148 research outputs found
Chinese medicine targets cellular autophagy against cardiovascular diseases: research progress and future prospects
Get PDFCardiovascular diseases (CVDs) pose a serious threat to human health and represent one of the leading causes of death worldwide. Cellular autophagy, an essential intracellular self-degradation and homeostasis maintenance mechanism, plays a pivotal role in the pathogenesis of cardiovascular diseases. Traditional Chinese Medicine (TCM), with its unique theoretical framework and therapeutic principles, has demonstrated remarkable efficacy in CVDs management, garnering increasing scientific attention. In recent years, growing research attention has focused on TCM's autophagy regulation for CVDs treatment. However, most studies remain limited to cellular and animal models, with insufficient clinical data and unclear specific metabolic pathways and targets. Therefore, it is imperative to (1) investigate autophagy mechanisms in depth (2), explore methods for autophagy balance, and (3) clarify drug interactions to establish a foundation for clinical applications. This article comprehensively summarizes relevant research findings, provides an in-depth discussion of TCM's mechanisms in autophagy regulation for CVDs treatment, reviews current research status, and outlines future development trends, aiming to offer valuable theoretical foundations and therapeutic strategies for clinical CVDs management
CALCULATION RESEARCH ON THE RESIDUAL COMPRESSIVE STRENGTH OF STITCHED COMPOSITE LAMINATES AFTER IMPACT DAMAGE
No full textStitched composite material not only suppresses delamination expansion, but also improves inter-laminar toughness and compressive characteristics after impact by introducing stitch in the thickness direction. Equivalent hole method simulates the initial damage of stitched plate. The finite element analysis method with damage evolution process based on threedimensional Hashin criterion with 3D solid element modelling laminates,3D bar element modelling stitch simulated the stitched composite laminates damage evolution effectively. The calculation results were in good agreement with the experimental data
Sublethal and hormesis effects of beta-cypermethrin on the biology, life table parameters and reproductive potential of soybean aphid Aphis glycines
No full textBeta-cypermethrin has long been recommended as an effective pesticide to control the soybean aphid, Aphis glycines Matsumura, a serious pest in soybean crops. Besides acute toxicity, it leads to changes in life history traits of A. glycines, notably its reproductive potential. This study has assessed the effects of five sublethal concentrations (0.625, 1.25, 2.5, 5 and 10 μg/L) of beta-cypermethrin on different life history traits of A. glycines. Exposure to these concentrations caused shorter oviposition period and reduced adult longevity. The strongest stimulatory effect on aphid reproduction was achieved when exposed to a higher sublethal beta-cypermethrin concentration (5 μg/L). Net reproduction rate (R 0 ), intrinsic rate of increase (r m ) and finite rate of increase (λ) were significantly higher than that of the control, increasing by 20.58, 4.89 and 2.06%, respectively. We found no significant difference in mean generation time (T) between the treatment of 5 μg/L beta-cypermethrin and the control. However, when the concentration increased to 10 μg/L, the reproduction behavior was restrained and the mean generation time (T) was shortened, resulting in significant decrease in R 0 and T by 16.58 and 3.83%, respectively. In conclusion, a sublethal concentration (5 μg/L) of beta-cypermethrin triggered the strongest hormesis on A.glycines, thus providing valuable knowledge on the sublethal effects of this insecticide on soybean aphids. Hormesis may be one of the mechanisms underlying pest resurgences, and better knowledge would enable a more effective use of insecticides in Integrated Pest Management programs
Goniurosaurus zhoui Zhou & Wang & Chen & Liang 2018, sp. nov.
