100,425 research outputs found
Application of a Fibrous Electrostatic Filter for Treatment of Diesel Exhaust
No full textThe paper presents results of investigations of a novel method for diesel exhaust filtration in a fibrous filter supplemented by the external electrostatic field (FEF), which may be used to eliminate the occupational hazard near sources of diesel emission. The reported research follows the preliminary basic study of soot removal in such systems (Ciach, Sosnowski, & Podgorski, 1995), and is focused on the construction and testing of a prototype technical-scale FEF device. The results suggest a strong relation between applied voltage and filtration efficiency of the system and demonstrate the influence of aerosol precharging on the efficiency, which can be more than 95%
Drug delivery from the oral cavity: focus on a novel mechatronic delivery device
No full textDental drug delivery systems have been used for a long time, in particular for the local therapy of diseases affecting the oral cavity. Research today concentrates on the design of formulations to increase their retention time. Even today, however, prosthetic devices incorporating drug delivery are rarely used. Mainly, they are focused on prophylaxis and the release of antibacterial agents. However, as buccal delivery, because of its undeniable advantages, has become popular for systemic drug delivery, and prolonged well-controlled release has been identified as beneficial, especially for chronic diseases, a new class of delivery systems is evolving: highly miniaturized computerized delivery systems, integrated into a dental appliance. Dental delivery systems today are used in two ways: the main application is the local treatment of diseases affecting the oral cavity itself like periodontitis or fungal infections. The second is for systemic drug delivery
Letter, [Author unclear] to Paulina T. Merritt
No full textHandwritten letter to Paulina Merritt from an unknown author, October 1, 1876.
The fate of Jews in Gdańsk and Sopot in the first half of the XX century and it’s reflection in the works of Mieczysław Abramowic
No full textIn the article titled ‘The fate of Jews in Gdańsk and Sopot in the first half of the XX century and it’s reflection in the works of Mieczysław Abramowicz’ the author deals with the issue of the place of a human being in historical processes. She shows an example of the Free City of Gdańsk (specifically in Gdańsk and Sopot) during the inter war period and II World War. The author analyses the political situation in both of the city and how the situation influenced the fate of Jews characters living on this territory. Then in the article the some quotes of Abramowicz’s books in which he creates fictional literary heroes who could live in Free City of Gdańsk. The goal of the article is to show how important is to remember about representatives of minorities which have created the character of some well-known area.DOMINIKA CIACH – mgr, absolwentka filologii polskiej na Uniwersytecie Gdańskim. Pochodzi z małej miejscowości położonej pod Gdańskiem, ale od lat związana jest z Trójmiastem. Na co dzień zajmuje się nauczaniem języka polskiego jako obcego w polskich placówkach oraz we włoskiej szkole polonijnej. Jej zainteresowania skupiają się wokół literatury romantyzmu, zagadnienia stereotypu, które uwidocznia się w językowej kreacji bohaterów literackich, oraz zagadnienia regionalności, co potwierdza członkostwo w Stowarzyszeniu „Żuławy Gdańskie” oraz ukończenie kursu na przewodnika miejskiego po Gdańsku, Gdyni i Sopocie organizowanego przez gdański oddział PTTK.Uniwersytet GdańskiAbramowicz M., Bowiem jak śmierć potężna jest pamięć, Gdańsk 2013.Abramowicz M., Każdy przyniósł, co miał najlepszego, Gdańsk 2006.Abramowicz M., Teatr żydowski w Gdańsku 1876–1968, Gdańsk 2022.Andrzejewski M., Dzieje Sopotu w latach 1920–1945, [w:] Dzieje Sopotu do roku 1945, red. B. Śliwiński, Gdańsk 1998.Andrzejewski M., Wolne Miasto Gdańsk, 1920–1939, [w:] Encyklopedia Gdańska, Gdańsk 2012.Berendt B., Żydzi na terenie Wolnego Miasta Gdańska w latach 1920–1945, Gdańsk 1997.Brzeziński P., Wysocy Komisarze Ligi Narodów, 1919-39, [w:] Encyklopedia Gdańska, Gdańsk 2012.Dąbrowski B., Pamięć protetyczna, nostalgia i archiwum. Sopockie widma Mieczysława Abramowicza, [w:] Sopot