863 research outputs found
Author Correction: A shared neural basis underlying psychiatric comorbidity
No full textCorrection to: Nature Medicine. Published online 24 April 2023. In the version of this article initially published, the STRATIFY data also included cohort data from the ESTRA consortium, though this was not acknowledged in the author list and the section in Methods on the Stratify dataset. The Methods are now updated, and the author list is amended to combine the STRATIFY and ESTRA consortium names and to include the following authors: Marina Bobou, M. John Broulidakis, Betteke Maria van Noort, Zuo Zhang, Lauren Robinson, Nilakshi Vaidya, Jeanne Winterer, Yuning Zhang, Sinead King, Hervé Lemaître, Ulrike Schmidt, Julia Sinclair, Argyris Stringaris and Sylvane Desrivières. The STRATIFY and ESTRA consortia are now combined to list Marina Bobou, M. John Broulidakis, Betteke Maria van Noort, Zuo Zhang, Lauren Robinson, Nilakshi Vaidya, Jeanne Winterer, Yuning Zhang, Sinead King, Gareth J. Barker, Arun L. W. Bokde, Hervé Lemaître, Frauke Nees, Dimitri Papadopoulos Orfanos, Ulrike Schmidt, Julia Sinclair, Argyris Stringaris, Henrik Walter, Robert Whelan, Sylvane Desrivières and Gunter Schumann as members, and the IMAGEN consortium is updated to also include Sylvane Desrivières. Affiliations, author contributions and acknowledgements have been updated to reflect the new authorship, and all changes have been made in the HTML and PDF versions of the article
Author Correction: A shared neural basis underlying psychiatric comorbidity
No full textCorrection to: Nature Medicine https://doi.org/10.1038/s41591-023-02317-4. Published online 24 April 2023. In the version of this article initially published, the STRATIFY data also included cohort data from the ESTRA consortium, though this was not acknowledged in the author list and the section in Methods on the Stratify dataset. The Methods are now updated, and the author list is amended to combine the STRATIFY and ESTRA consortium names and to include the following authors: Marina Bobou, M. John Broulidakis, Betteke Maria van Noort, Zuo Zhang, Lauren Robinson, Nilakshi Vaidya, Jeanne Winterer, Yuning Zhang, Sinead King, Hervé Lemaître, Ulrike Schmidt, Julia Sinclair, Argyris Stringaris and Sylvane Desrivières. The STRATIFY and ESTRA consortia are now combined to list Marina Bobou, M. John Broulidakis, Betteke Maria van Noort, Zuo Zhang, Lauren Robinson, Nilakshi Vaidya, Jeanne Winterer, Yuning Zhang, Sinead King, Gareth J. Barker, Arun L. W. Bokde, Hervé Lemaître, Frauke Nees, Dimitri Papadopoulos Orfanos, Ulrike Schmidt, Julia Sinclair, Argyris Stringaris, Henrik Walter, Robert Whelan, Sylvane Desrivières and Gunter Schumann as members, and the IMAGEN consortium is updated to also include Sylvane Desrivières. Affiliations, author contributions and acknowledgements have been updated to reflect the new authorship, and all changes have been made in the HTML and PDF versions of the article.</p
From the headwater to the delta: A synthesis of the basin-scale sediment load regime in the Changjiang River
No full textMany large rivers in the world delivers decreasing sediment loads to coastal oceans owing to reductions in sediment yield and disrupted sediment deliver. Understanding the sediment load regime is a prerequisite of sediment management and fluvial and deltaic ecosystem restoration. This work examines sediment load changes across the Changjiang River basin based on a long time series (1950–2017) of sediment load data stretching from the headwater to the delta. We find that the sediment loads have decreased progressively throughout the basin at multiple time scales. The