58,886 research outputs found
Choi Seong Jun
No full text학위논문(박사)--아주대학교 일반대학원 :의학과,2014. 2ABSTRACT i
TABLE OF CONTENTS ii
LIST OF FIGURES iii
ABBREVIATION iv
Ⅰ. INTRODUCTION 1
Ⅱ. MATERIAL AND METHODS 7
A. In vitro experiments – apoptosis of auditory cells 7
1. Auditory cell culture 7
2. Cell viability assay 7
3. 4'6-Diamidino-2-phenylindole (DAPI) staining 8
4. Western blot analysis of caspase-3, poly-ADP-ribose polymerase (PARP), Cx26, and Cx43 8
5. Quantitative real time-polymerase chain reaction (qRT-PCR) of Cx26, Cx30, Cx31, and Cx43 9
6. Immunocytochemistry of Cx26, Cx30, Cx31, and Cx43 10
7. Scrape-loading dye transfer (SLDT) assay 10
B. Exvivo experiments - invitro organ of Corti culture 12
C. In vivo experiments 13
1. Auditory Brainstem Response (ABR) Test 13
2. Phalloidin staining 14
3. Scanning electron microscope (SEM) 14
Ⅲ. RESULTS 16
A. In vitro experiments – apoptosis of auditory cells 16
1. Protective effects of EGB 761 on cisplatin-induced death in HEI-OC1 cells 16
2. Protective effects of EGB 761 on cisplatin-induced apoptosis 18
3. Protective effects of EGb 761 on the inhibition of GJIC by cisplatin 20
B. Ex vivo experiments - in vitro oC culture 26
C. In vivo experiments 28
1. Shift of ABR thresholds 28
2. Cochlear morphology - phalloidin staining and SEM 30
Ⅳ. DISCUSSION 32
Ⅴ. CONCLUSION 39
REFERENCES 40
국문요약 56MasterGap junctional intercellular communication (GJIC) may play an important role in the hearing process. Cisplatin is an anticancer drug that causes hearing loss and Gingko biloba extracts (EGb 761) have been used as an antioxidant and enhancer for GJIC. The purpose of this study was to examine the efficiency of EGb 761 in protecting against cisplatin-induced apoptosis and disturbance of GJIC. HEI-OC1 auditory cells were cultured and treated with cisplatin (50µM) and EGb (300µg/ml) for 24 h, and then analyzed by immunocytochemistry (Annexin V/ propidium iodide) and Western blots. The function of GJIC was evaluated by scrape-loading dye transfer (SLDT). Basal turn organ of Corti (oC) explants from neonatal (p3) rats were exposed to cisplatin (1–10µM) and EGb (50–400µg/ml). The number of intact hair cells was counted by co-labeling with phalloidin and MyoVIIa. EGb prevented cisplatin-induced apoptosis in immunostaining and decreased caspase 3 and poly-ADP- ribose polymerase (PARP) bands, which were increased in cisplatin-treated cells in Western blots. EGb prevented abnormal intracellular locations of Cx 26, 30, 31, and 43 in cells treated with cisplatin and increased quantities of Cx bands. EGb also prevented cisplatin-induced disturbance of GJIC in SLDT. In oC explants, EGb significantly prevented hair cell damage induced by cisplatin. In animal studies, EGb significantly prevented cisplatin-induced hearing loss across 16 kHz and 32 kHz. These results show that cisplatin induces ototoxicity including hearing loss as well as down-regulation of GJIC and inhibition of Cxs in auditory cells. EGb prevents hearing loss in cisplatin-treated rats by inhibiting down-regulation of Cx expression and GJIC. The disturbance of GJIC or Cx expression may be one of important mechanisms of cisplatin-induced ototoxicity
Choi Sung Jun
No full text학위논문(석사)--아주대학교 일반대학원 :의학과,2010. 2TABLE OF CONTENTS
ABSTRACT ⅰ
TABLE OF CONTENTS iii
LIST OF FIGURES iv
LIST OF TABLES v
Ⅰ. INTRODUCTION 1
Ⅱ. PATIENTS AND METHODS 3
A. Study design 3
B. Patients 4
C. Stent and stent insertion 4
D. Statistics 4
Ⅲ. RESULTS 6
Ⅳ. DISCUSSION 13
REFERENCES 18
국문요약 24MasterBackground: The covered self expanding metal stent (SEMS) has become the main treatment option of malignant esophageal obstruction. However, the fully covered SEMS has not been as popular as the partially covered one for the fear of migration in spite of much advantage. So, we performed a prospective study to evaluate clinical efficacy of the fully covered SEMS.
Methods: Between October 1998 and February 2009, 100 consecutive patients with malignant esophageal obstruction who were treated with the fully covered Niti-S stent (Niti-S, Taewoong Medical, Seoul, Korea) were included. Data collected contained technical success rate of deployment and retrieval, dysphagia score changes, success rate of esophagorespiratory fistula (ERF) resolution, survival, stent patency and complications. We also conducted analyses concerning the associations between results and variables.
