1,721,006 research outputs found
Mesenchymal Stem Cell Response to Micropatterns and Dynamic Topographies
No full textThe native extracellular matrix is a dynamic environment, but it is not clear how cells react to time changing signals. To investigate this, we exploited light responsive azobenzene based platforms, able to display spatiotemporal changes of topographic signals. Mesenchymal stem cells were cultivated on either rectangular or circular adhesive islets in order to promote either a high or low contractile phenotype. Submicron scale topography was switched on at selected time points to interfere with adhesion and cytoskeleton assembly. Cells responded to the dynamic changes by altering their mechanical properties, lamins expression and YAP nuclear import. Changes at receptor or cytoskeleton level are observed a relatively small timeframes, whereas Lamins and YAP nuclear accumulation required longer times. Our data could be useful to develop culturing systems able to challenge stem cells with specific programmes of mechanical/topographical signals thus understanding how cells integrate those in time
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Relationship between alexithymia and panic disorder: a longitudinal study to answer an open question
No full textBackground: In the present study, we evaluated whether patients with panic disorder (PD) in complete remission were more alexithymic than normal controls. Methods: Fifty-two PD patients ( both during the acute phase of the disorder and after at least 2 months of complete remission) and 52 age- and sex-matched normal subjects completed the Toronto Alexithymia Scale-20 and the Hamilton Rating Scales for Anxiety (Ham-A) and for Depression. Results: A higher rate of alexithymia was found in PD patients than in controls (3.8%) both during the acute phase (44.2%; p < 0.001) and after remission of the disorder (21.2%; p = 0.008). During remission, PD patients showed: ( 1) Ham-A scores significantly higher than controls (p < 0.001); ( 2) only an elevation of the 'difficulty in identifying feeling' (DIF) dimension of alexithymia, and ( 3) a positive relationship between Ham-A scores and DIF levels (p < 0.001). Conclusion: After remission of panic attacks, phobic avoidance and anticipatory anxiety, PD patients are more alexithymic ( even though the levels of alexithymia decreased after the resolution of the acute phase of PD) and anxious than controls. This finding might be explained by an overlap between cognitive aspects of PD and the DIF dimension of alexithymia, since alexithymic and anxious levels are positively related
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