2,564 research outputs found

    Author Correction: Cardioprotection induced in a mouse model of neuropathic pain via anterior nucleus of paraventricular thalamus

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    The original version of this Article contained an error in the affiliation of the second author, Ya-Ting Chang. The correct affiliations for Ya-Ting Chang are Institute of Biomedical Sciences, Academia Sinica, Taipei, 115, Taiwan and International Graduate Program in Molecular Medicine, National Yang-Ming University and Academia Sinica, Taipei 115, Taiwan.</jats:p

    Remarks on "The Sun Shines over the Sangkan River, " a Novel by Ting Ling

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    Land reform, the most important undertaking of the People's Republic, is the subject of Ting Ling's novel, The Sun Shines over the Sangkan River. Her realistic portrayal of the farmer deserves high praise, but the author must herself be conscious of a lessening of realism in the latter half of the book. This may be partly due to the fact that Mrs. Ting has for some time been accustomed to depicting city life. On the other hand, her talent may have been impaired precisely because she felt compelled to represent land reform as an immediate success

    Co-First Author and Co-Corresponding Author:A Case Study of High-Impact Factor Journals in Pharmacy and Anesthesia Area

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    本研究採用書目計量法,以1995年至2014年收錄於WOS資料庫之藥學及麻醉學期刊論文為研究對象,觀察兩個領域的並列第一作者及並列通訊作者現象。研究中先針對兩個領域進行論文數、國家與機構分布、合著率、平均作者人數以及被引次數分析,建構兩個領域的整體概況。接著分別進行並列第一作者論文及並列通訊作者論文分析,先從論文數、國家與機構分布、以及並列作者數及署名序建構並列第一作者論文及並列通訊作者論文概況,再從合著作者數、跨領域合作和研究經費來源三個面向探討並列第一作者和並列通訊作者現象與合著特性之關聯,接著觀察並列第一作者論文和並列通訊作者論文之被引次數的高低。最後則進行藥學及麻醉學領域並列第一作者及並列通訊作者整體概況、論文合著特性及被引次數的比較。 研究結果顯示,藥學及麻醉學領域之合著論文數與合著作者人數均增加,近二十年合著率分別為90.37%和95.17%,麻醉學歷年合著率均在90%以上,且麻醉學平均作者人數為4.82人高於藥學的4.41人。藥學及麻醉學分別於2001年及1998年出現第一篇並列第一作者論文,兩個領域均從1995年就出現第一篇並列通訊作者論文,顯示並列通訊作者論文較早出現於兩個領域。近二十年藥學及麻醉學並列第一作者論文各有888篇及769篇,並列第一作者率分別為4.99%和2.15%,兩個領域各有1,507篇及227篇並列通訊作者論文,並列通訊作者率則分別為8.47%和0.63%,藥學並列第一作者率及並列通訊作者率均高於麻醉學。藥學及麻醉學的並列第一作者論文中,並列前兩位作者為第一作者所佔的比例皆高達90%以上;但兩個領域在並列通訊作者論文的署名序的分布則較為不一致,藥學以並列全部作者為通訊作者為主,麻醉學則以第一作者和最後作者並列為通訊作者為最主要的署名方式,並列通訊作者署名序的方式較多元。 在合著作者人數方面,並列第一作者論文之合著者人數主要介於6至10位之間,高於並列通訊作者論文主要的2至5位之間,且合著作者數與並列第一作者率或並列通訊作者率均不具顯著關聯性,即合著作者數越多的論文,未必越傾向有並列第一作者或並列通訊作者現象。在跨領域合作方面,近半數的並列第一作者論文和並列通訊作者論文有跨領域合作,在有跨領域合作的論文中,絕大多數的合著者是來自兩個不同領域進行合作,且並列第一作者論文和並列通訊作者論文之跨領域數普遍高於一般論文。在研究經費來源方面,並列第一作者論文與並列通訊作者論文均從研究、政府、基金會及企業等多元機構取得研究經費,但普遍從研究機構獲得補助的比例最高。在被引次數方面,並列第一作者論文之被引次數低於一般合著論文,並列通訊作者論文之被引次數高於一般合著論文,且並列通訊作者論文之被引次數高於並列第一作者論文。 藥學及麻醉學分別於2004年及2005年出現第一篇同時並列第一作者和並列通訊作者論文,藥學整體並列第一作者且並列通訊作者率為1.05%,高於麻醉學的0.11%。除了並列第一作者及並列通訊作者論文外,兩個領域均出現其他並列作者現象,包含並列最後作者、並列資深作者和並列第二作者。The purpose of this study is to examine the co-first author and co-corresponding author in pharmacy and anesthesia area by bibliometric methods. The subjects are articles published in high-impact factor journals in the pharmacy and anesthesia area during 1995-2014 which recorded in Web of Science. The study analyzes the country and institution distribution of co-first author and co-corresponding author articles, and also analyzes the numbers and byline position of co-first author and co-corresponding author. In addition, the paper also investigates the influence of the number of coauthors, inter-disciplinary collaboration, and fund sources on the tendency of