sediment loads have decreased by ~96% and ~74% at the outlets of the upper basin and entire basin, respectively, in 2006–2017 compared to 1950–1985. The hydropower dams in the mainstem have become a dominant cause of the reduction, although downstream channel erosion causes moderate sediment load recovery. The basin-scale sediment connectivity has declined as the upper river is progressively dammed, the middle-lower river is leveed and river-lake interplay weakens. The middle-lower river has changed from a slight depositional to a severe erosional environment, from a sediment transport conduit to a new sediment source zone, and from a transport-limited to a supply-limited condition. These low-level sediment loads will likely persist in the future considering the cumulative dam trapping and depleted channel erosion. As a result, substantial hydro-morphological changes have occurred that affect the water supply, flood mitigation, and the aquatic ecosystem. The findings and lessons in this work can shed light on other large river systems subject to intensified human interference.Green Open Access added to TU Delft Institutional Repository ‘You share, we take care!’ – Taverne project https://www.openaccess.nl/en/you-share-we-take-care Otherwise as indicated in the copyright section: the publisher is the copyright holder of this work and the author uses the Dutch legislation to make this work public.Coastal Engineerin
High-sensitivity all-optical ultrafast spectroscopy of cold molecular beams
No full textMade available in DSpace on 2020-06-26T03:04:39Z (GMT). No. of bitstreams: 2
4647.pdf: 23569 bytes, checksum: cd99ccd5633b9301811b235c866f47cf (MD5)
license.txt: 4802 bytes, checksum: 58353f9dd6876860dd5221f3d7872a95 (MD5)
Previous issue date: 26Time-resolved nonlinear spectroscopy techniques, such as transient absorption spectroscopy and 2D spectroscopy, are routinely used to study ultrafast dynamics. Due to the limited sensitivity of these techniques, they are most commonly applied to optically thick samples, such as solid and liquid solutions. Using a frequency comb laser and optical cavities, we present a technique for performing ultrafast optical spectroscopy with high sensitivity, enabling work in dilute gas-phase molecules and clusters. Resonantly enhancing the probe pulses, we have demonstrated transient absorption measurements with a detection limit of \footnote{M. A. R. Reber, Y. Chen, T. K. Allison, Optica 3, 311 (2016)}. Resonantly enhancing the pump pulses allows us to produce a high excitation fraction at a high repetition rate, so that signals can be recorded from samples with OD as low as , or column densities molecules/cm. This sensitivity enables ultrafast spectroscopy in dilute molecular beams, where cold isolated designer molecules, radicals, and clusters can be produced that do not exist in solution.
In this talk, I will discuss the basic principles of cavity-enhanced ultrafast spectroscopy, initial one-color demonstration experiments, and the development of widely tunable cavity-enhanced ultrafast spectrometers\footnote{Y. Chen, M. C. Silfies et al., Appl. Phys. B. 125, 81 (2019); M. C. Silfies et al. arXiv:2001.10680 (2020)} operating in the ultraviolet, visible, and infrared. Finally, I will discuss progress on the development of cavity-enhanced 2DIR spectroscopy for the study of hydrogen-bonded clusters\footnote{T. K. Allison, J. Phys. B. 50, 044004 (2017)}
Rezension/Review/Mapitio: Yuning Shen. 2018. Transitivität und Verbvalenz im Swahili. [Transitivity and Verb Valence in Swahili/Uelekezi na Mpangilio wa Vitenzi katika Lugha ya Kiswahili]. Köln: Rüdiger Köppe, 104 pp., ISBN 978-3-89645-712-7.
