149 research outputs found
FTIR OBSERVATION AND DFT STUDY OF THE AlC and AlCAl LINEAR CHAINS TRAPPED IN SOLID Ar
No full textAuthor Institution: Department of Physics and Astronomy, Texas Christian University, Fort Worth, TX 76129The vibrational spectra of linear AlC and AlCAlwere observed after trapping the products of the dual laser evaporation of aluminum and carbon rods in solid Ar at 10 K. Fourier transform infrared (FTIR) measurements of C isotopic shifts are in good agreement with the predictions of density functional theory (DFT) B3LYP/6-311G+(3\textit{df}) calculations and have enabled the first identification of the (\textit{})1624.0 and (\textit{})528.3 cm fundamentals of linear AlCAl and the tentative assignment of the ()1210.9 cm fundamental of linear AlC
Increased Levels of Plasma p3-Alc alpha 35, a Major Fragment of Alcadein alpha by gamma-Secretase Cleavage, in Alzheimer's Disease
No full textp3-Alc alpha is a metabolic fragment of Alcadein alpha (Alc alpha). Similar to the generation of the p3 fragment from amyloid-beta protein precursor (A beta PP) processing, Alc alpha is cleaved by alpha- and gamma-secretases, leading to the secretion of p3-Alc alpha peptides into cerebrospinal fluid (CSF). p3-Alc alpha is also detected in the plasma, similar to amyloid-beta (A beta), which is a metabolic fragment of A beta PP cleaved by amyloidogenic beta- and gamma-secretases. Because p3-Alc alpha is a non-aggregatable and stable peptide, unlike aggregatable A beta and metabolically labile p3 of A beta PP, the changes of p3-Alc alpha in quality and/or quantity in CSF and plasma are expected to be a marker for assessing alteration of substrate cleavage by gamma-secretase, such as A beta generation from A beta PP. The present study describes a sandwich enzyme-linked immunosorbent assay for quantifying levels of p3-Alc alpha 35, the major form of the p3-Alc alpha species, and examines levels of p3-Alc alpha 35 in the plasma of three independent Japanese cohorts. In two of the three cohorts, the p3-Alc alpha 35 levels were significantly increased with a concomitant decrease in the Mini-Mental State Examination score, or in clinically diagnosed Alzheimer's disease (AD) patients, when compared with age-matched non-demented subjects. The values were significantly lower in AD subjects who were administered donepezil, when compared to AD subjects without donepezil treatment. The increase in plasma p3-Alc alpha 35 levels may indicate an endophenotype in subjects in whom AD is due to a progressing cognitive impairment in subjects with a gamma-secretase malfunction, or a disorder of the clearance of peptides
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Coyote Papers Volume 25 Proceedings of ALC 16 2023
No full textCoyote Papers 25 (2023) served as the proceedings for Arizona Linguistics Circle 16. ALC16 was held on October 21-22, 2022. The theme for ALC16 was "World in Crisis: Linguistics in an ever-changing context", and our invited speakers included Rosemary Beam De Azcona (ENAH, Mexico), Chandan Narayan (York University, Canada), Qing Zhang (University of Arizona, USA) and Leanne Hinton (University of California, USA). These proceedings are single-blind peer reviewed.
If you wish to cite a paper from this volume, we recommend the following format: "Author Name. 2023. Title. Coyote Papers 25: Proceedings of ALC 16: page numbers."The Coyote Papers are made available by the Arizona Linguistics Circle at the University of Arizona and the University of Arizona Libraries. Contact [email protected] with questions about these materials
Espelho da Cruz (cód. alc. 221): edição e estudo
No full textThis dissertation contains a paleographic edition of the medieval manuscript in Portuguese Mirror of the Cross of the Alc. cod. 221 and a study of the interventions in this testimony in comparison to the Alc. cod. 89, also a testimony in Portuguese of the same text, both kept in the National Library of Portugal, in Lisbon. The work is structured in seven sections, with the first one containing comments on the chosen theme and the approach on which it was produced, reaffirming its importance in the fields of Linguistics and Textual Criticism. The intended objectives are also discussed and the results achieved are briefly presented. In section 2 aspects related to the object of study are described, such as the biography of the author of the text, the Italian Domenico Cavalca, the main information about the copy/translation (authorship, structure and content) and the codicological and paleographic descriptions, including the alphabet of graphemes used in the testimony. In section 4, a review of the Romance and Portuguese traditions of the text is made, presenting how this discussion currently stands. The fifth section contains the edition norms used and the paleographic edition. Next, in section 6
there is the study of the interventions carried out by the actors involved in the production of the copy in Portuguese. To develop it, the methodology used went through the phases of data collection (interventions in the testimony), its classification (in the relevant linguistic
