196,570 research outputs found
Chthamalus williamsi Chan & Cheang, 2015, sp. nov.
No full textChthamalus williamsi sp. nov. Figures 2–5 Material examined. Holotype. NMNS-006534-00001. Intertidal rocks (low shores, at the same tidal zone as Megabalanus volcano) at Shi-Ti-Ping, Hualien, Taiwan (23 ° 29.30 ’N, 121 ° 30.30 ’E, 12 May 2009). Paratype. NMNS-006534-00002. Cheng Gong, Taitung, Taiwan (23 °05.46’N, 121 ° 22.33 ’E, 0 2 Sep. 2008). Paratype. ASIZCR-000328. Cheng Gong, Taitung, Taiwan (23 °05.46’N, 121 ° 22.33 ’E, 0 2 Sep. 2008). Diagnosis. Shell conical; 6 plates, external surfaces white, smooth or with faint ribs; scutum equilateral triangular, tergal articular margin straight, external surface of scutum with horizontal striations; tergum triangular, scutal articular margin straight, spur blunt. Description. Shell small, about 3.0 mm basal diameter, conical; 6 plates (rostrum, carina, paired lateral and paired rostral-lateral; Fig. 2 A–D), externally white, surface smooth or with faint ribs, inner operculum pale orangecoloured; carina and rostrum with a pair of alae, carina short and wide, alae large; rostrum long and narrow, alae large; rostral-lateral triangular, interior surface with central mid rib, radii wide; lateral base wide, alae and radii present (Fig. 2 D); scutum white, triangular, tergal articular margin straight, perpendicular to basal margin, articular ridge not prominent, long with length extending 2 / 3 length of tergal articular margin, articular furrow narrow, deep, occludent margin inclined with fine teeth, scutal adductor scar oval, obvious, external surface of scutum with horizontal striations (Fig. 2 E, F); tergum white, triangular, scutal articular margin straight, extending down to spur, spur blunt, wide, about ½ width of basal margin, articular furrow wide, shallow, basal margin slightly concave (Fig. 2 E, F), 5 fine depressor crests at basal margin, external surface striated. Cirrus I without conical spines on dorsal surface, posterior ramus 5 -segmented, anterior ramus 6 -segmented (Fig. 3 A), both rami with serrulate setae, setae without basal guard (Fig. 4 A–C); cirrus II, anterior ramus 5 - segmented, posterior ramus 7 -segmented (Fig. 3 B), both rami with 2 types of serrulate setae, bidentate and plumose setae, all setae without basal guard (Figs 4 D–F, 5 K, L); cirrus III with rami equal length, anterior ramus 14 -segmented, posterior ramus 12 -segmented (Figs 3 C, 4 G), intermediate segments of cirrus III composed of 5 pairs of long serrulate setae (Fig. 4 H, I); cirrus IV with anterior ramus 14 -segmented, posterior ramus 15 - segmented (Fig. 3 D); cirrus V with anterior ramus 18 -segmented, posterior ramus 15 -segmented (Fig. 3 E), intermediate segments of both rami with 3 pairs of long serrulate setae and 2 pairs of shorter setae (Fig. 4 J); cirrus VI with anterior ramus 19 -segmented, posterior ramus 17 -segmented, intermediate segments of anterior and posterior rami composed of 3 pairs of long serrulate setae and 2 pairs of shorter setae (Fig. 4 K); penis long, slender, sparse setae along length, tip with dense bundle of setae (Fig. 5 I, J). Maxilla bilobed, serrulate setae on both lobes (Fig. 5 A, B); maxillule notched, 3 large setae above notch, 16 setae below notch (Fig. 5 C, D); mandible with 4 teeth, fourth bidentate, lower margin straight, with 14 setae, inferior angle with pair of large setae (Fig. 5 E, F); labrum concave, notch absent, dense setae at mid region of cutting margin, latter with numerous fine teeth (Fig. 5 G, H). Etymology. Chthamalus williamsi is named in honour of Prof. Gray A. Williams, Director of the Swire Institute