1,720,976 research outputs found
Pterostilbene Alleviates Diabetic Nephropathy in Experimental Diabetic Rats; Inhibition of Aldose Reductase and Advanced Glycation End Products Formation
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Pharmacokinetic and Pharmacodynamic Interaction of Boswellic Acids and Andrographolide with Glyburide in Diabetic Rats: Including Its PK/PD Modeling
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Insulinotropic Activity of Methanolic Extract of Mesua ferrea Linn.
No full textMesua ferrea flowers have been used in the Indian traditional medicine for treating various diseases. In present study, the Mesua ferrea flowers methanolic extract (MFME, 200 mg/kg bw) was studied for anti diabetic activity and underlying mechanisms for its activity. In Streptozotocin induced diabetes rats model, MFME treatment enhanced plasma insulin levels by 69.53% (
Andrographolide Pretreatment Enhances the Bioavailability and Hypoglycemic Action of Glimepiride and Metformin
No full textHerbal antidiabetic preparations are often used as an add-on therapy in diabetes. Hence, in the present investigation the effect of andrographolide (AD) on the pharmacokinetics and pharmacodynamics of glimepiride and metformin in normal as well as in STZ - induced diabetic rats was studied. In normal and diabetic rats the combination of glimepiride and metformin with AD increased significantly (p < 0.01) all the pharmacokinetic parameters, such as Cmax, AUC0 to n, AUCtotal, t½, MRT and decreased the clearance, Vd markedly as compared with the control group. In pharmacodynamic studies, the combination of glimepiride and metformin with AD provided significant protection against the diabetes induced alterations in the biochemical parameters. In addition, the combination of glimepiride and metformin with AD also improved the total antioxidant status and decreased lipid peroxide levels significantly in diabetic rats compared with AD, glimepiride and metformin alone treated groups. The results revealed that combination of glimepiride and metformin with AD led to the enhancement of the bioavailability of glimepiride and metformin by inhibiting the CYP450 enzymes. In conclusion, add-on preparations containing AD may increase the bioavailability of glimepiride and metformin, which suggested that AD might be beneficial as an adjuvant to glimepiride and metformin in a proper dose, in diabetic patients and hence the doses should be monitored
Production of camptothecines from callus cultures of <i style="">Nothapodytes foetida</i> (Wight) Sleumer
No full text452-453Murashige and Skoog (MS) medium supplemented with picloram (2 mg/l), N6- benzyladenine(BA) (1 mg/l) and gibberellic acid (GA3) (1 mg/l) was found to be suitable for the establishment of callus cultures from leaves of Nothapodytes foetida (Wight) Sleumer. The callus upon extraction and analysis revealed the presence of a cytotoxic quinoline alkaloid, camptothecine (CPT) (2.893±2.38 mg %) and 9-methoxy camptothecine (MCPT) (0.4±0.4 mg %)
<b style="">An overview on <i style="">Hypericum perforatum</i> Linn.</b>
No full text368-381Population of
the modern world is suffering from dangerous ailments like cancer, AIDS and
depression which have been successfully treated by some herbal medicines. The potentiality of Hypericum perforatum Linn.
has been proven in treating these diseases. Hypericin, hyperforin and their
analogs are the phytoconstituents of this plant having therapeutic value. The
significance of these constituents is attributed to their botanical safety and
therapeutic efficacy. This review discusses the pharmacology, , extraction and
analytical methods of chemical constituents reported from the plant tissue
cultures. </b
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