No full textYuning Shen’s study deals with transitivity and verb valency in Kiswahili using a corpus-based approach. The author relates the methods used and results with previous studies dealing with the same topic, namely Whiteley (1968), Abdulaziz (1996) and Olejarnik (2005). He uses the meta-function-rank-matrix (MF/R) from Chinese to point out the fallacy of adopting such a matrix from one language and imposing it on another. Using the parts of speech annotation TreeTagger (Schmid 1994, 1995) to examine previous verb classifications, the author discusses the divergent use of concepts such as verb radicals, verb stems and verb bases as used in different theoretical approaches.Kitabu hiki cha Yuning Shen kinahusu uelekezi na mpangilio wa vitenzi katika lugha ya Kiswahili kwa kutumia mkabala wenye msingi wa kopasi ya kiisimu. Mwandishi anazihusisha mbinu zilizotumika na matokeo yake na kazi za utafiti zilizotangulia zilizoshughulikia mada hiyo yaani Whiteley (1968), Abdulaziz (1996), na Olejarnik (2005). Shen anatumia mkabala wa mpangilio wa viwango tofauti vya matumizi ya lugha (meta-function-rank-matrix, MF/R) iliyotumika kwa utafiti wa lugha ya Kichina kwa ajili ya kuonesha udhaifu wa mkabala huo kwani unaiga mfumo unaofanya kazi katika lugha moja na kuutumia kwa lugha nyingine bila kuzingatia kuwa lugha ni tofauti. Kwa kutumia njia ya matawi ya kutenganisha vipashio vya maneno (TreeTagger) iliyobuniwa na Schmid (1994, 1995) kwa lengo la kuchunguza njia za awali za kuainisha vitenzi, mwandishi anayajadili matumizi yanayotofautiana ya dhana mbalimbali kama vile viini vya vitenzi, mashina ya vitenzi, na mizizi ya vitenzi jinsi ambavyo zimetumika katika mikabala mbalimbali ya kinadharia
WIDELY TUNABLE UV/VIS CAVITY-ENHANCED ULTRAFAST SPECTROSCOPY AND EXCITED STATE PROTON TRANSFER IN JET-COOLED MOLECULES AND CLUSTERS
No full textUltrafast optical spectroscopy methods, such as transient absorption spectroscopy and 2D spectroscopy, are typically restricted to optically thick samples, such as solids and liquid solutions. We have developed a technique, Cavity-Enhanced Ultrafast Spectroscopy, to study dynamics in a molecular beam with femtosecond temporal resolution. By coupling frequency combs into optical cavities, we previously demonstrated ultrafast transient absorption measurements with a detection limit of OD .\footnote{M. A. R. Reber, Y. Chen, and T. K. Allison, Optica \textbf{3}, 311 (2016)} In this talk, I will present a widely tunable version of this spectrometer operating at probe wavelengths between 450 and 700 nm (8000 \wn) using only one set of dispersion managed cavity mirrors. The tunable probe comb is generated using an intracavity doubled optical parametric oscillator. I will discuss the technical details of this spectrometer and its application to the dynamics of excited state intramolecular proton transfer (ESIPT) in jet-cooled molecules and clusters
Cavity-enhanced ultrafast spectroscopy: ultrafast meets ultrasensitive
No full textUltrafast optical spectroscopy methods, such as transient absorption spectroscopy and 2D-spectroscopy, are widely used across many disciplines. However, these techniques are typically restricted to optically thick samples, such as solids and liquid solutions. Using a frequency comb laser and optical cavities, we present a new technique for performing ultrafast optical spectroscopy with high sensitivity, enabling work in dilute gas-phase molecular beams. Resonantly enhancing the probe pulses, we demonstrate transient absorption measurements with a detection limit of OD = (1 \times 10^{-9}/\sqrt{\mbox{Hz}}). Resonantly enhancing the pump pulses allows us to produce a high excitation fraction at high repetition-rate, so that signals can be recorded from samples with optical densities as low as OD , or column densities molecules/cm. To our knowledge, this represents a 5,000-fold improvement of the state-of-the-art.
\begin{wrapfigure}{r}{0pt}
\includegraphics[scale=0.5]{Fig4SideBySideForISMS.eps}
\caption{Noise performance of CE-TAS. (a), Transient absorption measurements taken with reduced gas flow and perpendicular polarizations. The red dots represent the average of 60 consecutive scans taken over a 1 hour period. Black curves are every 10th scan from the data set. Inset: Zoom-in around 0.8 ps delay. Error bars represent the uncertainty in the mean. (b), The green squares show the average of the Allan deviations obtained independently for each delay point. Error bars here are the standard deviation (not the uncertainty in the mean) of this ensemble, to represent the spread in the data. The blue diamond is the average of the error bars of (a), along with their standard deviation. The grey line has a slope of -1/2 on the log-log plot, the expected slope for white noise performance}
\end{wrapfigure}Made available in DSpace on 2017-01-26T21:40:23Z (GMT). No. of bitstreams: 3
license.txt: 4848 bytes, checksum: 96035ab3f5e1c23cc7138a224ce498bd (MD5)
1917.pdf: 49077 bytes, checksum: 788a521622a4f176e69f8f8e3389826b (MD5)
703539.pptx: 5882895 bytes, checksum: 4edb34fd614e433072eaacfde1b834f0 (MD5)
Previous issue date: 2016-06-2
Cavity enhanced ultrafast transient absorption spectroscopy
