1,720,985 research outputs found
Transient lower oesophageal sphincter relaxation and mechanisms of gastrooesophageal reflux in twins discordant for gastrooesophageal reflux symptoms
No full textP.19
TRANSIENT LOWER OESOPHAGEAL SPHINCTER RELAXATION
AND MECHANISMS OF GASTROOESOPHAGEAL REFLUX IN
TWINS DISCORDANT FOR GASTROOESOPHAGEAL REFLUX
SYMPTOMS
P. Iovino ∗,1, I. Mohammed2, R. Annggiansah 3, A. Anngiansah 3 ,
F. Cherkas 3, T. Spector3, N. Trudgill2
1Università Federico II, Napoli; 2Sandwell General Hospital, Birmingham;
3St Thomas Hospital, London
Background and aim: Transient Lower Oesophageal Sphincter Relaxation
(TLOSR) is the most frequent mechanism among several mechanical patterns
associated with reflux episodes. The aim of this study is to investigate TLOSR
in twin pairs who are discordant for gastrooesophageal reflux disease (GORD)
symptoms, i.e. only one of the pair has GORD symptoms to establish whether
differences in TLOSR may contribute to the aetiology of GORD.
Material and methods: 4 monozygotic (MZ) and 12 dizygotic (DZ) twin
pairs, who were repeatedly discordant for GORD symptoms over 2 years, were
studied. LOS function using a sleeve sensor and oesophageal pH were monitored
for 30 mins before and 60 mins after a 300 mls (1200 kcal) lipid meal.
Results: MZ twins were aged mean 63 (range 53-75) yrs and DZ twins
57 (44-74) years. TLOSR frequency increased from 1(0-2) to 2.5 (1-8)
per hour post-prandially (p= 0.001) in the symptomatic twins and from 0
(0-2) to 3(1-6) post-prandially in the asymptomatic twins (Median (range),
p=0.001). Comparison between groups revealed that there was no difference
in pre-prandial and post prandial TLOSR frequency. However no pre prandial
TLOSR were associated with acidic reflux (pH<4) compared with 38% of
post-prandial TLOSR. Acid reflux episodes (pH<4) increased post-prandiallyin both symptomatic and asymptomatic twins, but there was no differences
between the groups in pre or post-prandial acid reflux episode frequency
or total post-prandial acid exposure (symptomatic twins median 11 (range
0-1051)s, asymptomatic twins 4(0-487)s (p=0.4). Moreover preprandial LOS
pressure of 13 (4-29) mmHg fell to 8 (2-13)after the meal (p= 0.0001). No
difference was found in basal and post prandial lower esophageal sphincter
pressure readings between asymptomatic and symptomatic twins (p=0.2).
Conclusions: There was no difference in pre and post prandial TLOSR and in
LOS pressure in twins discordant for GORD symptoms.
# A. Oesophagus - 1. GER
A study of pathophysiological factors associated with gastro-esophageal reflux disease in twins discordant for gastro-esophageal reflux symptoms.
No full text
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
koamabayili/VECTRON-author-checklist: VECTRON author checklist
No full textWe have done our best to complete the author checklist relating to the use of animals in the hut study. Note that the objective for the hut study was to evaluate the IRS treatment applications for residual efficacy against Anopheles mosquitoes, including the local An. coluzzii mosquito population. Cows were only used to attract mosquitoes into the huts and no tests were carried out directly on the cows. The author checklist is intended for use with studies where experiments are carried out on animals, which is why we have had such difficulty in completing this for the hut study, as many of the questions do not relate to how the cows were used
Author-wise bibliometric analysis based on entropy.
No full textAuthor-wise bibliometric analysis based on entropy.</p
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