158 research outputs found
XXX. Deutscher Orientalistentag : Orientalistik im 21. Jahrhundert : welche Vergangenheit, welche Zukunft : Freiburg, 24.-28. September 2007 : ausgewählte Vorträge / von Brunner, Rainer / Kurz oder lang, hoch oder quer : Über das Buchformat der Sogder
No full textChristiane Rec
Ahreman and Narcissus
No full textThe article deals with the sexual behavior of Ahreman, the primordial antagonist of Ohrmazd, in the framework of the Iranian Zoroastrian cosmology. The negative creation of the dark Lord of the demons is obtained throughout an act of self-sodomy. This event shows some of the most important destructive and negative characters of Ahreman, whose target is the nihilistic negation of life and reproduction. The author demonstrates that the Mazdean mythographers imagined the evil Lord as the main representative of all the negatives drives, and focuses on the coherence of this story in the context of Zoroastrian theology with the help of some psychoanalitical means of interpretation, in particular with reference to the so-called narcissistic patterns.This article is part of a wide research dedicated to unconscious archetypes attested in the Iranian Pre-Islamic religious literature
The RECK tumor-suppressor protein binds and stabilizes ADAMTS10
No full textThe tumor suppressor protein RECK has been implicated in the regulation of matrix metalloproteinases (MMPs), NOTCH-signaling and WNT7-signaling. It remains unclear, however, how broad the spectrum of RECK targets extends. To find novel RECK binding partners, we took the unbiased approach of yeast two-hybrid screening. This approach detected ADAMTS10 as a RECK-interactor. ADAMTS10 has been characterized as a metalloproteinase involved in fibrillin-rich microfibril biogenesis, and its mutations have been implicated in the connective tissue disorder Weill-Marchesani syndrome. Experiments in vitro using recombinant proteins expressed in mammalian cells indicated that RECK indeed binds ADAMTS10 directly, that RECK protects ADAMTS10 from fragmentation following chemical activation and that ADAMTS10 interferes with the activity of RECK to inhibit MT1-MMP. In cultured cells, RECK increases the amount of ADAMTS10 associated with the cells. Hence, the present study has uncovered novel interactions between two molecules of known clinical importance, RECK and ADAMTS10. This article has an associated First Person interview with the first author of the paper
RECK-mediated β1-integrin regulation by TGF-β1 is critical for wound contraction in mice
No full textPublisher Copyright: © 2015 Gutiérrez et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.Fibroblasts are critical for wound contraction; a pivotal step in wound healing. They produce and modify the extracellular matrix (ECM) required for the proper tissue remodeling. Reversion- inducing cysteine-rich protein with Kazal motifs (RECK) is a key regulator of ECM homeostasis and turnover. However, its role in wound contraction is presently unknown. Here we describe that Transforming growth factor type β1 (TGF-β1), one of the main profibrotic wound-healing promoting factors, decreases RECK expression in fibroblasts through the Smad and JNK dependent pathways. This TGF-β1 dependent downregulation of RECK occurs with the concomitant increase of β1-integrin, which is required for fibroblasts adhesion and wound contraction through the activation of focal adhesion kinase (FAK). Loss and gain RECK expression experiments performed in different types of fibroblasts indicate that RECK downregulation mediates TGF-β1 dependent β1-integrin expression. Also, reduced levels of RECK potentiate TGF-β1 effects over fibroblasts FAKdependent contraction, without affecting its cognate signaling. The above results were confirmed on fibroblasts derived from the Reck+/- mice compared to wild type-derived fibroblasts. We observed that Reck+/- mice heal dermal wounds more efficiently than wild type mice. Our results reveal a critical role for RECK in skin wound contraction as a key mediator in the axis: TGF-β1-RECK- β1-integrin
Introduction to William James
No full textIn an extended essay with related texts, Mr. Reck presents a reappraisal of James' work which offers an excellent introduction to one of the most fertile and original minds America ever produced. An eight-part essay parallels and offers commentary on selections from Principles of Psychology, Briefer Course, Essays in Radical Empiricism, The Will to Believe, The Varieties of Religious Experience, Pragmatism, and A Pluralistic Universe. The author closely examines James' intellectual development, emphasizing the influence of his European education and experience, and assesses his relevance to contemporary philosophy. He also provides notes, a chronology of James' life, and a bibliography
Introduction to William James
No full textIn an extended essay with related texts, Mr. Reck presents a reappraisal of James' work which offers an excellent introduction to one of the most fertile and original minds America ever produced. An eight-part essay parallels and offers commentary on selections from Principles of Psychology, Briefer Course, Essays in Radical Empiricism, The Will to Believe, The Varieties of Religious Experience, Pragmatism, and A Pluralistic Universe. The author closely examines James' intellectual development, emphasizing the influence of his European education and experience, and assesses his relevance to contemporary philosophy. He also provides notes, a chronology of James' life, and a bibliography
