1,721,827 research outputs found
Manuale di Gastroenterologia UNIGASTRO - edizione 2007-2009 capitolo Fisiopatologia esofagea.
No full textLong-term treatment with infliximab in inflammatory bowel disease: Safety and tolerability issues
No full textCrohn's disease and ulcerative colitis represent the most common forms of inflammatory bowel disease (IBD), clinical conditions affecting the small and/or large bowel. It is well known that IBD is an immune-mediated condition and that TNF-α plays a pivotal role in the pathogenesis of the disease. TNF-α has been scrupulously studied as a target for therapeutic intervention in this setting. A number of biologic compounds have been developed, including the European Medicine Agency (EMEA)-approved agents, infliximab and adalimumab. Although their efficacy in induction and maintenance of remission has been established by several clinical trials, many issues regarding safety remain to be elucidated. In fact, anti-TNF treatment may be associated with a number of rare, but serious, adverse events, including infusion reactions, infections, lymphomas and other malignancies. A black-box warning has to be taken into consideration when looking at potential serious infections such as tuberculosis. Active infections, demyelinating disorders and severe heart failure are contraindications for anti-TNF treatment. This review focuses on drug toxicity and adverse events related to infliximab treatment in IBD. © 2008 Informa UK Ltd
Data extraction from vintage well sonic log graphs in the ViDEPI project (offshore the Apulia, southern Italy): A multi-useful dataset
Full text linkTwelve files have been obtained after the extraction of data from raster PDF images of sonic log graphs. These files data regard exploration wells placed in the Adriatic Sea pertaining the Apulia (Branzino-1, Chiara-1, Cristina-1, Famoso-1, Giove-1, Giove-2, Grazia-1, Grifone-1, Medusa-1, Sabrina-1, Simona-1, and Sparviero-1bis), and the related raster sonic log graphs are free accessible at the ViDEPI Project (www.videpi.com) of the Ministry for the Economic Development of the Italian Government. Two columns A and B of data, i.e., interval transit time Δt [μs/ft] and depth [m], respectively, characterise each file. Hence, 18,396 pairs of Δt-depth values have been obtained. The picking of the data occurred by the use of WebPlotDigitizer© free software. These data are relevant for the interpretation of reflection seismic lines throughout the Adriatic Sea, mainly in the offshore the Apulia. Moreover, the interpretation of those reflection seismic lines located in the adjacent offshore zones, such as the Ionian Sea, can benefit from these data; the values can be important for seismological goals around the Apulia, as well. From these data, Δt-depth diagrams can be originated by the use of software capable of building 2D graphs from values in CSV files (e.g. Matlab©)
The Curinga–Girifalco Line in the framework of the tectonic evolution of the remnant Alpine chain in Calabria (southern Italy)
No full textIn the peri-Mediterranean metamorphic belts, the tectonic evolution of the Calabria–Peloritani terrane during the dominant compressive tectonics of the Eocene represents one of the most problematic points in palinspastic restorations. A matter of particular debate is its shortening, which could have occurred during the Alpine or the Apennine subduction. In this regard, a crucial joint is provided by the kinematics of one of the most relevant shear zones such as the Curinga–Girifalco Line, cropping out in central Calabria. This shear zone juxtaposed a nearly complete Hercynian crustal section (i.e. the Sila and Serre Unit) onto the remnants of the Castagna Unit. The data in the available literature on ductile kinematics from the south-eastern branch of the Curinga–Girifalco Line indicate a downward movement of the hanging wall. In the present paper we show new, ductile kinematic data and petrographic evidence from outcrops in the north-western and south-eastern branches of the Curinga–Girifalco Line. Our results highlight the coherent kinematics of the Eocene shortening during the Alpine subduction system, followed by (late Eocene?)Oligocene to early Miocene, dominantly ductile extensional reworking, relating to the Apennines subduction system
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Conventional data display and implications for the interpretation of seismic profiles: a discussion on the ViDEPI seismic database offshore Apulia (southern Italy)
No full textThe present paper analyses old seismic profiles and exploration well logs, from the marine zones B, D and F (offshore the Apulia region, southern Italy), included in the Visibility of Petroleum Exploration Data in Italy (ViDEPI) project. The public seismic profiles available from this project present several limitations since basic information for an accurate geological interpretation are missing, such as the basic shape of the seismic wavelets and the seismic polarity. In this study, a review of the basic pulse shape and polarity of seismic wavelets, as well as the shape and polarity of principal reflectors, has been addressed. With the purpose of revealing the shape and polarity of the seismic profiles from the marine zones B, D and F, the seismic pattern of the reflectors at the sea floor has been analysed. Finally, lithostratigraphic and sonic logs have been used to identify abrupt interval velocity variations between different lithostratigraphic successions, resulting in a geological meaning of the principal reflectors
Dispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
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