of Marine Sciences, School of Biological Science, the University of Hong Kong, for life-long friendship and mentorship with the first author and for his contributions to the intertidal ecology in the South China Sea. Distribution. Chthamalus williamsi sp. nov. is common inside crevices of the mid shore of the intertidal zone, and on the shell surfaces of the barnacle Megabalanus volcano (Pilsbry, 1916) and M. tintinnabulum (Linnaeus, 1758) on low shores of the eastern waters of Taiwan. Chthamalus williamsi has not been identified previously from Taiwan as it is not easily spotted, due to its small size and low shore location. This species is absent from the N and NE coasts of Taiwan although intensive sampling was conducted (Fig. 1), suggesting its distribution may be associated with the Kuroshio Current. Molecular analysis. From both maximum likelihood and Bayesian inference trees of a COI region, Chthamalus williamsi shows a distinct divergence from C. challengeri, C. dalli, C. moro, C. malayensis and C. sinensis (sequence divergence> 0.13 K 2 P distance from all the Chthamalus species compared; Table 1). Chthamalus sinensis and C. neglectus grouped in the same clade, suggesting C. neglectus is a synonym of C. sinensis (see Liu & Ren 2007 for synonyms of C. neglectus and C. sinensis).Published as part of Chan, Benny K. K. & Cheang, Chi Chiu, 2015, A new Chthamalus (Crustacea: Cirripedia) from the challengeri subgroup on Taiwan rocky intertidal shores, pp. 547-558 in Zootaxa 4000 (5) on pages 549-550, DOI: 10.11646/zootaxa.4000.5.4, http://zenodo.org/record/23674
Lights and Shadows in Immuno-Oncology Drug Development.
No full textThe rapidly evolving landscape of immuno-oncology (IO) is redefining the treatment of a number of cancer types. IO treatments are becoming increasingly complex, with different types of drugs emerging beyond checkpoint inhibitors. However, many of the new drugs either do not progress from phase I-II clinical trials or even fail in late-phase trials. We have identified at least five areas in the development of promising IO treatments that should be redefined for more efficient designs and accelerated approvals. Here we review those critical aspects of IO drug development that could be optimized for more successful outcome rates in all cancer types. It is important to focus our efforts on the mechanisms of action, types of response and adverse events of these novel agents. The use of appropriate clinical trial designs with robust biomarkers of response and surrogate endpoints will undoubtedly facilitate the development and subsequent approval of these drugs. Further research is also needed to establish biomarker-driven strategies to select which patients may benefit from immunotherapy and identify potential mechanisms of resistance
Dr. Duane M. Jackson, Morehouse College, July 2011
No full textThis video is a conversation with Dr. Duane M. Jackson. Dr. Jackson talks about his paper, "Recall and the Serial Position Effect: The Role of Primacy and Recency on Accounting Students' Performance." Jackie Daniel, AUC Woodruff Library, is the interviewer
"Reflections on the subject of Emigration from Europe with a view to Settlement in the United States" By M. Carey.
No full text"Reflections on the subject of Emigration from Europe with a view to Settlement in the United States: containing bried sketches of the moral and political character of those states.
By M. Carey, member of the American philosophical, and of the American Antiquarian Society, and author of The Olive Branch, Cindiciae Hibernicae, essays on banking, on political economy, and on internal improvement.
