26 research outputs found
Ananda K. Coomaraswamy, Benoy Kumar Sarkar, and the Śukranīti
No full textThe English-raised Ananda K. Coomaraswamy, the twentieth century’s leading historian of Indian art, is well known for prizing tradition and anonymity and for upholding the position that visualization exercises were an essential part of the creative process. The first part of this article addresses the role of the English Arts and Crafts Movement and of such lesser-known figures as Sister Nivedita and Lionel de Fonseka in shaping Coomaraswamy’s views. The middle part consists of a discussion of the passages in the nineteenth-century Sanskrit treatise the Śukranīti that Coomaraswamy depended upon to support his opinions. The final part of the article is devoted to the writings of the sociologist Benoy Kumar Sarkar, author of the standard translation of the Śukranīti. As an opponent of the over-spiritualisation of Indian civilisation, he constructed a universal grammar of art. In this enterprise, he was heavily influenced by the American painter Max Weber
Phytosomes as a Possible Nano-Delivery System for Enhanced Oral Bioavailability and Hepatoprotective Activity of Indigofera barberi
No full textIndigofera barberi Gamble, a Fabaceae plant, has traditionally been used to treat skin, renal, and liver problems. Documented phytochemicals include glycosides, steroids, tannins, phenolic compounds, and flavonoids. Its low bioavailability and solubility hinder GI absorption. This study sought to improve Indigofera barberi extract bioavailability by making the ethanolic extract more soluble and absorbable. We optimized Indigofera barberi-loaded phytosomes utilizing solvent evaporation. This study developed IBPCs-NPs, a novel phytosome-nanosuspensions for IB shielding, to improve IB bioavailability and hepatoprotection. In in vivo pharmacokinetic studies, the IBPCs-NP formulation had higher plasma concentration and in vitro dissolution rate. IBPCs-NPs also demonstrated stronger hepatoprotective effects in pharmacodynamic studies. Crystalline variation and IB-phospholipid interactions are also physicochemical features of optimized IBPCs-NPs. The synthesised IB phytosomes were cylindrical, smooth-surfaced, and distinct, with a diameter of 332.52 ± 1.54 nm. According to dissolving trials, the enhanced IB phytosomal formulation released silymarin faster and in greater proportions than pure silymarin, with better water solubility (~360 µg/mL). The optimized silymarin phytosomal formulation normalized antioxidant enzymes and helped CCl4-intoxicated cells. In in vivo experiments, it protected the liver from CCl4-induced hepatotoxicity in rats. The optimized phytosomal formulation enhanced oral silymarin bioavailability compared to pure silymarin. This was shown by six-fold systemic bioavailability. Whole phytosomes may increase water-insoluble phyto-constituent oral bioavailability as phospholipid-based nanocarriers
Studies on statistically optimized binary ethosomal gel encapsulated with Carvedilol: Ex-vivo permeation and Pharmacodynamic assessment in male Wistar albino rats
No full textPharmacological and Phytochemical Evaluation Of Gastric Anti-Ulcer Activity of Parthenium hysterophorus In Different Models
No full textThe cause of ulceration in patients is mainly due to hyper secretion of gastric juice and also due to hyper secretion of pepsin. In traditional system of medicine a number of herbal preparations have been used for the treatment of peptic ulcers. There are various medicinal plants has been used for the treatment of gastrointestinal disorders. In view of this, in present study we have to evaluate the anti-ulcer activity of parathenium hysterophorus. Study was carried out, by using three methods i.e., alcohol, paracetamol and stress induced ulcers in rats pretreated with the doses of 250 mg/kg AQPH and ALPH, 20mg/kg Omeoprazole and 50 mg/kg Ranitidine. To evaluate the antiulcer activity of aqueous and alcoholic extracts of parathenium hysterophorus leaves (AQPH and ALPH) at 250 doses using different experimentally induced gastric ulcer models in rats. Gastric ulcers were induced in rats by 80% alcohol, paracetamol and forced immersion stress induced methods. In alcohol induced ulcer model, paracetamol induced ulcer model and stress induced model the ulcer index was determined. Where as in stress induced ulcers stress plays an important role in ulcerogenesis. In alcohol-induced ulcers, AQPH and ALPH were effective in reducing lesion index and increasing the gastric mucus content. It was also effective in decreasing ulcer index in paracetamol-induced ulcers. All the results obtained with parathenium hysterophorus were dose dependent. The results suggest that AQPH and ALPH possesses significant and dose dependent antiulcer activity. The antiulcer activity of AQPH and ALPH can be attributed to its cytoprotective and antisecretory action.</jats:p
