169,821 research outputs found
Going Beyond Counting First Authors in Author Co-citation Analysis
No full textThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Mitomycin C in highly myopic eyes - Author reply
No full textOphthalmology. 2005 Feb;112(2):208-18; discussion 219.
Mitomycin C modulation of corneal wound healing after photorefractive keratectomy in highly myopic eyes.
Gambato C, Ghirlando A, Moretto E, Busato F, Midena E.
SourceRefractive Surgery Service and Antimetabolite Therapy Research Unit, Department of Ophthalmology, University of Padova, Padova, Italy.
Abstract
PURPOSE: To evaluate the role of topical mitomycin C in corneal wound healing (CWH) after photorefractive keratectomy (PRK) in highly myopic eyes.
DESIGN: Prospective, double-masked, randomized clinical trial.
PARTICIPANTS: Seventy-two eyes of 36 patients affected by high (>7 diopters) myopia.
METHODS: In each patient, one eye was randomly assigned to PRK with intraoperative topical 0.02% mitomycin C application, and the fellow eye was treated with a placebo. Postoperatively, mitomycin C-treated eyes received artificial tears (3 times daily, tapered in 3 months), whereas the fellow eye was treated with fluorometholone sodium 2% and artificial tears (3 times daily, tapered in 3 months).
MAIN OUTCOME MEASURES: Uncorrected visual acuity (UCVA) and best-corrected visual acuity (BCVA), contrast sensitivity, manifest refraction, and biomicroscopy. Contrast sensitivity was determined using the Pelli-Robson chart. Corneal confocal microscopy documented CWH.
RESULTS: Mean follow-up was 18 months (range, 12-36). No side effects or toxic effects were documented. At 12-month follow-up examination, UCVAs (logarithm of the minimum angle of resolution) were 0.4+/-0.48 and 0.5+/-0.53 (P = .03) in mitomycin C-treated eyes and corticosteroid-treated eyes, respectively. At 1 year, corneal haze developed in 20% of corticosteroid-treated eyes, versus 0% of mitomycin C-treated eyes. At 12, 24, and 36 months, corneal confocal microscopy showed activated keratocytes and extracellular matrix significantly more evident in untreated eyes (Ps = 0.004, 0.024, and 0.046, respectively).
CONCLUSION: Topical intraoperative application of 0.02% mitomycin C can reduce haze formation in highly myopic eyes undergoing PRK.
Comment in
Ophthalmology. 2006 Feb;113(2):357; author reply 357-8
Dispelling the Myths Behind First-author Citation Counts
No full textWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
A Multi-Language Comparison of Influences on Author Verification using Character N-Grams
No full textWe create a new multi-language corpus for author verification based on Wikipedia talkpages, and evaluate the influence that differences in topic and time have on character n-gram author profiles. Topic alignment between two texts is found to increase author verification precision, and an authors writing style is found to change over time, but not more significantly after 3 years than after 1 year.Information ArchitectureWISElectrical Engineering, Mathematics and Computer Scienc
Connected gradings and fundamental group
No full textThe main purpose of this paper is to provide explicit computations of the fundamental group of several algebras. For this purpose, given a k-algebra A, we consider the category of all connected gradings of A by a group G and we study the relation between gradings and Galois coverings. This theoretical tool gives information about the fundamental group of A, which allows its computation using complete lists of gradings.Fil: Cibils, Claude. Universite Montpellier II; FranciaFil: Redondo, Maria Julia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Bahía Blanca. Instituto de Matemática Bahía Blanca (i); Argentina. Universidad Nacional del Sur. Departamento de Matemática; ArgentinaFil: Solotar, Andrea Leonor. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Matemática; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentin
Papel de la policistina-1 en la regulación de la expresión de c-Myc y BIN1 en los cardiomiocitos
No full textMemoria para optar al título de Químico FarmacéuticoLa Policistina-1 (PC1) es un mecanosensor fundamental para la correcta contractilidad
cardiaca y su ausencia en los cardiomiocitos se relaciona con la disminución de los niveles
proteicos de los canales de calcio tipo-L (LTCC). Los túbulos-T, invaginaciones del sarcolema
cruciales para la función cardiaca, son estructuras que mantienen en las diadas a los LTCC,
evitando su rápida degradación, por lo que cualquier alteración en su formación, redunda en la
degradación de los canales y disminución de la función contráctil. Una de las proteínas
involucradas en la formación de los túbulos-T es BIN1, la cual presenta en el corazón 2
isoformas ubicuas (BIN1 y BIN1+17) e isoformas 2 cardio-específicas (BIN1+13 y BIN1+13+17).
A pesar de su importancia, se desconoce hasta el momento las vías que regulan la expresión de
BIN1 en los cardiomiocitos. Por otro lado, mientras en células cancerosas la expresión de BIN1
es regulada negativamente por el factor transcripcional c-Myc, en células renales la PC1 es un
supresor de la expresión de c-Myc, por lo cual en esta tesis se propuso estudiar la relación entre
la PC1, c-Myc y BIN1 en los cardiomiocitos.