No full textGoniurosaurus zhoui sp. nov. Holotype. An adult male (Voucher number: BL-RBZ-002) collected by Run-Bang Zhou on March 18th, 2017 from a typical karst area (at an altitude of 220-300 meters aboVe sea leVel) in the central area of Hainan Island, China; exact locality withheld; aVailable to qualified researchers upon request. Paratypes. Four paratypes, including two adult males (BL-RBZ-001, 007) and two adult females (BL-RBZ- 0 0 3, 008) collected by Run-Bang Zhou from the same locality as the holotype. BL-RBZ-001 was collected on NoVember 28th, 2015; BL-RBZ-003 on March 18th, 2017; BL-RBZ-007, and 0 0 8 on April 16th, 2017. Other standard collecting information (e.g., weather and coordinates) were recorded and kept in Bin Liang’s herpetological collection catalog. Diagnosis. Goniurosaurus zhoui sp. nov. differs from all other congeners by a combination of the following characters: moderate size, SVL (93.41–97.35 mm in adults); light purple-brown dorsal ground color of head, body and limbs in adults and mottled with irregularly shaped dark brown blotches; a posteriorly protracted nuchal loop present on nape, and four faint, purple-gray dorsal body bands with dark spots between the nuchal loop and the caudal constriction, bordered by wide dark bands anteriorly and posteriorly; blurred margins of these body bands and dark spots; dark tubercles in the dark spots within the light-colored body bands are always present; iris brown; eight nasal scales surrounding nares; one internasal; 49–62 eyelid fringe scales; upper eyelid scales similar in size with granular scales on the top of the head; absent of a row of slightly enlarged supraorbital tubercles; eight or nine supralabials, 7– 9 infralabials; 130–140 scales around midbody; 19–22 dorsal tubercle rows at midbody; 24–32 paraVertebral tubercles between limb insertions; dorsal body tubercles surrounded by 11 granular scales; 36–38 precloacal pores in males and pores absent in females; claws sheathed by four scales, two lateral scales long and curVed; two postcloacal tubercles. Description. Adult male with original tail (Table 1): SVL 93.41 mm; TaL 84.34 mm; AG 44.39 mm; SE 10.40 mm; EE 10.52 mm; HW 18.07 mm; HH 13.44 mm; HL 25.24 mm; head triangular, wider than neck, coVered with uniform granular scales interspersed with tubercles in the temporal and occipital regions; rostral wider than high, bordered laterally by first supralabial and prenasal, dorsolaterally by supranasal, and dorsally by one internasal, three granular scales bordering the internasal; external nares each surrounded by eight nasals; supralabials 9/9; eyelid fringe scales 49/54; preorbital scales 18/18; mental triangular, bordered laterally by first infralabial and posteriorly by three postmentals; postmentals bordered by fiVe gular scales; infralabials 8/9; uniform granular scales interspersed with conical tubercles on nape and dorsal surface of body; dorsal body tubercles surrounded by 11 granular scales; 19 dorsal tubercle rows at midbody; 27 paraVertebral tubercles between limb insertions; 139 scales around midbody; large Ventral scales grade abruptly into smaller granular scales (at the leVel of the precloacal pores) immediately before Vent; 36 precloacal pores in a continuous transVerse series extending on to the middle of the thighs; two enlarged postcloacal tubercles on each side of Vent; limbs relatiVely short and robust, hindlimbs slightly larger and more robust than forelimbs; deep axillary pockets present; digits kinked, claws sheathed by four scales; subdigital lamellae 9/9 under the first finger, 15/15 under the fourth finger, as well as 9/9 under the first toe, 20/20 under the fourth toe; the original tail long and thin, thickest at base, anteriorly with whorls, gradually narrowing to the tip; dorsal granular scales of tail flat, smooth, about 1.5-2.0 times the size of dorsal body scales, arranged in more or less transVerse rows; the first, fourth and eighth caudal whorls with nine, eight, and seVen scale rows, and seVen, four, and two tubercles in a transVerse row, respectiVely; dorsal caudal tubercles also surrounded by 11 dorsal caudals; midVentral caudals about six times the size of dorsal caudals. Coloration in life. Dorsal ground color of head, body and limbs light purple-brown and mottled with irregularly shaped dark brown blotches; iris brown; a posteriorly protracted purple-gray nuchal loop on nape, extending anteriorly to lower eyelids; four wide purple-gray body bands, three between limb insertions, and the last one on tail base; nuchal loop and body bands bordered anteriorly and posteriorly by wide dark bands; all dark brown spots and bands on dorsal