1,917 research outputs found
Biogeochemical redox proxies in sediments from Dotternhausen during the Toarcian (Early Jurassic)
No full textAuthor contributions:
The lead author is Angela L. Coe. Measurements were performed by Stephan M. Harding, with supervision of Angela L. Coe and Anthony S. Cohen. Measurements were gathered, processed and analysed by Itzel Ruvalcaba Baroni
Biogeochemical redox proxies in sediments from Yorkshire during the Toarcian (Early Jurassic)
No full textAuthor contributions:
The lead author is Angela L. Coe. Measurements were performed by Stephan M. Harding, with supervision of Angela L. Coe and Anthony S. Cohen. Measurements were gathered, processed and analysed by Itzel Ruvalcaba Baroni
Cognitive and sensory expectations independently shape musical expectancy and pleasure
No full textStimuli, data, and code for "Cognitive and sensory expectations independently shape
musical expectancy and pleasure" by Vincent K.M. Cheung, Peter M.C. Harrison, Stefan Koelsch, Marcus T. Pearce, Angela D. Friederici, & Lars Meyer
Published at Philosophical Transactions of Royal Society B (https://doi.org/10.1098/rstb.2022.0420
Cognitive and sensory expectations independently shape musical expectancy and pleasure
No full textStimuli, data, and code for "Cognitive and sensory expectations independently shape
musical expectancy and pleasure" by Vincent K.M. Cheung, Peter M.C. Harrison, Stefan Koelsch, Marcus T. Pearce, Angela D. Friederici, & Lars Meyer
Published at Philosophical Transactions of Royal Society B (https://doi.org/10.1098/rstb.2022.0420
Nitric oxide mediates the neuroproliferative effect of Neuropeptide Y
No full textNeuropeptide Y (NPY) is widely expressed in both the central and peripheral nervous system and has an important role in the regulation of adult hippocampal neurogenesis by mediating the proliferation of neural precursor cells in both health and disease. The mechanisms underlying this neuroproliferative effect of NPY, however, are unknown. The aim of this project was to investigate these cellular pathways and the possible involvement of nitric oxide (NO) in NPY-mediated neuroproliferation using postnatal rat hippocampal cultures in vitro. NPY was found to have a purely proliferative effect on hippocampal neural precursor cells. The role of NO was explored by inhibiting the NO synthesising enzyme, nitric oxide synthase (NOS), which abolished the proliferative effect of NPY and supported the involvement of NO in NPY-mediated proliferation. Pharmacological analyses using subtype-selective inhibitors suggested that the neuronal isoform of NOS is the sole NOS subtype involved, which was expressed by both nestin+ precursors and class III ?-tubulin+ neurons, the cell types previously shown to be responsive to NPY. The involvement of NO was further verified through loading hippocampal cells with an NO indicator, diaminofluorescein diacetate, where an increase in NO/N2O3 production was observed in nestin+ precursors and class III ?-tubulin+ neurons in response to NPY treatment. The downstream signalling pathways coupling NPY-mediated NO synthesis to cell proliferation were identified, through the use of selective pharmacological agonists and antagonists, as soluble guanylate cyclase, cGMP-dependent protein kinase (PKG) and the extracellular signal-regulated kinases (ERK) 1/2. By assessing levels of NPY-mediated ERK 1/2 phosphorylation in response to NOS inhibition, it was found that ERK 1/2 activation was mediated only via NOS/NO mechanisms. This proliferative cGMP-PKG-ERK 1/2 signalling cascade appears to be mediated by intracellularly released NO, while on the other hand, the addition of extracellular NO through the application of NO donors exerted an inhibitory effect on neural precursor cell proliferation. In addition to demonstrating the dual nature of NO, this is the first time that the signalling mechanisms underlying the proliferative effect of NPY on neural precursor cells have been described. Understanding the mechanisms underlying the proliferation of neural precursor cells will ultimately be beneficial by allowing the development of novel therapeutic interventions for promoting hippocampal neurogenesis.To analyse the role of NO in the NPY-mediated neuroproliferation of hippocampal cells in three-dimensional (3D) cultures, Laponite, a novel synthetic silica hydrogel, was used. Culture medium-based Laponite hydrogels were developed before cell viability within the hydrogels were assessed by culturing hippocampal monolayers under gel cover. Hydrogel cover, however, resulted in cell behaviour reminiscent of preservation/fixation as monolayers showed no spatial or morphological changes over time, with one possible explanation being the high gel osmolarity. Although attempts at cell seeding showed more positive results, with cells adhering to a low heavy metal content variation of the hydrogel, determination of cell viability remained a problem due to prominent dye-gel binding. Although the rheological properties of Laponite make its use attractive, the biocompatibility of the hydrogels with hippocampal cells still require further optimisation if they are to be used as cell culture matrices
Food and eating in fiction since 1950 with particular reference to the writing of Angela Carter, Doris Lessing, Michele Roberts and Alice Thomas Ellis.
No full textPhDEating is a fundamental activity. What people eat, how and with whom, what
they feel about food, what they do or do not want to eat and why - even who
they eat - are of crucial significance in any reading of human behaviour.