categories) and the analysis (quantitative and qualitative), leaving room for a meticulous appreciation of the most relevant data, taking into account facts previously described by Cambraia and Santos (2019) and other authors about the presence of multilingualism in the Al.c cod. 221, especially traces of Spanish and Catalan. Finally, in the last section, the most relevant features of the work are recalled and future developments are envisaged.Nesta dissertação apresenta-se uma edição paleográfica do manuscrito medieval em português Espelho da Cruz do cód. alc. 221 e um estudo das intervenções presentes neste testemunho em comparação ao cód. alc. 89, outro testemunho em português do mesmo texto, estando ambos guardados na Biblioteca Nacional de Portugal, em Lisboa. O trabalho está estruturado em sete seções, com a primeira trazendo comentários sobre o tema escolhido e a abordagem sobre a qual ele foi produzido, reafirmando sua importância no âmbito da Linguística e, principalmente, da Crítica Textual. Discute-se ainda os objetivos pretendidos e adianta-se, de maneira breve, os resultados alcançados. Na seção 2 são descritos aspectos ligados ao objeto de estudo, como a biografia do autor do texto, o italiano Domenico Cavalca, as principais informações sobre a cópia/tradução (autoria, estrutura e conteúdo) e as descrições codicológica e paleográfica, incluindo o alfabeto de grafemas utilizados no testemunho. Faz-se, na seção 4, uma recensão
das tradições românica e portuguesa do texto, apresentando como se encontra atualmente essa discussão. Na quinta seção apresentam-se as normas de edição utilizadas e a edição paleográfica. Seguindo, na seção 6 há o estudo das intervenções perpetradas pelos atores envolvidos na produção da cópia em português. Para desenvolvê-lo, a metodologia empregada
perpassou as fases de coleta dos dados (as intervenções presentes no testemunho), sua classificação (nas categorias linguísticas pertinentes) e a análise (quantitativa e qualitativa), havendo espaço para uma apreciação meticulosa dos dados mais relevantes levando em conta fatos descritos anteriormente por Cambraia e Santos (2019) e outros autores sobre a presença de multilinguismo no cód. alc. 221, especialmente traços do espanhol e do catalão. Por fim, nas considerações finais rememora-se os traços mais relevantes do trabalho e vislumbra-se desdobramentos futuros.CAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superio
Stabilization of intracellular trafficking and metabolism of amyloid β-protein precursor and Alcadein β by apolipoprotein E
No full textIntracellular metabolism of amyloid beta-protein precursor (APP) is important for the pathogenesis of Alzheimer's disease (AD). Alcadeins (Alc alpha, Alc beta, and Alc gamma) are neural membrane proteins similar to APP in their localization, metabolism, and cellular function. Isoform epsilon 4 of apolipoprotein E (ApoE) is a major risk factor for AD. We found that ApoE expression attenuated intracellular trafficking of APP and Alc beta, resulting in metabolic stabilization of both proteins. By contrast, Alc alpha intracellular proteolysis was facilitated by ApoE expression, which was not due to an increase in the primary cleavage of Alc alpha. This difference may result from binding of ApoE to membrane proteins
Cytoplasmic Fragment of Alcadein alpha Generated by Regulated Intramembrane Proteolysis Enhances Amyloid beta-Protein Precursor (APP) Transport into the Late Secretory Pathway and Facilitates APP Cleavage
No full textThe neural type I membrane protein Alcadein alpha (Alc alpha), is primarily cleaved by amyloid beta-protein precursor (APP) alpha-secretase to generate a membrane-associated carboxyl-terminal fragment (Alc alpha CTF), which is further cleaved by gamma-secretase to secrete p3-Alc alpha peptides and generate an intracellular cytoplasmic domain fragment (Alc alpha ICD) in the late secretory pathway. By association with the neural adaptor protein X11L (X11-like), Alc alpha and APP form a ternary complex that suppresses the cleavage of both Alc alpha and APP by regulating the transport of these membrane proteins into the late secretory pathway where secretases are active. However, it has not been revealed how Alc alpha and APP are directed from the ternary complex formed largely in the Golgi into the late secretory pathway to reach a nerve terminus. Using a novel transgenic mouse line expressing excess amounts of human Alc alpha CTF (hAlc alpha CTF) in neurons, we found that expression of hAlc alpha CTF induced excess production of hAlc alpha ICD, which facilitated APP transport into the nerve terminus and enhanced APP metabolism, including A beta generation. In vitro cell studies also demonstrated that excess expression of Alc alpha ICD released both APP and Alc alpha from the ternary complex. These results indicate that regulated intramembrane proteolysis of Alc alpha by gamma-secretase regulates APP trafficking and the production of A beta in vivo
Factors Associated with Alternate Level of Care Status Designation: a Case-Control Study and Model to Optimize Care Trajectories
No full textBackground
As health-care demand is growing, our health-care system will require the optimization of the care trajectories. Patients with an alternate level of care (ALC) status could be a target for flow optimization. We aimed to characterize ALC patients and risk factors for ALC status, and to propose an integrated model to analyze the trajectory of ALC patients and discuss solutions to reduce their burden.
