115 research outputs found
KEBIJAKAN BELT AND ROAD INITIATIVE (BRI) TIONGKOK PADA MASA PEMERINTAHAN XI JINPING. AUTHOR: Syaiful Anam, Ristiyani Ristiyani
No full textKEBIJAKAN BELT AND ROAD INITIATIVE (BRI) TIONGKOK PADA MASA PEMERINTAHAN XI JINPING
Syaiful Anam, Ristiyani Ristiyan
Cell and tissue culture: an overview
No full textIntroduction
This book, Cell/Tissue Culture Research and Technology from Islamic Perspective, deals and discusses on issues pertaining to the applications of cell and tissue culture in the light of the advancements made in modern technology, particularly in biotechnology and nanotechnology. To dissect the many topics pertaining to this matter, the book is divided into 10 chapters.
In Chapter 1, which is entitled, “Integration of Islamic Principles in Modern Science: Its Philosophy and Method”, Ibrahim A. Shogar, the writer, gives an in depth explanation of the approaches used by scholars, jurists and scientists of this modernized world in order to integrate Islamic principles in science and technology. He explains the many challenges that have, and will, be faced by Muslims in order to achieve Islamic integration in modern science, taking into account the opinions of old and new Muslim scholars. Through the philosophies and methods presented, the aim of showing the steady progression of Islamic integration in the promising field of science and technology is achieved.
In Chapter 2, “Cell and Tissue Culture: An Overview”, Mohammad Syaiful Bahari Abdull Rasad and his co-author, focuses upon the basic requirements and arrangements that are necessary for the purpose of setting up, or working, in a cell/tissue culture laboratory. Brief explanations of protocols, equipment handling and maintenance are also incorporated into this chapter with the aim of exposing readers on the various regulations and equipment needed in a culture laboratory. A concise elucidation on a collection of cell lines is provided as an introductory towards the types of cells/tissues that can be found cultured in a normal cell/tissue culture laboratory. Overall, readers should have a fundamental understanding of the setup and requirements of a cell/tissue culture laboratory.
Rahmatul Wahida Ahmad, in Chapter 3, which is entitled “Risk Assessment and Regulatory Aspects of Cell Culture”, stresses that safety and health of the occupants of the cell/tissue culture laboratory is to be the focal point of any cell/tissue culture research as the risks one is exposed to are aplenty. The level of risks, and the regulations that are established in most cell/tissue culture laboratory in order to counter and reduce the amount of exposure towards those risks, are highlighted in this chapter, with the hopes of putting cautions in readers who are involved with cell/tissue culture research. As Islam prioritizes safety and wellbeing of mankind, this chapter is of great significance before going further with other aspects of integrated science and Islamic principles.
In Chapter 4, “Basic Techniques and Research in Cell Culture: Integration of Islamic Approach”, Mohammad Syaiful Bahari Abdull Rasad provides an explanation on how Islamic laws and regulations (shariah) could be applied in cell culture research with proper usage of alternative resources and materials. Discussions and suggestions in utilizing alternative approaches for cell culture research are stressed upon, with the aim of exposing readers with the possibilities of making modern science and technology more acceptable for Muslims, as well as other, communities. As a result, a perceptive on how to approach and integrate Islam into cell culture research is accomplished.
The focus of Chapter 5 is on the “Diagnostic and Therapeutic Application of Cell and Tissue Culture from Islamic Perspective”. The writer, Mohammad Syaiful Bahari Abdull Rasad and his co-writer, Nur Aizura Mat Alewi, writes at great length on the various dilemmas as well as ethical and social issues posed by the utilization of cell and tissue culture in the field of diagnostic and therapeutic research. The writers emphasize that with the advancement in cell/tissue culture application in an assortment of researches, many issues, of old and new, have also arisen. Thus, it is the duty of Muslim scholars and scientists to search for knowledge and ascertain proper regulations that are in accordance to Islamic shariah as this would assist in safeguarding the interest of the Muslim ummah and at the same time, promote its progression in modern science.
In Chapter 6, “New Era of Regenerative Medicine: An Islamic Perspective”, Ahmad Sukari Halim and his co-authors highlight the headway made by scientists and researches of this century on regenerative medicine. Diverse methods and approaches applied in modern science are stated thoroughly, keeping in mind on how Islam perceives and accepts advancement in life, as long as they are within the bound of Islamic rules and regulations (shariah).
