941 research outputs found
Variations on the Author
No full text“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Term Variation in Institutional Languages: Degrees of Specialization in Municipal Waste Management Terminology
No full textInstitutional Italian is a variety of Italian used in the official communications of institutions, especially in public administrations. Besides legal and administrative languages, it comprises the language used in websites, social media and advertising material produced by public administrations. To understand the lexical profile of institutional languages completely, standard measures of lexical complexity, like the type-token ratio and the percentage of basic vocabulary, should be complemented with the examination of the terminological variation. This study compares the terminology of three types of institutional texts: administrative acts, technical-operational texts, and informative texts. In particular, we collected 86 terms with various degrees of specialization and analysed their distribution within the subcorpora of ItaIst-DdAC{\_}GRU, a corpus composed of institutional texts drafted by Italian municipalities about municipal waste management. Results suggest that administrative acts employ high-specialization terms compliant with the law, often in the form of acronyms. Conversely, informative texts contain more low-specialization terms, privileging single-word terms to remain self-contained. Finally, the terminology of technical-operational texts is characterised by standardized and formulaic phrases
A forma da cidade e sua apropriação: análise propositiva de diretrizes de arquitetura da cidade para Cumbayá em Quito/Equador
No full textDissertação (mestrado) - Universidade Federal de Santa Catarina, Centro Tecnológico, Programa de Pós-Graduação em Urbanismo, História e Arquitetura da CidadeEste trabalho busca entender a relação entre as diversas formas que a cidade vem adquirindo com o passar do tempo e as formas de apropriação contemporâneas, a partir de discussão teórica de conceitos e critérios de autores que discutem o desempenho da forma da cidade em relação à apropriação dos espaços públicos. Com base neste debate, elegemos critérios relacionados à apropriação nas escalas da estrutura da cidade e da configuração dos lugares, e procedeu-se à caracterização e análise da cidade contemporânea de Quito para verificar padrões espaciais diretamente associados com uma apropriação positiva da cidade na cultura quitenha. A partir dos critérios selecionados e dos padrões positivos identificados, lançamos diretrizes de projeto de arquitetura da cidade para uma área de expansão da cidade contemporânea de Quito no Equador - a Paróquia de Cumbayá - buscando responder a critérios de bom desempenho da forma urbana que potencializem a apropriação de seus espaços públicos.The research seeks to understand the relationship between the different forms that the city has acquired over time and contemporary forms of appropriation, based on a theoretical discussion of concepts and criteria of authors who discuss the performance of the form of the city in relation to the appropriation of public spaces. Based on this debate, we selected criteria related to appropriation, both at the scale of city structure and at the scale of place configuration, and proceeded to the characterization and analysis of the contemporary city of Quito in a search to identify spatial patterns directly associated with a positive appropriation of the city in Quito´s culture. The selected criteria and the positive patterns identified oriented the design guidelines here proposed for the architectural design of the Paróquia of Cumbayá - an area of expansion in the city of Quito, Ecuador - in an attempt to comply with the criteria of good urban form performance so as to enhance the appropriation of its public spaces
Transcriptional regulation and drug resistance in Mycobacterium tuberculosis
No full textBacterial drug resistance is one of the major challenges to present and future human health, as the continuous selection of multidrug resistant bacteria poses at serious risk the possibility to treat infectious diseases in the near future. One of the infection at higher risk to become incurable is tuberculosis, due to the few drugs available in the market against Mycobacterium tuberculosis. Drug resistance in this species is usually due to point mutations in the drug target or in proteins required to activate prodrugs. However, another interesting and underexplored aspect of bacterial physiology with important impact on drug susceptibility is represented by the changes in transcriptional regulation following drug exposure. The main regulators involved in this phenomenon in M. tuberculosis are the sigma factors, and regulators belonging to the WhiB, GntR, XRE, Mar and TetR families. Better understanding the impact of these regulators in survival to drug treatment might contribute to identify new drug targets and/or to design new strategies of intervention
Recent advances and unmet needs in the treatment of drug-resistant tuberculosis
