in East Africa: a multicentre observational study.
No full textBACKGROUND: Global health investment has reduced HIV mortality and transmission. However, little is known of patient-reported outcomes alongside ART rollout. This study aimed to measure wellbeing using patient-reported outcome measures (PROMS) among outpatients at PEPFAR-funded facilities. METHODS: In a multicentre 2 country cross-sectional study, adults attending 12 facilities in Kenya and Uganda gave self-reported data on quality of life (physical and mental wellbeing dimensions), functional and a measure of multidimensional problems (physical, psychological, social and spiritual). RESULTS: Among the 1,337 participants, multidimensional problems were more common in psychological, spiritual and social domains than in physical. In multivariable analysis using GEE to adjust for facility effect, the mental health subscale of quality of life was lower for people with limited functional status (B = -5.27, 95% CI -5.99, 1. -4.56 p < 0.001) and higher for wealthier people (B = 0.91, 95% CI 0.48, 1.33, p < 0.001). The physical health subscale of quality of life was lower for those with limited functional status (B = -8.58, 95% CI -9.46 to -7.70, p < 0.001) and those who had a caregiver present (B = -1.97, 95% CI -3.72 to -0.23, p = 0.027), higher for wealthier people (B = 1.14, 95% CI 0.65, 1.64, p < 0.001), and positively associated with CD4 count (B = 1.61, 95% CI 1.08-2.14, p < 0.001). Multidimensional problems were more burdensome for people with limited functional status (B = -2.06, 95% CI -2.46 to -1.66, p < 0.001), and less burdensome with more education (B = 0.63, 95% CI 0.25-1.00, p = 0.001) or ART use (B = 0.94, 95% CI 0.34-1.53, p = 0.002). CONCLUSIONS: Multidimensional problems are highly prevalent, and worse with declining function. Importantly, ART use does not appear to be protective for self-reported physical and mental dimensions of quality of life. Assessment and management of self-reported wellbeing must form part of HIV care and treatment services to ensure maximum benefit from ART investment
Isolating Exosomes on OBU\u27s Campus
No full textExosomes are membranous extracellular vesicles that originate from the budding of endosomal compartments within a cell. These vesicles were discovered in 1983 and, since then, it has been shown that exosomes play a large role in physiology and disease (Harding, Clifford V., et al 2004). This early discovery has been recognized over the following three decades by an explosive growth in the field of exosome research and biology, resulting in the formation of various societies (International Society for Extracellular Vesicles and The American Society for Exosomes and Microvesicles) and even a dedicated journal (Journal of Extracellular Vesicles), plus numerous international meetings and well over a thousand publications on exosomes, to date (Harding, Clifford V., et al 2004). At the point of discovery, researchers noticed that transferrin receptors were jutted out from maturing blood reticulocytes in the extracellular space (Harding, Clifford V., et al 2004). The mechanism of the receptor release eluded the researchers until the previously mentioned explosion of research. It was found that these vesicles are transported to the plasma membrane through the vesicular system that then fuses with the plasma membrane to release its contents to the environment (Lane, Rebecca E., et al). This is similar to normal exocytosis except the contents within these vesicles are also membrane bound vesicles. Instead of simply releasing contents into the extracellular space, the exosomes keep the contents within a membrane to allow for further transport. The contents within the exosomes can include mRNA, miRNA, and proteins from the cell of its origin. Since exosomes contain these micro-molecules, it has been implicated that they have a large role in cell-to-cell communications (Lane, Rebecca E., et al 2015). Research into the role of these micro-vesicles\u27 hand in disease transduction has taken the forefront in the journey to better understand the exact purpose of exosomes. It is also the main goal behind the research that has been started at OBU under the Exosome Project
Proteomics and network analyses reveal inhibition of Akt-mTOR signaling in CD4+ T cells by mycobacterium tuberculosis Mannose-capped lipoarabinomannan
No full textMycobacterium tuberculosis (Mtb) cell wall glycolipid mannose‐capped lipoarabinomannan (ManLAM) inhibits CD4+ T‐cell activation by inhibiting proximal T‐cell receptor (TCR) signaling when activated by anti‐CD3. To understand the impact of ManLAM on CD4+ T‐cell function when both the TCR–CD3 complex and major costimulator CD28 are engaged, we performed label‐free quantitative MS and network analysis. Mixed‐effect model analysis of peptide intensity identified 149 unique peptides representing 131 proteins that were differentially regulated by ManLAM in anti‐CD3‐ and anti‐CD28‐activated CD4+ T cells. Crosstalker, a novel network analysis tool identified dysregulated translation, TCA cycle, and RNA metabolism network modules. PCNA, Akt, mTOR, and UBC were found to be bridge node proteins connecting these modules of dysregulated proteins. Altered PCNA expression and cell cycle analysis showed arrest at the G2M phase. Western blot confirmed that ManLAM inhibited Akt and mTOR phosphorylation, and decreased expression of deubiquitinating enzymes Usp9x and Otub1. Decreased NF‐κB phosphorylation suggested interference with CD28 signaling through inhibition of the Usp9x‐Akt‐mTOR pathway. Thus, ManLAM induced global changes in the CD4+ T‐cell proteome by affecting Akt‐mTOR signaling, resulting in broad functional impairment of CD4+ T‐cell activation beyond inhibition of proximal TCR–CD3 signaling
gp96 Leads the Way for Toll-like Receptors
No full textThe role of the gp96 heat-shock protein in regulating Toll-like-receptor expression is incompletely understood. Yang et al. (2007) generated mice with conditional deficiency of gp96 in macrophages and found that this protein is an important chaperone for all Toll-like receptors that have been tested
Chapter 17: Techniques for Studying Phagocytic Processing of Bacteria for Class I or II MHC-Restricted Antigen Recognition by T Lymphocytes
No full text
Cellular Proliferation and Regeneration Following Tissue Damage. Final Report.
No full textThe main objective is to elucidate the mechanisms which control cellular proliferation during wound healing in tissues of the eye
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