El objetivo de este trabajo fue determinar el papel de la PC1 en la expresión de c-Myc y
su relación con la expresión de BIN1 y sus isoformas en los cardiomiocitos, para lo cual se
utilizaron ratones KnockOut cardio-específicos para la PC1 y cultivo de cardiomiocitos de ratas
neonatas. Se utilizaron siRNAs para la PC1 o c-Myc y adenovirus para sobreexpresar la cola
C-terminal de la PC1. Se detectaron los niveles proteicos de c-Myc a través de inmunoblot,
mientras que el mRNA de la PC1, las isoformas de BIN1 y el mRNA de c-Myc se detectaron por
RT-qPCR. Se utilizó t-Test o ANOVA de una vía seguido de un post test de Tukey para el
análisis estadístico.
Nuestros resultados muestran que la disminución de la expresión de la PC1 induce la
expresión de c-Myc, mientras que su sobreexpresión la inhibe. Sin embargo, tanto la disminución
de la expresión de c-Myc como de la PC1 regulan de manera similar la expresión diferencial de
las isoformas de BIN1, sin cambios en la expresión de BIN1 total. Más aún, la disminución de
c-Myc o la sobreexpresión de la cola c-terminal de PC1, aumentan la expresión de BIN1+13 y
disminuyen la de BIN1+13+17. Esta aparente contradicción, podría deberse a que cualquier
desregulación de la expresión de la PC1 tiene como efecto la misma respuesta celular, como
está descrito en células renales.
Estos datos sugieren por primera vez que la PC1 es un inhibidor negativo de c-Myc en
los cardiomiocitos, lo cual se relaciona con la expresión diferencial de las isoformas de BIN1Polycystin-1 (PC1) is a fundamental mechanosensor for correct cardiac contractility
and its absence in cardiomyocytes is related to the decrease in protein levels of L-type
calcium channels (LTCC). T-tubules, invaginations of the sarcolemma crucial for cardiac
function, are structures that maintain LTCCs in dyads, preventing their rapid degradation, so
that any alteration in their formation, results in the degradation of channels and decreased
contractile function. One of the proteins involved in the formation of T-tubules is BIN1, which
has 2 ubiquitous isoforms in the heart (BIN1 and BIN1+17) and 2 cardio-specific isoforms
(BIN1+13 and BIN1+13+17). Despite its importance, the pathways that regulate BIN1
expression in cardiomyocytes are so far unknown. On the other hand, while in cancer cells
the expression of BIN1 is negatively regulated by the transcriptional factor c-Myc, in renal
cells PC1 is a suppressor of c-Myc expression, which is why in this thesis it was proposed to
study the relationship between PC1, c-Myc and BIN1 in cardiomyocytes.
The objective of this work was to determine the role of PC1 in the expression of
c-Myc and its relationship with the expression of BIN1 and its isoforms in cardiomyocytes, for
which PC1-specific KnockOut mice were used and culture of cardiomyocytes from neonatal
rats. siRNAs for PC1 or c-Myc and adenoviruses were used to overexpress the C-terminal
tail of PC1. Protein levels of c-Myc were detected through immunoblot, while PC1 mRNA,
BIN1 isoforms and c-Myc mRNA were detected by RT-qPCR. One-way t-Test or ANOVA
followed by a Tukey post test was used for statistical analysis.
Our results show that the decrease in the expression of PC1 induces the expression
of c-Myc, while its overexpression inhibits it. However, both decreased c-Myc and PC1
expression similarly regulate differential expression of BIN1 isoforms, with no change in total
BIN1 expression. Furthermore, the decrease in c-Myc or the overexpression of the Cterminal
tail of PC1, increases the expression of BIN1+13 and decreases that of
BIN1+13+17. This apparent contradiction could be because any deregulation of PC1
expression has the same cellular response as described in kidney cells.