Methods
A case-control design was used to compare 60 ALC and 60 non-ALC patients admitted to the geriatric unit of the Centre hospitalier de l’Université de Montréal in 2021, collecting medical and sociodemographic data. Based on our model, univariate statistical analyses were computed to compare groups and identify risk factors for ALC status.
Results
ALC patients were less independent (22% performed five to six activities of daily living vs. 43%, p = .03). Both groups were comparable in terms of mobility and neurocognitive disorders. ALC patients were more likely to receive a new diagnosis of a neurocognitive disorder or new behavioural or psychological symptoms (37% vs. 15%, p = .008). Up to 25% of ALC patients were admitted despite presenting no active medical condition (vs. 3% of non-ALC patients, p = .002).
Conclusions
The optimization of the care trajectory of ALC patients is mainly based on pre-hospital and post-hospital factors. A proportion of ALC admissions might be avoidable with additional investment in home care resources and relocation procedures. Fluidity of ALC trajectory may benefit from improved orientation at discharge procedures. Full optimization of ALC trajectories requires a systemic understanding of the health-care system
High lymphocyte counts before antithymocyte globulin administration predict acute graft-versus-host disease
No full textAntithymocyte globulin (ATG) reduces severe acute and chronic graft-versus-host disease (GVHD) in allogeneic peripheral blood stem cell transplantation (PBSCT). However, risk factors for severe acute GVHD in PBSCT using ATG remain to be determined. We conducted a single-center, retrospective study to analyze the association of acute GVHD requiring systemic corticosteroid (SC-aGVHD) with absolute lymphocyte counts (ALC) before the administration of ATG or conditioning in 53 patients with HLA-matched PBSCT using low-dose thymoglobulin (2 mg/kg) after myeloablative conditioning. The cumulative incidence of SC-aGVHD was 17.0% and ALC before ATG were significantly higher in patients with SC-aGVHD compared to that in patients without it (median, 0.15 x 10(9)/L vs 0.06 x 10(9)/L, P = 0.047). The cumulative incidence of SC-aGVHD was significantly higher in patients with high ALC before ATG (>= 0.15 x 10(9)/L) than in those with low ALC (38.5% vs 10.0%, P = 0.016). Non-relapse mortality (NRM) was also significantly higher in the high ALC before ATG group than the low ALC before ATG group (2-year NRM: 23.9% vs 6.0%, P = 0.048), leading to worse survival (2-year overall survival: 69.2% vs 83.5%, P = 0.039). Our study suggested that high ALC before ATG is a risk factor for SC-aGVHD
Self-healing of indentation damage in Ti<sub>2</sub>AlC MAX phase ceramics
No full textAlthough the crack-healing capacity of Ti2AlC ceramics has been sufficiently studied, the ability of Ti2AlC to self-heal large-scale damage, such as foreign object damage (FOD), remains unknown. This paper investigates the self-healing ability of Ti2AlC ceramics with large-scale damage (∼1000 μm in diameter). Extensive healing was observed even in the plastic damage and radial cracks. The damage and cracks caused by indentations made using a tungsten carbide sphere were filled and covered with newly formed oxides, such as titanium oxide and alumina, by the oxidation of Ti2AlC after heat treatment in air at 1000 °C. The strength, hardness, toughness, and elastic modulus of the Ti2AlC samples were measured before and after healing. The results show that the mechanical properties of Ti2AlC were similar or even slightly higher after the damage had been healed. Thus, Ti2AlC ceramics are attractive healing agents for foreign object damage in high-temperature applications.Green Open Access added to TU Delft Institutional Repository 'You share, we take care!' - Taverne project https://www.openaccess.nl/en/you-share-we-take-care Otherwise as indicated in the copyright section: the publisher is the copyright holder of this work and the author uses the Dutch legislation to make this work public.Team Kevin Ross
Steering a future through Scenarios : into the academic library of the future
No full textAuthor name used in this publication: Lai-chong AuAccepted ManuscriptPublishedGreen (AAM
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