1,720,960 research outputs found
Etiological Treatment of Cardiac Amyloidosis: Standard of Care and Future Directions
No full textPurpose of Review: Cardiac amyloidosis (CA) is a condition caused by interstitial infiltration of misfolded proteins structured into amyloid fibrils. Transthyretin (ATTR) and immunoglobulin light chain (AL) amyloidosis represent the most common forms of CA. CA was traditionally perceived as a rare and incurable disease, but diagnostic and therapeutic advances have undermined the conventional paradigm. Recent Findings: The standard of care for ATTR-CA include agents capable of selectively stabilizing the precursor protein (e.g., tafamidis), whereas the plasma cell clone is the main target of chemotherapy for AL-CA. For long, tafamidis represented the only drug approved for patients with ATTR-CA. Recent data from ATTRibute-CM led to the approval of acoramidis, whereas patisiran received refusal based on the APOLLO-B trial. Novel CRISPR-Cas9-based drugs (i.e., NTLA-2001) hold great potential in the setting of ATTR-CA. Several hematological regimens are available to treat AL-CA. The main limit of current therapies is their inability to trigger removal of amyloid from tissues. However, the investigation of monoclonal antibodies targeting misfolded ATTR (e.g., PRX004, NI301A) or AL (e.g., birtamimab, anselamimab) has led to encouraging results. Summary: Various cutting-edge strategies are being tested for treatment of CA and may change the prognostic landscape of this condition in the next years
Cardiac amyloidosis in Tuscany and Umbria regions: incidence, diagnostic pathways, clinical characteristics
No full textWhile previously considered a rare disease, cardiac amyloidosis (CA), either associated to tranthyretin (TTR-CA) or to immunoglobulin light-chain (AL-CA) is likely underdiagnosed. However real incidence and prevalence of CA remain unknown and shared diagnostic pathways are not fully defined.
Aim: to assess incidence, diagnostic pathways and clinical characteristics of patients with CA in Tuscany and Umbria regions.
Methods: Patients with suspected CA underwent diagnostic work-up in XX Centers in Tuscany and Umbria regions within the CARRY registry and were then followed-up for 12 month for the end-points of all-cause mortality and hospitalization.
Results: 516 patients were enrolled; 448 finaly received an established diagnosis of CA. Incidence rate of CA in 2022 in Tuscany and Umbria regions was estimated at 4.64 new cases per 100000 adult population and for ATTR CA 10.64 new cases per 100000 population . Patients with CA had more often past history of carpal tunnel syndrome, spontaneous tendon ruptures, heart failure, higher levels of NT-proBNP and hs troponin T; they also showed lower left ventricular (LV) ejection fraction, higher LV mass, worse diastolic function. The main referral pathway was cardiological. Median time from clinical suspicion to diagnosis of CA was 73 days (71 days for ATTR-CA, 76 days for AL-CA). Follow-up was available in 66/448 patients. In such subset, cumulative survival free for outcomes was significantly lower in patients with CA (49 weeks(95% CI 46.7-51.3) vs 51 week (95% CI 50.2-51.8), p =0.046).
Conclusion: Incidence of CA is higher than previously reported. The introduction of shared diagnostic pathways may improve outcome of patients with ATTR- and AL-CA
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
koamabayili/VECTRON-author-checklist: VECTRON author checklist
No full textWe have done our best to complete the author checklist relating to the use of animals in the hut study. Note that the objective for the hut study was to evaluate the IRS treatment applications for residual efficacy against Anopheles mosquitoes, including the local An. coluzzii mosquito population. Cows were only used to attract mosquitoes into the huts and no tests were carried out directly on the cows. The author checklist is intended for use with studies where experiments are carried out on animals, which is why we have had such difficulty in completing this for the hut study, as many of the questions do not relate to how the cows were used
Author-wise bibliometric analysis based on entropy.
No full textAuthor-wise bibliometric analysis based on entropy.</p
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