co-first author and co-corresponding author. The major findings are summarized as follows. The coauthored articles and the number of coauthors in pharmacy and anesthesia area are increasing. The percentage of co-authorship in pharmacy and anesthesia area is 90.37% and 95.17% respectively, and the annual percentage of co-authorship in anesthesia area are all above 90%. The average coauthors in anesthesia area is 4.82 which is higher than that in pharmacy area (4.41). The co-first author article first appeared in 2001 in pharmacy and 1998 in anesthesia area, and the co-corresponding author article both first appeared in 1995 in the two area, which co-corresponding author phenomenon emerged earlier. In the late twenty years, the number of co-first author articles in pharmacy and anesthesia area are 888 and 769 respectively, and the percentages of co-first author articles are 4.99% and 2.15%. The number of corresponding author articles in pharmacy and anesthesia area are 1,507 and 227 respectively, and the percentages of co-corresponding author are 8.47% and 0.63%.It shows the rate of co-first author and the rate of co-corresponding author in pharmacy are higher than that in anesthesia. More than 90% of co-first author articles in the two areas list the first two authors as co-first authors. Most co-corresponding author articles list all authors as co-corresponding authors in pharmacy area, while most co-corresponding author articles list the first author and last author as co-corresponding authors in anesthesia area. The number of coauthors of co-first author articles mainly vary from 6 to 10, while that of co-corresponding author articles from 2 to 5. The number of coauthors has no significantly correlation with the rate of co-first or the rate of co-corresponding author, that is, the articles with more coauthors may not result in more co-first author or co-corresponding author. In terms of inter-disciplinary collaboration, most coauthors come from two different disciplines in inter-disciplinary collaboration articles. Compared with general articles, the authors of co-first and co-corresponding author articles come from more diverse disciplines. It is found out that co-first author or co-corresponding author articles obtain research fund from different resources including research institutions, governments, foundations and industries. In most cases, the articles get most research fund from research institutions. The cited numbers of co-first author articles are lower than general coauthor articles, while the cited numbers of co-corresponding author articles are higher than general coauthor articles. The cited numbers of co-corresponding author articles are higher than co-first author articles. The paper with co-first author and co-corresponding author occurred at the same time in pharmacy and anesthesia area, which appeared first in 2004 in pharmacy and appeared in 2005 in anesthesia . The rate of co-first and co-corresponding in pharmacy area is 1.05%, which is higher than that in anesthesia area (0.11%). In addition to co-first and co-corresponding articles, there are other co-author phenomenon, which includes co-last author, co-senior author, and co-second author

    Corrigendum to “High-pressure adsorptive storage of hydrogen in MIL-101 (Cr) and AX-21 for mobile applications: Cryocharging and cryokinetics” [Mater & Des 89 (2016) 1086–1094]

