387 research outputs found
On Forms and Regulations of Han Poetry
No full textTraditional poetics is gradually disappearing under the impact of modernization. Aiming to provide Chinese with specific ways to understand the poetics of Chinese characters, this article articulates and analyzes most of the Han Poetry forms and regulations illustrated with the author-created poems, such as the traditional quatrains and regulated poems and many more. It is the author’s hope that more people will appreciate and inherit classic poetry but also be innovative
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Risk factors and protective strategies for cancer treatment-associated cardiotoxicity
No full textSurvival with cancer has dramatically improved over the last few years. The increased survival with cancer has driven a renewed focus on minimizing cardiovascular sources of morbidity and mortality. Consistent data have shown that cancer patients are at an increased rate of cardiovascular disease, likely due to the effects of cancer therapies, underlying cancer biology, and cardiovascular risk factors. The occurrence of these cardiovascular events affects the survival and quality of life of patients, hence necessitating the need to better identify and manage cancer-associated cardiotoxicity. In my first project, I examined the incidence and risk factors associated with the use of immune checkpoint inhibitors. Immune checkpoint inhibitors are associated with adverse cardiovascular events, but there are no data characterizing immune checkpoint inhibitor-associated cardiovascular events among Asians. To address this knowledge gap, I performed a retrospective, propensity score-matched cohort study at two tertiary referral centers in Taiwan to describe the incidence and identify clinical factors associated with immune checkpoint inhibitor-associated cardiovascular events. In my second project, I evaluated the effects of sodium-glucose cotransporter 2 inhibitors on cardiovascular diseases and mortality in patients with cancer. Sodium-glucose cotransporter 2 inhibitors have been found to protect against cardiovascular outcomes, principally heart failure, in the non-cancer population. Their effects on heart failure in the cancer population are unknown. Furthermore, preclinical studies suggest an antitumor effect associated with sodium-glucose cotransporter 2 inhibitors. I conducted a retrospective, propensity score-matched cohort study at two tertiary referral centers in Taiwan to evaluate the effects of sodium-glucose cotransporter 2 inhibitors on the risk of cardiovascular outcomes and all-cause mortality
The lost tradition : changing interpretations of music in the three Chinese Confucian ritual classics from the Han to the Qing dynasty.
No full textSIGLEAvailable from British Library Document Supply Centre- DSC:DX185476 / BLDSC - British Library Document Supply CentreGBUnited Kingdo
Learning to Improve Area-Under-FROC for Imbalanced Medical Data Classification Using an Ensemble Method
No full text[[alternative]]The Study of Improving Chinese Input Methods and The Implementation of NTNU-Master Input Method
No full text[[abstract]]Chinese Character Input on computers is the basic ability in the east, especially in Taiwan, Hong Kong and China. If someone can input Chinese characters quickly, then he can improve his ability in using computers to do many things.
In this study, we stand on some famous input methods, like ChangJie, and other input methods based on ChangJie’s method. We try to develop some techniques, such as rearranging the ChangJie alphabets, encoding the characters with 3 codes, reducing the numbers of strokes using space bar, etc. We compare our results with ChangJie and Dy-Sin-Cang-Jie by statistical techniques in typing lots of articles. We named this method as NTNU-Master input method. The basic concept was originally designed by Dr. Shun-Shii Lin. This study is the first one to implement the system and analyze it.
After some experiments, we get some encouraging results. Successfully, we are able to reduce the average number of strokes for typing Chinese characters.
A Mechanistic Dissection of Polyethylenimine Mediated Transfection of Chinese Hamster Ovary Cells
No full textBiopharmaceutical production through transient gene expression (TGE) is used within industry for the rapid supply of product for early stage testing. A key requirement of the process is the large scale transfection of mammalian cells, for which the cationic polymer, polyethylenimine (PEI), is widely used.
In this thesis, the mechanism of PEI mediated transfection of CHO-S cells is explored at the cell surface, a fundamental barrier to successful transgene delivery. By approaching the question from first principles, exploring the kinetics of transfection at the cell surface, bio-physical and bio-molecular interactions governing polyplex binding to the cell surface, three key findings were made.
