196 research outputs found
Ovarian steroid cell tumor in pregnancy-a rare occurrence: Report of a case and review of the literature
No full textBackground: Steroid-cell tumors of the ovary are very rare, especially during pregnancy, and they must be distinguished from luteoma of pregnancy.
Case: An 18-year-old female, gravida 3, para 1-0-1-1, at 38 weeks' of gestation, had an adnexal mass that was discovered incidentally during a Caesarean section. The tumor was excised and her male infant was normal.
Results: Histologic workup revealed the tumor to be a steroid-cell tumor, which is exceedingly rare in pregnancy.
Conclusions: Ovarian steroid-cell tumors, which are malignant one-third of the time, are difficult to distinguish from luteoma of pregnancy.Peer reviewe
Gender and climate change framework for analysis, policy & action
No full text"This paper by Jyoti Parikh provides a framework to anlayse gender and climate change concerns keeping in view the strengths and vulnerability of poor ‐ women in particular. The author also provides policy recommendations for policies and actions.
The Neuropeptide VGF is Reduced in Human Bipolar Postmortem Brain and Contributes to Some of the Behavioral and Molecular Effects of Lithium
No full textRecent studies demonstrate that the neuropeptide VGF (non-acronymic) is regulated in the hippocampus by antidepressant therapies and animal models of depression and that acute VGF treatment has antidepressant-like activity in animal paradigms. However, the role of VGF in human psychiatric disorders is unknown. We now demonstrate using in situ hybridization that VGF is downregulated in bipolar disorder in the CA region of the hippocampus and Brodmann’s Area 9 (BA9) of the prefrontal cortex. The mechanism of VGF in relation to LiCl was explored. Both LiCl intraperitoneally (IP) and VGF intracerebroventricularly (ICV) reduced latency to drink in novelty-induced hypophagia and LiCl was not effective in VGF+/- mice suggesting that VGF may contribute to the effects of LiCl in this behavioral procedure that responds to chronic antidepressant treatment. VGF by intrahippocampal injection also had novel activity in an amphetamineinduced hyperlocomotion assay thus mimicking the actions of LiCl injected IP in a system that phenocopies manic-like behavior. Moreover, VGF+/- mice exhibited increased locomotion following amphetamine and did not respond to LiCl, suggesting that VGF is required for the effects of LiCl in curbing the response to amphetamine. Finally, VGF by ICV in vivo activated the same signaling pathways as LiCl and is necessary for the induction of MAPK and AKT by LiCl thus lending insight into the molecular mechanisms underlying the actions of VGF. The dysregulation of VGF in bipolar disorder as well as the behavioral effects of the neuropeptide similar to LiCl suggests that VGF may underlie the pathophysiology of bipolar disorder.Peer reviewe
Guillain–Barre syndrome following subclinical COVID-19 infection in a child
No full textThe entire world is coping up with the challenges imposed by COVID-19 pandemic caused by a novel coronavirus, which started from a single case in Wuhan city of China in November 2019. Its outcomes range from asymptomatic cases to most severe diseases like severe acute respiratory syndrome. Neurological manifestations have also been reported as an outcome of coronavirus infection and Guillain–Barre Syndrome (GBS) is one of them. In our present case, we describe the correlation of GBS with subclinical SARS-CoV-2 in a pediatric patient. The patient was successfully managed with intravenous immunoglobulin and physiotherapy. In the current pandemic, any case of GBS should be evaluated for recent or remote SARS-CoV-2 infection
Assessing the effect of exercise on dial-task cognitive impairment in patients with Parkinson's disease
No full textThis work was produced while the author was an undergraduate student in the Summer Research Institute of the Ronald E. McNair Post Baccalaureate Degree Achievement Program at Rutgers University
Examining mechanical properties of single acetaminophen crystal using nanoindentation methods
No full textThe pharmaceutical industry incurs substantial loss in revenue and consumer confidence with inefficient manufacturing practices. Large scale processing of organic compounds is challenging due to its sensitivity to environmental conditions and the unpredictable breakage behavior of tablets under applied stress. Tablet compaction and particle size reduction through milling induces variability in the end product. Variability in powder flow, stress induced transformation in polymorphic compounds, re-crystallization after compaction, and lack of content uniformity are some factors that translate into poor product quality. These challenges can be partially resolved by a better understanding of mechanical properties of crystalline pharmaceutical materials at single particle level. The endeavor of this study was to understand the breakage behavior of various planes of a single Acetaminophen crystal using nanoindentation instrumentation. The results of the study indicated that the Acetaminophen crystal is anisotropic with respect to hardness and Young’s modulus values. Analysis of the load-depth curve, discontinuities on the loading and unloading cycle were observed, as well as pop-in events during constant load intervals. Furthermore, the frequency of pop-in events on the loading depth curve was found to correlate with the elasticity of the planes in question. It was also apparent that the organic compound was sensitive to environmental conditions. Varying strain rates effects different planes of the same crystal and also in adhesion reflected sensitivity to environmental conditions. The exact mechanism by which the crystal deforms is still unknown. However it is theorized that it could be through partial dislocations and crack propagations.M.S.Includes bibliographical referencesby Hiral Parik
Awareness and Practices about Skin Care among Medical Students: A cross-sectional study
No full textIntroduction: Skin care is defined as practices that help in maintaining the structural and functional integrity of the skin. Routine skin care focuses on keeping it clean, balanced, protected and free from irritation. This can be achieved with a simple regimen including gentle cleansing, moisturizing and protecting the skin from UV rays.
Aim: To evaluate the awareness and practices regarding skin care among medical students.
Materials and Methods: This was a cross-sectional study involving medical students studying at a medical college in Western India. A questionnaire consisting of close-ended questions regarding skin care awareness and practices was used as study tool. Data was analyzed using the STATA14 software.
Results: The study group comprised of 300 participants of which 201 (67%) were females and the rest 99 (33%) were males. The age of participants ranged from 17 to 23 years. Ninety-three (31%) felt that ideally face should be washed twice in a day, while 153 (51%) students were having the awareness regarding makeup removal before sleep. The ideal sunscreen SPF was not known by 211 (70.3%) students while 47 (15.7%) knew that it should be 30-50. Awareness regarding physical exercise, yoga and meditation improving the skin health was seen in 201 (67%) and 235 (78.3%), respectively. Awareness regarding adequate sleep and healthy diet necessary for healthy skin was reported by 261 (87%) and 250 (83.3%) students, respectively. Total 129 (43%) students used Over-The-Counter (OTC) products or face wash to wash their face, 167 (55.7%) used some or other cosmetic products, 226 (75.3%) students didn't share their cosmetic products with others while 277 (92.3%) students didn't use sunscreen routinely.
Conclusion: Medical students need to be aware about skin care practices, so that they can educate the general public about its importance particularly in country like India where most of the general population is under the influence of advertisements in newspaper and television about routine skin care
Generalized Einstein’s Equations from Wald Entropy
No full textWe derive the gravitational equations of motion of general theories of gravity from thermodynamics applied to a local Rindler horizon through any point in spacetime. Specifically, for a given theory of gravity, we substitute the corresponding Wald entropy into the Clausius relation. Our approach works for all diffeomorphism-invariant theories of gravity in which the Lagrangian is a polynomial in the Riemann tensor
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