In Chapter 7, Mohd. Arifin Kaderi explains the various aspects of genetic engineering and how cells are utilized in this advancing field of biotechnology, taking into deliberation the issues that may arise based on Islamic perspective. Hence, this chapter entitled, “Applications of Cultured Cells in Genetic Engineering: An Islamic Perspective”, discusses topics such as gene/genome applications in genetic engineering, vaccines and antibodies productions and so forth.
Elaborating further on the matter which have a degree of association, Munirah Sha’ban and her co-author, in Chapter 8, under the title, “Tissue Engineering: An Islamic Perspective”, write on a variety of aspects that need to be understood by Muslims concerning the utilization of tissue engineering from medical and scientific perspectives, with religious (Islamic) perspective playing a focal role in the discussions. It is indicated in the chapter that although the issues surrounding tissue engineering are continuously being reviewed and debated, Muslims should move forward with researches concerning tissue engineering while keeping in adherence to the shariah.
Meanwhile, Muhammad Lokman Md. Isa in Chapter 9, “Stem Cells Research: Value, Ethical and Religious Views”, draws attention to several other religions, including Islam, and their opinions and views on the subject of stem cell research. It is interesting to note that the religions which have strong traditions of legal and religious laws, namely Judaism and Islam, support most forms of stem cell research.
Finally, in the last chapter (Chapter 10) which was written by Shaharum Shamsuddin, entitled, “Nanobiotechnology and Nanomedicine: The Impact, Implication and The Unknown”, the writer puts forward a lengthy elaboration on a topic that has piqued the attention of many researchers and scientists of this era, which is the topic of nanotechnology. With in-depth input on different applications of nanotechnology, readers are able to further immerse themselves in the many prospects of nanotechnology, both known and unknown, that could benefit mankind in the future
Assessment of the synergistic effect of a poly-herbals combination on the antioxidant activity through a statistical approach
No full textThis project focused on assessing the synergistic effect of five traditional Indonesian herbal extracts on the antioxidant activity by using a simplex lattice design. The novelties of our study were:
- this study provides scientific justification of main effect and interaction between five traditional Indonesian herbal extracts according to the constructed statistical model. The evaluation based on simultaneous interaction.
- explores the combination of local and frequenly applied of Indonesian herbal plants on antioxidant activity.
- understands both synergistic and antagonism interaction between polyherbal combination on the antioxidant activity
DoE-based formulation development of nanoliposomes containing apigenin from Apium Graveolens incorporated into dissolving microneedle patch
No full textDevelopment nanoliposomes formulation using QbD concept containing Apium graveolens extract incorporated dissolving microneedle device
THE INFLUENCE OF MAGNESIUM STEARATE, PURIFIED TALC AND COMBINATION OF BOTH ON TERNARY/QUATERNARY INTERACTIVE MIXTURE OF FREELY AND POORLY WATER-SOLUBLE DRUG
Get PDFObjective: This research purposed to describe and evaluate the influence of magnesium stearate (MgSt), purified talc (talc) and combination of both (MgSt-PT) on ternary/quaternary mixture of freely and poorly water-soluble drug.Methods: Chlorpheniramine maleate (CPM) and prednisone (PDN) were used as the drug model of freely and poorly water-soluble drug, respectively. Compatibility studies between drugs and lubricants were carried out using Fourier transform infrared spectroscopy (FTIR). Ternary/quaternary interactive mixture of drugs, lubricants and carriers were conducted using granules of lactose-starch (1:1) as carriers with particle size 250 – 425 µm. Characterizations were conducted by homogeneity of mixture, physical properties of granules and tablets and drug releases. The results were analyzed statistically using one-way analysis of variance (ANOVA) with 95% of confidence interval level and dependent method for drug release.Results: Homogeneity of binary mixture within drug and carrier was achieved in 60 minutes with 20 revolutions per minute. MgSt, talc and combination of both provided stable ternary/quaternary interactive mixture. MgSt affected the reduction of compactibility, prolong the disintegration time, retardation the drug release and talc improved flowability.Conclusion: Talc provided more preferable effects than MgSt, and combination of both lubricants showed desirable physical properties of tablet. MgSt, talc and combination of both provided no significant effect on physical properties and drug release of CPM as freely water-soluble drug and the significant effect was observed on PDN as poorly water-soluble drug
MODEL AND RELEASE PATTERN OF WATER SOLUBLE DRUG FROM NATURAL-POLYMER BASED SUSTAINED RELEASE TABLET DOSAGE FORM
Get PDFObjective: The aim of this research was to investigate and evaluate the drug release characteristics (models and drug release profiles) using natural polymers (pectin, carrageenan and glucomannan) in water soluble drug of sustained release tablet.