In this thesis, I consider the diverse and complex uses of food and eating
in fiction since 1950, especially that written by women. I argue both that food
and eating carry much of the meaning of a novel or story and that the acts of
cooking, feeding and eating depicted are inseparable from issues of power and
control: individually, interpersonally, culturally, politically.
My discussion centres on the writing of Angela Carter, Doris Lessing,
Michele Roberts and Alice Thomas Ellis. Drawing on psychoanalytic theory,
sociology, anthropology, Foucault, Bakhtin and others, the thesis aims to
construct an interdisciplinary perspective which both resists reductive
interpretations and emphasises the centrality, complexity and diversity of food
and eating in literature in our culture.
I begin with an examination of the ambiguities of maternal feeding and
nurturing, moving on to explore the links between appetite, eating and sexuality.
I explore cannibalism and vampirism as manifestations of oppression, but also as
indicating insatiable emptiness and transgressive appetite. The body itself is
crucial, and my argument considers the paradox of not eating as
control/enslavement, also tracing self-starvation as a positive route towards
wholeness and connection. The last part of my argument focuses on social
eating, examining conventions, rituals and food itself in connection with power
relations, and finally considers how we might truly speak of food and eating in
the context of society as a whole
Regulation of store-operated calcium channel by Mitsugumin29 in skeletal muscle aging:
No full textThe study of store-operated Ca2+ channel entry (SOCE) and its role in muscle contractility in young and aged skeletal muscle necessitates a thorough knowledge of the Ca2+ signaling from the sarcoplasmic reticulum (SR) that activates SOCE. Yet, all of the molecular components involved have yet to be fully elucidated, as neither T-tubule voltage sensors, nor SR ryanodine receptor Ca2+ channels, together or independently, are necessary or sufficient for the establishment of a close association between the T-tubule and SR membranes. Therefore, other protein components must be involved for the formation of triad junctional complexes.
Mitsugumin29 (MG29), a protein localized to the triad junction, may function as a structural component involved in the coupling between the SR and T-tubule, as abnormalities in both T-tubule and SR membranes have been reported in mg29(-/-) mice. In addition, muscles from these mice share many morphological and functional characteristics with muscle from aged mice, including increased susceptibility to fatigue, defective SR Ca2+ release and defective SOC function. Either of these may be responsible for the altered Ca2+ signaling in skeletal muscle during exercise and aging.
Our data suggests that SOCE is not merely important for skeletal muscle function in aging; but, it is also required for maintenance of Ca2+ signaling during repetitive stimulation under intensive muscle activity (i.e., fatigue) in the healthy state. In addition, we propose that SOCE diminishes with age, contributing to the age-associated muscle weakness. Finally, we find that while SOCE is a functional marker of muscle performance in aging, MG29 is a molecular marker, as SOCE is compromised in aged wild type mice through the decreased expression of MG29. Therefore, mg29(-/-) mice can serve as an appropriate model for the study of skeletal muscle aging. Through this project, we have begun to understand the physiological function of SOCE and MG29 and their contribution to muscle contractility in both young and aged mice.Ph.D.Includes bibliographical references (p. 71-87)by Angela M. Thornto
Angela Carter as Fiction: Refiguring the real author as Performative Author
No full textIn a 2006 article in The Independent, Christina Patterson echoes Gore Vidal by stating ‘Death, as any biographer knows, can be an excellent career move’. Commenting on a brief revival of Angela Carter’s work in 2006 concomitant with Emma Rice’s bringing of Nights at the Circus to the stage, and Vintage’s reissuing of six of her works with new introductions, Patterson refers to Carter’s ‘whole new lease on life’ suggesting the metamorphic potential and curious temporality of the authorial figure with regard to reader reception. The Vintage editions suggest, as Stephen Benson observes, the ‘legend’ of the ‘Carter effect’, identified by The British Academy Humanities Research Board, which distributes postgraduate studentships. This ‘Carter’ effect was also fostered by the theatricality of Carter’s authorial performances. Sarah Gamble has observed the ‘screen’ of authorial identity upon which readers are led to project impressions, which functions as a ‘hall of mirrors’ in relation to penetrating to the authentic author. Such attempts at authorial effacement and control are certainly not unusual. However, Carter’s postmodern enactment of the play of surfaces in the realm of authorial identity appears to heighten the consequent shifting of boundaries between fiction and life staged in her fiction. This article will address the interaction between the games with identity inscribed in Carter’s short stories and the complex identity and temporality of the Performative Author
MARC 21 para recursos contínuos.
No full textTradução e adaptação de MARC 21 Format for Bibliographic Data e MARC 21 Format for Holdings Data, da Network Development and MARC Standards Office, da Library of Congress, USA, por Angela Salles
MARC 21 para recursos contínuos
No full textTranslation and adaptation of the MARC 21 Format for Bibliographic Data, and MARC 21 Format for Holdings Data, Network Development and MARC Standards Office, Library of Congress, USA, by Angela Salles. Rio de Janeiro, 2010. 2 v. V.1 MARC 21 format for bibliographic data (updated until October 2010). V.2 MARC 21 format for data collection (Holdings) (updated until October 2008)
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