FORMULATION DEVELOPMENT AND EVALUATION OF ALLOPURINOL SOLID DISPERSIONS BY SOLVENT EVAPORATION TECHNIQUE
No full textObjective: The main objective of the research work is to develop and characterize allopurinol (ALPN) solid dispersions with different polymers to enhance solubility, enrich dissolution profile and improve patient compliance.Methods: ALPN solid dispersions were prepared by solvent evaporation technique using various grades of polyethelene glycol (PEG) such as PEG 4000 and PEG 6000 with different ratios like 1:0.5, 1:1, 1:1.5 and 1:2 and after formation of solid dispersions all physicochemical properties were examined.Results: All the formulations were found within the permissible pharmacopoeial limits for various physicochemical parameters. The pre-formulation studies, like Fourier, transform infrared spectroscopy (FTIR) showed the absence of drug-excipient interactions. The solubility and dissolution profiles of the sample were increased with increasing the concentration of ALPN solid dispersions. Solvent evaporation was proved to be a successful technique for the development of stable solid dispersion of ALPN. The dissolution amount percentage of ALPN formulations was found between 39.58±2.5 to 94.95±1.8 % within 60 min.Conclusion: Hence, from the all evaluation studies, it was evident that F1 formulation was the better formulation. F1 formulation (ALPN: PEG 4000 in the ratio of 1:0.5), 94.95±1.8 % drug released within 50 min. Â
Development and evaluation of empagliflozin-loaded solid lipid nanoparticles: Pharmacokinetics and pharmacodynamics for oral delivery
No full textType 2 diabetes mellitus is frequently treated with empagliflozin (EZN), a sodium-glucose cotransporter 2 inhibitor. Solid lipid nanoparticles (SLNs) shield the drug from gastrointestinal breakdown and improve the bioavailability of lipophilic drugs. The aim of the study is to use SLNs to enhance EZN's pharmacokinetics and pharmacodynamics in the treatment of diabetes mellitus. To prepare EZN-loaded SLNs, central composite design (CCD) was employed. The optimized batch (optimized EZN-loaded SLNs) had the desired values of dependent variables Vesicle size (R1), Entrapment Efficiency (R2), and Cumulative Drug Release (CDR) (R3). This was achieved by using analysis of variance (ANOVA) to analyse independent variables such as lipid concentration (X1), surfactant concentration (X2), sonication time (X3), and homogenization speed (X4). F8 exhibited the highest drug entrapment (90.6% ± 2.8%), CDR (89.2 ± 3.6), and average particle size (98.6 ± 2.1 nm) among the 30 distinct formulated formulae (F1–F30). Based on the F-value and p-value, the model was determined to be significant for particle size, entrapment efficiency, and CDR. The actual values of particle size entrapment efficiency and CDR closely matched the projected values of the optimized batch. The in vitro release trials produced a burst release followed by a continuous release. When compared to the EZN solution, the relative bioavailability of EZN-loaded SLNs was 1.2 times higher, indicating superior protection against the gastrointestinal environment. In rats with streptozotocin-induced diabetes mellitus, the optimized EZN-loaded SLNs outperformed the basic drug suspension in terms of antidiabetic efficacy. One promising method for administering EZN in the treatment of diabetes mellitus is by SLNs
Recent Changes in the Climatological Characteristics of Daily Contiguous Rain Areas over India Mansi Bhowmick, Sandeep Sahany, Ananda Kumar Das
No full textCodes for data analysis and plotting.Processed data is available from first author upon reasonable request.THIS DATASET IS ARCHIVED AT DANS/EASY, BUT NOT ACCESSIBLE HERE. TO VIEW A LIST OF FILES AND ACCESS THE FILES IN THIS DATASET CLICK ON THE DOI-LINK ABOV
Evaluation of Energy Consumption using Receiver–Centric MAC Protocol in Wireless Sensor Networks
No full textAt present day’s wireless sensor networks, obtain a lot consideration to researchers. Maximum number of sensor nodes are scattered that can communicate with all others. Reliable data communication and energy consumption are the mainly significant parameters that are required in wireless sensor networks. Many of MAC protocols have been planned to improve the efficiency more by enhancing the throughput and energy consumption. The majority of the presented medium access control protocols to only make available, reliable data delivery or energy efficiency does not offer together at the same time. In this research work the author proposes a novel approach based on Receiver Centric-MAC is implemented using NS2 simulator. Here, the author focuses on the following parametric measures like - energy consumption, reliability and bandwidth. RC-MAC provides high bandwidth without decreasing energy efficiency. The results show that 0.12% of less energy consumption, reliability improved by 20.86% and bandwidth increased by 27.32% of RC-MAC compared with MAC IEEE 802.11