surface margin-blurred; rostral purple-brown; infralabials and supralabials dull white without spots; Ventral surfaces of head, body and limbs white and immaculate; six immaculate white caudal bands edged anteriorly and posteriorly in solid black and incomplete Ventrally; a small white tip to the tail (Fig. 1B, Fig. 2 A-D, Fig. 4). Variation. All paratypes including the two females resemble the male holotype in oVerall morphology (see Table 1 for Variations in measurements, proportions, and scale counts). The PPs are present in males but absent in females. The female paratypes BL-RBZ-003 and BL-RBZ-008 haVe two granular scales bordering the internasals, fewer than males (three or four). MoreoVer, there are 130 and 133 scales around midbody in female paratypes BL- RBZ-003 and BL-RBZ-008, respectiVely, fewer than in males (139–140). The color pattern of adults is similar (Fig. 4). Comparisons. GiVen the collection locality of the new species, it is likely to be related to other species distributed in Hainan. Thus, morphometric comparison of the undescribed species was mainly conducted with species endemic to Hainan Island and G. lichtenfelderi from the nearby continent (although we reViewed the essential characters to distinguish it from other Goniurosaurus groups below). We also compared egg features of these taxa. Goniurosaurus zhoui sp. nov. lays two eggs per clutch, like its congeners (KratochVil & Frynta 2006). HoweVer, it has larger eggs (length: 22.56 mm, width: 13.15 mm, weight: 2.25 g, n=2; Fig. 1A) compared with the species noted aboVe (G. hainanensis: length: 15.97 mm, width: 11.97 mm, weight: 1.28 g, n=2; G. bawanglingensis: length: 19.52 mm, width: 10.42 mm, weight: 1.25 g, n=2; G. lichtenfelderi: length: 19.98 mm, width: 12.00 mm, weight: 1.57 g, n=8, at Day 1 fide KratochVil & Frynta 2006). Goniurosaurus G. lichtenfelderi G. zhoui G. hainanensis et al !" G. bawanglingenesis G. lichtenfelderi # et al ! % &’ () * ’ (+, G. zhoui(.! G. hainanensis (/! G. bawanglingenesis(00! G. lichtenfelderi (0/! 12 %12 % As to adult morphological traits, G. zhoui sp. nov. has a moderate body size, with adult SVL significantly longer than G. hainanensis (95.34 versus 80.93 mm, p<0.01, Table 2), but possibly shorter than G. bawanglingensis (holotype SVL = 104 mm) and other members of the G. luii group. MoreoVer, the TaL of the new species is also significantly longer than G. hainanensis (p<0.001, Table 2). The precloacal pores (PPs) are important traits that typically exist in male eublepharid geckos (Fairbairn et al. 2007). The number of PP Varies considerably among Goniurosaurus species and is a key trait for species discrimination. The new species has 36–38 PPs (Fig. 2D) — fewer than G. bawanglingensis (37–46, p<0.01), but more than G. hainanensis (24–31, p<0.001), G. lichtenfelderi (21–31, p<0.001) and other Goniurosaurus species (Table 2). Indeed, all Hainan Goniurosaurus as well as G. lichtenfelderi haVe a greater number of PPs than members of the other groups (members of the G. luii group exclusiVe of G. bawanglingensis haVe 16–29 PPs; members of the G. yingdeensis group haVe 9–13 PPs; species in the G. kuroiwae group haVe no PPs, Wang et al. 2014). This suggests that the species in Hainan Island may be closely related, although future molecular work is needed to elucidate the phylogenetic and biogeographic history of this genus. Scalation data also support the distinctiVeness of G. zhoui sp. nov. (Tables 1–2, Fig. 2), which has significantly fewer eyelid fringe scales (49–62) and more scales around midbody (130–140) than G. hainanensis and G. bawanglingensis (Table 2). MoreoVer, we found that the new species has fewer (11) granular scales surrounding dorsal tubercles than does G. hainanensis (11–15, p<0.05), and a smaller number of paraVertebral tubercles between limb insertions (24–32) than G. bawanglingensis (32–36, p<0.001). In addition, Goniurosaurus zhoui sp. nov. exhibits a pale purple-brown dorsal ground color in adults, which easily distinguishes it from G. hainanensis (Fig. 1 B-D) and G. lichtenfelderi, both of which haVe a dark purple-brown ground color, and from G. bawanglingensis which has immaculate dull yellow-gray color (Fig. 1 B-C, E-F). A posteriorly protracted nuchal loop on nape and four body bands in the new species are also different from the round nuchal loop and three bands in G. hainanensis and G. lichtenfelderi. The new species differs from the G. kuroiwae group in haVing a posteriorly protracted nuchal loop as opposed to being rounded posteriorly, haVing 36–38 precloacal pores in males (versus pores lacking), haVing deep axillary pockets rather than shallow pockets