w literaturze, literatura w Sopocie, red. J. Mosakowski, A. Nowaczewski, S. Pavlenko, R. Młynarczyk, Gdańsk 2019.Domańska H., Kamienne drzewo płaczu. Gminy żydowskie województwa gdańskiego, ich dzieje i zabytki, Gdańsk 1991.Domańska H., Lifsches L., Żydzi znad gdańskiej zatoki, wyd. 2, Warszawa 2000.Drywa D., Zagłada Żydów w obozie koncentracyjnym Stutthof 1939–1945, Gdańsk 2001.Echt S., Dzieje Żydów Gdańskich, przeł. W. Łygaś, Gdańsk 2012.Golec J., Sopot. Kronika XX wieku, Gdynia 2004.Mierzwiński Z., W Wolnym Mieście Gdańsku, „Niepodległość i Pamięć” 2009, t. 16, nr 2 (30).Nowy leksykon judaistyczny, red. J. H. Schoeps, W. Jasper i in., Warszawa 2007.Tarkowska A., Sopot między wojnami. Opowieść o życiu miasta 1918–1939, Łódź 2011.[hasło: Mieczysław Abramowicz], [w:] http://shalom.org.pl/mieczyslaw-abramowicz/ [dostęp: 6.05.2022].28129
Tablets for buccal administration of carbamazepine: comparative behavior of PAA microspheres and matrices
No full textHandwritten biographical information on Paulina T. McClung Merritt
No full textA handwritten biography of Paulina T. McClung Merritt by an unknown author, 1892.
Heterogeneous and tissue-specific regulation of effector T cell responses by IFN-gamma during Plasmodium berghei ANKA infection.
No full textIFN-γ and T cells are both required for the development of experimental cerebral malaria during Plasmodium berghei ANKA infection. Surprisingly, however, the role of IFN-γ in shaping the effector CD4(+) and CD8(+) T cell response during this infection has not been examined in detail. To address this, we have compared the effector T cell responses in wild-type and IFN-γ(-/-) mice during P. berghei ANKA infection. The expansion of splenic CD4(+) and CD8(+) T cells during P. berghei ANKA infection was unaffected by the absence of IFN-γ, but the contraction phase of the T cell response was significantly attenuated. Splenic T cell activation and effector function were essentially normal in IFN-γ(-/-) mice; however, the migration to, and accumulation of, effector CD4(+) and CD8(+) T cells in the lung, liver, and brain was altered in IFN-γ(-/-) mice. Interestingly, activation and accumulation of T cells in various nonlymphoid organs was differently affected by lack of IFN-γ, suggesting that IFN-γ influences T cell effector function to varying levels in different anatomical locations. Importantly, control of splenic T cell numbers during P. berghei ANKA infection depended on active IFN-γ-dependent environmental signals--leading to T cell apoptosis--rather than upon intrinsic alterations in T cell programming. To our knowledge, this is the first study to fully investigate the role of IFN-γ in modulating T cell function during P. berghei ANKA infection and reveals that IFN-γ is required for efficient contraction of the pool of activated T cells
Dispelling the Myths Behind First-author Citation Counts
No full textWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
Diffusion of naltrexone across reconstituted human oral epithelium and histomorphological features
No full textIn transbuccal absorption a major limitation could be the low permeability of the mucosa which implies low drug bioavailability. The ability of naltrexone hydrochloride(NLX)to penetrate a resembling histologically human buccal mucosa was assessed and the occurrence of any histomorphological changes observed. We used reconstituted human oral (RHO) non-keratinised epithelium as mucosal section and a Transwell diffusion cells system as bicompartmental model. Buccal permeation was expressed in terms of drug flux (Js) and permeability coefficients (Kp). Data were collected using both artificial and natural human saliva. The main finding was that RHO does not restrain NLX permeation. Drug transport across the epithelium was observed also in presence of various concentrations of penetration enhancers, without any significant differences. On the contrary, the flux throughout the mucosa was extensively affected by iontophoresis. Histologically, no sign of flogosis was observed in any specimen under experiment without iontophoresis, whereas cytoarchitectural changes, up to nuclear pycnosis or cellular swelling, were determined as a consequence of the application of electric fields
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