No full textUltrafast spectroscopy on gas phase systems is typically restricted to techniques involving photoionization, whereas solution phase experiments utilize the detection of light. At Stony Brook, we are developing new techniques for performing femtosecond time-resolved spectroscopy using frequency combs and high-finesse optical resonators. A large detection sensitivity enhancement over traditional methods enables the extension of all-optical ultrafast spectroscopies, such as broad-band transient absorption spectroscopy (TAS) and 2D spectroscopy, to dilute gas phase samples produced in molecular beams. Here, gas phase data can be directly compared to solution phase data. Initial demonstration experiments are focusing on the photodissociation of iodine in small neutral argon clusters, where cluster size strongly influences the effects solvent-caging and geminate recombination. I will discuss these initial results, our high power home-built Yb:fiber laser systems, and also extensions of the methods to the mid-IR to study the vibrational dynamics of hydrogen bonded clusters.Made available in DSpace on 2016-01-05T20:06:29Z (GMT). No. of bitstreams: 3
1116.pdf: 14059 bytes, checksum: 925238167e132329723ec248834b7e89 (MD5)
409572.pdf: 38402526 bytes, checksum: 674ed4e38aec887f631b7715197154e5 (MD5)
license.txt: 4813 bytes, checksum: 715c4321821a960fa1a1e91d2ac7ebce (MD5)
Previous issue date: 2
Enterprise architecture modeling for cybersecurity analysis in critical infrastructures — A systematic literature review
No full textAs digital landscapes become increasingly complex, safeguarding sensitive information and systems against cyber threats has become a paramount concern for organizations. This paper provides a comprehensive review of how enterprise architecture modeling is used in the context of cybersecurity assessment, particularly focusing on critical infrastructures. The use of enterprise architecture models for cybersecurity is motivated by the main purpose of enterprise architecture, namely to represent and manage business and IT assets and their interdependence. While enterprise architecture modeling originally served to assess Business/IT alignment, they are increasingly used to assess the cybersecurity of the enterprise. The research questions explored include the types of enterprise architecture models used for cybersecurity assessment, how security aspects are incorporated into these models, the theoretical frameworks and reference theories applied, the research methods used for evaluation, and the strengths and limitations of these models in supporting cybersecurity assessment. This review encompasses research papers published before 2024, focusing on high-quality research from peer-reviewed journals and reputable conferences, thereby providing a structured and comprehensive overview of the current state of research in this domain.CC BY-NC 4.0Corresponding author: Yuning JiangE-mail addresses: [email protected]</p
Recommended from our members
Studying chemical and biological systems using high-throughput sequencing: analytical challenges and solutions
No full textHigh-throughput sequencing (HTS) can identify unique DNA sequences and quantify their abundances from mixed DNA pools. HTS-based assays can profile complex biological or chemical systems with entities that can convert to unique DNA sequences. Computational models are also developed to analyze these HTS data at a larger scale. However, such data contain unique analytical challenges, including discrete counts, relative measurement, and small sample size. Careful assessments of these computational tools are required for robust interpretations of results.In this dissertation, we investigated the computational challenges, proposed and assess the solutions for two applications of HTS-based assays. In the first work, we proposed k-Seq, a kinetic assay to measure the activity of self-aminoacylation ribozymes (catalytic RNA). Characterizing the kinetics for different molecules in a heterogeneous pool is challenging as their abundance and activities can vary in several orders of magnitude. We explored different designs of experiments and identified critical factors affecting the estimation of kinetic coefficients in the pseudo-first-order kinetic model for these ribozymes. Using bootstrapping, we robustly quantified the uncertainty of estimation for individual sequences and determined the minimum sequencing counts required for reliable estimations. Combining the improved experimental design and new analytical tools, we robustly quantified the kinetics for 10^5 different ribozymes.In the second work, we constructed the correlation networks between microorganisms from metagenomic data and studied the structure of a human skin microbiome in patients with chronic wounds. We designed a variation of Gaussian graphical models to capture the direct correlations between the abundances of bacteria and viruses while accounting for the structure and limitations in the data. To minimize the discovery of false correlations from the small noisy dataset, we applied a two-step model selection to regularize the results. Lastly, we demonstrated the utility of the constructed correlation network in recovering the strong correlations between microbes, identifying potentially important microbes, and microbial clusters
- …