or no pockets, and haVing claws being sheathed by four scales, as opposed to being unsheathed. Goniurosaurus zhoui sp. nov. further differs from G. yingdeensis Wang, Yang & Cui, 2010 and G. zhelongi Wang, Jin, Li & Grismer, 2014 in haVing dark spots and dark tubercles within the light-colored body bands and in haVing more precloacal pores. Distribution and Natural history. Goniurosaurus zhoui sp. nov. is a nocturnal limestone-dwelling specialist, which inhabits a typical karst area with an eleVation of 220–300 meters in the central area of Hainan Island. Their habitat is surrounded by some hills 50–100 meters high, and coVered by moist tropical eVergreen broad-leaVed forests (Fig. 3). All specimens were collected between 21:00 and 02:00 on limestone walls (<1.5 meters aboVe the ground) or on the ground in the adjacent forest litter. The surface of the limestone has been eroded and formed some cracks and holes, which the lizards can use as refuge (Fig. 3). GraVid females were obserVed in the field in March and April, but not in September, indicating spring as the major breeding season for G. zhoui sp. nov. Etymology. Goniurosaurus zhoui sp. nov. is named after Mr. Hai-quan Zhou, the great-grandfather of the discoVerer, who was a landlord and a prestige patriarch in Xiwu Village, Hangzhou, Zhejiang ProVince, China. He was a wild animal enthusiast and he educated all his descendants to contribute to the wildlife conserVation. Additionally, since Goniurosaurus zhoui sp. nov. is the third eyelid gecko found in Hainan Island, this specific epithet also commemorates the Zhou Dynasty, the third dynasty in Chinese history. We propose the English name “Zhou’s Leopard Gecko”, and the Chinese name “Zhou Shi Jian Hu”.Published as part of Zhou, Run-Bang, Wang, Ning, Chen, Bei & Liang, Bin, 2018, Morphological evidence uncovers a new species of Goniurosaurus (Squamata: Eublepharidae) from the Hainan Island, China, pp. 281-291 in Zootaxa 4369 (2) on pages 283-288, DOI: 10.11646/zootaxa.4369.2.8, http://zenodo.org/record/113575
Cognition, Application and Discussion on Shaped Charge Hydraulic Smooth Blasting Technology
No full textIn the past, the main method of tunnel excavation in China was drilling and blasting, but the biggest shortcoming of the traditional drilling and blasting method is that it is easy to cause serious overexcavation and underexcavation. At the same time, the operation cycle time of this method is long, which leads to a serious waste of resources. Not only that, a large number of toxic gases and dust produced after blasting also do harm to the health of construction workers. So this is an urgent need for a new construction technology to solve this worldwide problem. In this situation, the leading experts in the field of tunnel, "The survey and design master of China" Shi Yuxin, Liu Pei, and well known expert in explosion field, yan-sheng ding, professor Chen Chengguang and Gu Yicheng, the experts group, cooperate with The Fifth Branch of China Railway 18th Bureau in northwest project management department, developed a new technology. This technology has passed the appraisal of scientific and technological achievements organized by Tianjin Science and Technology Commission, which is shaped hydraulic smooth blasting technology. The comprehensive evaluation of the technology is "international leading" level.This paper is mainly aimed at the drawbacks of drilling and blasting construction,combined with the author's cognition and discussion on the introduction of the new technology of cumulative hydraulic blasting and the practical application effect in the tunnel excavation process of the fourth company of China Railway 14th Bureau Group in the second division of the 9th bid section of Zhangjihuai Railway in Huainan Province
Semantic Interconnection Scheme for Industrial Wireless Sensor Networks and Industrial Internet with OPC UA Pub/Sub
No full textIn the Industry 4.0 era, with the continuous integration of industrial field systems and upper-layer facilities, interconnection between industrial wireless sensor networks (IWSNs) and industrial Internet networks is becoming increasingly pivotal. However, when deployed in real industrial scenarios, IWSNs are often connected to legacy control systems, through some wired industrial network protocols via gateways. Complex protocol translation is required in these gateways, and semantic interoperability is lacking between IWSNs and the industrial Internet. To fill this gap, our study focuses on realizing the interconnection and interoperability between an IWSN and the industrial Internet. The Open Platform Communications Unified Architecture (OPC UA) and