28,789 research outputs found
Time Capsule Letter - Christie Clark, Amay James Elementary School
No full textThis letter was written by Christie Clark, 6th grade student of Amay James Elementary School. It was added to a time capsule that was buried in honor of Central Piedmont's 25th anniversary in 1988. The time capsule was reopened in 2013 during the 50th anniversary celebrations
Inactivation of ID4 Promotes a CRPC Phenotype with Constitutive AR Activation Through FKBP52
No full textCastration-resistant prostate cancer (CRPC) is the emergence of prostate cancer cells that have adapted to the androgen-depleted environment of the prostate. In recent years, targeting multiple chaperones and co-chaperones (e.g., Hsp27, FKBP52) that promote androgen receptor (AR) signaling and/or novel AR regulatory mechanisms have emerged as promising alter- native treatments for CRPC. We have shown that inactivation of inhibitor of differentiation 4 (ID4), a dominant-negative helix loop helix protein, promotes de novo steroidogenesis and CRPC with a gene expression signature that resembles constitutive AR activity in castrated mice. In this study, we investigated the underlying mechanism through which loss of ID4 potentiates AR signaling. Proteomic analysis between prostate cancer cell line LNCaP (L+ns) and LNCaP lacking ID4 (L(?)ID4) revealed elevated levels of Hsp27 and FKBP52, suggesting a role for these AR-associated co- chaperones in promoting constitutively active AR signaling in L(?)ID4 cells. Interestingly, protein interaction studies demonstrated a direct interaction between ID4 and the 52-kDa FK506-binding protein (FKBP52) in vitro, but not with AR. An increase in FKBP52-dependent AR transcriptional activity was observed in L(?)ID4 cells. Moreover, pharmacological inhibition of FKBP52-AR signaling, by treatment with MJC13, attenuated the tumor growth, weight, and volume in L(?)ID4 xenografts. Together, our results demonstrate that ID4 selectively regulates AR activity through direct interaction with FKBP52, and its loss, promotes CRPC through FKBP52-mediated AR signaling
Dreams Program: Cory Clark
No full textAn audio recording on Cory Clark and the Dreams Program at Morehead State University by Aysia Gilbert
Carta del Dr. Dean A. Clark a Leloir
No full textCarta del Dr. Dean A. Clark, Director del Massachusetts General Hospital, institución asociada a la Escuela de Medicina de Harvard, en la que le propone a Leloir el puesto de Director del Biochemical Research Laboratories, para suceder en el cargo al Dr. Fritz Lipmann.original mecanografiadaFil: Clark, Dean A..2 páginas en papelLFL-PE. Correspondencia GeneralUnidad documental simplenul
Ittijahat Abi Dhu'ayb Al-Hudhali fi Qasidatihi Ar-Ritsa’
No full textThis article aims to know Ittijahat of Abu Dhu’ayb Al-Hudhali in his poem of Ritsa’. Ittijahat in this study is a description of the poet's tendency to divide Ar-Ritsa', namely Nadb and Ta'ziyah. Ar-Ritsa 'is one of the various forms of Arabic poetry. To analyze the discussion problem, the author uses descriptive analysis method, because this method is very appropriate to find out the picture and state of a thing by describing it in as much detail as possible based on the facts found in the data in question. The results obtained are: In the beginning of the poem, he tends to mourn (Nadb) their five children. He describes in it that he does not stop crying and has trouble sleeping until he becomes weak emaciated due to the intensity of the grief, pain and worries that dominated in his pysche. As for the middle of the poem to the end, the poet turns to the consolation (Ta’ziyah) of his children’s death, as he reflects on the reality of life and death, the poet declares that death is inevitable for every human being that he must accept it and let it go, which the poet portrayed in the exciting narrative style. The story is divided into three stories: the zebra, the bull of the beast, and the two knights.</jats:p
Disclosing the Interaction Between Scml2 and Yap1 in Prostate Cancer
No full textIn this study, sex comb on midleg-like-2 (SCML2) was identified as a binding partner of the YAP1 protein complexes isolated from nuclei of prostate cancer cell lines. Both SCML2 and YAP1 are known to regulate cellular biology. Western blot analysis showed that AR-positive cell lines express elevated levels of SCML2, suggesting a possible link between androgen hormonal signaling and SCML2. Immunofluorescence imaging revealed that androgen hormone signaling promoted the subcellular localization of SCML2 and YAP1 compared with mock control. Proximity ligation assay demonstrated that androgen regulated the physical interaction between SCML2 and YAP1 proteins. GST-pulldown revealed that SCML2 and YAP proteins physically interact in the test tube. Cell growth assays suggest that SCML2 could contribute to androgen independence. These observations indicate that the interaction between SCML2 and YAP1 has a crucial role in prostate cancer progression
Program “I’dad Lughowi” dalam Upaya Membekali Kemampuan Bahasa Arab Mahasiswa STIBA Ar-Raayah, Sukabumi