Result: Technical success rate of stent deployment was 100%. Dysphagia score was improved significantly from a mean of 3.1±0.8 to 1.3±0.7 (p=0.000) and 13 of 14 patients(14/100,14%) with ERF were resolved successfully with the initial stent(13/14, 92.9%). Median survival and stent patency was 74(51~97) and 54(47~67) days respectively. Recurrent dysphagia occurred in 19 patients (19/100,19%) with tumor ingrowth (2/100,2%), tumor overgrowth(7/100,7%), stent migration(6/100,6%), and food impaction(4/100,4%). Among other complications, early(≤7days) complications were chest pain (12/100, 12%), regurgitation (2/100 2%), tracheal compression (1/100, 1%) and late(>7days) ones were bleeding (2/100, 2%), persistent chest pain (2/100, 2%), and GERD (7/100, 7%). Reintervention had to be done in 19 patients (19/100,19%). Among them, endoscopic stent retrieval and replacement was done in 17 patients (17%) with 100% success rate and additional stents were inserted for the remaining two patients. There was no stent related mortality or 30 day mortality. In our analyses, there was no significant variable associated with clinical outcomes and complications.
Conclusions: The fully covered Niti-S metal stent has proved its effectiveness in palliation of malignant dysphagia and safety of endoscopic retrieval with a comparably low migration rate maintaining its good advantage of lower incidence of tumor ingrowth and overgrowth.
Key words; malignant dysphagia, fully covered SEMS, stent migration, stent retrieval
Making of nationalistic dance: Agrippina Vaganova and Choi Seung-Hee
No full textThis thesis applies nationalism theories from Eric Hobsbawm\u27s Inventing Tradition and Benedict Anderson\u27s Imagined Communities to show how Agrippina Vaganova and Choi Seung-hee\u27s dances became their nation\u27s representative dance forms. Agrippina Vaganova\u27s Modern Russian Ballet and Choi Seung-hee\u27s Sinmuyong (New Dance) made significant impacts in their respective countries in the twentieth century by each becoming a systematic dance form that became synonymous with the nation. This thesis argues that Agrippina Vaganova\u27s Modern Russian Ballet and Choi Seung-hee\u27s Sinmuyong (New Dance) became their nation\u27s representative dance forms due to interactions between performance, social changes, and discourses of media. These, along with the need to increase national patriotism, helped transform these dances into national and nationalistic art forms
English education in a neoliberal era: Its history and implications for educational equity
No full textChoi Tae Hee focuses on the most recent developments in relation to education fever, focusing on the neoliberal era, using English education as a case. She will present a historic overview of neoliberalism around English education as reflected in related policies and initiatives, from the introduction of the neoliberal discourse into English education to a recent movement aiming to reflect an alternative, counter‐discourse. She also analyses how different initiatives reflecting diverse degrees of neoliberal ideals have created or mitigated English fever, and hypothetical implications they have had or may have on life chances of students from less affluent backgrounds. She will depict a rather complex landscape in this endeavour, trying to capture the lived experiences of both the majority and outliers within these socio‐economically marginalised students. The discussion will draw on policy documents, media reports, and data from a multi‐case study. The findings will highlight the important role played by the global and local contexts, which are going through continuous changes, in shaping and reshaping the meaning and impact of the policy initiatives of and on the English fever, and explore whether Korean society is now ready to outgrow it. Copyright © 2018 ISCHE 40
sj-pdf-1-jit-10.1177_15280837211073361 – Supplemental Material for A fully textile-based skin pH sensor
No full textSupplemental Material, sj-pdf-1-jit-10.1177_15280837211073361 for A fully textile-based skin pH sensor by Choi Minyoung, Minji Lee, Ji-Hye Kim, Sooyoung Kim, Jonghoon Choi, Ju-Hee So and Hyung-Jun Koo in Journal of Industrial Textiles</p
Phantom Power, ‘Unperforming the Dream House’
No full textPhantom Power1: Listening as socio-political practice, conversation with Thibault Walter and Salomé Voegelin, Teatrino di Palazzo Grassi / Atrium of Palazzo Grassi, Venice, 20.11.2021
Phantom Power2: ‘Unperforming the Dream House’, Talk and workshop at écal (école cantonale d’art de Lausanne), Switzerland with public conversation with LaMonte Young and Jun Hee Choi. 10.12.2021
A study on the formation of thin films prepared by selenizing sputtered Cu-In precursors
No full text학위논문(석사) - 한국과학기술원 : 전자재료공학과, 1994.2, [ iii, 53 p. ]한국과학기술원 : 전자재료공학과
Urban food futures : ICTs and opportunities
No full textFood is a vital foundation of all human life. It is essential to a myriad of political, socio-cultural, economic and environmental practices throughout history. However, those practices of food production, consumption, and distribution have the potential to now go through immensely transformative shifts as network technologies become increasingly embedded in every domain of contemporary life. Information and communication technologies (ICTs) are one of the key foundations of global functionality and sustenance today and undoubtedly will continue to present new challenges and opportunities for the future. As such, this Symposium will bring together leading scholars across disciplines to address challenges and opportunities at the intersection of food and ICTs in everyday urban environment. In particular, the discussion will revolve around the question: What are the key roles that network technologies play in re-shaping the food systems at micro- to macroscopic level?\ud