No full textIntroductionDrug-resistant tuberculosis (DR-TB) still represents a critical global health threat despite recent therapeutic advances. The shift from long, injectable-based regimens to shorter, all-oral regimens has improved outcomes, yet substantial challenges remain in ensuring efficacy, safety, and equitable access.Areas coveredWe reviewed recent literature (2020-2025) searching PubMed, Medline, Google Scholar, clinicaltrials.gov, WHO guidelines, conference abstract books focusing on recent policy-changing, or knowledge-advancing Phase II/III clinical trials assessing novel DR-TB drugs/regimens.We reported the persisting issues of drug toxicity and acquisition of drug resistance, reviewing evidence from trials, surveillance data, and real-life studies. We provided an overview of new compounds and regimens in the pipeline and underlined the critical role of drug-susceptibility testingAreas coveredWe reviewed recent literature (2020-2025) searching PubMed, Medline, Google Scholar, clinicaltrials.gov, WHO guidelines, conference abstract books focusing on recent policy-changing, or knowledge-advancing Phase II/III clinical trials assessing novel DR-TB drugs/regimens.We reported the persisting issues of drug toxicity and acquisition of drug resistance, reviewing evidence from trials, surveillance data, and real-life studies. We provided an overview of new compounds and regimens in the pipeline and underlined the critical role of drug-susceptibility testingExpert opinionThe availability of multiple short, all-oral regimens offers unprecedented therapeutic opportunities for drug-resistant tuberculosis. At the same time, the rise in bedaquiline resistance hampers the efficacy of these regimens and represents a global health threat. A promising rich pipeline of new compounds under development holds an important transformational potential in TB treatment; however, integrated drug-diagnostic development is needed to avoid past mistakes. Global advocacy for equitable access to TB treatment is fundamental to pairing scientific progress with concrete impact
Fulminant autoimmune hepatitis in a girl with 22q13 deletion syndrome: a previously unreported association
No full textWe report a 7-year-old girl with 22q13 deletion syndrome, 46,XX,Ish del(22)(q13.3)(ARSA-; D22S1726), who developed a fulminant autoimmune hepatitis requiring orthotopic liver transplantation. Recently, it has been suggested that the Shank3 gene product, whose deficiency is responsible for the features observed in this syndrome, could play a role in immunological response. Despite an increased incidence of respiratory infections, autoimmune diseases have thus far not been reported in patients with this syndrome. This is the first case of fulminant autoimmune hepatitis associated with the 22q13 deletion syndrome. The possible relationships between immune system dysfunctions peculiar of this syndrome and autoimmune hepatitis are discussed
Tests for tuberculosis infection: landscape analysis
No full textOnly tuberculin skin tests (TST) and two interferon-γ release assays (IGRA) – QuantiFERON-TB Gold In-Tube and T-SPOT.TB – are currently endorsed by the World Health Organization as tests for tuberculosis (TB) infection. While IGRAs are more specific than TST, they require sophisticated laboratory infrastructure and are costly to perform. However, both types of tests have limited performance to predict development of active TB. Tests with improved predictive performance and operational characteristics are needed.
We reviewed the current landscape of tests for TB infection identified through a web-based survey targeting diagnostic manufacturers globally.
We identified 20 tests for TB infection including 15 in-vitro tests and five skin tests. Thirteen of the in-vitro tests are whole-blood IGRA and 14 uses early secreted antigenic target 6 (ESAT-6) and culture filtrate protein 10 (CFP-10), with or without additional antigens. Ten are based on assays other than an enzyme-linked immunosorbent assay such as a fluorescent lateral flow assay, which requires less manual operation and shorter assay time and hence is more suitable for decentralisation compared to the existing IGRA.
Four of the five skin tests use ESAT-6 and CFP-10 proteins while the remaining one uses a new antigen that is specific to Mycobacterium tuberculosis complex.
New tests have the potential to improve accuracy, operational characteristics and end-user access to tests for TB infection. However, published data in various populations and settings are limited for most new tests. Evaluation of these new tests in a standardised design would facilitate their endorsement and programmatic scale-up
Parlare insieme. Studi per Daniela Zorzi
No full textIl volume è dedicato a Daniela Zorzi, per lungo tempo docente di Linguistica applicata presso la Facoltà di Lettere e Filosofia e successivamente presso la Scuola Superiore di Lingue Moderne per Interpreti e Traduttori (ora Dipartimento di Interpretazione e Traduzione) dell’Università di Bologna. I saggi di colleghe e colleghi, di allieve e allievi, si iscrivono principalmente negli ambiti di ricerca di Daniela Zorzi, cioè la didattica e l’apprendimento linguistico, la comunicazione istituzionale, l’analisi linguistica per l’interpretazione e la traduzione, l’interazione dialogica
Scelte varietali nei distretti tradizionali e nei nuovi areali
No full textTonda di Giffoni, Tonda Gentile Romana e Tonda Gentile Trilobata: il panorama varietale italiano è piuttosto ristretto e anche le nuove aree in cui il nocciolo è in espansione puntano sulle cultivar tradizionali più apprezzate dall’industria. Ma dopo l’esperienza positiva della Tonda Francescana alcune isolate iniziative di miglioramento genetico puntano ad ampliare la piattaforma varietale e clonal
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