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    Refers To Nuno Bimbo, Wesley Xu, Jessica E. Sharpe, Valeska P. Ting, Timothy J. Mays High-pressure adsorptive storage of hydrogen in MIL-101 (Cr) and AX-21 for mobile applications: Cryocharging and cryokinetics Materials & Design, Volume 89, 5 January 2016, Pages 1086-1094 The authors regret to inform that….. The Supplementary Information should have been included in the original paper and is now provided with this corrigendum. All the data and figures, contained in the manuscript and supporting information, are available and can be accessed free of charge at http://dx.doi.org/10.15125/BATH-00099. Any questions related to the data should be addressed to the corresponding author. Authors would like to apologize for the inconvenience caused

    The Structure of Plasmodium falciparum GTP:AMP Phosphotransferase

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    Ting, Kai Yiu.Thesis M.Phil. Chinese University of Hong Kong 2016.Includes bibliographical references (leaves ).Abstracts also in Chinese.Title from PDF title page (viewed on …)

    Ricin-A-chain (RTA) inhibits the unfolded protein response (UPR) in mammalian cells

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    Ricin, a type II ribosome-inactivating protein, has been used as a biochemical weapon due to its ability to inhibit protein synthesis and induce cytotoxicity. The unfolded protein response (UPR) is a survival response that helps cells to recover from stress that occurs following the accumulation of misfolded proteins in the ER. Failure to recover from ER stress can lead to apoptosis. In yeast, ricin-A-chain (RTA), the enzymatic component of ricin, inhibits the unfolded protein response (UPR). However, the ability of RTA to affect UPR has not been investigated in mammalian cells. The goals of this project were to determine if RTA could inhibit the UPR in mammalian cells and if altering the UPR affected RTA cytotoxicity. The UPR consists of three signaling cascades, IRE1, PERK, and ATF6. In HeLa cells, a human cervical carcinoma cell line, we found that RTA could inhibit tunicamycin (Tm)-induced IRE1 phosphoryation and XBP-1 mRNA splicing at 4 h. A similar effect was observed in the non-transformed mammary epithelial cell line MAC-T. RTA also inhibited the ability of dithiothreitol (DTT) to activate the PERK pathway in HeLa cells, as shown by inhibition of DTT-induced eIF2α phosphorylation at 4 h. In both cell types, RTA decreased expression of the downstream chaperone BiP in response to Tm. To determine if inhibition of the IRE1 and PERK pathways by RTA affected its cytotoxicity, cells were treated with RTA in combination with DTT or Tm. Cleavage of both caspase-3 and -7 was greater in both HeLa and MAC-T cells when they were treated with RTA and DTT or RTA and Tm compared to cells treated with RTA, DTT, or Tm alone. These results indicate that RTA is more cytotoxic when UPR is inhibited.M.S.Includes bibliographical referencesby Chao-Ting Wan

    [[alternative]]The Adaptation Discussion and Interpretation of Liuqin Concerto “The Bell of Sha Yun” by Hsu, Wei-Ting

