2,698 research outputs found
A novel molecular class that recruits HDAC/MECP2 complexes to PU.1 motifs reduces neuroinflammation
No full textPervasive neuroinflammation occurs in many neurodegenerative diseases, including Alzheimer’s disease (AD). SPI1/PU.1 is a transcription factor located at a genome-wide significant AD-risk locus and its reduced expression is associated with delayed onset of AD. We analyzed single-cell transcriptomic datasets from microglia of human AD patients and found an enrichment of PU.1-binding motifs in the differentially expressed genes. In hippocampal tissues from transgenic mice with neurodegeneration, we found vastly increased genomic PU.1 binding. We then screened for PU.1 inhibitors using a PU.1 reporter cell line and discovered A11, a molecule with anti-inflammatory efficacy and nanomolar potency. A11 regulated genes putatively by recruiting a repressive complex containing MECP2, HDAC1, SIN3A, and DNMT3A to PU.1 motifs, thus representing a novel mechanism and class of molecules. In mouse models of AD, A11 ameliorated neuroinflammation, loss of neuronal integrity, AD pathology, and improved cognitive performance. This study uncovers a novel class of anti-inflammatory molecules with therapeutic potential for neurodegenerative disorders
Automating the determination of wave speed using the pu-loop method
No full textThe PU-loop (pressure-velocity loop) is a method for determining wave speed and relies on the linear relationship between the pressure and velocity in the absence of reflected waves. This linearity of the PU-loop during early systole, which is directly related to wave speed, has always been established by eye. This paper presents a new technique that establishes this linearity and thus determining wave speed online. Pressure and flow were measured in the ascending aorta of 11 anesthetised dogs. The slope of the PU-loop, indicating wave speed was determined by eye and by using the new technique. The difference between the slopes of the two methods is in the order of 3%. The new technique is convenient and allows for the online assessment of wave speed, which could be used as a bedside tool for the assessment of arterial compliance
A pu -k lativusrag fejleményei a déli szamojédban
No full textIn the light of newly published material, the author investigates various Selkup and Kamassian suffixes containing the developments of PU -K and gives her reasons why she does interpret them as continuations of the PU lative suffix
KELVIN-HELMHOLTZ INSTABILITY IN COLLISIONLESS SPACE PLASMAS
No full textPhysics, Fluids & PlasmasSCI(E)9ARTICLE2440-447
Literacy and the vernacular : a case study based on the post-colonial history of Mauritius, with particular reference to Mauritian Creole
No full textThis thesis examines the process of the literization of the vernacular, and seeks to establish the island of Mauritius as a case study of this process. The concept of literization equates standardization of the vernacular with its use as a written language. Four issues are established as central to this process: ideological, educational, sociocultural and technical.
The thesis investigates the particular sociolinguistic situation of Mauritius, and examines each of these issues in relation to Mauritian Creole. It demonstrates the role that Mauritian Creole plays in Mauritian society, and how, since independence, issues relating to ideology, education, and the cultural and technical aspects of standardization, have been involved in the promotion of the language. The interaction between these issues is apparent throughout the thesis, and manifested in the work of Ledikasyon pu Travayer (LPT), the only organization in Mauritius to provide literacy tuition in Mauritian Creole. The thesis seeks to show that their unified approach to literacy, standardization, and the promotion of Mauritian Creole exemplifies the issues involved, and provides the best basis for the establishment of Mauritian Creole as a standard language.
The analysis of the situation in Mauritius within the framework of wider issues of the literization of the vernacular permits a comparison to other former colonies facing problems of language choice, and places these issues within the wider sociolinguistic context of standardization
Molecular size distribution of Pu in the presence of humic substances in river and groundwaters
No full textThe association properties of Pu with aquatic humic substances in a 0.01M NaClO4 solution at pH 6–8 were studied on the basis of molecular size distribution. Seven humic substances were isolated from river water and groundwaters using XAD extraction technique. They were used for comparing their effects on the association of Pu. In the presence of humic acid, the dominant molecular size of Pu was 100–30 kDa. In the presence of fulvic acid, Pu exhibited three dominant molecular sizes: 30–10 kDa, 30–5 kDa, and less than 5 kDa. The association of Pu-humus complexes might be controlled by the molecular size distribution of humic substances and characteristics of their respective size fractions
Electron Elastic Collisions with Pu, Am and Lr Actinide Atoms
No full textSynopsis The robust Regge-pole methodology which embeds the crucial electron correlations and the vital core-polarization interaction is used to explore negative-ion formation in the actinide atoms Pu, Am and Lr through the electron elastic total cross sections (TCSs) calculation. The TCSs are found to be characterized by ground, metastable and excited anionic formation, whence we extract the anionic binding energies and compare them with existing electron affinities. The TCSs exhibit both atomic and molecular behavior in addition to polar- ization-induced metastable TCSs
Author Correction: Massively parallel in vivo CRISPR screening identifies RNF20/40 as epigenetic regulators of cardiomyocyte maturation
No full textCorrection to: Nature Communications 10.1038/s41467-021-24743-z, published online 21 July 2021.
The original version of this Article contained an error in the spelling of the author William T. Pu, which was incorrectly given as William William Pu. This has now been corrected in both the PDF and HTML versions of the Article
The Research of Rou Pu Tuan
No full textSpeaking to the erotological fiction, people would often refer to Rou Pu Tuan. Besides Jin Ping Mei, Rou Pu Tuan is also frequently mentioned by people when it comes to the classic in those sexual stories. The book was even translated to many different languages in other countries. However, according to the prosperous publishing business during the Ming and Cing dynasties, Rou Pu Tuan is obviously not the only erotological fiction that had been published during those years. Why the Rou Pu Tuan can become such a famous erotological fiction? People would definitely curious about it. Therefore, my research is mainly focused on the Rou Pu Tuan itself. First step, I summarize the whole story. I also make a brief introduction to illustrate the dissemination and editions of Rou Pu Tuan. Moreover, I mention the background about the author and the time that Rou Pu Tuan had been written. Second step, I analyze male and female characters and discuss the power from both genders in the story. Finally, I try to find out the subjects of the whole story. According to my observation, the attraction of Rou Pu Tuan is based on its exquisite characterization and subjects that emphasize by some narrative way. This fiction does improve its value by giving different images and personalities to every role, but its main power is still possessed by the male. Retributive justice and appropriate sex are the subjects of the story. The story emphasized the subjects by using the coincidences that based on daily life, corresponding clues and the illustration from active narrator. Therefore, exquisite characterization and unique narrative for subjects are the factors that make Rou Pu Tuan a famous erotological fiction
High-Spin States in Transuranium Nuclei Pu-242,Pu-244
No full textWe investigate the structure of yrast bands in the transuranium nuclei Pu-242 and Pu-244 in the framework of the projected shell model, which is a fully quantum mechanical and microscopic approach. It is found that an appropriate modification of the standard Nilsson spin-orbital parameters in the N = 6 proton shell is necessary to correctly describe the high-spin backbending phenomenon in nucleus Pu-244. In order to test whether this modification is correct, the same modified parameters are used to calculate the yrast band of its neighboring isotope Pu-242. It is found that without this modification, a backbending will occur at spin I = 20, which is not supported by the experimental data.Physics, MultidisciplinarySCI(E)中国科技核心期刊(ISTIC)0ARTICLE5null2
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