Analysis of the inhibiting activity of reversion-inducing cysteine-rich protein with Kazal motifs (RECK) on matrix metalloproteinases
No full text© The Author(s) 2020.Matrix metalloproteinases (MMPs) occur in 23 human paralogues with key functions in physiology, and their activity is controlled by protein inhibitors. Reversion-inducing cysteine-rich protein with Kazal motifs (RECK), which is essential for embryogenesis and tumour suppression, has been reported to inhibit MMPs. Here, we developed eukaryotic and bacterial expression systems for different RECK variants and analysed their inhibitory capacity against representative MMPs in vitro. We could not detect any significant inhibition. Instead, we found that partially purified RECK from the conditioned medium of transfected Expi293F cells but not that of ExpiCHO-S or Drosophila Schneider cells contained a contaminant with proteolytic activity. The contaminant was removed through treatment with a small-molecule serine peptidase inhibitor and additional chromatographic purification. A tantamount contaminant was further detected in an equivalent expression system of the N-terminal fragment of the proteoglycan testican 3, but not in those of two other proteins. These results indicate that previous reports of inhibitory activity of recombinant RECK on MMPs, which were performed with partially purified samples, were probably masked by a coeluting contaminant present in the supernatant of HEK293-derived cells. Thus, RECK is probably not a direct inhibitor of MMP catalytic activity but may still regulate MMPs through other mechanisms.This study was supported in part by grants from Spanish and Catalan public and private bodies (grant/ fellowship references BFU2015–64487R, MDM-2014–0435, BES-2015–074583, BES-2016–076877, 2017SGR3 and Fundació “La Marató de TV3” 201815)
Actual Care and Funding Situation with Regard to Mother-Child Units for Psychic Disorders Associated with Pregnancy in Germany
No full textConcern: The current care and financial situation of mother-child units for psychic disorders associated with pregnancies in Germany should be documented in preparation for the development of the new reimbursement system for psychiatry and psychosomatics. Method: In accordance with the last survey of 2005, a brief questionnaire was developed and a nationwide poll was conducted. Results: The survey revealed severe (10 fold) service deficits for severely and gravely mentally ill mothers, who require an inpatient treatment with specific professional competence. Compared with the last poll, these service deficits have increased. This is due to continued insufficient funding and unresolved financing in the new reimbursement system. With the establishment of an additional code for mother-child treatment the precondition for ensuring the funding of this important care form in the new reimbursement system was created. Conclusion: It is to be hoped that the decision-makers of health policy will finally face up to their social responsibility and ensure adequate funding of the additional diagnostic and therapeutic expenditure of mother-child treatment. The health care providers have an obligation to implement a transparent record of services of the additional expenditure and to augment the national evaluation approaches to inpatient mother-child treatments
The Sogdians and Their Religions in Turfan: Evidence in the Catalogue of the Middle Iranian Fragments in Sogdian Script of the Berlin Turfan Collection
No full textWe are able to verify the variety of the religions of the Sogdians by the text fragments found in the Turfan oasis (East Turkistan, today’s Xinjiang Autonomous Region of China). They are housed in several libraries and museums in Europe, Japan, and China. The Berlin Turfan collection contains a large part of them. The catalogue of the Sogdian text fragments in the indigenous Sogdian script of that collection was completed in 2018. The fragments represent parts of the literature of Christian, Manichaean and Buddhist communities in Turfan from the eighth to eleventh century CE. The best represented religion in the homeland of the Sogdians is a type of the Zoroastrian religion, as evidenced by archaeological findings and wall paintings. However, there are only very few texts found in Turfan and other locations in Central Asia which could be interpreted as Zoroastrian. The discussion about the religious affiliation of those texts is going on. The religious background of some other text fragments from Turfan is difficult to identify as well. Two of these examples will be published here. A remarkable feature of the religious communities in Turfan is the multilingual character of their literature, reflecting the development and path of the believers and the multi-ethnical structure of the community
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