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    [[abstract]]  本論文探討徐瑋廷將其所創作之國樂合奏曲《莎韻》改編至柳琴獨奏曲《莎韻之鐘》之過程,以及後續由柳琴演奏者進行樂曲修改的經過,包含由胡雅茹修改的獨奏曲V2,以及由鄭家芸老師及筆者進行修改的獨奏曲V3,修改的同時也會根據演奏者詮釋想法,增加演奏技法和手法進行樂曲詮釋。  本文於第三章先整理《莎韻》保留給柳琴演奏的旋律後,再探討作曲家移植與改編後的《莎韻之鐘》獨奏譜V1,從中得知作曲家在改編上是有規律性的;獨奏曲交由胡雅茹修改時,是先針對曲譜中無法演奏的音域及和弦兩部分進行調整(V2);獨奏的第二版本(V3)則是由筆者與鄭家芸根據前譜進行修改,V3也為筆者音樂會上的詮釋版本。  透過研究,筆者歸整出樂曲在改編時的規律性以及作曲家與演奏者在修改上的想法,前者重視樂曲的層次豐富度與呈現出的情緒,後者更重視演奏時的技法與手法是否能呈現柳琴的特色及樂曲呈現的畫面。希望本研究能對柳琴音樂的文獻提供一些資料。[[abstract]]  This paper explores the process of composer Hsu Wei-ting adapting his original Chinese ensemble piece “Sha Yun” into a solo Liuqin composition titled “The Bell of Sha Yun”. It also delves into the subsequent modifications of Liuqin performer Hu Ya-ru, including the Solo Version 2 (V2) she modified. Furthermore, it discusses the revisions made by teacher Cheng Chia-yun and the author, resulting in Solo Version 3 (V3). During the modification process, playing techniques and methods were added based on the performer's interpretation, enhancing the musical interpretation.  In the third chapter of this paper, the preserved melodies of “Sha Yun” for Liuqin performance were organized. The composer's process of transplantation and adaptation to create the solo score of “The Bell of Sha Yun” (V1) was then explored, revealing a systematic approach to the transformation. When the solo version was handed over to Hu Ya-ru for modification, adjustments were made primarily to address the score's unplayable range of notes and chords, resulting in version 2 (V2). The second version of the solo (V3) was subsequently modified by the author and Cheng Chia-yun, building upon the previous version. V3 represents the interpretation version performed by the author in a concert setting.  Through research, the author has summarized the regularity of music adaptation and the ideas of composers and performers in making modifications. The former emphasizes the musical layers' richness and emotions' expression. At the same time, the latter focuses more on whether the techniques and skills used in the performance can showcase the characteristics of the Liuqin instrument and depict the imagery conveyed by the music. It is hoped that this study can provide some information for the documentation of Liuqin music

    Parametric modeling and optimization of thermal systems with design uncertainties

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    Thermal systems play significant roles in the engineering practices and our lives. To improve those thermal systems, it is necessary to model and optimize the operating conditions. More importantly, the design uncertainties should be considered because the failures of the thermal systems may be very dangerous and produce large loss. This study focuses on the parametric modeling and the optimization of the thermal systems with the considerations of the design uncertainties. As an example, the material processing thermal system, the Chemical Vapor Deposition (CVD), is simulated with different inlet velocities and susceptor temperatures. Several responses are considered to represent the performance of the thin-film deposition, including the percentage of the working area, the mean of the deposition rate, the root mean square of the deposition, and the surface kurtosis. Those responses are then parametrically modeled by one of the Response Surface Method (RSM), the Radial Basis Function (RBF), and utilized to formulate the optimization problems to enhance the system performances. However, it is not until the design uncertainties are considered that the thermal system designs have high risk of the violations of the performance constraints. One of the Reliability-Based Design Optimization (RBDO) algorithms, the Reliability Index Approach (RIA), is used to solve the optimization problems with the design uncertainties However, the algorithm suffers from a convergence problem when the design point falls into the infeasible domain during the optimization process. A Modified Reliability Index Approach (MRIA) is proposed with a modified definition of the reliability index, and utilized to solve the RBDO problems of the CVD process. The MRIA converts the design space to the standard normal space and finds the Most Probable Points (MPPs) to evaluate the failure probabilities of the performance constraints. The probabilistic optimization problem is then solved using the approximate probabilistic constraints generated in terms of the MPPs. The MRIA has been used to solve several different optimization formulations with both normally and lognormally distributed random variables. The Monte Carlo Simulation (MCS) results verify that the optimal solutions have acceptable failure probabilities. As a result, the proposed strategy of parametrically modeling and optimizing with design uncertainties can be applied to the experiments or the simulations of other thermal systems to improve their productivity, maintain the quality control, and reduce the probability of system failure.Ph.D.Includes abstractVitaIncludes bibliographical referencesby Po Ting Li

    General Chiang Kai-shek : the builder of new China

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    General Chiang Kai-shek"Significant speeches [by General Chiang]": p. [51]-107.by Chen Tsung-hsi, Wang An-tsiang and Wang I-ting; with an introduction by Dr. Chenting T. Wang and a preface by Dr. Wang Chung-hui
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