Firstly, polyplex uptake was biphasic. Initial, rapid endocytosis of polyplex and heparan sulphate proteoglycans (HSPG) was followed by a slower phase of polyplex uptake, on depletion of cell surface HSPGs. Enzymatic depletion of cell surface HSPGs was found to reduce TGE by 25%, whereas sequestration of cholesterol using methyl-β-cyclodextrin abrogated TGE. Taken together, the data indicate that HSPGs mediate maximal TGE (via an early, rapid phase of endocytosis) but that the predominant mechanism of polyplex uptake is through the clustering of lipid rafts, occurring at depleted cell surface HSPG levels.
Secondly, the role of both electrostatic and hydrophobic interactions in polyplex binding to the cell surface was investigated. These experiments revealed that at statistically optimized conditions for TGE (with respect to PEI:DNA ratio) the net charge of the polyplex in chemically defined medium was approximately neutral. Under these conditions polyplexes bound to the cell surface, predominantly, via a hydrophobic interaction, independent of cell surface HSPGs. Accordingly polyplex binding to the cell surface was disrupted by both non-ionic surfactant and depletion of plasma membrane cholesterol by methyl-β-cyclodextrin. An increase in polyplex zeta potential at elevated polyplex PEI:DNA ratio increased polyplex binding to the cell surface, but was accompanied by increased cytotoxicity with elevated PEI internalization. A decrease in polyplex zeta potential using ferric (III) citrate resulted in decreased polyplex binding to the cell surface. Both alterations in polyplex charge reduced TGE. Taken together, these data indicate that hydrophobic binding of polyplexes to cell surface lipid rafts (bearing passenger HSPGs) is the primary molecular interaction that promotes subsequent lipid raft clustering and polyplex micro/macropinocytosis to facilitate maximal TGE.
Lastly, in order to engineer increased binding and endocytosis of recombinant DNA, alkylated PEIs varying in alkyl chain length and degree of substitution were chemically synthesized in order to increase polyplex hydrophobicity. Compared to unmodified PEI in TGE processes, optimized by Design of Experiments Response Surface Modelling, propyl-PEI was found to mediate more efficient TGE at similar reporter gene titre via a reduction in plasmid DNA load. Propyl-PEI formed polyplexes were found to mediate enhanced polyplex uptake relative to polyplexes formed of unmodified PEI
A Study of Xunzi\ue2s Political Philosophy and His Theory of Human Nature
No full textThe dissertation aims to illuminate Xunzi\ue2s political philosophy and his theory about human nature. After discussing the Confucian inheritance of Xunzi\ue2s thoughts, the author analyzes his formulation of the model social order and political structure. In general, Pre-Qin\ue2s philosophers all commit themselves to political stability. Xunzi\ue2s intellectual achievement in political philosophy lies in his distinctive theory about human nature and his elaboration of the debate over heaven and man. The last part of the dissertation is an investigation about \ue2controlling\ue2 and \ue2nurturing\ue2, two characteristics in Xunzi\ue2s thoughts and related economic and political aspects of his model society
Wavelength-dependent photocycle activity of xanthorhodopsin in the visible region
No full textAbstractXanthorhodopsin (xR) is a dual-chromophore proton-pump photosynthetic protein comprising one retinal Schiff base and one light-harvesting antenna salinixanthin (SX). The excitation wavelength-dependent transient population of the intermediate M demonstrates that the excitation of the retinal at 570nm leads to the highest photocycle activity and the excitations of SX at 460 and 430nm reduce the activity to ca. 37% relatively, suggesting an energy transfer pathway from the S2 state of the SX to the S1 state of the retinal and a quick internal vibrational relaxation in the S2 state of SX prior to the energy transfer from SX to retinal
Performance of the European Society of Cardiology 0/1-hour, 0/2-hour, and 0/3-hour algorithms for rapid triage of acute myocardial infarction : an international collaborative meta-analysis
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