These data suggest for the first time that PC1 is a negative inhibitor of c-Myc in
cardiomyocytes, which is related to the differential expression of BIN1 isoformsFONDECYT N° 118061
A 0.12mm<sup>2</sup> Wien-Bridge Temperature Sensor with 0.1°C (3σ) Inaccuracy from -40°C to 180°C
No full text Resistor-based temperature sensors can achieve much higher resolution and energy efficiency than conventional BJT-based sensors [1], but they typically occupy more area (> 0.25 mm 2 ) and have lower operating temperatures (le 125 {circ} {C}) [2]-[4]. This work describes a 0.12mm 2 resistor-based sensor that uses a Wien-bridge (WB) filter to achieve 0.1 {circ} {C} (3 sigma) inaccuracy from - 40 {circ} {C} to 180 {circ} {C}. Compared to a state-of-the-art WB sensor [4], it occupies 6 × less area and achieves comparable relative accuracy over a 76% wider operating range. Session 10.3 Green Open Access added to TU Delft Institutional Repository ‘You share, we take care!’ – Taverne project https://www.openaccess.nl/en/you-share-we-take-care Otherwise as indicated in the copyright section: the publisher is the copyright holder of this work and the author uses the Dutch legislation to make this work public.Electronic InstrumentationMicroelectronic
A ±25A Versatile Shunt-Based Current Sensor with 10kHz Bandwidth and ±0.25% Gain Error from -40°C to 85°C Using 2-Current Calibration
No full textAccurate current sensing is critical in many industrial applications, such as battery management and motor control. Precise shunt-based current sensors have been reported with gain errors of less than 1% over the industrial temperature range (-40°C to 85°C) [1]–[4]. However, since they are intended for coulomb counting, their bandwidth is limited to a few tens of Hz, making them unsuitable for battery impedance or motor-current sensing. This paper presents a current sensor with a wide (10kHz) bandwidth and a tunable temperature compensation scheme (TCS), which allows it to be flexibly used with different types of shunts while maintaining high accuracy. A low-cost room-temperature calibration scheme is proposed to optimize gain flatness over temperature by exploiting the shunt's self-heating at large currents. Over the industrial temperature range and a ±25A current range, it achieves state-of-the-art gain error (±0.25%) with both low-cost PCB and stable metal-alloy shunts.Green Open Access added to TU Delft Institutional Repository 'You share, we take care!' - Taverne project https://www.openaccess.nl/en/you-share-we-take-care Otherwise as indicated in the copyright section: the publisher is the copyright holder of this work and the author uses the Dutch legislation to make this work public.Electronic InstrumentationMicroelectronic
An Article About Albertus C. Van Raalte, Author Unknown, Except for Parts Taken from an Article by Anna C. Post
No full textAn article about Albertus C. Van Raalte, author unknown, except for parts taken from an article by Anna C. Post. The author knew first generation persons in the Holland settlement and therefore, the article has some value.https://digitalcommons.hope.edu/vrp_1890s/1012/thumbnail.jp
Archivist, Archaeologist, Author and the Tactile Window
No full textThe idea that the predominant way of engaging with architecture is through vision is not uncommon but also not always the most appropriate given that buildings are also experienced through tactile interventions. This consequence that emphasises visual aesthetics in order to appreciate and understand architecture probably has much to do with the assumed but rather vaguely defined role of the architect as designer in the practice of architectural design. A resulting misapprehension is that architects designing for visual appreciation think that they are actually designing physical space for embodied tactile engagement.
This prioritisation of vision in the way architects think about and approach design is questioned through the design project of the Tactile Window in which the position of the architect is redefined through inhabiting the roles of archivist, archaeologist and author during the design process.
A 16th century portrait of Queen Elizabeth I known as the Ditchley portrait, currently on display at the National Portrait Gallery is used as the source from which the design of the Tactile Window is derived from and refers back to. Questioning the validity of vision as the sole means of engaging with the work, information about the portrait and working methods gathered from the three carefully chosen positions mentioned above are drawn on and applied to the making of this Tactile Window that becomes an alternative Ditchley portrait. Through exploring the hidden historical and current narratives of and in the existing portrait, the presence of the portrait is alluded to on an alternative physical site. Key to this are the working methods of an invented archival system of design reasoning, the unearthing of archaeological texts and assuming of authorship within the individual frameworks of the roles of archivist, archaeologist and author.
The redefined role of the architect as archaeologist takes onboard the unearthing of associated drawings and writings as well as the methods of organising and applying the recovered information to the system set up by the archivist. This analysis of the graphic and text based information is used to formulate historical narratives that are woven into the design project. Whereas traditional archaeology stresses on the study of a site from a site with quantifiable limits to the physical context, the notion of archaeological sites in this instance refers to the places where the stored information is unearthed. Through the careful process of archiving and analysing this information, a new site that is located within both the physical and historical contexts of interest is discovered. The author then draws upon the elements in the archival system that includes the findings of the archaeologist to construct the alternative Ditchley portrait in this new site of the Echoing Cedar, the result of which bears no visual resemblance to the existing work.
The Tactile Window is a reading of the Ditchley portrait in which information about and in the painting is transformed into a design proposal for an inhabited structure. The intended method of interaction with this alternative portrait is not merely restricted to vision but relies on engagement with the other senses. This experience is enhanced by the interplay with certain site conditions such as wind and rain in order to allude to specific aspects of the Ditchley portrait that are not visually apparent in the existing work.
In the processes of excavating, finding and revealing the hidden information to create this alternative portrait, the effects of the visuals afforded by the existing portrait inadvertently begin to fade as the validity of a single means of visual expression is questioned
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