1,721,034 research outputs found
Is the natural history of hepatitis C virus carriers with normal aminotransferase really benign?
Full text linkIs the natural history of hepatitis C virus carriers with normal aminotransferase really benign?
No full textIs the natural history of hepatitis C virus carriers with normal aminotransferase really bening?
No full textFinite element analysis of fluid phase nonlinearity effects on the undrained dynamic behaviour of nearly saturated porous media
No full textA simple time integration scheme is presented, able to take into account a particular nonlinearity of the fluid phase in a dynamically loaded, nearly saturated porous medium. The analysis is
confined to the dynamic undrained case, under the assumptions of small displacements and linear elastic behaviour for the solid phase. A mixed finite element approach is adopted, in conjunction with an explicit time integration scheme. The resulting overall algorithm may be theoretically framed within the context of the Linear Inequalities. Some applications indicate that the nonlinear behaviour of the fluid phase alone may play an important role in the global two-phase medium response. The results obtained by means of more traditional approaches in some cases may be un conservative
Neurocisticercosi: valutazioni critiche su una casistica clinica e sul trattamento farmacologico
No full text
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Hypervariable region 1 (HVR1) of HCV: immunological decoy or biologically relevant domain?
No full textThe hypervariable region 1 (HVR1) of the E2 protein of hepatitis C virus (HCV) is highly heterogeneous and is responsible for significant inter- and intra-individual variation of the infecting virus, which may represent an important pathogenetic mechanism leading to escape and persistent infection. Moreover, a binding site for neutralizing antibodies (Ab) has been allegedly identified in this region. Prospective studies of serological responses to synthetic oligopeptides derived form HVR1 sequences of patients with acute and chronic HCV infection showed extensive serological cross-reactivity for unrelated HVR1 peptides in the majority of the patients. A significant correlation was found between HVR1 sequences variation, and intensity, and cross-reactivity of humoral immune responses providing strong evidence in support of the contention that HCV variant seletion is driven by the host immune pressure. Monoclonal Ab (mAb) generated following immunization of mice with peptides derived from natural HVR1 sequences also showed cross-reactivity for several HVR1 sequences attesting to the existence of conserved amino acid motifs among different variants. These findings suggest that it is possible to induce a broadly cross-reactive immune response to HVR1 and that this mechanism can be used to generalte protective immunity for a large repertoire of HCV variants
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