No full textNowdays, Arabic already has its own charm. Apart from the Al-Quran and Hadith as sources of Islamic Shari'a which are imported from the original source in Arabic, the emergence of scientific disciplines linked to Shari'a adds to the public's attraction and interest in studying Shari'a directly from its Arabic sources. Arabic language learning is starting to emerge with various strategies and methods applied. Some are successful and others need review. In this article, the author wants to examine Arabic language learning in the STIBA Ar-Raayah i'dad lughowi program which is considered successful because it has produced many regional, national and even international achievements. This article aims to examine the background of students in the STIBA Ar-Raayah i'dad lughowi program, the teaching and learning activities of the i'dad lughowi program at STIBA Ar-Raayah and the examination system implemented in the i'dad lughowi program. This article is a case study at STIBA Ar-Raayah using a descriptive qualitative approach. The results found in this research are (1) the background of students in the STIBA Ar-Raayah i'dad lughowi program who come from various regions and schools, (2) learning using the Arabiyyah book Baina Yadaik by maximizing the direct method and activities outside the classroom, (4) a unique exam system with Al-Qur'an exams, subject exams, syahri exams, nihai exams, as well as a rosib system for students who do not reach the minimum completion criteria. The results and conclusions of this research can be used as a reference for Arabic language educational institutions to make them more effective in the future
The Poetry Anthology Ar-Robi fii qalbi by Sofi Ghoniyah: A Sociology of Author Perspective
No full textThis study aims to determine the sociology of the author in the poetry anthology Ar-Robi fii Qalbi by Sofi Ghoniyah based on the perspective of Rene Wellek and Austin Warren. This research focuses on four aspects, namely (1) the social background of the author in the anthology of poetry Ar-Robi fii Qalbi by Sofi Ghoniyah based on the perspective of Rene Wellek and Austin Warren; (2) the author\u27s social integration in the poetry anthology Ar-Robi fii Qalbi by Sofi Ghoniyah based on the perspective of Rene Wellek and Austin Warren; (3) author\u27s economic sources in the poetry anthology Ar-Robi fii Qalbi by Sofi Ghoniyah based on the perspective of Rene Wellek and Austin Warren; (4) professionalism in the authorship of Sofi Ghoniyah\u27s anthology of poetry Ar-Robi fii Qalbi based on the perspective of Rene Wellek and Austin Warren. This type of research is qualitative research. The data source of this research uses an anthology of poetry entitled "Ar-robi fii qalbi" by Sofi Ghoniyah. While the secondary data sources of this research were obtained from reading books or journals discussing the sociological theory of the authors Rene Wellek and Austin Warren. Data collection techniques in this study used interview techniques and note-taking techniques. The data validation technique used in this study is to increase persistence, triangulate data, and discuss with colleagues and experts. Meanwhile, for the data analysis technique, this research uses the Miles and Huberman method, namely data reduction, data presentation, and drawing conclusions. The researchers produced several data, namely (1) the author of the poetry anthology Ar-Robi fii qalbi is an educated author and has close interactions with her environment. (2) The author of the poetry anthology Ar-Robi fii qalbi has a high degree of integration. He mingles with the general public. (3) The main economic source of the author in Ar-Robi\u27s poetry anthology is not through her work but in her educational activities. As a teacher, her work is often used as learning material for her students. (4) The author of the poetry anthology Ar-Robi fii qalbi has high professionalism in the authorship of her work
Pustakawan Dalam Perspektif Manajer Informasi: Studi Kasus Pada Mahasiswa Jurusan S1 Ilmu Perpustakaan Fakultas Adab dan Humaniora UIN Ar-Raniry
No full textThis study aims to find out Librarian in Perspective of Information Manager (Case Study on Library Science Undergraduate Student of Adab and Humanities Faculty of UIN Ar-Raniry, Banda Aceh). This research uses quality descriptive approach, an approach that emphasizes more on the deductive and inductive deduc- tion process and on the analysis of the dynamics of relationship between observed phenomena, using scientific logic. The students of Library Science were observed to be 54 people for three months. For this research the author will explain in detail about UIN Ar-Raniry Banda Aceh Main Library in the perspective of information managers for llibrary users especially Library Science students class of 2016 intake. The research results are; Librarians are not yet fully able to become information managers at UIN Ar-Raniry Main Library of Banda Aceh, due the small number of librarians for this size of a college library. Lack of librarian contribution to be- come information manager, in order to be able to fulfill requirement of information for their users, in this case undergraduate student of Library Science. Regarding the perspective that a library must be able to provide all forms of information required has not been done well, especially the information needs fot this such of users in this case Library Science students
Teacher Candidates' opinions about Augmented Reality(AR) as a supplemental educational tool
No full textThis poster was presented by Alam, I., Teacher Candidates' opinions about Augmented Reality(AR) as a supplemental educational tool. Presented at 10th Annual Graduate and Professional Student Conference, held at Memorial Union, Ames, IA, April 6 2022. Posted with permission.In recent years, augmented reality (AR) technology has been widely proposed as innovative technology. AR technology superimposes digitally simulated information on the physical environment, which can be a unique element for learning experiences. Despite the potential of AR, there has been relatively little integration of AR into the
classroom. The purpose of this pilot study is to examine the acceptance and intentional use of AR technology by teacher candidates and their opinions of AR as a supplemental educational tool. The study has utilized a phenomenological design that is comprised of System Usability Scale survey and interview questions. Based on the participants' answers, research data has been analyzed and discussed
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