To which are now added the English editor's comments on the subject; together with Important Advice to Emigrants, and Cautions Against Impositions Practiced in the Outports
Dispelling the Myths Behind First-author Citation Counts
No full textWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
Dr. Glendon Swarthout
No full textHosted by Roger M. Busfield, MSU Assistant Professor of Speech and Theater, Meet the Author is designed to introduce a general audience to a contemporary author and their work through in-depth interviews. This episode features a conversation between Dr. Glendon Swarthout, prolific author and English professor at MSU, and assistant professors Sam S. Baskett and Theodore B. Strandness
Simulation of thermal plant optimization and hydraulic aspects of thermal distribution loops for large campuses
No full textFollowing an introduction, the author describes Texas A&M University and its utilities system. After that, the author presents how to construct simulation models for chilled water and heating hot water distribution systems. The simulation model was used in a $2.3 million Ross Street chilled water pipe replacement project at Texas A&M University. A second project conducted at the University of Texas at San Antonio was used as an example to demonstrate how to identify and design an optimal distribution system by using a simulation model. The author found that the minor losses of these closed loop thermal distribution systems are significantly higher than potable water distribution systems. In the second part of the report, the author presents the latest development of software called the Plant Optimization Program, which can simulate cogeneration plant operation, estimate its operation cost and provide optimized operation suggestions. The author also developed detailed simulation models for a gas turbine and heat recovery steam generator and identified significant potential savings. Finally, the author also used a steam turbine as an example to present a multi-regression method on constructing simulation models by using basic statistics and optimization algorithms. This report presents a survey of the author??s working experience at the Energy Systems Laboratory (ESL) at Texas A&M University during the period of January 2002 through March 2004. The purpose of the above work was to allow the author to become familiar with the practice of engineering. The result is that the author knows how to complete a project from start to finish and understands how both technical and nontechnical aspects of a project need to be considered in order to ensure a quality deliverable and bring a project to successful completion. This report concludes that the objectives of the internship were successfully accomplished and that the requirements for the degree of Degree of Engineering have been satisfied
Changes in expression of genes representing key biologic processes after neoadjuvant chemotherapy in breast cancer, and prognostic implications in residual disease
No full textPurpose: The primary aim was to derive evidence for or against the clinical importance of several biologic processes in patients treated with neoadjuvant chemotherapy (NAC) by assessing expression of selected genes with prior implications in prognosis or treatment resistance. The secondary aim was to determine the prognostic impact in residual disease of the genes' expression. Experimental Design: Expression levels of 24 genes were quantified by NanoString nCounter on formalin-fixed paraffinembedded residual tumors from 126 patients treated with NAC and 56 paired presurgical biopsies. The paired t test was used for testing changes in gene expression, and Cox regression and penalized elastic-net Cox Regression for estimating HRs. Results: After NAC, 12 genes were significantly up- and 8 downregulated. Fourteen genes were significantly associated with time to recurrence in univariable analysis in residual disease. In a multivariable model, ACACB, CD3D, MKI67, and TOP2A added prognostic value independent of clinical ER-, PgR-, and HER2- status. In ER+/HER2- patients, ACACB, PAWR, and ERBB2 predicted outcome, whereas CD3D and PAWR were prognostic in ER-/HER2- patients. By use of elastic-net analysis, a 6-gene signature (ACACB, CD3D, DECORIN, ESR1, MKI67, PLAU) was identified adding prognostic value independent of ER, PgR, and HER2. Conclusions: Most of the tested genes were significantly enriched or depleted in response to NAC. Expression levels of genes representing proliferation, stromal activation, metabolism, apoptosis, stemcellness, immunologic response, and Ras-ERK activation predicted outcome in residual disease. Themultivariable gene models identified could, if validated, be used to identify patients needing additional post-neoadjuvant treatment to improve prognosis
Intern experience at CH���M Hill, Inc.: an internship report
No full textIncludes author's vita"Submitted to the College of Engineering of Texas A&M University in partial
fulfillment of the requirement for the degree of Doctor of Engineering."Includes bibliographical referencesA review of the author's internship experience with CH���M HILL, Inc.
during the period September 1975 through May 1976 is presented. During this nine month
internship the author worked as an Engineer II in the Industrial Processes discipline of this
large consulting engineering firm... The author's prime responsibility was as one of three
lead design engineers on the design of a large wastewater treatment facility for a pulp mill
in Hoquiam, Washington owned by ITT Rayonier Inc. The work generally consisted of the design
of individual treatment units and associated piping and pumping. The purpose of the project
was to provide wastewater treatment capabilities that would satisfy the effluent limitations
(standards) imposed upon the mill by the State of Washington Department of Ecology and the
U.S. Environmental Protection Agency. The author's assignment also entailed necessary
interaction with the project manager and other CH���M HILL design engineers and support staff
members, the client's representatives, and representatives of two other consulting engineering
firms working on the project. Thus, the internship position at CH���M HILL provided considerable
experience coordinating the author's work with the work of other engineers, guiding the design
and administrative efforts of a support staff, and interacting regularly with the client and
other consulting firms. This broad exposure to a variety of engineering and organizational
problems provided a valuable educational experience
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