joint publish/subscribe (pub/sub) communication between the two networks are used to achieve efficient transmission. Taking the Wireless Networks for Industrial Automation Process Automation (WIA-PA), a typical technology in IWSNs, as an example, we develop a communication architecture that adopts OPC UA as a communication bridge to integrate the WIA-PA network into the industrial Internet. A WIA-PA virtualization method for OPC UA pub/sub data sources is designed to solve the data mapping problem between WIA-PA and OPC UA. Then, the WIA-PA/OPC UA joint pub/sub transmission mechanism and the corresponding configuration mechanism are designed. Finally, a laboratory-level verification system is implemented to validate the proposed architecture, and the experimental results demonstrate its promising feasibility and capability
Detection of insecticide resistance in Bradysia odoriphaga Yang et Zhang (Diptera: Sciaridae) in China
No full textInternational audienceBradysia odoriphaga Yang et Zhang is a destructive insect pest of Chinese chives. To understand the current status of insecticide resistance of B. odoriphaga in China, the sensitivity variation of eight field populations to six commonly used insecticides, including chlorpyrifos, phoxim, imidacloprid, thiamethoxam, clothianidin and beta-cypermethrin were evaluated. The results showed that almost all the tested B. odoriphaga populations had developed moderate to high resistance to chlorpyrifos and phoxim. There were different resistance levels found in the eight field populations among the three neonicotinoids, imidacloprid, thiamethoxam and clothianidin. Imidacloprid was very effective against B. odoriphaga in most tested populations except those from Yangzhou (10.35-fold) and Tangshan (14.56-fold). While four populations kept susceptible to thiamethoxam, the other four populations showed decreased susceptibility or low resistance. To clothianidin, five populations displayed moderate resistance, two populations displayed low resistance, and one population exhibited susceptibility, respectively. All the tested populations were resistance to beta-cypermethrin, the highest resistance was found in the Tangshan population with a resistance ratio of 172.56-fold. The results of this study provided valuable information for choosing insecticides for control and integrated resistance management of B. odoriphaga
A palladium-catalyzed intramolecular carbonylative annulation reaction for the synthesis of 4,5-fused tricyclic 2-quinolones
No full textA concise and efficient synthetic route to 4,5-fused tricyclic 2-quinolones through the palladium-catalyzed carbonylative annulation of alkyne-tethered N-substituted o-iodoanilines has been developed. This reaction proceeds smoothly under mild reaction conditions and exhibits exceptional tolerance to a variety of functional groups. It has been successfully applied to the efficient synthesis of BI 224436, an HIV integrase inhibitor.National Natural Science Foundation of China [21372017, 21290183, 21572008]SCI(E)[email protected]
Seed-borne viral dsRNA elements in three cultivated Raphanus and Brassica plants suggest three cryptoviruses
Get PDFSince the 1970s, several dsRNA viruses, including radish yellow edge virus (RYEV), Raphanus sativus virus 1 (RsV1), Raphanus sativus virus 2 (RsV2) and Raphanus sativus virus 3 (RsV3) have been identified and reported as infecting radish. Here, in conjunction with a survey of seed-borne viruses in cultivated Brassica and Raphanus using the dsRNA diagnostic method, we discovered three novel cryptoviruses that infect Brassica and Raphanus: Raphanus sativus partitivirus 1 (RsPV1), which infects radish (Raphanus sativus); Sinapis alba cryptic virus 1 (SaCV1), which infects Sinapis alba; and Brassica rapa cryptic virus 1 (BrCV1), which infects Brassica rapa. The genomic organization of these cryptoviruses was analyzed and characterized. BrCV1 might represent the first plant partitivirus found in Gammapartitivirus. Additionally, the evolutionary relationships among all of the partitiviruses reported in Raphanus and Brassica were analyzed.The accepted manuscript in pdf format is listed with the files at the bottom of this page. The presentation of the authors' names and (or) special characters in the title of the manuscript may differ slightly between what is listed on this page and what is listed in the pdf file of the accepted manuscript; that in the pdf file of the accepted manuscript is what was submitted by the author
Experimental Study on the Impact Properties of Concrete Bridge Pier Reinforced with Stainless Steel Rebar
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