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The symposium will contribute a unique perspective on urban food futures through the lens of network society paradigm where ICTs enable innovations in production, organisation, and communication within society. Some of the topics addressed will include encouraging transparency in food commodity chains; value of cultural understanding and communication in global food sustainability; and technologies to social inclusion; all of which evoke and examine the question surrounding networked individuals as changes catalysts for urban food futures. The event will provide an avenue for new discussions and speculations on key issues surrounding urban food futures in the network era, with a particular focus on bottom-up micro actions that challenge the existing food systems towards a broader sociocultural, political, technological, and environmental transformations.\ud
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One central area of concern is that current systems of food production, distribution, and consumption do not ensure food security for the future, but rather seriously threaten it. With the recent unprecedented scale of urban growth and rise of middle-class, the problem continues to intensify. This situation requires extensive distribution networks to feed urban residents, and therefore poses significant infrastructural challenges to both the public and private sectors. The symposium will also address the transferability of citizen empowerment that network technologies enable as demonstrated in various significant global political transformations from the bottom-up, such as the recent Egyptian Youth Revolution. Another key theme of the discussion will be the role of ICTs (and the practices that they mediate) in fostering transparency in commodity chains. The symposium will ask what differences these technologies can make on the practices of food consumption and production.\ud
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After discussions, we will initiate an international network of food-thinkers and actors that will function as a platform for knowledge sharing and collaborations. The participants will be invited to engage in planning for the on-going future development of the network
Mun Hee Choi
No full text학위논문(석사)--아주대학교 일반대학원 :의학과,2017. 2I. INTRODUCTION 1
II. PATIENTS AND METHODS 3
A. Patients and protocols 3
B. Endovascular treatment 3
C. Clinical and radiological evaluation 5
D. Histopathologic analysis 5
E. Statistical analysis 6
III. RESULTS 8
A. Comparison between the thrombus-available and thrombus-unavailable groups 8
B. Comparison between the IVT-responsive and IVT-unresponsive groups 11
C. Predictors of the response to IVT 14
D. Patient characteristics according to RBC ratio 16
IV. DISCUSSION 20
V. CONCLUSION 22
REFERENCES 23
국문요약 29MasterWith the advance of endovascular retrieval device for the cerebral thrombosis, it enables us to obtain a fresh thrombus of cerebral occlusion-site even in stroke survivors. We investigated the histological composition of retrieved thrombus and different effect of intravenous thrombolysis (IVT) according to the histological compositions of clots. We reviewed clinical, radiological, and interventional data of acute ischemic stroke patients from prospectively collected stroke and neurointervention registry at a stroke referral center from July 2014 to Jan 2016. The response to IVT was assessed by the change of clot burden score from initial CT angiography to digital subtraction angiography. The proportion of red blood cells (RBC), congregated fibrin/platelet, and white blood cells of the thrombus was analyzed by semi-automated color-based segmentation method (Positive Pixel Count Algorithm, Aperio scanscope). Patients were classified into RBC-dominant and fibrin-dominant or mixed group using receiver operating characteristic (ROC) curve analysis. Sixty patients were enrolled including 33 thrombus-available and 27 thrombus-unavailable patients. Thrombus-available group more likely to have cardioembolism and vessel sign, worse clot burden score, and use of retrieval stent. All 60 patients who received IVT, 35 patients showed IVT response and 25 patients did not show. The IVT-responsive group had more severe stroke (baseline NIHSS; 16.8±4.0 vs. 13.8±5.1, p=0.012), and showed more RBC-dominance (50.0% vs. 5.9%, p=0.007). Multivariate logistic regression analysis model revealed RBC dominance was an only variable influencing the good response to IVT (OR 15.816; 95% confidence interval 1.368-182.897, p=0.027). In analysis of characteristics according RBC ratio, the vessel signs and symptomatic hemorrhage according to the RBC ratio was more prevalent in patients with higher tertile than in those with lower levels. This study shows the histological composition of thrombus might lead to the different clinical characteristics, especially the response to IVT. The RBC dominance can be an important factor affecting the response to IVT, comparable with clinical or radiological findings in this study. The response to IVT appears to be influenced by histopathological features of retrieved thrombi and further studies are need to evaluate clinical implication
Dr Choi Hee-Yoon President Korea Institute of Science and Technology Information Republic of Korea
No full textVisit by Dr Choi Hee-Yoon President Korea Institute of Science and Technology Information Republic of Kore
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