Methods: Captopril was used as drug model. Tablet were prepared using wet granulation method. Pectin, carrageenan and glucomannan were used as matrix with concentration 20%, 30% and 40%" with "matrices with various concentration. Physyical properties inpections were conducted on granules and tablets. Dissolution test using apparatus II USP model with 50 rpm of speed rotation, 900 ml of HCl 0.1N as medium. The results were analyzed statistically by MANOVA, dependent model and independent model.
Results: The results showed that enhancement of matrix concentrations decreased the fluidity and compact-ability. Drug release of soluble drug using pectin as matrix not significant different than without matrix.
Conclusion: Tablet using glucomannan and carrageenan as matrix controlled the drug release with initial burst release effect. Weibull models was the best fitting model of release kinetics with the highest coefficient of determination and similarity between predicted and observed data  and the release mechanisms were controlled by anomalous transport
Development and optimization of a meloxicam/β-cyclodextrin complex for orally disintegrating tablet using statistical analysis
No full textRational Design and Development of a Soluble Mesoporous Carrier for the Solidification of a Preconcentrated Self-Nanoemulsion Formulation
No full textThe solidification of self-preconcentrated nanoemulsion
without
changes in nanodroplet formation gains particular consideration due
to the interaction between solidified carriers. This work aimed to
develop mannitol mesoporous as a soluble carrier for supersaturated
self-nanoemulsion (SSNE) using a design of experiment (DoE) approach.
The mesoporous carrier was prepared by a spray-drying technique. The
type of templating agent (TA) used to form a porous system, the amount
of TA, and solid loading in the spray-drying process were studied.
Several characterizations were performed for mannitol mesoporous formation,
namely, powder X-ray diffraction, thermal analysis, scanning electron
microscopy, and surface area analyzer. Solidification of SSNE incorporated
into the mesoporous mannitol was carried out, followed by compaction
behavior, flowability, and nanodroplet formation. The results revealed
several process parameters for preparing the mesoporous mannitol,
notably TA, which gained more significant consideration. Solid loading
in the mesoporous preparation system reduced the surface area and
pore size and did not affect solid SSNE flowability. The amount of
TA increased the pore size and volume dramatically as well as the
compactibility and flowability. Ammonium carbonate was the preferable
TA for preparing the mesoporous carrier, particularly for the nanodroplet
formulation process. In addition, synergistic and antagonistic interactions
between factors were also observed. The optimized mesoporous carrier
was applied for solidification, and there was no difference between
SSNE and solid SSNE in the performance of nanodroplet formation
Perbandingan Model Dan Profil Pelepasan Obat Sukar Larut Dari Matriks Berbasis Natural-gum Pada Sediaan Tablet Lepas Lambat
Get PDFVarious natural polymers had been used as a control drug release in sustained release dosage form. Carrageenan, pectin, and glucomannan were potential as a matrix to control the release of drugs. This study is aimed at determining and comparing the patterns and methods of drug release from matrix natural-gum based (carrageenan, pectin, and glucomannan) with different models of drug release kinetics in sustained release theophylline tablets. Theophylline was used as a drug model and tablets which was made by wet granulation method. The matrix used is pectin, carrageenan, and glucomannan with the concentration 20%, 30%, and 40%. Physical quality inspection was conducted on granules and tablets. Drug release was carried out with apparatus type II USP at 75 rpm rotation, medium phosphate buffer pH 4,5 for 6 hours. The results were statistically compared by ANOVA level of 95%, dependent model and independent model. The results showed that the increasing concentration of glucomannan and pectin matrix decreased the flow time and increased concentrations of matrix lowers compatibility. Matrix of pectin and carrageenan showed a constant release. The most dominant release kinetics followed zero order kinetics with the highest determination coefficient and the difference between the observed data and the data predicted low (AICC and RMSE) and the release mechanism was controlled by the erosion of the matrix.
Key words: pectin, carrageenan, glucomannan, drug releas
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